{"id":22266,"date":"2015-10-22T00:12:27","date_gmt":"2015-10-21T16:12:27","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=22266"},"modified":"2018-08-01T16:15:03","modified_gmt":"2018-08-01T08:15:03","slug":"%e3%80%90%e4%ba%ba%e9%ab%94%e5%a5%a7%e5%a6%99%e3%80%91%e7%87%92%e5%82%b7%e5%8f%af%e4%bb%a5%e4%bd%bf%e7%99%bd%e8%89%b2%e8%84%82%e8%82%aa%e7%b5%84%e7%b9%94%e8%bd%89%e8%ae%8a%e7%82%ba%e6%a3%95%e8%89%b2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=22266","title":{"rendered":"\u3010\u4eba\u9ad4\u5967\u5999\u3011\u71d2\u50b7\u53ef\u4ee5\u4f7f\u767d\u8272\u8102\u80aa\u7d44\u7e54\u8f49\u8b8a\u70ba\u68d5\u8272"},"content":{"rendered":"<figure id=\"attachment_22267\" aria-describedby=\"caption-attachment-22267\" style=\"width: 450px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-22267\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue-1024x819.png\" alt=\"\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\" width=\"450\" height=\"360\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue-1024x819.png 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue-300x240.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue-800x640.png 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue-600x480.png 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue.png 1280w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><figcaption id=\"caption-attachment-22267\" class=\"wp-caption-text\">\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u71d2\u50b7\u7684\u75c5\u4eba\u9700\u8981\u6bd4\u4e00\u822c\u4eba\u591a\u651d\u53d640%\u7684\u5361\u8def\u91cc\uff0c\u5176\u4e2d\u6709\u4e00\u90e8\u4efd\u56fa\u7136\u662f\u70ba\u4e86\u5fa9\u539f\uff0c\u4f46\u4e5f\u6709\u4e00\u90e8\u4efd\u662f\u70ba\u4e86\u4fdd\u6eab\u3002\u70ba\u4ec0\u9ebc\u5462\uff1f\u56e0\u70ba\u5927\u9762\u7a4d\u71d2\u50b7\u5f8c\uff0c\u5931\u53bb\u4e86\u76ae\u819a\u7684\u5c4f\u969c\uff0c\u75c5\u4eba\u4fbf\u6703\u6709\u5931\u6eab\u7684\u5371\u96aa\uff1b\u70ba\u4e86\u9632\u6b62\u5931\u6eab\uff0c\u71d2\u50b7\u7684\u75c5\u4eba\u6703\u555f\u52d5\u808c\u8089\u4ee5\u53ca\u68d5\u8272\u8102\u80aa\u7d44\u7e54\uff08brown fat tissue\uff09\u7684\u7522\u71b1\u4f5c\u7528\uff08thermogenesis\uff09\uff0c\u4fdd\u8b77\u81ea\u5df1\u514d\u65bc\u5931\u6eab\u3002<\/p>\n<p>\u6240\u8b02\u68d5\u8272\u8102\u80aa\u7684\u7522\u71b1\u4f5c\u7528\uff0c\u662f\u5c07\u539f\u672c\u8981\u7528\u65bc\u7522\u751f\u80fd\u91cf\uff08ATP\uff09\u7684\u6c2b\u96e2\u5b50\uff08H<sup>+<\/sup>\uff09\u76f4\u63a5\u7d93\u7531\u68d5\u8272\u8102\u80aa\u7279\u6709\u7684\u7522\u71b1\u86cb\u767d\uff08UCP1\uff09\u9001\u56de\u7c92\u7dda\u9ad4\u3002\u5982\u6b64\uff0c\u6c2b\u96e2\u5b50\u6240\u651c\u5e36\u7684\u80fd\u91cf\u5168\u90e8\u7528\u65bc\u7522\u71b1\uff0c\u5927\u91cf\u7684\u71b1\u80fd\u4fbf\u91cb\u51fa\u4e86\u3002<\/p>\n<p>\u68d5\u8272\u8102\u80aa\u7684\u7522\u71b1\u4f5c\u7528\uff0c\u5c0d\u5b30\u5e7c\u5152\u7684\u9ad4\u6eab\u7dad\u6301\u975e\u5e38\u91cd\u8981\uff1b\u6b63\u5e38\u72c0\u6cc1\u4e0b\uff0c\u6210\u4eba\u7684\u9ad4\u6eab\u4e5f\u6709\u4e00\u90e8\u4efd\u4f86\u81ea\u65bc\u5b83\u3002\u7576\u7136\uff0c\u5927\u9762\u7a4d\u71d2\u50b7\u5f8c\uff0c\u9ad4\u6eab\u7684\u7dad\u6301\u4fbf\u9700\u8981\u68d5\u8272\u8102\u80aa\u7684\u5927\u529b\u652f\u6301\u4e86\u3002<!