{"id":22092,"date":"2015-09-24T00:46:48","date_gmt":"2015-09-23T16:46:48","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=22092"},"modified":"2018-08-01T16:09:21","modified_gmt":"2018-08-01T08:09:21","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e8%bc%b8%e8%a1%80%e5%9b%9e%e6%98%a5%e7%9a%84%e9%97%9c%e9%8d%b5%e8%9b%8b%e7%99%bd%ef%bc%9a%ce%b22%e5%be%ae%e7%90%83%e8%9b%8b%e7%99%bd","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=22092","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u8f38\u8840\u56de\u6625\u7684\u95dc\u9375\u86cb\u767d\uff1a\u03b22\u5fae\u7403\u86cb\u767d"},"content":{"rendered":"<p><strong style=\"color: #000000;\"><span style=\"color: #333399;\">\u25a0<\/span><\/strong><strong><span style=\"color: #333399;\">\u8f38\u8840\u56de\u6625\uff1f\u6709\u5f71\u7121\uff1f<\/span><\/strong><\/p>\n<figure id=\"attachment_22095\" aria-describedby=\"caption-attachment-22095\" style=\"width: 252px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-22095\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/PBB_Protein_B2M_image.jpg\" alt=\"\u03b22-microglobulin\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\" width=\"252\" height=\"400\" \/><figcaption id=\"caption-attachment-22095\" class=\"wp-caption-text\">\u03b22-microglobulin\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u8f38\u8840\u53ef\u4ee5\u6297\u8001\uff0c\u9019\u7121\u8ad6\u5982\u4f55\u807d\u8d77\u4f86\u90fd\u50cf\u5deb\u8853\uff1b\u4f46\u662f\u57282014\u5e74\u7684\u300c\u81ea\u7136\u91ab\u5b78\u300d\u671f\u520a\uff08<em>Nature Medicine<\/em>\uff09\u88e1\uff0c\u7f8e\u570b\u7684\u7814\u7a76\u5718\u968a\u8b49\u660e\u4e86\uff0c\u5c07\u5e74\u8f15\u5c0f\u9f20\u7684\u8840\u6db2\u8f38\u5165\u5e74\u8001\u5c0f\u9f20\u7684\u9ad4\u5167\u4ee5\u5f8c\uff0c\u5c0f\u9f20\u7684\u795e\u7d93\u7d30\u80de\u589e\u751f\uff0c\u8a8d\u77e5\u529f\u80fd\u6539\u5584\uff0c\u986f\u793a\u300c\u8f38\u8840\u6297\u8001\u300d\u4f3c\u4e4e\u662f\u771f\u6709\u5176\u4e8b\uff01\u4f46\u662f\uff0c\u7a76\u7adf\u300c\u5e74\u8f15\u4eba\u300d\u7684\u8840\u88e1\u9762\u6709\u4ec0\u9ebc\u6297\u8001\u7684\u6210\u5206\u5462\uff1f\u6216\u8005\u662f\uff0c\u300c\u8001\u4eba\u300d\u7684\u8840\u88e1\u9762\u6709\u4ec0\u9ebc\u4e0d\u597d\u7684\u6771\u897f\u55ce\uff1f<\/p>\n<p>\u6700\u8fd1\uff0c\u540c\u4e00\u500b\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u539f\u4f86\u4e26\u4e0d\u662f\u300c\u5e74\u8f15\u4eba\u300d\u7684\u8840\u88