{"id":21778,"date":"2015-07-24T00:10:46","date_gmt":"2015-07-23T16:10:46","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21778"},"modified":"2018-08-01T15:54:14","modified_gmt":"2018-08-01T07:54:14","slug":"%e3%80%90%e9%a3%b2%e9%a3%9f%e5%81%a5%e5%ba%b7%e3%80%91%e6%9e%9c%e7%b3%96%e5%8a%a0%e9%80%9f%e4%bd%a0%e7%9a%84%e5%bf%83%e8%87%9f%e8%a1%b0%e7%ab%ad","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21778","title":{"rendered":"\u3010\u98f2\u98df\u5065\u5eb7\u3011\u679c\u7cd6\u52a0\u901f\u4f60\u7684\u5fc3\u81df\u8870\u7aed"},"content":{"rendered":"
\"\u5716\u7247\u4f86\u6e90\uff5c\u7dad\u57fa\u767e\u79d1\"
\u5716\u7247\u4f86\u6e90\uff5c\u7dad\u57fa\u767e\u79d1<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n

\u4eba\u985e\u5f9e\u5403\u6a39\u8449\u3001\u5403\u679c\u5be6\uff0c\u5230\u5403\u52a0\u5de5\u98df\u54c1\uff0c\u5c0d\u65bc\u7cd6\u7684\u559c\u611b\u59cb\u7d42\u6709\u589e\u7121\u6e1b\u3002\u5b8c\u5168\u4e0d\u611b\u751c\u98df\u7684\u4eba\u4e26\u4e0d\u662f\u6c92\u6709\uff0c\u4f46\u7562\u7adf\u662f\u6975\u5c11\u6578\u3002<\/p>\n

\u53ea\u662f\u96a8\u8457\u6642\u9593\u904e\u53bb\uff0c\u6211\u5011\u5403\u7684\u7cd6\u6709\u4e86\u8b8a\u5316\u3002\u5403\u6a39\u8449\u3001\u5403\u679c\u5be6\u7684\u6642\u4ee3\uff0c\u6211\u5011\u4e3b\u8981\u651d\u53d6\u7684\u78b3\u6c34\u5316\u5408\u7269\u662f\u8517\u7cd6\u3001\u6fb1\u7c89\u8207\u679c\u7cd6\uff1b\u800c\u4ee5\u8517\u7cd6\u8207\u6fb1\u7c89\u70ba\u5927\u5b97\u3002\u5f9e1960\u5e74\u4ee3\u958b\u59cb\uff0c\u7531\u65bc\u98df\u54c1\u52a0\u5de5\u6280\u8853\u7684\u9032\u6b65\uff0c\u6211\u5011\u5f97\u4ee5\u628a\u7389\u7c73\u7684\u6fb1\u7c89\u8f49\u5316\u6210\u70ba\u9ad8\u679c\u7cd6\u7cd6\u6f3f\uff08HFCS\uff0chigh-fructose corn syrup\uff0c\u4fd7\u7a31\u8c50\u5e74\u679c\u7cd6\uff09\u3002\u9ad8\u679c\u7cd6\u7cd6\u6f3f\u5927\u7d0455%\u662f\u679c\u7cd6\u300142%\u662f\u8461\u8404\u7cd6\u3002\u7531\u65bc\u50f9\u9322\u4fbf\u5b9c\u3001\u4f7f\u7528\u65b9\u4fbf\uff0c\u5b83\u958b\u59cb\u5927\u91cf\u51fa\u73fe\u5728\u98f2\u98df\u4e2d\uff0c\u4f7f\u6211\u5011\u7684\u98f2\u98df\u7531\u651d\u53d6\u96d9\u7cd6\u8207\u591a\u91a3\u70ba\u4e3b\uff0c\u6539\u4ee5\u55ae\u7cd6\u70ba\u4e3b\u3002\u5728\u7f8e\u570b\uff0c1970\u5e74\u6642\u5e73\u5747\u6bcf\u4eba\u6bcf\u5e74\u98df\u7528230\u516c\u514b\u7684\u9ad8\u679c\u7cd6\u7cd6\u6f3f\uff1b\u5230\u4e861997\u5e74\u662f28\u516c\u65a4\uff08\u53c31\uff09\u3002\u800c2013\u5e74\u66f4\u589e\u70ba53.6\u516c\u65a4\uff08\u53c32\uff09\u3002\u00a0<\/p>\n