--more--><\/p>\n<figure id=\"attachment_22270\" aria-describedby=\"caption-attachment-22270\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/ThermogeneseAdipozyten-en.svg_.png\"><img decoding=\"async\" class=\"wp-image-22270\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/ThermogeneseAdipozyten-en.svg_.png\" alt=\"UCP1\uff08\u5716\u4e0b\u65b9\u7d2b\u8272\u6a62\u5713\uff09\u7684\u4f5c\u7528\u6a5f\u5236\u3002\u5716\u7247\u4f86\u6e90\uff1awiki \" width=\"500\" height=\"581\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/ThermogeneseAdipozyten-en.svg_.png 744w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/ThermogeneseAdipozyten-en.svg_-258x300.png 258w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><figcaption id=\"caption-attachment-22270\" class=\"wp-caption-text\">UCP1\uff08\u5716\u4e0b\u65b9\u7d2b\u8272\u6a62\u5713\uff09\u7684\u4f5c\u7528\u6a5f\u5236\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p>\u4f46\u662f\uff0c\u6210\u4eba\u7684\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u53ea\u6709\u6578\u767e\u514b\uff0c\u4e3b\u8981\u96c6\u4e2d\u5728\u9396\u9aa8\u5468\u570d\u8207\u9838\u90e8\uff0c\u5982\u4f55\u80fd\u7522\u751f\u8db3\u5920\u7684\u71b1\u5462\uff1f\u5fb7\u5dde\u5927\u5b78\uff08University of Texas\uff09\u7684\u7814\u7a76\u5718\u968a\u6536\u96c6\u4e8642\u540d\u5152\u7ae5\u82076\u540d\u6210\u4eba\u71d2\u50b7\u75c5\u60a3\u7684\u7d44\u7e54\u9032\u884c\u7814\u7a76\u5f8c\u767c\u73fe\uff0c\u5728\u71d2\u50b7\u521d\u671f\uff08\u4e00\u9031\u5167\uff09\u7684\u75c5\u4eba\uff0c\u7684\u78ba\u662f\u4f9d\u9760\u808c\u8089\u8207\u539f\u672c\u7684\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7522\u71b1\uff1b\u4f46\u662f\u5f9e\u7b2c\u4e8c\u9031\u958b\u59cb\uff0c\u75c5\u4eba\u7684\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\uff08subcutaneous white adipose tissue\uff0csWAT\uff09\u4fbf\u958b\u59cb\u6162\u6162\u8f49\u70ba\u68d5\u8272\u8102\u80aa\u7d44\u7e54\uff0c\u52a0\u5165\u7522\u71b1\u4fdd\u6eab\u7684\u884c\u5217\u3002<\/p>\n<p>\u9019\u4e9b\u75c5\u60a3\u90fd\u662f\u5927\u9762\u7a4d\u71d2\u50b7\u7684\u60a3\u8005\uff0c\u5152\u7ae5\u5e73\u5747\u670954%\u7684\u7e3d\u9ad4\u8868\u9762\u7a4d\uff08TBSA\uff0ctotal body surface