e1\u9762\u6709\u4ec0\u9ebc\u6297\u8001\u7684\u6210\u5206\uff0c\u800c\u662f\u300c\u8001\u4eba\u300d\u7684\u8840\u88e1\u9762\u6709\u4e0d\u597d\u7684\u6771\u897f\u3002\u90a3\u500b\u7269\u8cea\u7a31\u70ba\u03b22\u5fae\u7403\u86cb\u767d\u3002<\/p>\n<p>\u8840\u6db2\u88e1\u9762\u7684\u6210\u5206\u4e0d\u77e5\u9053\u591a\u5c11\u7a2e\uff0c\u600e\u9ebc\u624d\u77ed\u77ed\u4e00\u5e74\u5c31\u627e\u5230\u4e86\u5462\uff1f\u7576\u7136\u4e0d\u662f\u4e82\u731c\u7684\uff01\u9996\u5148\u6211\u5011\u4f86\u770b\u4e00\u4e0b\u03b22\u5fae\u7403\u86cb\u767d\u5982\u4f55\u5f97\u5230\u7814\u7a76\u5718\u968a\u7684\u95dc\u611b\u7684\u773c\u795e\u3002<\/p>\n<p>\u539f\u4f86\uff0c\u5728\u904e\u53bb\u5df2\u7d93\u77e5\u9053\uff0c\u03b22\u5fae\u7403\u86cb\u767d\u8207\u5927\u8166\u7684\u767c\u80b2\u6709\u95dc\u3002\u800c\u5728\u8840\u6db2\u900f\u6790\u7684\u75c5\u4eba\uff0c\u4e5f\u767c\u73fe\u03b22\u5fae\u7403\u86cb\u767d\u7684\u91cf\u8207\u610f\u8b58\u969c\u7919\u4e4b\u9593\u6709\u76f8\u95dc\uff1b\u53e6\u5916\uff0c\u8207HIV\u76f8\u95dc\u7684\u7661\u5446\u75c7\u3001\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u4e5f\u8207\u03b22\u5fae\u7403\u86cb\u767d\u5728\u8166\u810a\u9ad3\u6db2\u4e2d\u7684\u542b\u91cf\u4e0a\u6607\u6709\u95dc\u3002\u56e0\u70ba\u9019\u4e9b\u56e0\u7d20\uff0c\u6240\u4ee5\u7814\u7a76\u5718\u968a\u6c7a\u5b9a\u5148\u770b\u770b\u7a76\u7adf\u662f\u4e0d\u662f\u03b22\u5fae\u7403\u86cb\u767d\u3002<!--more--><!--more--><\/p>\n<p>\u65bc\u662f\uff0c\u7814\u7a76\u5718\u968a\u6c7a\u5b9a\u5148\u770b\u770b\u5c0f\u9f20\u8840\u6f3f\u4e2d\u7684\u03b22\u5fae\u7403\u86cb\u767d\u6fc3\u5ea6\u662f\u5426\u96a8\u5e74\u9f61\u800c\u905e\u589e\u3002\u7d50\u679c\u767c\u73fe\uff0c\u96a8\u8457\u5c0f\u9f20\u5e74\u7d00\u8d8a\u4f86\u8d8a\u5927\uff0c\u8840\u6f3f\u4e2d\u7684\u03b22\u5fae\u7403\u86cb\u767d\u4e5f\u6108\u4f86\u6108\u591a\u3002\u7576\u4ed6\u5011\u628a\u5e74\u8001\u5c0f\u9f20\u7684\u8840\u8f38\u5165\u5e74\u8f15\u5c0f\u9f20\u9ad4\u5167\u5f8c\uff0c\u5e74\u8f15\u5c0f\u9f20\u9ad4\u5167\u7684\u03b22\u5fae\u7403\u86cb\u767d\u6fc3\u5ea6\u4e5f\u4e0a\u6607\u4e86\u3002<\/p>\n<p>\u6709\u4e86\u9019\u4e9b\u7d50\u679c\uff0c\u7814\u7a76\u5718\u968a\u63a5\u8457\u4fbf\u958b\u59cb\u9032\u884c\u4e00\u9023\u4e32\u7684\u5be6\u9a57\u3002\u70ba\u4e86\u4e86\u89e3\u5c0f\u9f20\u5011\u7684\u7a7a\u9593\u8a8d\u77e5\u8207\u8a18\u61b6\u662f\u5426\u53d7\u5230\u5f71\u97ff\uff0c\u4ed6\u5011\u4f7f\u7528\u7684\u6e2c\u8a66\u7cfb\u7d71\u5305\u62ec\uff1a\u8b93\u5c0f\u9f20\u8d70\u8f3b\u5c04\u81c2\u6c34\u8ff7\u5bae\uff08radial