{"id":22037,"date":"2015-08-28T00:07:53","date_gmt":"2015-08-27T16:07:53","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=22037"},"modified":"2018-08-01T15:59:48","modified_gmt":"2018-08-01T07:59:48","slug":"%e3%80%90%e5%9f%ba%e5%9b%a0%e7%a0%94%e7%a9%b6%e3%80%91%e9%87%8e%e7%94%9f%e7%9a%84%e7%8e%89%e7%b1%b3%e5%a6%82%e4%bd%95%e8%ae%8a%e5%a5%bd%e5%90%83","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=22037","title":{"rendered":"\u3010\u57fa\u56e0\u7814\u7a76\u3011\u91ce\u751f\u7684\u7389\u7c73\u5982\u4f55\u8b8a\u597d\u5403"},"content":{"rendered":"
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\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n

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\u4f4d\u65bc\u7b2c\u56db\u865f\u67d3\u8272\u9ad4\u4e0a\u7684\u5340\u57df\uff0c\u4fbf\u662f\u5f71\u97ff\u7389\u7c73\u679c\u5be6\u7684\u57fa\u56e0\u6240\u5728\u3002\u7389\u7c73\u7684\u679c\u5be6\u5927\u3001\u7a2e\u5b50\u67d4\u8edf\uff1b\u800c\u8700\u9ecd\u7684\u679c\u5be6\u4e0d\u4f46\u5c0f\uff0c\u7a2e\u5b50\u5916\u9762\u9084\u6709\u4e00\u5c64\u786c\u6bbc\u3002\u7a76\u7adf\u8700\u9ecd\u662f\u600e\u9ebc\u8b8a\u6210\u597d\u5403\u7684\u7389\u7c73\u5462\uff1f<\/p>\n

\u5a01\u65af\u5eb7\u8f9b\u5927\u5b78\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u8b93\u8700\u9ecd\u7684\u786c\u6bbc\u6d88\u5931\u7684\u95dc\u9375\uff0c\u7adf\u7136\u5c31\u50c5\u50c5\u662f\u4e00\u500b\u57fa\u56e0\u4e0a\u9762\u7684\u4e00\u500b\u6c28\u57fa\u9178\u7684\u6539\u8b8a\uff01\uff08\u53c32\uff09<\/p>\n

\u9019\u500b\u57fa\u56e0\u7a31\u70ba\u300c\u8700\u9ecd\u7a4e\u7d50\u69cb\u57fa\u56e01\u300dtga1<\/em>\uff08teosinte glume architecture1<\/em>\uff09\u3002\u7531\u65bc\u5b83\u4f4d\u65bc\u7b2c\u5341\u516b\u500b\u9e7c\u57fa\u7684\u5e8f\u5217\u5f9eG\uff08\u9ce5\u7cde\u560c\u5464\uff0cguanine\uff09\u8b8a\u70baC\uff08\u80de\u5627\u5576\uff0ccytosine\uff09\uff0c\u4f7f\u5f97\u7389\u7c73\u7684tga1<\/em>\u7684\u7b2c\u516d\u865f\u6c28\u57fa\u9178\u7531\u539f\u4f86\u8700\u9ecd\u7684\u8cf4\u6c28\u9178\uff08Lys\uff0clysine\uff09\u8b8a\u70ba\u5929\u51ac\u9170\u80fa\uff08Asn\uff0cAsparagine\uff09\u3002<\/p>\n