\"\u679c\u7cd6\uff08fructose\uff09\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\"
\u679c\u7cd6\uff08fructose\uff09\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n

\u651d\u53d6\u55ae\u7cd6\u4e3b\u8981\u7684\u554f\u984c\u662f\uff0c\u5b83\u4e0d\u9700\u6d88\u5316\u5206\u89e3\u5c31\u53ef\u76f4\u63a5\u5438\u6536\u5229\u7528\uff0c\u9020\u6210\u6211\u5011\u5728\u98df\u7528\u542b\u6709\u9ad8\u679c\u7cd6\u7cd6\u6f3f\u7684\u98df\u54c1\u4e4b\u5f8c\uff0c\u8840\u7cd6\u6703\u6025\u901f\u4e0a\u5347\u3002\u6700\u8fd1\u9019\u5e7e\u5e74\u7684\u8a31\u591a\u7814\u7a76\u90fd\u767c\u73fe\uff0c\u651d\u53d6\u5927\u91cf\u7684\u55ae\u7cd6\uff0c\u5c24\u5176\u662f\u679c\u7cd6\uff0c\u5c0d\u6211\u5011\u6709\u5bb3\u7121\u76ca\u3002\u800c\u6700\u65b0\u767c\u8868\u5728\u300a\u81ea\u7136\u300b\u671f\u520a\u4e0a\u7684\u8ad6\u6587\uff0c\u9032\u4e00\u6b65\u5730\u544a\u8a34\u6211\u5011\u679c\u7cd6\u8ddf\u5fc3\u81df\u8870\u7aed\u6709\u95dc\uff08\u53c33\uff09\u3002<\/p>\n

\u679c\u7cd6\u600e\u9ebc\u6703\u8ddf\u5fc3\u81df\u8870\u7aed\u626f\u4e0a\u95dc\u4fc2\u5462\uff1f\u9019\u5c31\u8981\u5f9e\u982d\u8aaa\u8d77\u4e86\u3002<\/p>\n

\u7576\u6211\u5011\u6709\u9ad8\u8840\u58d3\u6642\uff0c\u5fc3\u81df\u8981\u628a\u8840\u6db2\u6253\u51fa\u53bb\u5c31\u6703\u8d8a\u4f86\u8d8a\u56f0\u96e3\uff0c\u65bc\u662f\u5fc3\u808c\u5c31\u6703\u958b\u59cb\u751f\u9577\uff0c\u9577\u591a\u9ede\u808c\u8089\u597d\u591a\u9ede\u529b\u6c23\u628a\u8840\u6db2\u6253\u51fa\u53bb\uff1b\u9019\u5c31\u9020\u6210\u4e86\u5fc3\u81df\u80a5\u5927\u3002<\/p>\n

\u4f46\u662f\uff0c\u9577\u5927\u7684\u5fc3\u81df\u9700\u8981\u66f4\u591a\u6c27\u6c23\uff1b\u7576\u808c\u8089\u9577\u4e86\uff0c\u8840\u7ba1\u537b\u6c92\u6709\u8ddf\u8457\u9577\uff0c\u65bc\u662f\u9577\u5927\u4e86\u7684\u5fc3\u81df\u6c27\u6c23\u66f4\u4e0d\u5920\u3002\u9019\u6642\uff0c\u5fc3\u81df\u5c31\u6703\u958b\u59cb\u9032\u884c\u53ad\u6c27\u91a3\u89e3\u4f5c\u7528\uff08anaerobic glycolysis\uff0c\u91a3\u89e3\u4f5c\u7528\u8207\u4e73\u9178\u767c\u9175\u7684\u5408\u4f75\u7a31\u547c\uff09\uff0c\u6700\u5f8c\u5c0e\u81f4\u5fc3\u8870\u7aed\u3002<\/p>\n