arm water maze\uff09\u8207\u89c0\u5bdf\u7260\u5011\u5728\u60c5\u5883\u6050\u61fc\u5236\u7d04\u5be6\u9a57\uff08contextual fear conditioning\uff09\u4e2d\u7684\u884c\u70ba\u3002<\/p>\n<p>\u4ed6\u5011\u767c\u73fe\uff0c\u7576\u4ed6\u5011\u628a\u03b22\u5fae\u7403\u86cb\u767d\u6ce8\u5c04\u5230\u4e09\u500b\u6708\u5927\u7684\u5c0f\u9f20\u9ad4\u5167\u4ee5\u5f8c\uff0c\u5c0f\u9f20\u4e0d\u50c5\u5728\u8d70\u8ff7\u5bae\u6642\u72af\u7684\u932f\u8aa4\u8f03\u591a\uff0c\u5728\u60c5\u5883\u6050\u61fc\u5236\u7d04\u5be6\u9a57\u4e2d\uff0c\u4e5f\u8f03\u7121\u6cd5\u8a18\u4f4f\u8b93\u7260\u6050\u61fc\u7684\u60c5\u5883\uff0c\u986f\u793a\u03b22\u5fae\u7403\u86cb\u767d\u53ef\u80fd\u5c0d\u5c0f\u9f20\u7684\u7a7a\u9593\u8a8d\u77e5\u8207\u8a18\u61b6\u9020\u6210\u640d\u5bb3\u3002\u6aa2\u67e5\u5c0f\u9f20\u7684\u8166\u4e5f\u767c\u73fe\uff0c\u6ce8\u5c04\u4e86\u03b22\u5fae\u7403\u86cb\u767d\u7684\u5c0f\u9f20\uff0c\u8166\u4e2d\u65b0\u751f\u7684\u795e\u7d93\u5143\u8b8a\u5c11\u3002<\/p>\n<p>\u7531\u65bc\u03b22\u5fae\u7403\u86cb\u767d\u9700\u8981TAP1\u86cb\u767d\u5c07\u5b83\u5011\u904b\u8f38\u5230\u7d30\u80de\u819c\u8868\u9762\uff0c\u65bc\u662f\u7814\u7a76\u5718\u968a\u89c0\u5bdf<em>TAP1<\/em>\u57fa\u56e0\u5254\u9664\u7684\u5c0f\u9f20\uff0c\u662f\u5426\u4e5f\u6703\u53d7\u5230\u03b22\u5fae\u7403\u86cb\u767d\u7684\u5f71\u97ff\u3002\u7d50\u679c\u767c\u73fe\uff0c\u5728<em>TAP1<\/em>\u57fa\u56e0\u5254\u9664\u7684\u5c0f\u9f20\u4e2d\uff0c\u6ce8\u5c04\u03b22\u5fae\u7403\u86cb\u767d\u4e0d\u80fd\u5c0d\u5c0f\u9f20\u7684\u7a7a\u9593\u8a8d\u77e5\u8207\u8a18\u61b6\u9020\u6210\u5f71\u97ff\uff0c\u9032\u4e00\u6b65\u986f\u793a\u4e86\u03b22\u5fae\u7403\u86cb\u767d\u8207\u8a8d\u77e5\u53ca\u8a18\u61b6\u7684\u95dc\u4fc2\u3002\u800c\u7814\u7a76\u5718\u968a\u5728\u5c0f\u9f20\u7684\u6d77\u99ac\u8ff4\uff08hippocampus\uff09\u4e2d\u4e5f\u770b\u5230\u4e86\u03b22\u5fae\u7403\u86cb\u767d\u7684\u8868\u73fe\uff0c\u800c\u4e14\u03b22\u5fae\u7403\u86cb\u767d\u8868\u73fe\u7684\u9ad8\u4f4e\u8207\u5c0f\u9f20\u6e2c\u8a66\u6642\u7684\u8868\u73fe\u597d\u58de\u6210\u53cd\u6bd4\u3002<\/p>\n<p>\u70ba\u4e86\u9032\u4e00\u6b65\u8b49\u5be6\u03b22\u5fae\u7403\u86cb\u767d\u679c\u771f\u662f\u300c\u56de\u6625\u300d\u7684\u95dc\u9375\u7269\u8cea\uff0c\u7814\u7a76\u5718\u968a\u89c0\u5bdf\u4e86\u03b22\u5fae\u7403\u86cb\u767d\u57fa\u56e0\u5254\u9664\u7684\u5c0f\u9f20\u3002\u7d50\u679c\u767c\u73fe\uff0c\u8207\u540