\u5c31\u53ea\u662f\u9019\u9ebc\u4e00\u500b\u6c28\u57fa\u9178\u7684\u8b8a\u5316\uff0c\u4f7f\u5f97\u7389\u7c73\u7684TGA1\u86cb\u767d\uff0c\u5f9e\u55ae\u7d14\u8fa8\u8a8dDNA\u4e0a\u9762\u7684GTAC\u5e8f\u5217\u7684\u555f\u52d5\u5b50\u7d50\u5408\u86cb\u767d\uff08promoter-binding protein\uff09\uff0c\u6210\u70ba\u6291\u5236\u57fa\u56e0\u8868\u73fe\u7684\u963b\u6291\u86cb\u767d\uff08repressor\uff09\u3002\u6210\u70ba\u963b\u6291\u86cb\u767d\u7684\u7389\u7c73TGA1\uff0c\u4e0d\u53ea\u662f\u8ddf\u8700\u9ecdTGA1\u4e00\u6a23\uff0c\u6703\u8fa8\u8a8dDNA\u4e0a\u9762\u7684GTAC\u5e8f\u5217\uff0c\u9084\u6703\u5169\u5169\u7d50\u5408\u5f62\u6210\u96d9\u9ad4\uff08dimer\uff09\uff0c\u6291\u5236\u76f8\u95dc\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u4f7f\u5f97\u7a2e\u5b50\u8b8a\u8edf\u3001\u5074\u679d\u6e1b\u5c11\u3001\u652f\u6301\u6839\u589e\u751f\u964d\u4f4e\uff08prop roots\uff09\u3002<\/p>\n

\u4e0d\u904e\uff0c\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff0cTGA1\u7684\u7a81\u8b8a\u4e3b\u8981\u7684\u5f71\u97ff\u767c\u751f\u5728\u7389\u7c73\u7a2e\u5b50\u4e0a\u3002\u70ba\u4ec0\u9ebc\u6703\u9019\u6a23\u8a8d\u70ba\u5462\uff1f\u56e0\u70ba\u904e\u53bb\u5728\u5176\u4ed6tga1<\/em>\u57fa\u56e0\u767c\u751f\u7f3a\u5931\u7684\u690d\u7269\u4e2d\uff0c\u4e5f\u4e26\u672a\u89c0\u5bdf\u5230\u9664\u4e86\u679c\u5be6\u578b\u614b\u4ee5\u5916\u7684\u6027\u72c0\uff1b\u56e0\u6b64\u7814\u7a76\u5718\u968a\u8a8d\u70baTGA1\u7684\u7a81\u8b8a\uff0c\u4e3b\u8981\u9020\u6210\u7a2e\u5b50\u4e0d\u518d\u88ab\u4e00\u5c64\u786c\u6bbc\u5305\u8986\uff1b\u9019\u5c64\u786c\u6bbc\u8f49\u800c\u5728\u7389\u7c73\u7684\u7a57\u8ef8\u91cd\u65b0\u90e8\u7f72\uff0c\u5f62\u6210\u8ef8\u5fc3\u3002\u81f3\u65bc\u5176\u5b83\u7684\u6027\u72c0\uff08\u5074\u679d\u7684\u7522\u751f\u4ee5\u53ca\u652f\u6301\u6839\u589e\u751f\u6e1b\u5c11\uff09\uff0c\u5247\u662f\u7531\u65bc\u7a81\u8b8a\u5f8c\u7684TGA1\u6210\u70ba\u963b\u6291\u86cb\u767d\u6240\u7522\u751f\u7684\u6548\u679c\u3002\u7389\u7c73TGA1\u6703\u6291\u5236\u53e6\u4e00\u500b\u57fa\u56e0\uff08\u7a31\u70banot1<\/em>\uff09\u7684\u8868\u73fe\uff0c\u800c\u8700\u9ecd\u7684TGA1\u5c0dnot1<\/em>\u7684\u8868\u73fe\u5247\u6c92\u6709\u5f71\u97ff\u3002<\/p>\n

\u7531\u4e0b\u5716\u53ef\u4ee5\u770b\u5230\uff0c\u5c31\u53ea\u662f\u9019\u500b\u6c28\u57fa\u9178\u7684\u8b8a\u5316\uff0c\u4f7f\u5f97\u7389\u7c73\u7531\u8700\u9ecd\u8f03\u5927\u7684\u7a4e\uff08K\uff09\u3001\u72f9\u9577\u7684\u7a2e\u5b50\uff08I\uff09\uff0c\u591a\u523a\u800c\u9ad8\u4f4e\u4e0d\u5e73\u7684\u679c\u5be6\uff08M\uff09\uff0c\u6210\u70ba\u5c0f\u7684\u7a4e\uff08J\uff09\u3001\u7a2e\u5b50\u8b8a\u5bec\uff08H\uff09\uff0c\u540c\u6642\u679c\u5be6\u4e5f\u8b8a\u5f97\u5e73\u6ed1\u800c\u7121\u523a\uff08L\uff09\uff1b\u4e5f\u5c31\u662f\u8aaa\uff0c\u91ce\u751f\u7684\u8700\u9ecd\u6210\u70ba\u67d4\u8edf\u53c8\u597d\u5403\u7684\u7389\u7c73\u4e86\u3002<\/p>\n