\u53e6\u5916\uff0c\u5fc3\u81df\u5728\u6c27\u6c23\u4e0d\u5920\u7684\u72c0\u6cc1\u4e0b\uff0c\u6703\u7522\u751f\u4e00\u500b\u7a31\u70baHIF1\u03b1\u7684\u86cb\u767d\u8cea\u3002\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0cHIF1\u03b1\u6703\u9020\u6210SF3B1\u86cb\u767d\u8cea\u7522\u751f\u3002\u679c\u7cd6\u5c31\u662f\u5728\u9019\u88e1\u8ddf\u5fc3\u81df\u8870\u7aed\u626f\u4e0a\u95dc\u4fc2\u7684\u3002<\/p>\n

\u600e\u9ebc\u8aaa\u5462\uff1f\u539f\u4f86SF3B1\u662f\u5207\u5272\u56e0\u5b50(splice factor)\uff0c\u5b83\u6703\u628aKhk<\/em>\u57fa\u56e0\u6240\u8f49\u9304\u51fa\u4f86\u7684RNA\u5207\u6210Khk-C mRNA\uff0c\u7522\u751fKHK-C\u86cb\u767d\u3002<\/p>\n

\u904e\u53bb\u7684\u7814\u7a76\u5df2\u7d93\u77e5\u9053\uff0c\u4ee3\u8b1d\u679c\u7cd6\u7684\u9175\u7d20\u6709\u53ea\u51fa\u73fe\u5728\u809d\u81df\u7684fructokinase\uff08KHK-C\u86cb\u767d\uff09\uff0c\u4ee5\u53ca\u51fa\u73fe\u5728\u5176\u4ed6\u7d44\u7e54\u7684KHK-A\u3002\u9019\u5169\u500b\u9175\u7d20\u96d6\u7136\u7279\u6027\u76f8\u5dee\u5f88\u5927\uff0c\u537b\u662f\u7531\u540c\u4e00\u57fa\u56e0\u7d93\u904e\u4e0d\u540c\u65b9\u5f0f\u5207\u5272\u6240\u7522\u751f\uff0cKHK-C\u5c0d\u679c\u7cd6\u7684\u5c08\u4e00\u6027\u9ad8\u3001\u53cd\u61c9\u901f\u7387\u9ad8\uff0cKHK-A\u5c0d\u679c\u7cd6\u7684\u5c08\u4e00\u6027\u4f4e\uff0c\u53cd\u61c9\u901f\u7387\u5dee\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u5728\u5fc3\u808c\u7f3a\u6c27\u6642\u6240\u7522\u751f\u7684HIF1\u03b1\uff0c\u7adf\u7136\u53ef\u4ee5\u900f\u904eSF3B1\u8b93\u5fc3\u808c\u4e5f\u53ef\u4ee5\u7522\u751fKHK-C\uff0c\u9019\u4e0b\u5b50\u5fc3\u81df\u5c31\u7372\u5f97\u4e86\u5229\u7528\u679c\u7cd6\u7684\u80fd\u529b\u3002<\/p>\n

