{"id":21765,"date":"2015-07-10T00:20:56","date_gmt":"2015-07-09T16:20:56","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21765"},"modified":"2018-08-01T15:55:20","modified_gmt":"2018-08-01T07:55:20","slug":"%e3%80%90%e4%bc%8a%e6%b3%a2%e6%8b%89%e5%b0%88%e9%a1%8c%e3%80%91%e6%98%af%e8%aa%b0%e8%ae%93%e4%bc%8a%e6%b3%a2%e6%8b%89%e7%99%bb%e5%a0%82%e5%85%a5%e5%ae%a4%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21765","title":{"rendered":"\u3010\u4f0a\u6ce2\u62c9\u5c08\u984c\u3011\u662f\u8ab0\u8b93\u4f0a\u6ce2\u62c9\u767b\u5802\u5165\u5ba4\uff1f"},"content":{"rendered":"

\u25a0\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u662f\u5982\u4f55\u611f\u67d3\u5bbf\u4e3b\u7d30\u80de\u7684\uff1f\u5982\u679c\u53ef\u4ee5\u60f3\u5230\u8fa6\u6cd5\u6291\u5236\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u9032\u5165\u7d30\u80de\uff0c\u6211\u5011\u662f\u4e0d\u662f\u5c31\u80fd\u6709\u6548\u5c0d\u6297\u4f0a\u6ce2\u62c9\u75c5\u6bd2\uff1f<\/strong><\/span><\/p>\n

\"Source:
Source: London School of Hygiene & Tropical Medicines \/ Science Photo Library<\/figcaption><\/figure>\n

\u00a0\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u5728\u4f0a\u6ce2\u62c9\u75ab\u60c5\u7206\u767c\u4e4b\u5f8c\uff0c\u56e0\u70ba\u81e8\u5e8a\u4e0a\u6b20\u7f3a\u6709\u6548\u7684\u75ab\u82d7\u8207\u85e5\u7269\uff0c\u8b93\u9632\u75ab\u5de5\u4f5c\u7d81\u624b\u7d81\u8173\u3002\u5c0d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u611f\u67d3\u5f8c\u85e5\u7269\u9078\u64c7\u4e0a\u7684\u7121\u8a08\u53ef\u65bd\uff0c\u4f7f\u5168\u7403\u5404\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u5de5\u4f5c\u90fd\u4e0a\u7dca\u767c\u689d\uff0c\u5e0c\u671b\u80fd\u65e9\u4e00\u9ede\u627e\u5230\u6709\u6548\u53c8\u597d\u7528\u7684\u6cbb\u7642\u6a19\u9776\uff0c\u8b93\u7b2c\u4e00\u7dda\u9632\u75ab\u4eba\u54e1\u7684\u91ab\u7642\u5de5\u4f5c\u4e0d\u518d\u88ab\u52d5\u5730\u5750\u5982\u56f0\u7378\u9b25\u3002<\/p>\n

\u800c\u627e\u5230\u597d\u7684\u85e5\u7269\u6a19\u9776\u9700\u5c0d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u6709\u5fb9\u982d\u5fb9\u5c3e\u7684\u4e86\u89e3\u3002\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u5c6c\u65bc\u7d72\u72c0\u75c5\u6bd2\u79d1(Filoviridae family)\uff0c\u8ca0\u93c8\u55ae\u80a1\u7684RNA\u75c5\u6bd2\uff0c\u85c9\u7531\u60a3\u8005\u7684\u9ad4\u6db2\u3001\u8840\u6db2\u3001\u5206\u6ccc\u7269\u7b49\u50b3\u67d3\uff0c\u611f\u67d3\u521d\u671f\u6703\u51fa\u73fe\u985e\u4f3c\u6d41\u884c\u6027\u611f\u5192\u7684\u75c7\u72c0\uff0c\u4f46\u75c5\u7a0b\u7684\u9032\u5c55\u53ef\u80fd\u5feb\u5982\u91ce\u706b\u71ce\u539f\uff0c\u8fc5\u901f\u60e1\u5316\u6210\u75c5\u6bd2\u6027\u51fa\u8840\u71b1\u3002<\/p>\n