area\uff09\u71d2\u50b7\uff0c\u4e14\u5e73\u5747\u7d04\u670937%\u7684\u7e3d\u9ad4\u8868\u9762\u7a4d\u70ba\u4e09\u5ea6\u707c\u50b7\u3002\u5927\u4eba\u5247\u670969%\u7684\u7e3d\u9ad4\u8868\u9762\u7a4d\u71d2\u50b7\uff0c\u5176\u4e2d\u670964%\u7684\u7e3d\u9ad4\u8868\u9762\u7a4d\u70ba\u4e09\u5ea6\u707c\u50b7\u3002\u5152\u7ae5\u670931\u4f4d\u7537\u6027\u300111\u4f4d\u5973\u6027\uff0c\u6210\u4eba\u5247\u67094\u4f4d\u7537\u6027\u30012\u4f4d\u5973\u6027\u3002\u540c\u6642\u4e5f\u5fb5\u6c42\u4e8619\u4f4d\u5fd7\u9858\u8005\uff0810\u4f4d\u5152\u7ae5\u30019\u4f4d\u6210\u4eba\uff09\u505a\u70ba\u63a7\u5236\u7d44\u3002<\/p>\n<p>\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u5247\u5206\u5225\u5728\u71d2\u50b7\u5f8c5\u5929\u5230\u4e00\u9031\u5167\uff0c\u4ee5\u53ca\u4e00\u9031\u4ee5\u5f8c\u76f4\u5230\u96e2\u958b\u52a0\u8b77\u75c5\u623f\u524d\u63a1\u96c6\u3002\u7d50\u679c\u767c\u73fe\uff0c\u71d2\u50b7\u75c5\u60a3\u7684\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\uff0c\u5728\u71d2\u50b7\u4e00\u9031\u5f8c\u958b\u59cb\u51fa\u73fe\u7d30\u80de\u8b8a\u5c0f\uff0c\u4ee5\u53caUCP1\u7522\u71b1\u86cb\u767d\uff08thermogenin\uff09\u8868\u73fe\u91cf\u5347\u9ad8\u7684\u73fe\u8c61\uff0c\u986f\u793a\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u6b63\u5728\u6162\u6162\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u3002<\/p>\n<p>UCP1\u7522\u71b1\u86cb\u767d\u4e0d\u662f\u552f\u4e00\u5728\u71d2\u50b7\u75c5\u60a3\u7684\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u4e2d\u8868\u73fe\u91cf\u5347\u9ad8\u7684\u86cb\u767d\u8cea\uff0c\u53e6\u5916\u9084\u6709\u6ab8\u6aac\u9178\u5faa\u74b0\u7684\u6ab8\u6aac\u9178\u5408\u6210\u9176\uff08citrate synthase\uff09\u7684\u8868\u73fe\u91cf\u4e5f\u9010\u6b65\u5347\u9ad8\uff0c\u4ee3\u8868\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u5df2\u7d93\u7531\u55ae\u7d14\u7684\u8102\u80aa\u5132\u5b58\u7d44\u7e54\u8f49\u8b8a\u70ba\u71c3\u71d2\u8102\u80aa\u7522\u71b1\u7684\u68d5\u8272\u8102\u80aa\u7d44\u7e54\uff1b\u540c\u6642\uff0c\u68d5\u8272\u8102\u80aa\u7684\u7d44\u7e54\u6a19\u8a18ZIC1\u4e5f\u51fa\u73fe\u4e86\u3002\u6240\u6709\u7684\u9019\u4e9b\u8f49\u8b8a\uff0c\u90fd\u610f\u5473\u8457\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u5df2\u7d93\u9010\u6f38\u5730\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u4e86\u3002<\/p>\n<p>\u70ba\u4ec0\u9ebc\u71d2\u50b7\u6703\u4f7f\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u5462\uff1f\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff0c\u53ef\u80fd\u8207\u71d2\u50b7\u5f8c\u814e\u4e0a\u817a\u7d20\uff08epinephrine\uff09\u8207\u6b63\u814e\u4e0a\u817a\u7d20\uff08norepinephrine\uff09\u5206\u6ccc\u4e0a\u6607\u6709\u95dc\u3002\u904e\u53bb\u7684\u7814\u7a76\u767c\u73fe\uff0c\u9f67\u9f52\u52d5\u7269\u9577\u671f\u66b4\u9732\u5728\u4f4e\u6eab\u74b0\u5883\u4e0b\uff0c\u6703\u4f7f\u7260\u5011\u7684\uff08\u6b63\uff09\u814e\u4e0a\u817a\u7d20\u5206\u6ccc\u589e\u52a0\uff0c\u5f9e\u800c\u4f7f\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u3002\u96d6\u7136\u9577\u671f\u4f4e\u6eab\u74b0\u5883\u4e26\u4e0d\u80fd\u4f7f\u4eba\u985e\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\uff0c\u4f46\u662f\u4f4e\u6eab\u50c5\u80fd\u4f7f\u4eba\u7684\uff08\u6b63\uff09\u814e\u4e0a