KHK-C\u7684\u7522\u751f\u4e0d\u5149\u662f\u8b93\u5fc3\u808c\u5c0d\u679c\u7cd6\u4ee3\u8b1d\u7684\u80fd\u529b\u4e0a\u6607\uff0c\u4e5f\u6703\u4f7f\u5f97\u91a3\u89e3\u4f5c\u7528(glycolysis)\u7684\u6d3b\u6027\u4e0a\u6607\uff0c\u9020\u6210\u5fc3\u81df\u80a5\u5927\u5f97\u66f4\u5feb\uff0c\u8d70\u5411\u5fc3\u81df\u8870\u7aed\u7684\u901f\u5ea6\u5c31\u66f4\u5feb\u3002\u70ba\u4ec0\u9ebc\uff1f<\/p>\n

\u6211\u5011\u5148\u4f86\u770bKHK\u7684\u53cd\u61c9\uff1a<\/p>\n

ATP + D-fructose \u2192 ADP + D-fructose-1-phosphate<\/strong><\/p>\n

\u7531\u65bcKHK\u53cd\u61c9\u6703\u6d88\u8017ATP\uff0c\u800c\u8ca0\u8cac\u91a3\u89e3\u4f5c\u7528\u7684\u95dc\u9375\u53cd\u61c9\u7684\u9175\u7d20phosphofructokinase-1(PFK-1)\u6703\u53d7\u5230ATP\u7684\u6291\u5236\u3002<\/p>\n

\u65bc\u662f\uff0c\u7576ATP\u88abKHK\u53cd\u61c9\u6d88\u8017\u6389\u4ee5\u5f8c\uff0c\u5c0dPFK-1\u7684\u6291\u5236\u5c31\u6e1b\u8f15\u4e86\u3002\u63a5\u8457\u91a3\u89e3\u4f5c\u7528\u52a0\u5feb\uff0c\u4f46\u4f9b\u61c9\u7d66\u5fc3\u808c\u7684\u6c27\u6c23\u9084\u662f\u4e0d\u5920\uff0c\u65bc\u662f\u5fc3\u808c\u7e7c\u7e8c\u9032\u884c\u7121\u6c27\u91a3\u89e3\u4f5c\u7528\uff0c\u7b49\u5230\u7522\u751f\u7684\u4ee3\u8b1d\u7269\uff08\u4e73\u9178\uff0clactic acid\uff09\u8d85\u904e\u7d30\u80de\u672c\u8eab\u6240\u80fd\u8ca0\u8377\u6642\uff0c\u5fc3\u808c\u7d30\u80de\u5c31\u6b7b\u4ea1\uff08\u5fc3\u81df\u8870\u7aed\uff09\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u7814\u7a76\u5718\u968a\u4e5f\u767c\u73feKHK-C\u7684\u53cd\u61c9\uff0c\u53ef\u80fd\u4e5f\u63d0\u4f9b\u4e86\u5fc3\u808c\u7d30\u80de\u5408\u6210\u8102\u80aa\u6240\u9700\u8981\u7684\u78b3\u9aa8\u67b6\u3002\u7531\u65bc\u904e\u53bb\u4fbf\u5df2\u7d93\u89c0\u5bdf\u5230\u7576\u5fc3\u808c\u767c\u751f\u7f3a\u6c27\u6642\uff0c\u80a5\u5927\u7684\u5fc3\u808c\u7d30\u80de\u5167\u6703\u51fa\u73fe\u8102\u80aa\u7d2f\u7a4d\u7684\u73fe\u8c61\uff1b\u65bc\u662f\u7814\u7a76\u5718\u968a\u4fbf\u628aKHK-C\u6216\u662fSF3B1\u95dc\u6389\uff0c\u7d50\u679c\u8102\u80aa\u7d2f\u7a4d\u7684\u73fe\u8c61\u5c31\u4e0d\u6703\u51fa\u73fe\u4e86\uff1b\u4f46\u5982\u679c\u95dc\u6389\u7684\u662fKHK-A\u7684\u8a71\uff0c\u5c0d\u8102\u80aa\u7d2f\u7a4d\u8207\u5426\u537b\u6beb\u7121\u5f71\u97ff\u3002\u7531\u65bc\u8102\u80aa\u7684\u5408\u6210\u5c0d\u65bc\u7c92\u7dda\u9ad4\u7684\u7d30\u80de\u547c\u5438\u4f5c\u7528\u6709\u6291\u5236\u7684\u6548\u679c\uff0c\u56e0\u6b64KHK-C\u53cd\u61c9\u4e5f\u6703\u4f7f\u5f97\u5fc3\u808c\u7d30\u80de\u66f4\u52a0\u4f9d\u8cf4\u7121\u6c27\u91a3\u89e3\u4f5c\u7528\uff0c\u52a0\u901f\u5fc3\u81df\u8870\u7aed\u7684\u767c\u751f\u3002<\/p>\n