\u6211\u5011\u5c0d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7684\u4e86\u89e3\uff0c\u5927\u591a\u96c6\u4e2d\u5728\u75c5\u6bd2\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u4e4b\u5f8c\u7684\u8907\u88fd\u3001\u7d44\u88dd\u53cd\u61c9\u3002\u5c0d\u65bc\u75c5\u6bd2\u662f\u5982\u4f55\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u7684\uff0c\u5247\u4e00\u76f4\u672a\u6709\u901a\u76e4\u4e86\u89e3\u3002<\/p>\n

\u75c5\u6bd2\u5916\u5957\u819c\u7684\u8868\u9762\u6709\u8a31\u591a\u5982\u5c16\u523a\u822c\u7a81\u8d77\u7684\u7684\u91a3\u86cb\u767d(spike glycoproteins; GP)\uff0c\u9019\u4e9b\u75c5\u6bd2\u91a3\u86cb\u767d\u53ef\u4ee5\u8ddf\u4eba\u985e\u7d30\u80de\u6216\u5176\u4ed6\u9748\u9577\u985e\u7d30\u80de\u7d30\u80de\u819c\u4e0a\u7684\u53d7\u9ad4\u7d50\u5408\u3002\u9019\u7d50\u5408\u591a\u534a\u4e0d\u5177\u6709\u5c08\u4e00\u6027\uff0c\u5c31\u53ea\u662f\u8ddf\u5bbf\u4e3b\u6240\u8868\u73fe\u5728\u7d30\u80de\u819c\u8868\u9762\u5404\u5f0f\u5404\u6a23\u7684\u91a3\u86cb\u767d\u76f8\u63a5\u5408\uff0c\u7136\u5f8c\u5f15\u767c\u5de8\u566c\u80de\u98f2\u4f5c\u7528(micropinocytosis)\uff0c\u88ab\u7d30\u80de\u300c\u541e\u300d\u5165\u5176\u5167\u3002\u5de8\u566c\u80de\u98f2\u4f5c\u7528\u662f\u5167\u98f2\u4f5c\u7528(endocytosis)\u7684\u4e00\u7a2e\uff0c\u5f88\u53ef\u60dc\u5730\u4e0d\u5177\u6709\u4ec0\u9ebc\u9078\u64c7\u6027\u3002\u88ab\u5167\u541e\u7684\u75c5\u6bd2\u9846\u7c92\u88ab\u5305\u5728\u80de\u5167\u56ca\u6ce1\u88e1(endosome)\uff0c\u53d7\u5230\u80de\u5167\u56ca\u6ce1\u5167\u9178\u6027\u74b0\u5883\u5f71\u97ff\uff0c \u5176\u5916\u5957\u819c\u8868\u9762\u7684\u91a3\u86cb\u767d\u6703\u88ab\u86cb\u767d\u9176\u5206\u89e3\uff0c\u75c5\u6bd2\u91a3\u86cb\u767d\u7d50\u69cb\u7522\u751f\u6539\u8b8a\u3002\u4e3b\u5c0e\u75c5\u6bd2\u7d30\u80de\u8ddf\u5bbf\u4e3b\u7d30\u80de\u9032\u884c\u7d30\u80de\u878d\u5408(fusion)\u7684\u86cb\u767d\u8cea\u90e8\u4f4d\u672c\u4f86\u88ab\u57cb\u85cf\u5728\u7d50\u69cb\u6df1\u8655\uff0c\u7d93\u86cb\u767d\u9176\u5206\u89e3\u4f5c\u7528\u4e4b\u5f8c\uff0c\u88ab\u66b4\u9732\u51fa\u4f86\uff0c\u800c\u80fd\u5f15\u767c\u878d\u5408\u53cd\u61c9\uff0c\u8b93\u75c5\u6bd2\u628a\u5176\u57fa\u56e0\u9ad4\u91cb\u653e\u5230\u5bbf\u4e3b\u7d30\u80de\u5167\u3002<\/p>\n

