{"id":22353,"date":"2015-09-25T00:25:35","date_gmt":"2015-09-24T16:25:35","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=22353"},"modified":"2018-08-01T16:09:15","modified_gmt":"2018-08-01T08:09:15","slug":"%e3%80%90%e4%ba%ba%e9%ab%94%e5%a5%a7%e5%a6%99%e3%80%91%e9%95%b7%e7%97%98%e7%97%98%e5%97%8e%ef%bc%9f%e5%8f%af%e8%83%bd%e6%98%af%e6%94%9d%e5%8f%96%e5%a4%aa%e5%a4%9a%e7%b6%ad%e7%94%9f%e7%b4%a0b12","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=22353","title":{"rendered":"\u3010\u4eba\u9ad4\u5967\u5999\u3011\u9577\u75d8\u75d8\u55ce\uff1f\u53ef\u80fd\u662f\u651d\u53d6\u592a\u591a\u7dad\u751f\u7d20B12\u4e86\u5594\uff01"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u4f60\u6700\u8fd1\u5728\u70ba\u81c9\u4e0a\u9577\u9752\u6625\u75d8\u6240\u82e6\u60f1\u55ce\uff1f\u6216\u8a31\u662f\u7dad\u751f\u7d20B12\u5403\u592a\u591a\u4e86\u5594\uff01<\/strong><\/span><\/p>\n<figure id=\"attachment_22354\" aria-describedby=\"caption-attachment-22354\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-22354\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/\u9752\u6625\u75d8.jpg\" alt=\"\u5716\u7247\u4f86\u6e90:\u7dad\u57fa\u767e\u79d1\" width=\"450\" height=\"307\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/\u9752\u6625\u75d8.jpg 666w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/\u9752\u6625\u75d8-300x204.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/\u9752\u6625\u75d8-600x409.jpg 600w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-22354\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90:\u7dad\u57fa\u767e\u79d1<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n<p>\u5c0b\u5e38\u6027\u75e4\u7621\uff08acne vulgaris\uff09\u6709\u500b\u89aa\u6c11\u537b\u7e3d\u662f\u8b93\u4eba\u982d\u75db\u7684\u540d\u5b57\uff1a\u9752\u6625\u75d8\u3002\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u6d1b\u6749\u78ef\u5206\u6821\u7684\u7814\u7a76\u4eba\u54e1\u767c\u73fe\u7dad\u751f\u7d20B12\u7684\u651d\u53d6\u91cf\u53ef\u80fd\u6703\u5f71\u97ff\u5230\u76ae\u819a\u9577\u4e0d\u9577\u9752\u6625\u75d8\u3002<\/p>\n<p>\u7dad\u751f\u7d20B12\u662f\u8eab\u9ad4\u529f\u80fd\u8981\u6b63\u5e38\u904b\u4f5c\u6240\u4e0d\u53ef\u6216\u7f3a\u7684\u91cd\u8981\u7dad\u751f\u7d20\u4e4b\u4e00\u3002\u5b83\u4e0d\u50c5\u662f\u7dad\u6301\u4e2d\u6a1e\u795e\u7d93\u529f\u80fd\u7684\u5fc5\u9700\u71df\u990a\u7d20\uff0c\u66f4\u662f\u8eab\u9ad4\u5167\u88fd\u9020\u7d05\u8840\u7403\u7684\u91cd\u8981\u56e0\u5b50\u3002\u7f3a\u4e4f\u7dad\u751f\u7d20B12\u7684\u6642\u5019\uff0c\u4e0d\u50c5\u5bb9\u6613\u8ca7\u8840\uff0c\u4e5f\u56e0\u70ba\u7d05\u8840\u7403\u4e0d\u8db3\uff0c\u800c\u7d05\u8840\u7403\u53c8\u662f\u8eab\u9ad4\u5167\u628a\u6c27\u6c23\u651c\u5e36\u5230\u5168\u8eab\u5404\u8655\u7684\u5c0f\u5175\uff0c\u800c\u4f7f\u5f97\u4eba\u5728\u7dad\u751f\u7d20B12\u7f3a\u4e4f\u7684\u60c5\u6cc1\u4e0b\u5bb9\u6613\u611f\u5230\u5026\u6020\u3002<\/p>\n<p>\u4