{"id":21930,"date":"2015-08-13T00:12:19","date_gmt":"2015-08-12T16:12:19","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21930"},"modified":"2018-08-01T16:01:15","modified_gmt":"2018-08-01T08:01:15","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e7%8b%82%e7%89%9b%e7%97%87%e7%9a%84%e8%a7%a3%e8%97%a5%e5%9c%a8%e6%96%b0%e5%b9%be%e5%85%a7%e4%ba%9e%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21930","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u72c2\u725b\u75c7\u7684\u89e3\u85e5\u5728\u65b0\u5e7e\u5167\u4e9e\uff1f"},"content":{"rendered":"
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\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n

\u72c2\u725b\u75c7(bovine spongiform encephalopathy\uff0cBSE)\u6700\u65e9\u61c9\u8a72\u662f\u5728\u65b0\u5e7e\u5167\u4e9e\u767c\u73fe\u7684\u3002\u7576\u6642\u88ab\u7a31\u70ba\u82e6\u9b6f(kuru)\u75c7\uff0c\u56e0\u70ba\u767c\u75c5\u662f\u7531\u982d\u75db\u958b\u59cb\uff0c\u63a5\u8457\u95dc\u7bc0\u75db\u3001\u56db\u80a2\u986b\u6296\uff08kuru\u662fFore\u8a9e\u4e2d\u7684kuria\/guria\uff0c\u5c31\u662f\u767c\u6296\u7684\u610f\u601d\uff09\u3002\u5b83\u7684\u75c5\u539f\u662f\u666e\u5229\u6602\u86cb\u767d(prion)\uff0c\u9664\u4e86\u9020\u6210\u72c2\u725b\u75c7\u8207\u82e6\u9b6f\u75c7\u4ee5\u5916\uff0c\u9084\u53ef\u4ee5\u5c0e\u81f4\u7f8a\u7684\u6414\u7662\u75c5(scrapie)\u8207\u4eba\u7684CJD(Creutzfeldt\u2013Jakob disease)\u3002<\/p>\n

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\u4f46\u662f\uff0c\u7576\u6642\u53c3\u8207\u7814\u7a76\u7684Simon Mead\u6ce8\u610f\u5230\uff0c\u6709\u4e9b\u539f\u4f4f\u6c11\u4f3c\u4e4e\u5c0d\u82e6\u9b6f\u75c7\u6709\u62b5\u6297\u529b\u3002\u7d93\u904e\u7814\u7a76\u4ee5\u5f8c\u767c\u73fe\uff0c\u539f\u4f86\u4ed6\u5011\u7684\u666e\u5229\u6602\u86cb\u767d\u5728\u7b2c127\u500b\u6c28\u57fa\u9178\u767c\u751f\u7a81\u8b8a\uff0c\u7531\u7518\u6c28\u9178\uff08glycine\uff0c\u7b26\u865f\u70baG\uff09\u8b8a\u70ba\u7e88\u6c28\u9178\uff08valine\uff0c\u7b26\u865f\u70baV\uff09\u3002<\/p>\n

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\u53c3\u8003\u6587\u737b\uff1a<\/strong>
\n1. John Collinge et. al.,1991.Homozygous prion protein genotype predisposes to sporadic Creutzfeldt\u2013Jakob disease. Nature. 352, 340 - 342 ; doi:10.1038\/352340a0
\n2. John Collinge et. al., 2015. A naturally occurring variant of the human prion protein completely prevents prion disease. Nature. doi:10.1038\/nature14510<\/p>\n

--<\/strong><\/span>
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 <\/p>\n

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\u64b0\u6587\uff5c\u8449\u7da0\u8212 \u72c2\u725b\u75c7(bovine sp<\/p>\n","protected":false},"author":20,"featured_media":21931,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2004,2006,2005,152,2003,1543,27],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/07\/Histology_bse.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21930"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21930"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21930\/revisions"}],"predecessor-version":[{"id":32312,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21930\/revisions\/32312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/21931"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}