

{"id":22338,"date":"2015-11-11T00:54:09","date_gmt":"2015-11-10T16:54:09","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=22338"},"modified":"2018-08-01T16:30:27","modified_gmt":"2018-08-01T08:30:27","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%88alzheimers%ef%bc%89%e6%98%af%e5%90%a6%e6%9c%83%e5%82%b3%e6%9f%93%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=22338","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheimer's\uff09\u662f\u5426\u6703\u50b3\u67d3\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u4e00\u822c\u8a8d\u77e5\u88e1\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheimer's\uff09\u7d55\u4e0d\u53ef\u80fd\u50b3\u67d3\uff0c\u4f46\u9019\u88e1\u6211\u5011\u8981\u8aaa\u7684\u662f\u53e6\u4e00\u7a2e\u300c\u50b3\u67d3\u300d\uff01<\/strong><\/span><\/p>\n<figure id=\"attachment_22341\" aria-describedby=\"caption-attachment-22341\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-22341\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/dependent-100343_640.jpg\" alt=\" CC0 Public Domain\" width=\"450\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/dependent-100343_640.jpg 640w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/dependent-100343_640-300x225.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/dependent-100343_640-600x450.jpg 600w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-22341\" class=\"wp-caption-text\">CC0 Public Domain<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u5f9e1958\u5e74\u52301985\u5e74\uff0c\u6709\u4e00\u7fa4\u4eba\uff08\u5927\u90e8\u5206\u662f\u5152\u7ae5\uff09\u56e0\u70ba\u63a5\u53d7\u4e86\u751f\u9577\u7d20\u7684\u6cbb\u7642\u800c\u611f\u67d3\u4e86\u72c2\u725b\u75c7\u3002\u9019\u4e9b\u751f\u9577\u7d20\u7684\u4f86\u6e90\u4f86\u81ea\u65bc\u5c4d\u9ad4\u7684\u8166\u4e0b\u5782\u9ad4\uff1b\u5728\u767c\u73fe\u4ee5\u5f8c\uff0c\u7531\u5c4d\u9ad4\u4e2d\u8403\u53d6\u751f\u9577\u7d20\u505a\u70ba\u751f\u7269\u88fd\u5291\u7684\u4f5c\u6cd5\u99ac\u4e0a\u5c31\u558a\u505c\u4e86\u3002\u4f46\u662f\uff0c\u5df2\u7d93\u5927\u7d04\u6709\u4e09\u842c\u4eba\u63a5\u53d7\u4e86\u9019\u6a23\u7684\u6cbb\u7642\uff0c\u800c\u5230\u76ee\u524d\u4e5f\u5df2\u7d93\u6709450\u500b\u4eba\u56e0\u6b64\u800c\u611f\u67d3\u4e86\u72c2\u725b\u75c7\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u5728\u89e3\u5256\u9019\u4e9b\u75c5\u4eba\u6642\uff0c\u7814\u7a76\u5718\u968a\u5728\u516b\u500b\u75c5\u4eba\u4e2d\uff0c\u767c\u73fe\u5176\u4e2d\u6709\u56db\u4f4d\u7684\u8166\u90e8\u90fd\u51fa\u73fe\u4e86\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u75c5\u8b8a\u3002\u9019\u4e9b\u4eba\u7684\u5927\u8166\u7070\u8cea\uff0c\u51fa\u73fe\u4e86\u03b2-\u985e\u6fb1\u7c89\u9ad4\uff08Amyloid \u03b2\uff09\u3002<!--more--><\/p>\n<figure id=\"attachment_22339\" aria-describedby=\"caption-attachment-22339\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-22339\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/nature15369-f1-864x1024.jpg\" alt=\"\u03b2-\u985e\u6fb1\u7c89\u9ad4\u7684\u6c88\u7a4d\u3002\u5716\u7247\u4f86\u6e90\uff1aNature\" width=\"500\" height=\"592\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/nature15369-f1-864x1024.jpg 864w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/nature15369-f1-253x300.jpg 253w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/nature15369-f1-800x948.