c\u9f61\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5254\u9664\u03b22\u5fae\u7403\u86cb\u767d\u57fa\u56e0\u5f8c\uff0c\u5e74\u8001\u5c0f\u9f20\u7684\u7a7a\u9593\u5b78\u7fd2\u80fd\u529b\u4e0d\u96a8\u8457\u5e74\u8001\u800c\u8870\u9000\uff0c\u800c\u5728\u6050\u61fc\u5236\u7d04\u5be6\u9a57\u4e2d\uff0c\u57fa\u56e0\u5254\u9664\u5c0f\u9f20\u5c0d\u60c5\u5883\u7684\u8a18\u61b6\u4e5f\u8b8a\u597d\u4e86\uff08\u4e0d\u904e\u5c0d\u8072\u97f3\u60c5\u5883\u7684\u8a18\u61b6\u4f3c\u4e4e\u6c92\u6709\u6539\u8b8a\uff09\u3002\u4e0d\u904e\uff0c\u03b22\u5fae\u7403\u86cb\u767d\u57fa\u56e0\u5254\u9664\u5c0f\u9f20\uff0c\u5728\u5e74\u8f15\u6642\u4e26\u6c92\u6709\u4ec0\u9ebc\u7279\u7570\u4e4b\u8655\uff1b\u4e5f\u5c31\u662f\u8aaa\uff0c\u4ed6\u5011\u5728\u5e74\u8f15\u6642\u4e26\u4e0d\u662f\u300c\u8a18\u61b6\u7684\u8d85\u4eba\u300d\u3002<\/p>\n<p>\u6240\u6709\u9019\u4e9b\u5be6\u9a57\u7d50\u679c\u90fd\u6307\u5411\uff1a\u03b22\u5fae\u7403\u86cb\u767d\u662f\u8870\u8001\u6642\u5927\u8166\u9000\u5316\u7684\u91cd\u8981\u56e0\u7d20\u3002\u4f46\u662f\uff0c\u5c0f\u9f20\u7684\u5be6\u9a57\u7d50\u679c\u53ef\u4ee5\u985e\u6bd4\u5230\u4eba\u55ce\uff1f<\/p>\n<p>\u7b54\u6848\u662f\uff1a\u61c9\u8a72\u53ef\u4ee5\u7684\uff01\u9664\u4e86\u4e00\u958b\u59cb\u63d0\u904e\u7684\u4e00\u4e9b\u904e\u53bb\u89c0\u5bdf\u5230\u7684\u73fe\u8c61\u4ee5\u5916\uff0c\u7814\u7a76\u5718\u968a\u4e5f\u767c\u73fe\uff0c\u4eba\u985e\u8840\u6f3f\u4e2d\u7684\u03b22\u5fae\u7403\u86cb\u767d\u6fc3\u5ea6\u4e5f\u96a8\u8457\u6f38\u6f38\u8001\u53bb\u800c\u4e0a\u6607\uff0c\u800c\u4e14\u91dd\u5c0d\u4eba\u9032\u884c\u7684\u5168\u57fa\u56e0\u9ad4\u95dc\u9023\u7814\u7a76\uff08genome-wide association studies\uff09\uff0c\u4e5f\u767c\u73fe\u4f4d\u65bc\u7b2c\u516d\u689d\u67d3\u8272\u9ad4\u4e0a\u76846p21\u4f4d\u5740\u8207\u8001\u5e74\u6027\u9000\u5316\u75be\u75c5\u6709\u95dc\uff1b\u800c\u9019\u500b\u4f4d\u5740\u6b63\u662fMHC\u57fa\u56e0\u7684\u4f4d\u5740\u3002\u6240\u4ee5\uff0c\u6216\u8a31\u904e\u53bb\u76f8\u4fe1\u7684\u8f38\u8840\u53ef\u4ee5\u56de\u6625\u679c\u7136\u70ba\u771f\u55ce\uff1f<\/p>\n<p>\u7a76\u7adf\u03b22\u5fae\u7403\u86cb\u767d\u662f\u5982\u4f55\u5f71\u97ff\u6211\u5011\u7684\u5927\u8166\u5462\uff1f\u904e\u53bb\u7684\u4e00\u4e9b\u7814\u7a76\u8b93\u6211\u5011\u77e5\u9053\uff0c\u03b22\u5fae\u7403\u86cb\u767d\u662f\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u8907\u5408\u9ad4\u7b2c\u4e00\u578b\uff08Major Histocompatibility Complex