{"id":22545,"date":"2015-10-16T00:22:44","date_gmt":"2015-10-15T16:22:44","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=22545"},"modified":"2018-08-01T16:15:40","modified_gmt":"2018-08-01T08:15:40","slug":"%e3%80%90%e5%8c%96%e5%ad%b8%e6%87%89%e7%94%a8%e3%80%91%e5%90%91%e5%89%8d%e9%82%81%e9%80%b2%e7%9a%84%e6%a9%9f%e5%99%a8","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=22545","title":{"rendered":"\u3010\u5316\u5b78\u61c9\u7528\u3011\u5411\u524d\u9081\u9032\u7684\u6a5f\u5668"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u53d7\u5230\u751f\u7269\u7684\u555f\u767c\uff0c\u5316\u5b78\u5bb6\u5011\u5275\u9020\u51fa\u4e00\u7cfb\u5217\u7cbe\u5f69\u7684\u5206\u5b50\u5143\u4ef6\uff0c\u53ef\u505a\u70ba\u958b\u95dc\u3001\u99ac\u9054\u3001\u4ee5\u53ca\u68d8\u8f2a\uff0c\u73fe\u5728\u662f\u5c07\u5b83\u5011\u7528\u4f86\u505a\u4e00\u4e9b\u6709\u7528\u7684\u4e8b\u60c5\u7684\u6642\u5019\u4e86\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_22660\" aria-describedby=\"caption-attachment-22660\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-22660\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/05-Ball-milling-50.jpg\" alt=\"\u5716\u7247\u4f86\u6e90\uff1a\u81fa\u5927\u5316\u5b78\u7cfb\u90b1\u52dd\u8ce2\u6559\u6388\" width=\"650\" height=\"294\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/05-Ball-milling-50.jpg 720w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/05-Ball-milling-50-300x135.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/05-Ball-milling-50-600x272.jpg 600w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption id=\"caption-attachment-22660\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1a\u81fa\u5927\u5316\u5b78\u7cfb\u90b1\u52dd\u8ce2\u6559\u6388<\/figcaption><\/figure>\n<p style=\"text-align: left;\"><strong>\u4f5c\u8005\uff5c<\/strong> Mark Peplow<br \/>\n<strong>\u8b6f\u8005\uff5c<\/strong>\u00a0\u81fa\u5927\u5316\u5b78\u7cfb\u6559\u6388 \u8521\u860a\u660e<\/p>\n<p>\u6a5f\u5668\u4eba\u5728\u5b83\u7684\u8ecc\u9053\u4e0a\u7de9\u6b65\u79fb\u52d5\uff0c\u5b9a\u671f\u7684\u505c\u4e0b\u4f86\u4e26\u4f38\u51fa\u81c2\u8180\u5c0f\u5fc3\u7684\u62ff\u8d77\u4e00\u500b\u96f6\u4ef6\uff0c\u81c2\u8180\u5c07\u9019\u500b\u96f6\u4ef6\u9023\u63a5\u5230\u6a5f\u5668\u4eba\u80cc\u4e0a\u7684\u4e00\u500b\u7cbe\u5de7\u7684\u88dd\u7f6e\u4e0a\uff0c\u63a5\u8457\uff0c\u6a5f\u5668\u4eba\u5f80\u524d\u7e7c\u7e8c\u884c\u9032\u4e26\u91cd\u8907\u4e0a\u8ff0\u7684\u52d5\u4f5c<span style=\"color: #000000;\">\u00a0\u2013\u00a0<\/span>\u7cfb\u7d71\u5316\u7684\u5c07\u96f6\u4ef6\u5011\u6309\u7167\u8a2d\u8a08\u5716\u6a23\u6e96\u78ba\u7684\u7d44\u88dd\u8d77\u4f86\u3002<\/p>\n<p>\u9019\u53ef\u80fd\u662f\u4e00\u500b\u9ad8\u79d1\u6280\u5de5\u5ee0\u88e1\u7684\u4e00\u5e55\u60c5\u666f<span style=\"color: #000000;\">\u00a0\u2013\u00a0<\/span> \u53ea\u4e0d\u904e\u9019\u500b\u7d44\u88dd\u7dda\u624d\u50c5\u6709\u5e7e\u500b\u5948\u7c73\u7684\u9577\u5ea6\uff0c\u96f6\u4ef6\u5011\u662f\u4e00\u4e9b\u80fa\u57fa\u9178\uff0c\u7522\u54c1\u662f\u4e00\u500b\u5c0f\u7684\u80dc\u80bd\uff0c\u800c\u6a5f\u5668\u4eba\u5247\u662f\u82f1\u570b\u66fc\u5fb9\u65af\u7279\u5927\u5b78\u7684\u5316\u5b78\u5bb6 David Leigh \u6240\u5275\u9020\u7684\uff0c\u90a3\u662f\u6709\u53f2\u4ee5\u4f86\u6240\u88fd\u9020\u904e\u6700\u8907\u96dc\u7684\u5206\u5b50\u5c3a\u5ea6\u7684\u6a5f\u5668\u4e4b\u4e00\u3002<!--more--><\/p>\n<p>\u9019\u4e26\u975e\u4e00\u500b\u5bc2\u5bde\u7684\u8def\u7a0b\uff0cLeigh\u662f\u5c6c\u65bc\u73fe\u5728\u6b63\u5728\u6210\u9577\u7684\u4e00\u7fa4\u5206\u5b50\u5efa\u7bc9\u5e2b\u4e4b\u4e00\uff0c\u4ed6\u5011\u53d7\u5230\u555f\u767c\u800c\u4f01\u5716\u6a21\u64ec\u7d30\u80de\u4e2d\u767c\u73fe\u4e4b\u985e\u4f3c\u5206\u5b50\u6a5f\u5668\u7684\u751f\u7269\u5206\u5b50<span style=\"color: #000000;\">\u00a0\u2013\u00a0<\/span>\u81f4\u52d5\u86cb\u767d(kinesin)\uff0c\u5b83\u53ef\u4ee5\u5728\u7d30\u80de\u4e2d\u7684\u5fae\u5c0f\u8173\u67b6\u4e0a\u884c\u9032\uff1b\u6216\u6838\u91a3\u9ad4\uff0c\u65bc\u5176\u4e0a\u900f\u904e\u57fa\u56e0\u5bc6\u78bc\u7684\u8b80\u53d6\u4f86\u88fd\u9020\u86cb\u767d\u8cea\u3002\u5728\u904e\u53bb\u768425\u5e74\u4e2d\uff0c\u9019\u4e9b\u7814\u7a76\u5de5\u4f5c\u8005\u8a2d\u8a08\u4e86\u4e00\u7cfb\u5217\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u958b\u95dc\u3001\u68d8\u8f2a(\u9632\u5012\u8f49)\u3001\u99ac\u9054\u3001\u687f\u5b50\u3001\u74b0\u3001\u87ba\u65cb\u69f3\u3001\u4ee5\u53ca\u66f4\u591a\u7684\uff0d\u5206\u5b50\u6a5f\u68b0\u88dd\u7f6e\uff0c\u597d\u4f3c\u5948\u7c73\u5c3a\u5ea6\u7684\u6a02\u9ad8\u7a4d\u6728\u822c\u80fd\u7d44\u88dd\u8d77\u4f86\u3002\u7531\u65bc\u5206\u6790\u5316\u5b78\u5de5\u5177\u7684\u9032\u6b65\uff0c\u4ee5\u53ca\u70ba\u4e86\u5408\u6210\u8907\u96dc\u7684\u6709\u6a5f\u5316\u5b78\u5206\u5b50\u6240\u7814\u767c\u7684\u8a31\u591a\u5316\u5b78\u53cd\u61c9\uff0c\u4f7f\u5f97\u9019\u500b\u9818\u57df\u7684\u767c\u5c55\u6b63\u5728\u52a0\u901f\u4e2d\u3002<\/p>\n<p>\u73fe\u5728\u9019\u500b\u9818\u57df\u5df2\u5230\u4e86\u4e00\u500b\u8f49\u6369\u9ede\uff0c\u8377\u862d\u683c\u7f85\u5be7\u6839\u5927\u5b78(Groningen