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/nature15369-f1.jpg 946w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-22339\" class=\"wp-caption-text\">\u03b2-\u985e\u6fb1\u7c89\u9ad4\u7684\u6c88\u7a4d\u3002\u5716\u7247\u4f86\u6e90\uff1aNature<\/figcaption><\/figure>\n<p>\u7531\u65bc\u9019\u4e9b\u75c5\u4eba\u7684\u5e74\u9f61\u4ecb\u65bc36\u523051\u6b72\u4e4b\u9593\uff0c\u6c92\u6709\u53ef\u80fd\u7522\u751f\u8001\u5e74\u6027\u963f\u8332\u6d77\u9ed8\u75c7\uff1b\u56e0\u6b64\u7814\u7a76\u5718\u968a\u6aa2\u67e5\u4ed6\u5011\u7684\u57fa\u56e0\u9ad4\uff0c\u770b\u770b\u662f\u5426\u6709\u57fa\u56e0\u7f3a\u640d\u9020\u6210\u907a\u50b3\u6027\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u53ef\u80fd\u3002\u7d50\u679c\u662f\uff0c\u9019\u4e9b\u75c5\u4eba\u7684\u57fa\u56e0\u9ad4\u4e2d\uff0c\u4e26\u4e0d\u5b58\u5728\u8457<em>APOE<\/em>\u00a0\u03b54\u6216\u662f\u5176\u4ed6\u76f8\u95dc\u57fa\u56e0\u7684\u7a81\u8b8a\u3002<\/p>\n<p>\u9019\u500b\u767c\u73fe\uff0c\u986f\u793a\u4e86\u9019\u56db\u4f4d\u75c5\u4eba\u7684\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u53ef\u80fd\u662f\u7531\u65bc\u4f7f\u7528\u4f86\u81ea\u5c4d\u9ad4\u7684\u751f\u7269\u88fd\u5291\u5c0e\u81f4\uff1b\u4f46\u7562\u7adf\u56db\u500b\u4eba\u7684\u6a23\u672c\u6578\u592a\u5c0f\u3001\u8981\u8ffd\u8e64\u4ed6\u5011\u7a76\u7adf\u662f\u5426\u4f7f\u7528\u540c\u4e00\u6279\u865f\u7684\u751f\u7269\u88fd\u5291\u4e5f\u5f88\u56f0\u96e3\u3002\u4e0d\u904e\uff0c\u904e\u53bb\u5728\u5c0f\u9f20\u8207\u7334\u5b50\u4e0a\u7684\u7814\u7a76\uff0c\u7684\u78ba\u767c\u73fe\u53ea\u9700\u8981\u4e00\u9ede\u9ede\u7684\u03b2-\u985e\u6fb1\u7c89\u9ad4\u7576\u4f5c\u300c\u7a2e\u5b50\u300d\uff0c\u5c31\u53ef\u4ee5\u5f15\u767c\u4e00\u9023\u4e32\u7684\u8b8a\u5316\uff0c\u7522\u751f\u985e\u4f3c\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u75c7\u72c0\u3002<\/p>\n<p>\u7576\u7136\uff0c\u9019\u7a2e\u50b3\u67d3\u7684\u9014\u5f91\uff0c\u8207\u6211\u5011\u901a\u5e38\u8aaa\u7684\u300c\u50b3\u67d3\u300d\u662f\u4e0d\u4e00\u6a23\u7684\uff1b\u4f46\u82e5\u662f\u63a5\u53d7\u751f\u7269\u88fd\u5291\u6703\u6709\u9020\u6210\u50b3\u67d3\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u98a8\u96aa\uff0c\u6216\u8a31\u672a\u4f86\u5728\u5176\u4ed6\u61c9\u7528\u5230\u4f86\u81ea\u4eba\u9ad4\u7684\u751f\u7269\u88fd\u5291\u7684\u6cbb\u7642\u6642\uff0c\u4e8b\u524d\u7684\u7be9\u6aa2\u8981\u66f4\u5c0f\u5fc3\uff1f\u4ee5\u76ee\u524d\u4f86\u8aaa\uff0c\u61c9\u8a72\u9084\u662f\u76ca\u8655\u5927\u65bc\u98a8\u96aa\uff0c\u4f46\u6301\u7e8c\u9032\u884c\u8ffd\u8e64\u7814\u7a76\uff0c\u4f86\u91d0\u6e05\u9019\u90e8\u5206\u7684\u98a8\u96aa\uff0c\u61c9\u8a72\u662f\u672a\u4f86\u9700\u8981\u4f5c\u7684\u3002<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong><br \/>\n1. John Collinge, Sebastian Brandner et. al., 2015.\u00a0<a href=\"http:\/\/www.nature.com\/nature\/journal\/v525\/n7568\/full\/nature15369.html\" target=\"_blank\" rel=\"noopener noreferrer\">Evidence for human transmission of amyloid-\u03b2 pathology and cerebral amyloid angiopathy<\/a>. Nature. doi:10.1038\/nature15369<br \/>\n2. Diana Kwon. 2015\/9\/9.\u00a0<a href=\"http:\/\/www.scientificamerican.com\/article\/evidence-for-person-to-person-transmission-of-alzheimer-s-pathology\/\" target=\"_blank\" rel=\"noopener noreferrer\">Evidence for Person-to-Person Transmission of Alzheimer's Pathology<\/a>. Scientific American.<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br style=\"color: #000000;\" \/><span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4e00\u822c\u8a8d\u77e5\u88e1\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheime<\/p>\n","protected":false},"author":20,"featured_media":22341,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2094,152,1233],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/09\/dependent-100343_640.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22338"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22338"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22338\/revisions"}],"predecessor-version":[{"id":32392,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22338\/revisions\/32392"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/22341"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}