f46\u662f\u65e9\u5728\u534a\u4e16\u7d00\u4e4b\u524d\uff0c\u5c31\u6709\u7814\u7a76\u767c\u73fe\u5728\u6709\u4e9b\u4eba\u8eab\u4e0a\uff0c\u5982\u679c\u8840\u6db2\u4e2d\u7684\u7dad\u751f\u7d20B12\u6fc3\u5ea6\u904e\u9ad8\u7684\u6642\u5019\uff0c\u5bb9\u6613\u9577\u9752\u6625\u75d8\u3002\u4f46\u7dad\u751f\u7d20B12\u548c\u9577\u9752\u6625\u75d8\u7684\u95dc\u4fc2\u4e5f\u59cb\u7d42\u53ea\u662f\u81e8\u5e8a\u7d93\u9a57\u4e0a\u4e09\u4eba\u6210\u864e\u7684\u81c6\u6e2c\uff0c\u65bc\u662f\uff0c\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u6d1b\u6749\u78ef\u5206\u6821\u7684\u7814\u7a76\u4eba\u54e1\u6c7a\u5b9a\u91dd\u5c0d\u9019\u500b\u6b77\u53f2\u8b0e\u5718\u4f86\u4e00\u63a2\u7a76\u7adf\u3002\u5230\u5e95\u904e\u91cf\u7684\u7dad\u751f\u7d20B12\u6703\u4e0d\u6703\u662f\u8b93\u4eba\u983b\u983b\u81c9\u4e0a\u5192\u51fa\u9752\u6625\u75d8\u7684\u7f6a\u9b41\u798d\u9996\u5462\uff1f<!--more--><\/p>\n<figure id=\"attachment_22359\" aria-describedby=\"caption-attachment-22359\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-22359\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/Untitled-2.0011.jpg\" alt=\"\u672c\u5716\u70ba\u4f5c\u8005\u81ea\u7e6a\" width=\"650\" height=\"387\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/Untitled-2.0011.jpg 853w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/Untitled-2.0011-300x178.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/Untitled-2.0011-800x476.jpg 800w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption id=\"caption-attachment-22359\" class=\"wp-caption-text\">\u672c\u5716\u70ba\u4f5c\u8005\u81ea\u7e6a<\/figcaption><\/figure>\n<p>\u7814\u7a76\u4eba\u54e1\u5f9e\u76ae\u819a\u72c0\u6cc1\u5065\u5eb7\u7684\u4eba\u81c9\u4e0a\u63a1\u96c6\u5fae\u751f\u83cc\u53e2\u7684\u6a23\u672c\uff0c\u4e5f\u5f9e\u5bb9\u6613\u9577\u9752\u6625\u75d8\u7684\u53d7\u8a66\u8005\u81c9\u4e0a\u63a1\u96c6\u5fae\u751f\u83cc\u53e2\u6a23\u672c\uff0c\u7136\u5f8c\u5c0d\u9019\u4e9b\u63a1\u96c6\u7684\u6aa2\u9ad4\u9032\u884c\u83cc\u53e2\u5206\u6790\u3002\u6beb\u7121\u610f\u5916\u5730\uff0c\u5728\u5bb9\u6613\u9577\u9752\u6625\u75d8\u7684\u53d7\u8a66\u8005\u81c9\u4e0a\uff0c\u4ed6\u5011\u767c\u73fe\u4e86\u52e2\u529b\u9f90\u5927\u7684\u75e4\u7621\u4e19\u9178\u687f\u83cc\uff08<em>Propionibacterium acnes<\/em>\uff09\u83cc\u53e2\u3002\u75e4\u7621\u4e19\u9178\u687f\u83cc\u662f\u9020\u6210\u9752\u6625\u75d8\u7684\u4e3b\u8981\u7d30\u83cc\u7a2e\u985e\uff0c\u5728\u53ad\u6c27\u74b0\u5883\u4e0b\u751f\u9577\uff0c\u662f\u5728\u6bdb\u56ca\u3001\u76ae\u8102\u817a\u4e2d\u90fd\u80fd\u8f15\u6613\u767c\u73fe\u4ed6\u5011\u8e64\u8de1\u7684\u6b63\u5e38\u76ae\u819a\u83cc\u53e2\u3002\u4e0d\u904e\u7576\u75e4\u7621\u4e19\u9178\u687f\u83cc\u904e\u5ea6\u7e41\u6b96\u7684\u6642\u5019\uff0c\u5c31\u5f88\u5bb9\u6613\u5f15\u8d77\u7c89\u523a\u3001\u9752\u6625\u75d8\u7b49\u64fe\u4eba\u7684\u76ae\u819a\u554f\u984c\u3002\u6240\u4ee5\uff0c\u7576\u7814\u7a76\u