University)\u7684\u5316\u5b78\u5bb6 Ben Feringa \u8aaa\u300c\u6211\u5011\u5df2\u7d93\u505a\u51fa\u4e8650\u523060\u591a\u500b\u4e0d\u540c\u7684\u99ac\u9054\uff0c\u4f46\u73fe\u5728\u88fd\u9020\u66f4\u591a\u7684\u99ac\u9054\u5df2\u7d93\u4e0d\u82e5\u5982\u4f55\u771f\u6b63\u904b\u7528\u5b83\u5011\u90a3\u9ebc\u5438\u5f15\u6211\u4e86\u3002\u300d<\/p>\n<p>\u4eca\u5e74\u4e94\u6708(2015\u5e74)\uff0c\u5728\u4e00\u500b\u6975\u5177\u5f71\u97ff\u529b\u7684\u7f8e\u570b\u6208\u767b\u6703\u8b70(Gordon conferences)\u4e2d\uff0c\u4e0a\u8ff0\u7684\u8ad6\u9ede\u5df2\u7d93\u6e05\u695a\u7684\u88ab\u807d\u5230\u3002\u9019\u662f\u7b2c\u4e00\u6b21\u7684\u5728\u6b64\u6703\u8b70\u4e2d\u6709\u4e00\u500b\u7d44\u7fa4\u805a\u7126\u5728\u5206\u5b50\u6a5f\u5668\u4ee5\u53ca\u5176\u904b\u7528\u7684\u8ab2\u984c\u4e0a\uff0c\u8a72\u6703\u8b70\u7684\u4e3b\u8fa6\u8005\uff0c\u4ee5\u8272\u5217\u96f7\u970d\u6c83\u7279(Rehovot)\u7684\u9b4f\u8328\u66fc\u79d1\u5b78\u7814\u7a76\u6240(Weizmann Institute of Science)\u7684\u5316\u5b78\u5bb6 Rafal Klajn \u8a8d\u70ba\u9019\u662f\u6975\u70ba\u660e\u986f\u7684\u5fb5\u5146\uff0c\u5ba3\u544a\u9019\u500b\u9818\u57df\u7684\u6642\u4ee3\u5df2\u7d93\u5230\u4f86\u3002Leigh \u6307\u51fa\u300c\u5728\u5341\u4e94\u5e74\u5167\uff0c\u6211\u8a8d\u70ba\u5b83\u5c07\u6210\u70ba\u5316\u5b78\u4ee5\u53ca\u6750\u6599\u8a2d\u8a08\u4e2d\u7684\u4e00\u500b\u6838\u5fc3\u90e8\u5206\u3002\u300d<\/p>\n<p>\u8981\u5230\u9054\u90a3\u500b\u968e\u6bb5\u5c07\u4e0d\u5bb9\u6613\uff0c\u7814\u7a76\u4eba\u54e1\u9700\u8981\u5b78\u7fd2\u5982\u4f55\u8b93\u4e0a\u5104\u7684\u5206\u5b50\u6a5f\u5668\u5354\u540c\u7684\u904b\u4f5c\u800c\u7522\u751f\u53ef\u91cf\u5ea6\u7684\u5de8\u89c0\u73fe\u8c61\uff0c\u4f8b\u5982\u6539\u8b8a\u4e00\u500b\u6750\u6599\u7684\u5f62\u72c0\u800c\u8b93\u5b83\u5982\u540c\u4e00\u500b\u4eba\u5de5\u808c\u8089\u822c\u904b\u4f5c\u3002\u4ed6\u5011\u4e5f\u9700\u8981\u8b93\u9019\u4e9b\u6a5f\u5668\u6613\u65bc\u63a7\u5236\uff0c\u4e26\u78ba\u4fdd\u5b83\u5011\u80fd\u57f7\u884c\u7121\u6578\u6b21\u7684\u904b\u4f5c\u800c\u7121\u640d\u58de\u3002<\/p>\n<p>\u9019\u662f\u70ba\u4f55\u8a31\u591a\u9019\u500b\u9818\u57df\u7684\u5de5\u4f5c\u8005\u4e26\u4e0d\u9810\u671f\u521d\u671f\u7684\u904b\u7528\u80fd\u6d89\u53ca\u8907\u96dc\u7684\u88dd\u7f6e\uff0c\u4e0d\u904e\u4ed6\u5011\u9810\u6e2c\u90a3\u4e9b\u57fa\u790e\u7684\u5206\u5b50\u6a5f\u5668\u4e4b\u96f6\u4ef6\u5c07\u53ef\u904b\u7528\u5728\u5404\u7a2e\u4e0d\u540c\u7684\u79d1\u5b78\u9818\u57df\u4e2d\uff1a\u50cf\u662f\u5149\u555f\u52d5\u7684\u958b\u95dc\u7528\u4f86\u91cb\u653e\u6a19\u9776\u85e5\u7269\uff1b\u6216\u88fd\u6210\u80fd\u5132\u5b58\u80fd\u91cf\u6216\u80fd\u547c\u61c9\u5149\u7dda\u800c\u81a8\u8139\u6536\u7e2e\u7684\u8070\u660e\u6750\u6599\u3002Klajn \u8a8d\u70ba\uff0c\u90a3\u610f\u5473\u8457\u5206\u5b50\u5efa\u7bc9\u5e2b\u5011\u9700\u8981\u806f\u7e6b\u90a3\u4e9b\u80fd\u5f9e\u9019\u4e9b\u5206\u5b50\u6a5f\u5668\u7684\u96f6\u4ef6\u5f97\u5230\u5e6b\u52a9\u7684\u7814\u7a76\u5de5\u4f5c\u8005\uff1a\u300c\u6211\u5011\u9700\u8981\u8aaa\u670d\u4ed6\u5011\u9019\u4e9b\u5206\u5b50\u7684\u78ba\u662f\u5f88\u7cbe\u5f69\u7684\u3002\u300d<\/p>\n<p><strong>\u68ad\u5177\u7684\u555f\u7528<br \/>\n<\/strong>\u56de\u6714\u8a31\u591a\u73fe\u4eca\u7684\u5206\u5b50\u6a5f\u5668\u4e4b\u6e90\u982d\uff0c\u90a3\u662f 1991\u5e74\u7684\u4e00\u4f4d\u5316\u5b78\u5bb6 Fraser Stoddart (\u73fe\u5728\u7f8e\u570b\u897f\u5317\u5927\u5b78)\u6240\u88fd\u9020\u7684\u4e00\u500b\u76f8\u7576\u7c21\u55ae\u7684\u88dd\u7f6e\uff0c\u8a72\u88dd\u7f6e\u88ab\u7a31\u70ba\u8f2a\u70f7(rotaxane)\uff0c\u65bc\u5176\u4e2d\uff0c\u4e00\u500b\u74b0\u72c0\u7684\u5206\u5b50\u5957\u5728\u4e00\u500b\u300c\u8ef8\u300d\u4e0a\uff0c\u90a3\u662f\u4e00\u500b\u76f4\u7dda\u578b\u7684\u5206\u5b50\uff0c\u5169\u7aef\u5404\u88dd\u6709\u4e00\u500b\u5de8\u5927\u7684\u585e\u5b50\u4f7f\u5f97\u74b0\u4e0d\u6703\u812b\u843d\u3002\u5728\u9019\u500b\u7279\u6b8a\u7684\u8ef8\u4e0a\uff0c\u5206\u5728\u5169\u908a\uff0c\u6709\u5169\u500b\u5316\u5b78\u5b98\u80fd\u57fa\u5718\uff0c\u4e8c\u8005\u7686\u80fd\u8207\u74b0\u72c0\u7684\u5206\u5b50\u7d50\u5408(\u5716\u4e00)\u3002Stoddart \u767c\u73fe\u90a3\u500b\u74b0\u53ef\u4ee5\u5728\u9019\u5169\u500b\u4f4d\u7f6e\u4e0a\u4f86\u56de\u8df3\u52d5\uff0c\u662f\u800c\u88fd\u9020\u51fa\u7b2c\u4e00\u500b\u5206\u5b50\u68ad(molecular shuttle)\u3002<\/p>\n<p>\u5230\u4e86 1994 \u5e74\uff0cStoddart \u5c07\u5176\u8a2d\u8a08\u505a\u4e86\u6539\u9032\uff0c\u8ef8\u4e0a\u9762\u5177\u6709\u5169\u500b\u4e0d\u540c\u7684\u7d50\u5408\u4f4d\u7f6e\uff0c\u5206\u5b50\u68ad\u5b58\u5728\u65bc\u6eb6\u6db2\u4e2d\uff0c\u7576\u6539\u8b8a\u6eb6\u6db2\u7684\u9178\u5ea6\u6642\u5c31\u53ef\u5f37\u8feb\u74b0\u5f9e\u4e00\u500b\u4f4d\u7f6e\u8df3\u5230\u53e6\u4e00\u500b\u4f4d\u7f6e\uff0c\u9019\u5c31\u8b93\u6b64\u5206\u5b50\u68ad\u8b8a\u6210\u70ba\u4e00\u500b\u53ef\u4ee5\u53cd\u8986\u5207\u63db\u7684\u958b\u95dc\u3002\u985e\u4f3c\u7684\u5206\u5b50\u958b\u95dc\u6709\u4e00\u5929\u53ef\u80fd\u88ab\u7528\u505a\u611f\u61c9\u5668\uff0c\u80fd\u5075\u6e2c\u71b1\u3001\u5149\u3001\u6216\u7279\u5b9a\u7684\u5316\u5b78\u54c1\uff0c\u53c8\u6216\u53ef\u7528\u4f86\u63a7\u5236\u4e00\u500b\u5948\u7c73\u5bb9\u5668\uff0c\u5728\u5bb9\u5668\u5230\u9054\u4eba\u9ad4\u5167\u6b63\u78ba\u7684\u4f4d\u7f6e\u4ee5\u53ca\u6b63\u78ba\u7684\u6642\u9593\u9ede\u6253\u958b\u8259\u9580\uff0c\u5c07\u5316\u5b78\u85e5\u7269\u5206\u5b50\u7684\u8ca8\u7269\u9001\u51fa\u3002<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-22546\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/01.png\" alt=\"01\" width=\"642\" height=\"133\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/01.png 642w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/01-300x62.png 300w\" sizes=\"(max-width: 642px) 100vw, 642px\" \/><strong>\u5716\u4e00\u00a0 \u5728\u8f2a\u70f7\u6eb6\u6db2\u4e2d\u5f15\u5165\u5916\u52a0\u523a\u6fc0(\u5982\u9178\u5ea6\u7684\u6539\u8b8a)\uff0c\u53ef\u9a45\u4f7f\u5167\u9396\u5927\u74b0\u5f9e\u85cd\u8272\u7684\u8fa8\u8b58\u4e2d\u5fc3\u79fb\u52d5\u5230\u7da0\u8272\u7684\u8fa8\u8b58\u4e2d\u5fc3\u4e0a\u3002\u800c\u79fb\u9664\u6b64\u5916\u52a0\u523a\u6fc0\u5f8c\uff0c\u5927\u74b0\u53c8\u6703\u56de\u5230\u539f\u5148\u570d\u7e5e\u85cd\u8272\u8fa8\u8b58\u4e2d\u5fc3\u7684\u72c0\u614b\u3002\u5169\u7a2e\u72c0\u614b\u53ef\u53d7\u64cd\u63a7\u7684\u76f8\u4e92\u8f49\u63db\uff0c\u597d\u4f3c\u4e00\u500b\u958b\u95dc\u88dd\u7f6e\u4e00\u822c\u3002(\u672c\u5716\u7531\u53f0\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u90b1\u52dd\u8ce2\u6559\u6388\u63d0\u4f9b)<\/strong><\/p>\n<p>Stoddart \u7684\u6a5f\u5668\u5c55\u73fe\u51fa\u7684\u5169\u7a2e\u6027\u8cea\uff0c\u5728\u4e4b\u5f8c\u6240\u767c\u5c55\u51fa\u7684\u5206\u5b50\u6a5f\u5668\u7576\u4e2d\u4e0d\u65b7\u51fa\u73fe\u3002\u9996\u5148\uff0c\u74b0\u8207\u8ef8\u5728\u7d50\u5408\u8655\u7684\u9023\u7d50\uff0c\u4e26\u975e\u539f\u5b50\u4e4b\u9593\u7d50\u5408\u5f62\u6210\u5206\u5b50\u7684\u90a3\u7a2e\u5f37\u7684\u5171\u50f9\u9375\uff0c\u76f8\u53cd\u7684\uff0c\u90a3\u662f\u900f\u904e\u524d\u8ff0\u7684\u5169\u500b\u90e8\u5206\u6240\u5177\u6709\u7684\u90e8\u5206\u96fb\u8377\u4e4b\u9593\u7684\u5fae\u5f31\u975c\u96fb\u5f15\u529b\u4f86\u7dad\u7e6b\uff0c\u9019\u4f7f\u5f97\u76f8\u4e92\u7684\u9023\u7d50\u5bb9\u6613\u751f\u6210\u4f46\u4e5f\u6613\u7834\u58de\uff0c\u5c31\u597d\u50cf\u662f\u5169\u80a1DNA \u4e4b\u9593\u900f\u904e\u6c2b\u9375\u5f62\u6210\u7684\u62c9\u934a\u4e00\u822c\uff0c\u53ef\u8f15\u6613\u7684\u95dc\u4e0a\u6216\u6253\u958b\u3002\u5176\u6b21\uff0c\u68ad\u5b50\u4e0d\u9700\u8981\u5916\u90e8\u7684\u80fd\u91cf\u4f86\u5c07\u4e4b\u62c9\u4f86\u62c9\u53bb\uff0c\u5b83\u50c5\u50c5\u662f\u900f\u904e\u5728\u6eb6\u6db2\u4e2d\u8207\u5176\u5b83\u5206\u5b50\u7684\u78b0\u649e\u4f86\u63a8\u52d5\uff0c\u9019\u7a2e\u649e\u64ca\u7684\u884c\u70ba\u7a31\u70ba\u5e03\u6717\u904b\u52d5(Brownian motion)\u3002<\/p>\n<p>\u8a31\u591a\u5176\u5b83\u7684\u958b\u95dc\u5f88\u5feb\u7684\u767c\u5c55\u4e86\u51fa\u4f86\uff0c\u6709\u4e9b\u662f\u900f\u904e\u5149\u6216\u662f\u6eab\u5ea6\u7684\u6539\u8b8a\u4f86\u63a7\u5236\uff0c\u53e6\u6709\u4e9b\u662f\u900f\u904e\u8207\u6eb6\u6db2\u4e2d\u7279\u5b9a\u7684\u96e2\u5b50\u6216\u5206\u5b50\u7d50\u5408\u4f86\u904b\u4f5c\uff0c\u5f88\u50cf\u662f\u7d30\u80de\u819c\u4e0a\u96e2\u5b50\u901a\u9053\u7684\u6a5f\u5236\uff0c\u900f\u904e\u5316\u5b78\u7684\u8a0a\u865f\u4f86\u958b\u555f\u6216\u95dc\u9589\u3002<\/p>\n<p>\u4e0d\u904e Stoddart \u53c8\u5c07\u4ed6\u7684\u7814\u7a76\u5e36\u5f80\u4e86\u53e6\u4e00\u500b\u65b9\u5411\uff0c\u4ed6\u8207\u5728\u7f8e\u570b\u52a0\u5dde\u7406\u5de5\u5b78\u9662\u7684 James Heath \u5408\u4f5c\uff0c\u7528\u4e0a\u767e\u842c\u500b\u7684\u8f2a\u70f7\u88fd\u6210\u4e00\u500b\u8a18\u61b6\u9ad4\uff0c\u90a3\u4e9b\u8f2a\u70f7\u593e\u5728\u77fd\u8207\u9226\u96fb\u6975\u4e4b\u9593\uff0c\u900f\u904e\u5169\u500b\u72c0\u614b\u4e4b\u9593\u7684\u5207\u63db\u4f86\u8a18\u61b6\u6578\u64da\uff0c\u9019\u500b\u5206\u5b50\u7b97\u76e4\u7d04\u517713 \u5fae\u7c73( <span class='MathJax_Preview'><img src='https:\/\/case.ntu.edu.tw\/blog\/wp-content\/plugins\/latex\/cache\/tex_dbed30b87205a65397b356aa3d6a40e3.gif' style='vertical-align: middle; border: none; padding-bottom:2px;' class='tex' alt=\"\" \/><\/span><script type='math\/tex'><\/script> m)\u7684\u9577\u5bec\uff0c\u542b\u6709 160,000 \u4f4d\u5143\uff0c\u6bcf\u4e00\u500b\u4f4d\u5143\u662f\u7531\u6578\u767e\u500b\u8f2a\u70f7\u6240\u69cb\u6210 \u2013 \u5176\u5bc6\u5ea6\u5927\u7d04\u662f\u6bcf\u5e73\u65b9\u516c\u5206100 GB (gigabits\uff0c\u5341\u5104\u4f4d\u5143)\uff0c\u9019\u8207\u73fe\u4eca\u5546\u696d\u4e0a\u6700\u597d\u7684\u786c\u789f\u53ef\u4ee5\u76f8\u63d0\u4e26\u8ad6\u3002<\/p>\n<p>\u7528\u4e86\u4e8c\u5341\u56db\u500b\u8868\u73fe\u6700\u597d\u7684\u4f4d\u5143\uff0cStoddart \u5be6\u9a57\u5c0f\u7d44\u4eba\u54e1\u5c55\u793a\u53ef\u5c07 \u300cCIT\u300d \u4e09\u500b\u5b57\u6bcd(\u4ee3\u8868\u52a0\u5dde\u7406\u5de5\u5b78\u9662)\u5132\u5b58\u548c\u53d6\u51fa\uff0c\u53ea\u4e0d\u904e\u9019\u4e9b\u958b\u95dc\u4e26\u4e0d\u5805\u56fa\uff0c\u901a\u5e38\u4f7f\u7528\u4e0d\u5230\u4e00\u767e\u6b21\u5c31\u6703\u58de\u6389\u3002\u4e00\u500b\u6709\u6f5b\u529b\u7684\u89e3\u6c7a\u65b9\u6848\u662f\u5c07\u5b83\u5011\u653e\u5165\u4e00\u7a2e\u7a31\u70ba\u91d1\u5c6c\u6709\u6a5f\u9aa8\u67b6(MOF, metal-organic frameworks)\u7576\u4e2d\uff0cMOF\u662f\u5805\u56fa\u800c\u5177\u6709\u5b54\u6d1e\u7684\u6676\u9ad4\uff0c\u5b83\u80fd\u4fdd\u8b77\u958b\u95dc\uff0c\u4e26\u5c07\u958b\u95dc\u6709\u79e9\u5e8f\u7684\u5b89\u6392\u6210\u4e00\u500b\u4e09\u5ea6\u7a7a\u9593\u7684\u9663\u5217\u3002<\/p>\n<p>\u4eca\u5e74\u521d\uff0c\u5728\u52a0\u62ff\u5927\u6eab\u838e\u5927\u5b78(University of Winsor)\u7684Robert Schurko\u8207Stephen Loeb\uff0c\u5c55\u793a\u4ed6\u5011\u80fd\u5728\u6bcf\u4e00\u7acb\u65b9\u516c\u5206\u7684MOF \u7576\u4e2d\u5c07\u7d04  <span class='MathJax_Preview'><img src='https:\/\/case.ntu.edu.tw\/blog\/wp-content\/plugins\/latex\/cache\/tex_525e856d7b1b982f61bdae72258b79b1.gif' style='vertical-align: middle; border: none; padding-bottom:2px;' class='tex' alt=\"\" \/><\/span><script type='math\/tex'><\/script>  \u500b\u5206\u5b50\u68ad\u88dd\u5165\uff1b\u800c\u4e0a\u500b\u6708Stoddart \u516c\u4f48\u4e86\u53e6\u4e00\u7a2e\u5167\u542b\u53ef\u958b\u95dc\u578b\u8f2a\u70f7\u7684 MOF\uff0c\u88dd\u5728\u4e00\u500b\u96fb\u6975\u4e0a\uff0c\u800c\u5176\u4e2d\u7684\u8f2a\u70f7\u53ef\u900f\u904e\u96fb\u58d3\u7684\u6539\u8b8a\u4e00\u8d77\u5207\u63db\u958b\u95dc\u3002<\/p>\n<p>\u9019\u4e9bMOF\u7814\u7a76\u5de5\u4f5c\u8005\uff0c\u5e0c\u671b\u9019\u7a2e\u4e09\u7dad\u56fa\u9ad4\u652f\u67b6\u80fd\u6bd4\u50b3\u7d71\u77fd\u7684\u96fb\u6676\u9ad4\u63d0\u4f9b\u66f4\u9ad8\u7684\u5bc6\u5ea6\uff0c\u800c\u4e14\u80fd\u8b93\u9019\u4e9b\u5206\u5b50\u8f03\u6613\u63a7\u5236\uff0c\u6700\u7d42\u5177\u6709\u5927\u91cf\u6578\u64da\u5132\u5b58\u7684\u6f5b\u529b\uff0cLoeb\u8aaa\u300c\u7528\u79d1\u5e7b\u5c0f\u8aaa\u7684\u65b9\u5f0f\u4f86\u60f3\uff0c\u8981\u505a\u5230\u8b93\u4e00\u500b\u5206\u5b50\u4f86\u4f5c\u70ba\u4e00\u500b\u4f4d\u5143\u300d\uff0c\u4e0d\u904e\u4ed6\u89ba\u5f97\u8f03\u5be6\u969b\u7684\u4f86\u770b\uff0c\u4e00\u5c0f\u7c92\u5167\u542b\u6578\u767e\u500b\u958b\u95dc\u7684MOF\uff0c\u53ef\u7528\u4f5c\u4e00\u500b\u4f4d\u5143\uff0c\u53ea\u8981\u90a3\u7c92\u4e2d\u5927\u90e8\u5206\u7684\u958b\u95dc\u90fd\u904b\u4f5c\u6b63\u5e38\uff0c\u5b83\u5011\u5c07\u53ef\u96c6\u9ad4\u6210\u70ba\u53ef\u4fe1\u8cf4\u7684\u6578\u78bc\u3002<\/p>\n<p>\u53e6\u6709\u5176\u4ed6\u7684\u7814\u7a76\u8005\u7528\u8f2a\u70f7\u4f5c\u70ba\u53ef\u5207\u63db\u7684\u50ac\u5316\u5291\u3002\u57282012\u5e74\uff0cLeigh \u5831\u5c0e\u4e86\u4e00\u500b\u7cfb\u7d71\uff0c\u5728\u5176\u8f2a\u70f7\u7684\u8ef8\u4e0a\u6709\u4e00\u500b\u6c2e\u539f\u5b50\uff0c\u901a\u5e38\u5b83\u662f\u8207\u74b0\u7d50\u5408\u7684\uff0c\u7576\u52a0\u5165\u9178\uff0c\u74b0\u5c31\u6703\u79fb\u5230\u4e00\u908a\u53bb\u800c\u5c07\u6c2e\u539f\u5b50\u66b4\u9732\u51fa\u4f86\u4ee5\u50ac\u5316\u4e00\u500b\u5e38\u898b\u7684\u5316\u5b78\u53cd\u61c9\u3002\u66f4\u9032\u4e00\u6b65\u7684\uff0c\u53bb\u5e74\u5341\u4e00\u6708Leigh\u767c\u8868\u4e86\u4e00\u500b\u8f2a\u70f7\u7684\u7cfb\u7d71\uff0c\u5176\u4e2d\u6709\u5169\u500b\u50ac\u5316\u7684\u4f4d\u7f6e\uff0c\u5c07\u74b0\u5f9e\u4e00\u500b\u4f4d\u7f6e\u79fb\u5230\u53e6\u4e00\u500b\u4f4d\u7f6e\uff0c\u5316\u5b78\u5bb6\u53ef\u4ee5\u5207\u63db\u8f2a\u70f7\u7684\u6d3b\u6027\uff0c\u4f7f\u5f97\u5169\u7a2e\u5316\u5b78\u53cd\u61c9\u53ef\u4ee5\u4f9d\u5e8f\u767c\u751f\u3002Leigh\u73fe\u5728\u6b63\u4f01\u5716\u5c07\u597d\u5e7e\u7a2e\u4e0d\u540c\u7684\u53ef\u958b\u95dc\u50ac\u5316\u5291\u653e\u5728\u540c\u4e00\u6eb6\u6db2\u4e2d\uff0c\u900f\u904e\u4e00\u7cfb\u5217\u7684\u958b\u95dc\u8a0a\u865f\u5c07\u5206\u5b50\u4f9d\u5e8f\u7d50\u5408\uff0c\u751f\u6210\u8907\u96dc\u7684\u7d50\u69cb\uff0c\u5c31\u5f88\u50cf\u7d30\u80de\u4e2d\u773e\u591a\u7684\u9175\u7d20\u6240\u505a\u7684\u4e8b\u4e00\u822c\u3002<\/p>\n<p><strong>\u5948\u7c73\u99ac\u9054<br \/>\n<\/strong>\u57281999\u5e74\uff0c\u65bc\u5206\u5b50\u68ad\u548c\u958b\u95dc\u7684\u521d\u6b65\u5be6\u9a57\u6210\u529f\u4e4b\u5f8c\uff0c\u9019\u500b\u9818\u57df\u53c8\u5411\u524d\u8de8\u8d8a\u4e86\u4e00\u5927\u6b65\u800c\u5275\u9020\u51fa\u4e86\u7b2c\u4e00\u500b\u4eba\u5de5\u5408\u6210\u7684\u5206\u5b50\u99ac\u9054\uff0c\u90a3\u662fFeringa\u7684\u7814\u7a76\u5c0f\u7d44\u6240\u88fd\u9020\u7684\uff0c\u9019\u500b\u88dd\u7f6e\u662f\u4e00\u500b\u55ae\u4e00\u5206\u5b50\uff0c\u4e0a\u9762\u5177\u6709\u5169\u500b\u76f8\u540c\u7684\u300c\u69f3\u300d\u7684\u55ae\u5143\uff0c\u76f8\u4e92\u900f\u904e\u4e00\u500b\u78b3-\u78b3\u96d9\u9375\u9023\u7d50\uff0c\u9019\u4f7f\u5f97\u5169\u500b\u69f3\u662f\u56fa\u5b9a\u4f4f\u7684\uff0c\u4f46\u7576\u4e00\u675f\u5149\u5c07\u96d9\u9375\u7834\u58de\u6210\u70ba\u55ae\u9375\u6642\uff0c\u69f3\u5c31\u53ef\u4ee5\u958b\u59cb\u65cb\u8f49\u4e86(\u898b\u5716\u4e8c\u7684\u4f8b\u5b50)\uff0c\u91cd\u8981\u7684\u662f\u53d7\u5230\u69f3\u7684\u5f62\u72c0\u9650\u5236\uff0c\u53ea\u80fd\u5f80\u4e00\u500b\u65b9\u5411\u8f49\u52d5 \u2013 \u800c\u53ea\u8981\u6301\u7e8c\u7684\u63d0\u4f9b\u5149\u548c\u4e00\u4e9b\u71b1\uff0c\u9019\u500b\u99ac\u9054\u5373\u53ef\u6301\u7e8c\u7684\u8f49\u52d5\u3002<\/p>\n<p>Feringa \u66f4\u9032\u4e00\u6b65\uff0c\u7528\u985e\u4f3c\u7684\u99ac\u9054\u5275\u9020\u4e86\u4e00\u500b\u56db\u8f2a\u8f49\u52d5\u7684\u301d\u5948\u7c73\u8eca\u301e\u3002\u4ed6\u4e5f\u5c55\u793a\u4e86\u9019\u7a2e\u99ac\u9054\u80fd\u7d66\u4e88\u6db2\u6676\u8db3\u5920\u7684\u626d\u529b\uff0c\u5c07\u5176\u4e0a\u7684\u4e00\u500b\u73bb\u7483\u68d2\u6162\u6162\u7684\u65cb\u8f49\uff0c\u90a3\u500b\u68d2\u5b50\u670928 \u5fae\u7c73\u9577 \u2013 \u662f\u99ac\u9054\u7684\u597d\u5e7e\u5343\u500d\u5927\u3002<\/p>\n<p>\u6709\u4e9b\u5316\u5b78\u5bb6\u6279\u8a55\u9019\u4e9b\u99ac\u9054\uff0c\u8a8d\u70ba\u5b83\u5011\u96d6\u7136\u5f88\u53ef\u611b\uff0c\u4f46\u7d42\u7a76\u6c92\u751a\u9ebc\u7528\u8655\u3002\u4e00\u4f4d\u5728\u5fb7\u570b\u6155\u5c3c\u9ed1\u7684Luwig Maximilian \u5927\u5b78\u7684\u5316\u5b78\u5bb6Dirk Trauner\u8aaa\u300c\u6211\u4e00\u76f4\u5c0d\u9019\u7a2e\u4eba\u9020\u99ac\u9054\u6709\u9ede\u7591\u616e \u2013 \u5b83\u5011\u592a\u96e3\u5408\u6210\uff0c\u4e5f\u592a\u96e3\u653e\u5927\u88fd\u7a0b\u3002\u300d<\/p>\n<p>\u4e0d\u8ad6\u5982\u4f55\uff0c\u5728\u5176\u80cc\u5f8c\u904b\u4f5c\u7684\u5316\u5b78\u539f\u7406\u7684\u78ba\u662f\u975e\u5e38\u6709\u7528\u7684\uff0c\u904b\u7528\u76f8\u540c\u7684\u5149\u9a45\u52d5\u6a5f\u5236\u3002\u7814\u7a76\u5de5\u4f5c\u8005\u5df2\u7d93\u958b\u767c\u51fa100\u7a2e\u985e\u4f3c\u85e5\u7269\u7684\u5316\u5408\u7269\uff0c\u53ef\u4ee5\u900f\u904e\u5149\u4f86\u958b\u555f\u6216\u95dc\u6389\u5176\u6d3b\u6027\u3002<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-22547\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/02.png\" alt=\"02\" width=\"612\" height=\"204\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/02.png 612w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/02-300x100.png 300w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><strong>\u5716\u4e8c \u00a0\u9019\u662f\u4e00\u500b\u53f0\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u694a\u5409\u6c34\u6559\u6388\u8a2d\u8a08\u7684\u8f49\u8f2a\u9ad4\u7cfb\uff0c\u5176\u4e2d\u6709\u4e00\u500b\u53ef\u4ee5\u900f\u904e\u5149\u7570\u69cb\u5316\u7684\u78b3-\u78b3\u96d9\u9375(\u5361\u901a\u5716\u4e2d\u7684\u7da0\u8272\u90e8\u5206)\uff0c\u5728\u5de6\u908a\u7684<em>E<\/em>-1R\u5206\u5b50\u7d50\u69cb\u4e2d\u96d9\u9375\u5169\u7aef\u7684\u53d6\u4ee3\u57fa\u76f8\u4e92\u9060\u96e2\uff0c\u65cb\u8f49\u662f\u88ab\u5141\u8a31\u7684\uff0c\u4f46\u900f\u904e\u5149\u7684\u7167\u5c04\uff0c\u53ef\u5c07\u96d9\u9375\u7570\u69cb\u5316\u6210\u70ba<em>Z<\/em>-1R\u7684\u7d50\u69cb\uff0c\u6b64\u6642\u96d9\u9375\u5169\u7aef\u7684\u53d6\u4ee3\u57fa\u76f8\u4e92\u63a5\u8fd1\uff0c\u7d05\u8272\u7684\u7d50\u69cb\u6703\u5361\u5728\u5169\u7247\u85cd\u8272\u6247\u8449\u4e4b\u9593\uff0c\u597d\u4f3c\u524e\u8eca\u4e00\u822c\uff0c\u6b64\u6642\u7121\u6cd5\u65cb\u8f49\uff0c\u900f\u904e\u53e6\u4e00\u9053\u983b\u7387(n)\u4e0d\u540c\u7684\u5149\u53c8\u53ef\u5c07\u96d9\u9375\u7570\u69cb\u6210<em>E<\/em>-1R\uff0c\u7b49\u65bc\u5c07\u524e\u8eca\u95dc\u9589\uff0c\u53c8\u53ef\u65cb\u8f49\u4e86\u3002(\u672c\u5716\u7531\u694a\u5409\u6c34\u6559\u6388\u63d0\u4f9b)<\/strong><\/p>\n<p>\u4f8b\u5982\u5728\u4e03\u6708\u4efd\uff0c\u7531Trauner\u6240\u9818\u5c0e\u7684\u7814\u7a76\u5c0f\u7d44\u767c\u8868\u4e86\u4e00\u500b\u85e5\u7269\uff0c\u662fcombretastatin A-4 (\u5eb7\u666e\u745e\u6c40)\u7684\u5149\u958b\u555f\u7248\u672c\uff0c\u5eb7\u666e\u745e\u6c40\u5177\u6709\u5f88\u9ad8\u7684\u6297\u764c\u85e5\u6548\u4f46\u4e5f\u6709\u56b4\u91cd\u7684\u526f\u4f5c\u7528\uff0c\u56e0\u70ba\u5b83\u4e0d\u4f46\u6703\u653b\u64ca\u816b\u7624\u7d30\u80de\u4f46\u662f\u4e5f\u6703\u653b\u64ca\u5065\u5eb7\u7684\u7d30\u80de\uff0c\u8a72\u7814\u7a76\u5c0f\u7d44\u6240\u958b\u767c\u7684\u9019\u7a2e\u53ef\u958b\u95dc\u7684\u85e5\uff0c\u80fd\u5927\u5e45\u5ea6\u964d\u4f4e\u7cfb\u7d71\u6027\u7684\u526f\u4f5c\u7528\uff1a\u6b64\u85e5\u7684\u7d50\u69cb\u5177\u6709\u4e00\u500b\u6c2e-\u6c2e\u96d9\u9375\uff0c\u8b93\u5176\u4e0a\u7684\u5169\u500b\u7d50\u69cb\u55ae\u5143\u56fa\u5b9a\u5728\u76f8\u4e92\u9060\u96e2\u7684\u4f4d\u7f6e\uff0c\u6b64\u6642\u6c92\u6709\u85e5\u7269\u6d3b\u6027\uff0c\u53ea\u6709\u5728\u7167\u5c04\u85cd\u5149\u6642\uff0c\u96d9\u9375\u7834\u58de\u6210\u70ba\u55ae\u9375\u5f8c(\u66ab\u6642\u6027\u7684\u6fc0\u767c\u614b\uff0c\u91cb\u653e\u80fd\u91cf\u5247\u56de\u5230\u96d9\u9375)\uff0c\u5169\u500b\u7d50\u69cb\u55ae\u5143\u5c31\u53ef\u85c9\u65cb\u8f49\u6539\u8b8a\u4f4d\u7f6e\u6210\u70ba\u6709\u85e5\u6548\u7684\u7d50\u69cb\u578b\u614b\u3002Trauner\u6307\u51fa\uff0c\u53ef\u4ee5\u900f\u904e\u4e00\u500b\u53ef\u5f4e\u66f2\u7684\u7ba1\u5b50\uff0c\u6216\u79fb\u690d\u624b\u8853\u7528\u7684\u88dd\u7f6e\uff0c\u5c07\u8a72\u85e5\u7269\u5f15\u5165\u4e00\u500b\u53ea\u670910 \u5fae\u7c73\u5bec\u5ea6\u7684\u7d44\u7e54\u5340\u57df\uff0cTrauner \u6b63\u8a08\u756b\u9032\u884c\u8001\u9f20\u8eab\u4e0a\u7684\u5be6\u9a57\u4f86\u6e2c\u8a66\u6b64\u5316\u5408\u7269\u5c0d\u764c\u75c7\u7684\u7642\u6548\u3002<\/p>\n<p>\u4ed6\u4e5f\u5e0c\u671b\u904b\u7528\u9019\u7a2e\u5229\u7528\u5149\u958b\u555f\u7684\u5316\u5408\u7269\uff0c\u4f86\u6062\u5fa9\u9ec3\u6591\u9ede\u9000\u5316\u75c7(macular degeneration)\u6216\u7db2\u819c\u8272\u7d20\u6c89\u8457\u75c7(retinitis pigmentosa)\u75c5\u60a3\u7684\u8996\u529b\uff0c\u9019\u985e\u7684\u75c5\u662f\u6e90\u81ea\u65bc\u773c\u775b\u611f\u5149\u7684\u687f\u7d30\u80de\u4ee5\u53ca\u9310\u72c0\u7d30\u80de\u7684\u640d\u58de\uff0c\u4ed6\u8aaa\u300c\u90a3\u6839\u672c\u662f\u4f38\u624b\u53ef\u63a1\u7684\u679c\u5be6 \u2013 \u56e0\u70ba\u662f\u5728\u773c\u775b\uff0c\u6211\u5011\u4e0d\u9700\u8981\u53bb\u64d4\u5fc3\u5982\u4f55\u5c07\u5149\u5f15\u5165\u300d\u3002\u53bb\u5e74\u4ed6\u5c55\u793a\u4e86\u5c07\u4e00\u500b\u7a31\u70baDENAQ\u7684\u5149\u555f\u52d5\u5206\u5b50\uff0c\u5c0d\u76f2\u9f20\u773c\u775b\u9032\u884c\u4e00\u6b21\u7684\u6ce8\u5c04\u5373\u53ef\u6062\u5fa9\u5176\u90e8\u5206\u7684\u8996\u529b\uff0c\u80fd\u5340\u5225\u660e\u6697\u4e26\u7dad\u6301\u597d\u5e7e\u5929\u3002\u8a72\u7814\u7a76\u5c0f\u7d44\u76ee\u524d\u6b63\u5728\u9032\u884c\u9748\u9577\u985e\u52d5\u7269\u7684\u85e5\u7269\u6e2c\u8a66\uff0c\u4e26\u5e0c\u671b\u80fd\u5728\u5169\u5e74\u5167\u958b\u59cb\u4eba\u9ad4\u5be6\u9a57\u3002<\/p>\n<p>Trauner\u8207Klajn\u90fd\u540c\u610f\uff0c\u4e3b\u8981\u7684\u6311\u6230\u5c07\u6703\u662f\u8aaa\u670d\u8b39\u614e\u7684\u88fd\u85e5\u754c\uff0c\u9ad4\u8a8d\u5149\u555f\u52d5\u85e5\u7269\u662f\u5177\u6709\u6f5b\u529b\u7684\uff0c\u5373\u4fbf\u6c92\u6709\u4efb\u4f55\u5728\u4eba\u9ad4\u4e0a\u4f7f\u7528\u7684\u5148\u4f8b\uff0cTrauner\u8aaa\u300c\u6211\u5011\u9700\u8981\u8b93\u88fd\u85e5\u754c\u5c0d\u5149\u85e5\u5b78\u611f\u5230\u8208\u596e\uff0c\u4e00\u65e6\u770b\u5230\u5176\u50f9\u503c\uff0c\u6211\u5011\u5c31\u6709\u6a5f\u6703\u4e86\u3002\u300d<\/p>\n<p><strong>\u6cbf\u8def\u884c\u8d70<br \/>\n<\/strong>\u65e9\u5728\u4efb\u4f55\u7269\u7a2e\u9032\u5316\u5230\u80fd\u5728\u9678\u5730\u4e0a\u884c\u52d5\u4e4b\u524d\uff0c\u7d30\u80de\u5c31\u5df2\u7d93\u5728\u904b\u7528\u8173\u4f86\u4f5c\u70ba\u5176\u6a5f\u5668\uff0c\u4e3b\u8981\u7684\u4f8b\u5b50\u5c31\u662f\u4e00\u985e\u5177\u6709\u96d9\u53c9\u7684\u86cb\u767d\u8cea\uff0c\u7a31\u70ba\u81f4\u52d5\u86cb\u767d(kinesins)\uff0c\u7576\u5b83\u5011\u651c\u5e36\u8457\u8ca8\u7269\u884c\u8d70\u5728\u7d30\u80de\u4e2d\u5fae\u7ba1\u69cb\u6210\u7684\u5805\u786c\u8173\u67b6\u4e0a\uff0c\u4ee5\u9054\u5230\u671d\u7279\u5b9a\u65b9\u5411\u7684\u904b\u8f38\u529f\u7528\u6642\uff0c\u4e00\u300c\u8173\u300d\u653e\u5728\u53e6\u4e00\u300c\u8173\u300d\u4e4b\u524d\u3002<\/p>\n<p>\u53d7\u5230\u81f4\u52d5\u86cb\u767d\u7684\u555f\u767c\uff0c\u7814\u7a76\u4eba\u54e1\u5229\u7528DNA\u88fd\u9020\u4e86\u4eba\u5de5\u7684\u884c\u8d70\u5668(\u53c3\u8003\u5716\u4e09\u7684\u4f8b\u5b50)\uff0c\u9019\u985e\u7684\u5206\u5b50\u901a\u5e38\u6709\u5169\u96bb\u8173\uff0c\u5206\u5225\u56fa\u5b9a\u5728\u5169\u80a1\u4e92\u88dc\u7684DNA\u6240\u92ea\u7684\u8def\u8ecc\u4e0a\uff0c\u7576\u52a0\u5165\u53e6\u4e00\u53ef\u4ee5\u7af6\u722d\u7684\u55ae\u80a1DNA\u6642\uff0c\u5c31\u53ef\u4ee5\u91cb\u653e\u4e00\u96bb\u8173\uff0c\u8b93\u884c\u8d70\u5668\u5411\u524d\u8de8\u51fa\u4e00\u6b65\u3002\u4e00\u500b\u975e\u5e38\u7a81\u51fa\u7684\u4f8b\u5b50\u662f\u57282010\u5e74\u7d10\u7d04\u5927\u5b78\u7684Nadrian Seeman\u6240\u767c\u8868\u7684\u7cfb\u7d71\uff0c\u4ed6\u7684DNA\u884c\u8d70\u5668\u5171\u6709\u56db\u96bb\u300c\u8173\u300d\u548c\u4e09\u96bb\u300c\u624b\u300d\uff0c\u5b83\u80fd\u651c\u5e36\u8457\u91d1\u5948\u7c73\u9846\u7c92\u5728\u6298\u758a\u7684DNA\u6240\u92ea\u6210\u7684\u5730\u78da\u4e0a\u884c\u8d70\u3002<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-22548\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/03.png\" alt=\"03\" width=\"329\" height=\"301\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/03.png 329w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/03-300x274.png 300w\" sizes=\"(max-width: 329px) 100vw, 329px\" \/><strong>\u5716\u4e09\u00a0 