\"\u5716\u7247\u4f86\u6e90\uff1aGenetics
\u5716\u7247\u4f86\u6e90\uff1aGenetics
\uff08\u8a3b\uff09<\/figcaption><\/figure>\n

\u8fb2\u4f5c\u7269\u7531\u65bc\u4eba\u64c7\u6240\u7522\u751f\u7684\u6f14\u5316\uff0c\u662f\u500b\u5f88\u6709\u8da3\u7684\u8ab2\u984c\uff1b\u4e0d\u904e\u5c0d\u7389\u7c73\u4f86\u8aaa\uff0c\u74b0\u5883\/\u6c23\u5019\u7684\u8b8a\u9077\u4e5f\u7522\u751f\u4e0d\u5c0f\u7684\u5f71\u97ff\u3002\u53bb\u5e74\uff082014\uff09\u7684\u7814\u7a76\u5831\u544a\u767c\u73fe\uff0c\u7576\u8700\u9ecd\uff08\u5927\u82bb\u8349\uff09\u88ab\u7a2e\u690d\u572812,000-14,000\u5e74\u524d\u7684\u6eab\u5ea6\uff08\u651d\u6c0f20.1\u523022.5\u5ea6\uff09\u8207\u4e8c\u6c27\u5316\u78b3\u6fc3\u5ea6\uff08260ppm\uff09\u6642\uff0c\u5b83\u7684\u578b\u614b\u5c31\u76f8\u7576\u63a5\u8fd1\u7389\u7c73\u4e86\uff01\uff08\u53c33\uff09<\/p>\n

\u8a3b\uff1a<\/strong>\u5716\u4e2d\u7389\u7c73\u985e\u4f3c\u8700\u9ecd\u7684\u6027\u72c0\u4f86\u81ea\u65bctga1<\/em>\u7684\u5e72\u64feRNA\u5be6\u9a57\u3002\u7531\u65bc\u7121\u6cd5\u53d6\u5f97\u5b8c\u5168\u4e0d\u8868\u73fetga1<\/em>\u7684\u7a81\u8b8a\u7a2e\uff0c\u7814\u7a76\u5718\u968a\u4ee5\u5e72\u64feRNA\u6280\u8853\u964d\u4f4etga1<\/em>\u7684\u8868\u73fe\u3002\u7531\u65bc\u7389\u7c73tga1<\/em>\u61c9\u70ba\u300c\u589e\u76ca\u529f\u80fd\u6027\u7a81\u8b8a\u300d\uff08gain-of-function mutation\uff09\uff0c\u56e0\u6b64\u53ef\u4ee5\u5c07tga1<\/em>\u7684\u5e72\u64feRNA\u7d50\u679c\u8996\u70ba\u5177\u6709\u8700\u9ecdtga1<\/em>\u7684\u7389\u7c73\u3002<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/strong>
\n1. Diebley J.F. et. al., 1990.\u00a0Genetic and morphological analysis of a maize-teosinte F2 population: implications for the origin of maize<\/a>. PNAS. 87:9888-9892.
\n2. Doebley J.F. et. al., 2015.\u00a0Evidence that the origin of naked kernels during maize domestication was caused by a single amino acid substitution in tga1<\/a>. Genetics. 200:965-974.
\n3. Dolores R. Piperno et. al. 2014.\u00a0Teosinte before domestication: Experimental study of growth and phenotypic variability in Late Pleistocene and early Holocene environments<\/a>. Quaternary International. 363:65-77.<\/p>\n

--<\/strong><\/span>
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 <\/p>\n

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