4eba\u54e1\u5728\u5f9e\u6709\u9752\u6625\u75d8\u56f0\u64fe\u7684\u53d7\u8a66\u8005\u81c9\u4e0a\u6240\u63a1\u96c6\u5230\u7684\u83cc\u53e2\u6a23\u672c\u4e2d\uff0c\u767c\u73fe\u5927\u91cf\u7684\u75e4\u7621\u4e19\u9178\u687f\u83cc\u6642\uff0c\u53ea\u662f\u4e00\u5982\u6240\u9810\u6599\u3002\u4f46\u662f\u4ee4\u4eba\u5403\u9a5a\u7684\u662f\uff0c\u9019\u4e9b\u6aa2\u9ad4\u4e2d\u7684\u75e4\u7621\u4e19\u9178\u687f\u83cc\uff0c\u90fd\u4e0d\u7d04\u800c\u540c\u5730\u6291\u5236\u4e86\u53ef\u4ee5\u81ea\u5df1\u5408\u6210\u7dad\u751f\u7d20B12\u7684\u76f8\u95dc\u57fa\u56e0\uff0c\u800c\u4e0d\u518d\u81ea\u5df1\u88fd\u9020\u7dad\u751f\u7d20B12\u4e86\uff01<\/p>\n<p>\u7814\u7a76\u5718\u968a\u89c0\u5bdf\u5230\u9019\u500b\u73fe\u8c61\u4e4b\u5f8c\u89ba\u5f97\u5f88\u6709\u8da3\uff0c\u63a5\u4e0b\u4f86\uff0c\u4ed6\u5011\u53cd\u5176\u9053\u800c\u884c\u5730\u8b93\u76ae\u819a\u72c0\u6cc1\u5065\u5eb7\u7684\u53d7\u8a66\u8005\u63a5\u53d7\u4e00\u6b21\u4e00\u6beb\u514b\u7fa5\u9237\u80fa\uff081 mg hydroxocobalamin\uff0c\u4e5f\u5c31\u662f\u7dad\u751f\u7d20B12\u03b1\uff09\u7684\u808c\u8089\u6ce8\u5c04\u3002\u5728\u81e8\u5e8a\u4e0a\uff0c\u4e00\u6beb\u514b\u7fa5\u9237\u80fa\u7684\u808c\u8089\u6ce8\u5c04\u53ef\u4ee5\u5f88\u6709\u6548\u5730\u589e\u52a0\u8840\u6db2\u5167\u7dad\u751f\u7d20B12\u7684\u6fc3\u5ea6\uff0c\u800c\u4e14\u901a\u5e38\u53ef\u4ee5\u6301\u7e8c\u5169\u500b\u79ae\u62dc\u5de6\u53f3\uff0c\u5927\u7d04\u5728\u56db\u661f\u671f\u4e4b\u5f8c\uff0c\u8840\u6db2\u4e2d\u7684\u7dad\u751f\u7d20B12\u6fc3\u5ea6\u6703\u56de\u5230\u6ce8\u5c04\u524d\u7684\u72c0\u614b\u3002\u5341\u500b\u63a5\u53d7\u7dad\u751f\u7d20B12\u6ce8\u5c04\u7684\u5065\u5eb7\u53d7\u8a66\u8005\u90fd\u5728\u6ce8\u5c04\u524d\u3001\u6ce8\u5c04\u5169\u5929\u5f8c\u8207\u5169\u500b\u79ae\u62dc\u5f8c\u7684\u4e09\u500b\u6642\u9593\u9ede\uff0c\u88ab\u7814\u7a76\u4eba\u54e1\u6536\u96c6\u76ae\u819a\u83cc\u53e2\u6a23\u672c\u3002\u5176\u4e2d\u4e00\u500b\u76ae\u819a\u5065\u5eb7\u7684\u53d7\u8a66\u8005\uff0c\u4ee5\u524d\u90fd\u6c92\u6709\u56e0\u70ba\u9752\u6625\u75d8\u7684\u554f\u984c\u9700\u8981\u53bb\u770b\u76ae\u819a\u79d1\u91ab\u751f\uff0c\u7d50\u679c\u5728\u63a5\u53d7\u6ce8\u5c04\u5f8c\u7684\u4e00\u500b\u79ae\u62dc\u4e4b\u5f8c\uff0c\u5c31\u958b\u59cb\u72c2\u5192\u75d8\u75d8\u3002\u800c\u4e14\uff0c\u7814\u7a76\u4eba\u54e1\u5728\u5206\u6790\u5341\u500b\u63a5\u53d7\u6ce8\u5c04\u7684\u53d7\u8a66\u8005\u76ae\u819a\u83cc\u53e2\u6240\u8868\u9054\u7684\u57fa\u56e0\u7d44\u4e4b\u5f8c\uff0c\u767c\u73fe\u6a23\u672c\u4e2d\u7684\u83cc\u53e2\uff0c\u4e5f\u90fd\u6291\u5236\u4e86\u5408\u6210\u7dad\u751f\u7d20B12\u7684\u76f8\u95dc\u57fa\u56e0\u8868\u9054\u3002\u53ef\u898b\u4eba\u9ad4\u5167\u7684\u7dad\u751f\u7d20B12\u6fc3\u5ea6\uff0c\u6703\u76f4\u63a5\u5f71\u97ff\u5230\u76ae\u819a\u83cc\u53e2\u75e4\u7621\u4e19\u9178\u687f\u83cc\u7684\u751f\u7406\u5408\u6210\u8207\u4ee3\u8b1d\u9014\u5f91\u3002<\/p>\n<p>\u7576\u76ae\u819a\u4e0a\u75e4\u7621\