DNA\u89e3\u65cb\u9175\u7d20\u662f\u53e6\u4e00\u500b\u81ea\u7136\u754c\u7684DNA\u884c\u8d70\u5668\uff0c\u53ef\u85c9\u7531\u8f49\u63dbATP\u6c34\u89e3\u6240\u7522\u751f\u7684\u80fd\u91cf\uff0c\u884c\u8d70\u5728DNA\u4e0a\uff0c\u9032\u800c\u9054\u5230\u5c07DNA\u7684\u96d9\u80a1\u89e3\u65cb\u3002\u672c\u5716\u4e2d\u85cd\u8272\u4e09\u89d2\u7684\u90e8\u5206\u5177\u8fa8\u8b58DNA\u5e8f\u5217\u7684\u529f\u80fd\uff0c\u65b9\u5f62\u8207\u5713\u5f62\u7684\u90e8\u4efd\uff0c\u5206\u8de8\u5728DNA\u7684\u5169\u80a1\u4e0a\u9762\u884c\u8d70\uff0c\u53f0\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u674e\u5f18\u6587\u6559\u6388\u7684\u7814\u7a76\u986f\u793a\u65b9\u5f62\u8207\u5713\u5f62\u7684\u90e8\u4efd\u80fd\u5404\u81ea\u8d70\u5728DNA\u7684\u55ae\u80a1\u4e0a\uff0c\u9054\u6210\u89e3\u65cb\u96d9\u80a1\u7684\u76ee\u7684\u3002(\u672c\u5716\u7531\u674e\u5f18\u6587\u6559\u6388\u63d0\u4f9b)<\/strong><\/p>\n<p>\u548c\u7d30\u80de\u4e2d\u5177\u65b9\u5411\u6027\u7684\u884c\u8d70\u5668\u76f8\u6bd4\uff0c\u5c0dDNA\u884c\u8d70\u5668\u4f86\u8aaa \u2013 \u4ee5\u53ca\u8fc5\u901f\u7684\u5f9e\u5176\u5b83\u5be6\u9a57\u5ba4\u7814\u88fd\u51fa\u7684\u8b8a\u9ad4 \u2013 \u9664\u975e\u8a2d\u8a08\u4e00\u500b\u5167\u5efa\u7684\u68d8\u8f2a\u4f86\u963b\u6b62\u5b83\u5f80\u5f8c\u65b9\u8de8\u6b65\uff0c\u5426\u5247\u5c07\u6f2b\u7121\u76ee\u7684\u7684\u904a\u8569\u8457\u3002\u5728\u8a31\u591a\u7684\u884c\u8d70\u5668\u4e2d\uff0c\u68d8\u8f2a\u63a7\u5236\u7684\u95dc\u9375\u662f\u5728\u65bc\u8207\u8173\u9ecf\u5408\u548c\u91cb\u653e\u76f8\u95dc\u7684\u5316\u5b78\u53cd\u61c9\u4e4b\u76f8\u5c0d\u901f\u7387\uff0c\u4e26\u85c9\u8457\u5e03\u6717\u904b\u52d5\uff0c\u63a8\u52d5\u91cb\u653e\u958b\u7684\u8173\u5411\u524d\u8d70\u52d5\u3002<\/p>\n<p>\u5728\u904e\u53bb\u7684\u9019\u5e7e\u5e74\uff0c\u4ed4\u7d30\u7684\u5316\u5b78\u7814\u7a76\u8207\u5206\u5b50\u52d5\u529b\u6a21\u64ec\uff0c\u986f\u793a\u9019\u7a2e\u300c\u5e03\u6717\u68d8\u8f2a\u300d\u7684\u6982\u5ff5\u662f\u6240\u6709\u5316\u5b78\u63a8\u52d5\u7684\u5206\u5b50\u6a5f\u5668\u80cc\u5f8c\u7684\u57fa\u790e\uff0c\u9019\u5305\u62ec\u4e86\u8a31\u591a\u751f\u7269\u99ac\u9054\u3002\u4f8b\u5982\u57282013\u5e74\uff0c\u4f4d\u65bc\u7f8e\u570b\u5b89\u7d0d\u4fdd\u7684\u5bc6\u897f\u6839\u5927\u5b78\uff0c\u7531Nils Walter\u6240\u9818\u5c0e\u7684\u7814\u7a76\u5c0f\u7d44\u767c\u73fe\u540c\u6a23\u7684\u6a5f\u5236\u904b\u4f5c\u65bc\u526a\u63a5\u9ad4(spliceosome)\uff0c\u90a3\u662f\u4e00\u500b\u7d30\u80de\u7684\u6a5f\u5668\uff0c\u7528\u4f86\u5f9eRNA\u4e0a\u526a\u4e0b\u4e00\u90e8\u4efd\uff0c\u7136\u5f8c\u5c07\u5176\u4e0a\u7684\u57fa\u56e0\u8cc7\u8a0a\u8f49\u8b6f\u4ee5\u88fd\u5099\u86cb\u767d\u8cea\uff0cWalter\u8aaa\u300c\u81f4\u52d5\u86cb\u767d\u7528\u5b83\uff0c\u6838\u91a3\u9ad4\u7528\u5b83\uff0c\u800c\u4e14\u526a\u63a5\u9ad4\u4e5f\u7528\u5b83\u3002\u300d<\/p>\n<p>\u65e2\u7136\u540c\u6a23\u7684\u539f\u7406\u5728\u751f\u7269\u6a5f\u5668\u8207\u5408\u6210\u5206\u5b50\u6a5f\u5668\u7684\u80cc\u5f8c\u904b\u4f5c\uff0c\u56e0\u6b64\u9019\u5169\u500b\u9818\u57df\u7684\u7814\u7a76\u5de5\u4f5c\u8005\u61c9\u8a72\u53ef\u4ee5\u76f8\u4e92\u5206\u4eab\u77e5\u8b58\uff0cWalter\u8aaa\u300c\u4e00\u822c\u800c\u8a00\uff0c\u5b83\u5011\u73fe\u5728\u662f\u76f8\u9694\u5f88\u9060\u7684\u9818\u57df\uff0c\u6211\u8a8d\u70ba\u5982\u679c\u5927\u5bb6\u80fd\u570d\u8457\u540c\u4e00\u5f35\u684c\u5b50\u4f86\u8a0e\u8ad6\u6642\uff0c\u5c07\u5c0e\u81f4\u4e0b\u4e00\u8f2a\u7684\u7a81\u7834\u3002\u300d<\/p>\n<p><strong>\u706b\u7bad\u79d1\u5b78<br 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\u7684\u5206\u5b50\u7d44\u88dd\u7dda\uff0c\u53d7\u5230\u6838\u91a3\u9ad4\u7684\u555f\u767c\uff0c\u5b83\u662f\u57fa\u65bc\u4e00\u500b\u8f2a\u70f7\u7cfb\u7d71\uff0c\u6cbf\u8457\u4e00\u500b\u8ef8\u5c07\u80fa\u57fa\u9178\u6293\u8d77\uff0c\u63a5\u8457\u5230\u4e00\u500b\u6b63\u5728\u6210\u9577\u7684\u80dc\u80bd\u93c8\u4e0a\u3002\u4f46\u662f\u9019\u500b\u88dd\u7f6e\u4e5f\u53ef\u80fd\u5177\u6709\u5927\u5c3a\u5ea6\u7684\u904b\u7528\u6027\uff0c\u572836\u5c0f\u6642\u4e4b\u4e2d\uff0c <span class='MathJax_Preview'><img src='https:\/\/case.ntu.edu.tw\/blog\/wp-content\/plugins\/latex\/cache\/tex_ba86b77c4d50566764163d5476c28b61.gif' style='vertical-align: middle; border: none; padding-bottom:2px;' class='tex' alt=\"\" \/><\/span><script type='math\/tex'><\/script>  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Scratch Shield \u7684iPhone\u5916\u6bbc\uff0c\u662f\u57fa\u65bc\u6771\u4eac\u5927\u5b78Kahzo Ito\u7684\u7814\u7a76\uff0c\u9019\u500b\u7cfb\u7d71\u5177\u6709\u8a31\u591a\u9023\u63a5\u62108\u5b57\u578b\u7684\u4e00\u5c0d\u5c0d\u6876\u72c0\u74b0\u7cca\u7cbe\u5206\u5b50\uff0c\u805a\u5408\u7269\u7684\u93c8\u5b50\u5206\u5225\u7a7f\u904e8\u5b57\u7684\u5169\u5b54(\u5404\u7a7f\u4e00\u80a1)\uff0c\u7576\u58d3\u529b\u65bd\u52a0\u5728\u5c0b\u5e38\u7684\u805a\u5408\u7269\u5857\u819c\u6642\uff0c\u805a\u5408\u7269\u80a1\u93c8\u4e4b\u9593\u7684\u9023\u7d50\u6703\u88ab\u7834\u58de\uff0c\u4f46\u662f8\u5b57\u5f62\u7684\u4e00\u5c0d\u74b0\u7cca\u7cbe\u5206\u5b50\u53ef\u626e\u6f14\u6ed1\u8f2a\u7cfb\u7d71\u7684\u8f2a\u5b50\uff0c\u7531\u65bc\u5177\u6709\u8a31\u591a\u9019\u7a2e\u53ef\u79fb\u52d5\u76848\u5b57\u5f62\u6ed1\u8f2a\u4ea4\u9023\u4f4d\u7f6e\uff0c\u4f7f\u805a\u5408\u7269\u7684\u4ea4\u9023\u80a1\u93c8\u76f8\u4e92\u6ed1\u52d5\u800c\u4e0d\u6703\u5206\u96e2\u4e26\u7d13\u89e3\u5f35\u529b\uff0c\u9019\u5c64\u819c\u751a\u81f3\u65bc\u80fd\u4fdd\u8b77\u6613\u788e\u7684\u87a2\u5e55\uff0c\u4e0d\u88ab\u69cc\u5b50\u7684\u6572\u64ca\u800c\u7834\u58de\u3002<\/p>\n<p>\u5c0dStoddart\u800c\u8a00\uff0c\u9019\u986f\u793a\u5206\u5b50\u5efa\u7bc9\u5bb6\u5011\u6240\u958b\u767c\u7684\u96f6\u4ef6\u5df2\u7d93\u6210\u719f\u5230\u5be6\u7528\u968e\u6bb5\u4e86\uff0cStoddart\u8aaa\u300c\u9019\u500b\u9818\u57df\u8d70\u4e86\u5f88\u9577\u7684\u4e00\u689d\u8def\uff0c\u73fe\u5728\u6211\u5011\u958b\u59cb\u5c55\u793a\u5b83\u662f\u6709\u7528\u7684\u3002\u300d<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u8b6f\u8005\u5f8c\u8a18<br \/>\n<\/strong>\u9019\u662f\u6700\u8fd1 Nature \u671f\u520a\u4e0a\u7684\u4e00\u4efd\u7279\u5beb\u6587\u7ae0\uff0c\u7c21\u4ecb\u65b0\u7a4e\u5206\u5b50\u6a5f\u5668\u4e4b\u7814\u7a76\u767c\u5c55\uff0c\u525b\u597d\u8b6f\u8005\u672c\u5b78\u671f\u6b63\u5728\u6559\u91ab\u5b78\u3001\u7259\u91ab\u3001\u8207\u96fb\u6a5f\u7cfb\u7684\u666e\u901a\u5316\u5b78\u8ab2\uff0c\u800c\u9019\u7bc7\u7279\u5beb\u525b\u597d\u5728\u4ecb\u7d39\u5316\u5b78\u3001\u91ab\u5b78\u3001\u8207\u5de5\u7a0b\u7684\u7d50\u5408\uff0c\u4e00\u6642\u8208\u8d77\uff0c\u6c7a\u5b9a\u5c07\u6b64\u6587\u7ffb\u8b6f\u6210\u4e2d\u6587\uff0c\u505a\u70ba\u5b78\u751f\u7684\u53c3\u8003\u8cc7\u6599\uff0c\u8a72\u6587\u6240\u5217\u4e4b\u53c3\u8003\u6587\u737b\u5c31\u4e0d\u518d\u91cd\u8907\u62f7\u8c9d\uff0c\u6709\u8208\u8da3\u7684\u5b78\u5b50\u53ef\u56de\u5230\u539f\u6587\u5c0b\u627e\u8a72\u6587\u5f15\u8ff0\u7684\u6587\u737b\u8cc7\u6599\u3002\u5176\u5be6\u5728\u9019\u500b\u65b9\u5411\u4e0a\uff0c\u53f0\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u7684\u90b1\u52dd\u8ce2\u6559\u6388\u5c31\u5728\u7814\u7a76\u5948\u7c73\u7d1a\u5206\u5b50\u96fb\u5b50\u5143\u4ef6\u4e4b\u8a2d\u8a08\u8207\u5efa\u69cb\uff1b\u674e\u5f18\u6587\u6559\u6388\u5728\u7814\u7a76\u5de8\u5927\u751f\u7269\u5206\u5b50\u884c\u8d70\u7684\u6a5f\u5236\uff1b\u694a\u5409\u6c34\u6559\u6388\u5728\u7814\u7a76\u5149\u5316\u5b78\u8207\u96fb\u5316\u5b78\u63a7\u5236\u4e4b\u5206\u5b50\u958b\u95dc\u548c\u5206\u5b50\u6a5f\u68b0\uff0c\u5305\u62ec\u6587\u4e2d\u6240\u63d0\u7684\u5206\u5b50\u87ba\u65cb\u69f3\uff0c\u9019\u4e9b\u8001\u5e2b\u7814\u7a76\u7684\u8ab2\u984c\u5747\u8207\u672c\u6587\u7ae0\u76f8\u95dc\uff0c\u56e0\u800c\u7279\u5225\u9080\u8acb\u4ed6\u5011\u4e09\u4f4d\u63d0\u4f9b\u76f8\u95dc\u4ecb\u7d39\u5716\u7247\uff0c\u8b93\u9019\u7bc7\u8b6f\u6587\u6709\u4e00\u9ede\u5728\u5730\u7684\u5473\u9053\u3002\u7531\u65bc\u6211\u6c92\u6709\u4f7f\u7528\u539f\u6587\u7684\u5716\u8aaa\uff0c\u6709\u8208\u8da3\u8005\u8acb\u53c3\u8003\u539f\u8457\u3002\u6b64\u5916\u6587\u4e2d\u672a\u80fd\u63d0\u53ca\u800c\u70ba\u53f0\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u8001\u5e2b\u6240\u5c08\u7cbe\u7684\uff0c\u5305\u62ec\u5f6d\u65ed\u660e\u9662\u58eb\u7814\u7a76\u7684\u5948\u7c73\u5c0e\u7dda\uff0c\u9673\u9038\u8070\u6559\u6388\u947d\u7814\u7684\u5948\u7c73\u6750\u6599\u8207\u5143\u4ef6\u548c\u751f\u7269\u611f\u6e2c\u5668\u7b49\u7b49\u3002\u5c0d\u65bc\u9019\u4e9b\u9818\u57df\u6709\u8208\u8da3\u7684\u9752\u5e74\u5b78\u5b50\u4ea6\u53ef\u9032\u5165\u4e0a\u8ff0\u6559\u6388\u7684\u7814\u7a76\u5ba4\u7db2\u9801\uff0c\u4e00\u7aba\u7a76\u7adf\uff0c\u7576\u7136\u66f4\u6b61\u8fce\u9078\u64c7\u5316\u5b78\u7cfb\uff0c\u52a0\u5165\u4ed6\u5011\u7684\u5be6\u9a57\u5ba4\uff0c\u89aa\u8eab\u53c3\u8207\u73fe\u4eca\u7684\u5c16\u7aef\u7814\u7a76\u3002<\/p>\n<p>(\u8521\u860a\u660e\u50c5\u8a8c\u65bc\u53f0\u5927\u5316\u5b78\u7cfb\uff0c2015\/10\/2)<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n<p>--<br \/>\n\u539f\u59cb\u6587\u7ae0\uff1a <em>Nature<\/em> <strong>2015<\/strong>, <em>525<\/em>, 18-21.<br \/>\n(\u672c\u8b6f\u6587\u7279\u5546\u8acb\u53f0\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u7684\u90b1\u52dd\u8ce2\u3001\u694a\u5409\u6c34\u3001\u8207\u674e\u5f18\u6587\u4e09\u4f4d\u6559\u6388\u63d0\u4f9b\u5716\u7247\uff0c\u4e26\u5e6b\u5fd9\u6821\u95b1\uff0c\u7279\u6b64\u81f4\u8b1d)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u53d7\u5230\u751f\u7269\u7684\u555f\u767c\uff0c\u5316\u5b78\u5bb6\u5011\u5275\u9020\u51fa\u4e00\u7cfb\u5217\u7cbe<\/p>\n","protected":false},"author":20,"featured_media":22660,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,3293],"tags":[450,2249,2157,509,2155,2154,2156],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/10\/05-Ball-milling-50.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22545"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22545"}],"version-history":[{"count":21,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22545\/revisions"}],"predecessor-version":[{"id":32359,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22545\/revisions\/32359"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/22660"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}