I\uff0cMHCI\uff09\u7684\u4e00\u90e8\u4efd\uff0c\u7d44\u6210\u6211\u5011\u7684\u514d\u75ab\u3001\u7d44\u7e54\u76f8\u5bb9\u6027\u7cfb\u7d71\u6975\u70ba\u91cd\u8981\u7684\u4e00\u90e8\u4efd\uff08\u5982\u4e0b\u5716\uff09\u3002<\/p>\n<figure id=\"attachment_22097\" aria-describedby=\"caption-attachment-22097\" style=\"width: 308px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-22097\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/308px-MHC_Class_1.svg_.png\" alt=\"MHCI\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\" width=\"308\" height=\"394\" \/><figcaption id=\"caption-attachment-22097\" class=\"wp-caption-text\">MHCI\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p>\u4f46\u662f\uff0c\u4e00\u500b\u5c0f\u5c0f\u7684\u7403\u86cb\u767d\uff0c\u53c8\u600e\u9ebc\u6703\u5c0d\u5927\u8166\u9000\u5316\u6709\u5982\u6b64\u5927\u7684\u5f71\u97ff\u5462\uff1f\u9019\u4e00\u5207\u90fd\u9700\u8981\u66f4\u9032\u4e00\u6b65\u7684\u7814\u7a76\u4f86\u7406\u89e3\u5176\u4e2d\u7684\u6a5f\u5236\uff0c\u4f46\u7b46\u8005\u53ef\u4ee5\u9810\u671f\u7684\u662f\uff0c\u63a5\u4e0b\u4f86\u61c9\u8a72\u6703\u6709\u4eba\u60f3\u8981\u958b\u767c\u6e05\u9664\u9019\u500b\u5fae\u7403\u86cb\u767d\u7684\u88fd\u5291\u4e86\u3002<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong>Saul A Villeda. et. al. 2015.\u00a0<a href=\"http:\/\/www.nature.com\/nm\/journal\/vaop\/ncurrent\/full\/nm.3898.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u03b22-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis<\/a>. Nature Medicine.<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br style=\"color: #000000;\" \/><span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u8f38\u8840\u56de\u6625\uff1f\u6709\u5f71\u7121\uff1f \u64b0\u6587\uff5c\u8449\u7da0\u8212 \u8f38\u8840<\/p>\n","protected":false},"author":20,"featured_media":22095,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2042,2043,2044,1543,712],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/08\/PBB_Protein_B2M_image.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22092"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22092"}],"version-history":[{"count":9,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22092\/revisions"}],"predecessor-version":[{"id":32325,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/22092\/revisions\/32325"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/22095"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}