\u6709\u610f\u601d\u7684\u662f\uff0c\u7576\u7814\u7a76\u5718\u968a\u628aKHK-C\u7684\u57fa\u56e0\u95dc\u6389\u4ee5\u5f8c\uff0c\u9664\u4e86\u679c\u7cd6\u4ee3\u8b1d\u901f\u7387\u4e0d\u6703\u4e0a\u6607\u4e4b\u5916\uff0c\u5fc3\u808c\u80a5\u5927\u7684\u73fe\u8c61\u4e5f\u89c0\u5bdf\u4e0d\u5230\u4e86\u3002\u96d6\u7136\u6574\u500b\u7814\u7a76\u6240\u6709\u7684\u5be6\u9a57\u90fd\u662f\u4ee5\u5c0f\u9f20\u70ba\u5be6\u9a57\u6a21\u578b\uff0c\u4f46\u7814\u7a76\u5718\u968a\u5728\u4eba\u7684\u5fc3\u81df\u75c5\u60a3\u8005\u7684\u5fc3\u808c\u5207\u7247\u4e2d\uff0c\u4e5f\u767c\u73fe\u6709HIF1\u03b1\u3001SF3B1\u4ee5\u53caKHK-C\u4e0a\u6607\u7684\u60c5\u5f62\uff0c\u986f\u793a\u5728\u4eba\u9ad4\u4e2d\u53ef\u80fd\u4e5f\u6709\u985e\u4f3c\u7684\u72c0\u6cc1\u767c\u751f\u3002<\/p>\n

\u7531\u65bc\u679c\u7cd6\u4e3b\u8981\u4f86\u81ea\u98f2\u6599\uff0c\u7814\u7a76\u5718\u968a\u4e5f\u63d0\u9192\u5927\u5bb6\uff0c\u5403\u6c34\u679cOK\uff08\u7b46\u8005\u8a8d\u70ba\u7279\u5225\u751c\u7684\u6c34\u679c\u9084\u662f\u8981\u6dfa\u5690\u5373\u6b62\u5c31\u597d\uff09\uff0c\u4f46\u662f\u98f2\u6599\u6700\u597d\u5225\u559d\u3002\u5373\u4f7f\u73fe\u5728\u60a8\u7684\u8840\u58d3\u5f88\u6b63\u5e38\u3001\u5fc3\u81df\u597d\u5f97\u5f88\uff0c\u5403\u4e0b\u53bb\u7684\u679c\u7cd6\u5230\u809d\u81df\u9084\u662f\u6703\u8f49\u6210\u8102\u80aa\uff0c\u8b93\u6211\u5011\u7684\u809d\u81df\u6709\u9d5d\u809d\u91ac\uff08\u8102\u80aa\u809d\uff09\u7684\u611f\u89ba\u5594\uff01<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/strong>
\n1. 2015\/6\/17.\u00a0Fructose powers a vicious circle<\/a>. Science Daily.
\n2. \u6797\u6770\u6a11\u3002\u5c11\u5403\u7389\u7c73\u679c\u7cd6<\/a>\u3002
\n3. Peter Mirtschink et. al. 2015.\u00a0HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease<\/a>. Nature.<\/p>\n

--<\/strong><\/span>
\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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