\u4ee5\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u4f86\u8aaa\uff0c\u75c5\u6bd2\u57fa\u56e0\u9ad4\u5305\u542b\u4e86\u4e03\u500b\u57fa\u56e0\uff0c\u53ef\u4ee5\u4e3b\u5c0e\u516b\u7a2e\u86cb\u767d\u8cea\u7684\u5408\u6210\uff0c\u800c\u5176\u4e2d\u4e00\u500b\u57fa\u56e0\u5c31\u8ca0\u8cac\u63a8\u52d5\u4f0a\u6ce2\u62c9\u8868\u9762\u91a3\u86cb\u767d(GP)\u7684\u8868\u73fe\u3002\u4f0a\u6ce2\u62c9\u8868\u9762\u7684\u91a3\u86cb\u767dGP\u5728\u88ab\u5408\u6210\u4e4b\u5f8c\uff0c\u8f49\u8b6f\u5f8c\u4fee\u98fe\u628a\u91a3\u86cb\u767d\u5207\u6210\u5169\u500b\u90e8\u5206\uff08GP1\u8207GP2\uff09\uff0c\u5169\u8005\u9593\u6709\u96d9\u786b\u9375\u7d50\u9023\u63a5\u8d77\u4f86\u3002GP1\u5c0d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u548c\u5bbf\u4e3b\u7d30\u80de\u8868\u73fe\u91a3\u86cb\u767d\u7684\u63a5\u5408\u6b65\u9a5f\u81f3\u95dc\u91cd\u8981\uff0cGP2\u5247\u8ca0\u8cac\u7d30\u80de\u878d\u5408\u3002\u9664\u4e86\u9019\u4e9b\uff0c\u79d1\u5b78\u5bb6\u4e00\u76f4\u5f88\u597d\u5947\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u6709\u6c92\u6709\u4ec0\u9ebc\u7279\u5225\u7684\u62db\u5f0f\u3002<\/p>\n

2015\u5e74\u4e8c\u6708\u5e95\u7684Science<\/em>\u671f\u520a\u4e0a\uff0c\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u751f\u91ab\u7814\u7a76\u4e2d\u5fc3\u7684Richard Davey\u5be6\u9a57\u5ba4\u628a\u6b20\u7f3a\u7684\u62fc\u5716\u88dc\u4e0a\uff0c \u4f0a\u6ce2\u62c9\u75c5\u6bd2\u9032\u5165\u7d30\u80de\u7684\u6a5f\u5236\u5c31\u66f4\u52a0\u6e05\u6670\u660e\u6717\u8d77\u4f86\u4e86\u3002<\/p>\n

\u5728\u4e4b\u524d\uff0cDavey\u535a\u58eb\u5be6\u9a57\u5ba4\u5c31\u767c\u73fe\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u5728\u7d30\u80de\u878d\u5408\u7684\u904e\u7a0b\u88e1\uff0c\u6975\u7aef\u4ef0\u8cf4\u5bbf\u4e3b\u80de\u5167\u56ca\u6ce1\u819c\u4e0a\u9223\u96e2\u5b50\u901a\u9053\u7684\u5408\u4f5c\u3002\u4f46\u9223\u96e2\u5b50\u901a\u9053\u662f\u500b\u6975\u7aef\u9f90\u5927\u7684\u5927\u5bb6\u65cf\uff0c\u4ed6\u5011\u7576\u5e74\u6c92\u6709\u627e\u5230\u662f\u54ea\u4e00\u500b\u9223\u96e2\u5b50\u901a\u9053\u5728\u878d\u5408\u904e\u7a0b\u88e1\u4e0d\u53ef\u6216\u7f3a\u3002\u5982\u4eca\uff0cDavey\u535a\u58eb\u5be6\u9a57\u5ba4\u4e0d\u50c5\u63ed\u958b\u4e86\u9019\u500b\u88ab\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u6240\u5229\u7528\u7684\u9223\u96e2\u5b50\u901a\u9053\u771f\u9762\u76ee\uff0c\u66f4\u767c\u73fe\u4e2d\u8349\u85e5\u77f3\u87fe\u870d(Stephania tetrandra)\u4e2d\u6240\u542b\u7684\u4e3b\u6210\u5206tetrandrine\u80fd\u5920\u6709\u6548\u6291\u5236\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u3002<\/p>\n