u4e19\u9178\u687f\u83cc\u300c\u611f\u6e2c\u300d\u5230\u74b0\u5883\u4e2d\u7684\u7dad\u751f\u7d20B12\u542b\u91cf\u589e\u52a0\u6216\u904e\u591a\u7684\u6642\u5019\uff0c\u5b83\u5011\u5c31\u6703\u628a\u5408\u6210\u7dad\u751f\u7d20B12\u7684\u4ee3\u8b1d\u9014\u5f91\u300c\u505c\u6a5f\u300d\uff0c\u4e26\u4e14\u6291\u5236\u5408\u6210\u7dad\u751f\u7d20B12\u7684\u76f8\u95dc\u57fa\u56e0\u3002\u65bc\u662f\uff0c\u672c\u4f86\u8981\u7528\u4f86\u5408\u6210\u7dad\u751f\u7d20B12\u7684\u916e\u620a\u4e8c\u9178\uff082-oxoglutarate\uff09\u8ddf\u8c37\u80fa\u9178\uff08L-glutamate\uff09\u542b\u91cf\u5927\u589e\uff0c\u904e\u91cf\u7684\u8c37\u80fa\u9178\u5c31\u88ab\u62ff\u53bb\u5408\u6210\u5167\u7d2b\u8cea\uff08prophyrin\uff09\u4e86\u3002\u5167\u7d2b\u8cea\u4e5f\u662f\u75e4\u7621\u4e19\u9178\u687f\u83cc\u6b63\u5e38\u4ee3\u8b1d\u6642\uff0c\u6703\u5408\u6210\u7684\u7522\u7269\u4e4b\u4e00\u3002\u4f46\u662f\u5728\u7dad\u751f\u7d20B12\u5408\u6210\u9014\u5f91\u6d3b\u8e8d\u7684\u6642\u5019\uff0c\u5167\u7d2b\u8cea\u7684\u7522\u751f\u91cf\u5f88\u5c11\uff1b\u4e00\u65e6\u7dad\u751f\u7d20B12\u5408\u6210\u9014\u5f91\u88ab\u6291\u5236\uff0c\u5167\u7d2b\u8cea\u7684\u7522\u91cf\u5c31\u6703\u6fc0\u589e\u3002\u800c\u5167\u7d2b\u8cea\u5df2\u7d93\u88ab\u8b49\u5be6\u6703\u5f15\u8d77\u76ae\u819a\u767c\u708e\u53cd\u61c9\uff0c\u800c\u4f7f\u5f97\u81c9\u4e0a\u75d8\u75d8\u72c2\u5192\u3002\u6240\u4ee5\u7576\u75e4\u7621\u4e19\u9178\u687f\u83cc\u6291\u5236\u5b83\u81ea\u5df1\u5408\u6210\u7dad\u751f\u7d20B12\u7684\u53cd\u61c9\u8def\u5f91\u5f8c\uff0c\u5c31\u6703\u5206\u6ccc\u904e\u591a\u7684\u5167\u7d2b\u8cea\uff0c\u800c\u5f15\u8d77\u9752\u6625\u75d8\u4e86\u3002<\/p>\n<p><strong>\u539f\u59cb\u8ad6\u6587\uff1a<\/strong><br \/>\nKang D, Shi B, Erfe MC, Craft N, Li H. Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. <em>Sci Transl Med<\/em>. 2015 Jun 24;7(293):293ra103. doi: 10.1126\/scitranslmed.aab2009. PMID: 26109103<\/p>\n<p><strong style=\"color: #000000;\"><span style=\"color: #333399;\">--<\/span><\/strong><br style=\"color: #000000;\" \/><strong style=\"color: #000000;\"><span style=\"color: #333399;\">\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4f60\u6700\u8fd1\u5728\u70ba\u81c9\u4e0a\u9577\u9752\u6625\u75d8\u6240\u82e6\u60f1\u55ce\uff1f\u6216\u8a31\u662f<\/p>\n","protected":false},"author":20,"featured_media":22354,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2098,2099,2100,2097,1573],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/\u9752\u6625\u75d8.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22353"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22353"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22353\/revisions"}],"predecessor-version":[{"id":32324,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22353\/revisions\/32324"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/22354"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}