\u817a\u7d20\u5206\u6ccc\u5fae\u91cf\u4e0a\u6607\u3002<\/p>\n<p>\u76f8\u5c0d\u7684\uff0c\u5728\u4eba\u985e\u7684\u71d2\u50b7\u75c5\u4eba\u7684\u7814\u7a76\u4e0a\u537b\u767c\u73fe\uff0c\u71d2\u50b7\u5f8c\u4e00\u9031\uff0c\u814e\u4e0a\u817a\u7d20\u7684\u5206\u6ccc\u4e0a\u6607\u4e8610\u500d\uff0c\u800c\u6b63\u814e\u4e0a\u817a\u7d20\u7684\u5206\u6ccc\u4e0a\u6607\u4e866\u500d\uff1b\u4e14\u7dad\u6301\u4e86\u81f3\u5c11\u4e09\u9031\u3002\u6216\u8a31\u4f4e\u6eab\u7121\u6cd5\u4f7f\u4eba\u9ad4\u7684\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\uff0c\u53cd\u800c\u71d2\u50b7\u624d\u80fd\uff0c\u6b63\u662f\u56e0\u70ba\uff08\u6b63\uff09\u814e\u4e0a\u817a\u7d20\u6fc3\u5ea6\u63d0\u5347\u7684\u7a0b\u5ea6\u4e0d\u540c\u3002<\/p>\n<p>\u6700\u8fd1\u9019\u4e9b\u5e74\uff0c\u7814\u7a76\u5982\u4f55\u4f7f\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\uff0c\u5df2\u7d93\u6210\u70ba\u71b1\u9580\u7684\u984c\u76ee\u3002\u70ba\u4ec0\u9ebc\u5462\uff1f\u56e0\u70ba\u6e1b\u80a5\u6700\u96e3\u6e1b\u7684\u5c31\u662f\u76ae\u4e0b\u767d\u8272\u8102\u80aa\uff01\u96d6\u7136\u9019\u7bc7\u7814\u7a76\u4e3b\u8981\u662f\u91dd\u5c0d\u71d2\u50b7\u75c5\u60a3\uff0c\u4f46\u5982\u679c\u80fd\u5920\u5728\u4e00\u822c\u7684\u72c0\u6cc1\u4e0b\uff0c\u4f7f\uff08\u6b63\uff09\u814e\u4e0a\u817a\u7d20\u63d0\u9ad8\u5230\u53ef\u4ee5\u4f7f\u6211\u5011\u7684\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u8f49\u8b8a\u70ba\u68d5\u8272\u8102\u80aa\u7d44\u7e54\uff0c\u6e1b\u80a5\u5c31\u6613\u5982\u53cd\u638c\u4e86\u4e0d\u662f\u55ce\uff1f\u7562\u7adf\u6bcf\u500b\u4eba\u8eab\u4e0a\u9802\u591a\u53ea\u6709\u5e7e\u767e\u514b\u7684\u68d5\u8272\u8102\u80aa\uff0c\u4f46\u537b\u90fd\u6709\u5341\u5e7e\u5230\u5e7e\u5341\u516c\u65a4\u7684\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u5462\uff01<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong>Sidossis L.S. et. al., 2015. Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress. Cell Metabolism. http:\/\/dx.doi.org\/10.1016\/j.cmet.2015.06.022<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br style=\"color: #000000;\" \/><span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u64b0\u6587\uff5c\u8449\u7da0\u8212 \u71d2\u50b7\u7684\u75c5\u4eba\u9700\u8981\u6bd4\u4e00\u822c\u4eba\u591a\u651d<\/p>\n","protected":false},"author":20,"featured_media":22267,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1938,2077,1940,1992,1543],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/1280px-Blausen_0012_AdiposeTissue.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22266"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22266"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22266\/revisions"}],"predecessor-version":[{"id":32354,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22266\/revisions\/32354"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/22267"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}