\u4ed6\u5011\u5de7\u5999\u5730\u5229\u7528\u5404\u7a2e\u9223\u96e2\u5b50\u901a\u9053\u6291\u5236\u5291\uff0c\u4f86\u63a2\u8a0e\u54ea\u4e00\u7a2e\u985e\u7684\u9223\u96e2\u5b50\u901a\u9053\u5728\u5931\u53bb\u6d3b\u6027\u4e4b\u5f8c\uff0c\u80fd\u5920\u4fdd\u8b77\u57f9\u990a\u76bf\u4e2d\u7684HeLa\u4eba\u985e\u7d30\u80de\u682a\u4e0d\u88ab\u75c5\u6bd2\u6240\u611f\u67d3\u3002\u5be6\u9a57\u767c\u73feL\u578b\u7684\u9223\u96e2\u5b50\u901a\u9053\u5c0d\u75c5\u6bd2\u9032\u884c\u7d30\u80de\u878d\u5408\u7684\u6b65\u9a5f\u5f88\u91cd\u8981\uff0c\u9019\u4e5f\u8ddf\u5176\u4ed6\u5be6\u9a57\u5ba4\u5be6\u9a57\u7d50\u679c\u7684\u731c\u60f3\u4e0d\u8b00\u800c\u5408\u3002\u4f46\u5728\u6240\u8a66\u9a57\u7684\u4e94\u7a2eL\u578b\u9223\u96e2\u5b50\u6291\u5236\u5291\u4e2d\uff0c\u6709\u4e00\u7a2e\u6291\u5236\u5291\u9084\u662f\u6beb\u7121\u4fdd\u8b77\u6548\u679c\uff0c\u9019\u8b93Davey\u5be6\u9a57\u5ba4\u61f7\u7591\u662f\u4e0d\u662f\u9084\u6709\u5176\u4ed6\u7684\u9223\u96e2\u5b50\u901a\u9053\u53c3\u8207\u5176\u4e2d\u3002\u9032\u4e00\u6b65\u4ea4\u53c9\u6bd4\u5c0d\u4e4b\u5f8c\uff0c\u4ed6\u5011\u767c\u73fe\u5176\u4e2d\u4e00\u7a2e\u53eb\u505aTPC2(two-pore channel 2)\u7684\u9223\u96e2\u5b50\u901a\u9053\u4e5f\u662f\u9846\u91cd\u8981\u7684\u87ba\u7d72\u91d8\u3002\u4ed6\u5011\u9032\u800c\u5229\u7528\u7f3a\u5931\u4e86TPC2\u9019\u500b\u57fa\u56e0\u7684\u5c0f\u9f20\u6a21\u578b\u9a57\u8b49\u4e86\u6240\u63d0\u51fa\u7684\u5047\u8aaa\uff1a\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u8981\u9032\u5165\u7d30\u80de\uff0c\u5c31\u9700\u8981\u5bbf\u4e3b\u7d30\u80de\u5167\u819c\u56ca\u6ce1\u4e0aTPC2\u9223\u96e2\u5b50\u901a\u9053\u7684\u5354\u52a9\u3002\u66f4\u6709\u8da3\u7684\u662f\uff0c\u80fd\u6709\u6548\u6291\u5236TPC2\u9223\u96e2\u5b50\u901a\u9053\u7684tetrandrine\uff0c\u5c31\u662f\u5f9e\u4e2d\u8349\u85e5\u77f3\u87fe\u870d\u4e2d\u6240\u8403\u53d6\u51fa\u4f86\u7684\u3002<\/p>\n

\u76ee\u524d\uff0c\u91dd\u5c0d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u6216\u662f\u99ac\u5821\u75c5\u6bd2\u611f\u67d3\u7684\u5be6\u9a57\u85e5\u7269\u6709\u8d85\u904e\u516d\u5341\u7a2e\uff0c\u4f46tetrandrine\u4e4b\u6240\u4ee5\u632f\u596e\u4eba\u5fc3\uff0c\u5728\u65bc\u5b83\u80cc\u5f8c\u7684\u4f5c\u7528\u539f\u7406\u662f\u5982\u6b64\u689d\u7406\u5206\u660e\u3002\u4e0d\u904e\uff0ctetrandrine\u96d6\u7136\u5728\u4e2d\u85e5\u5343\u5e74\u4f86\u7684\u6b77\u53f2\u5178\u7c4d\u88e1\u70ba\u4eba\u8033\u719f\u80fd\u8a73\uff0c\u5c0d\u6b50\u7f8e\u897f\u91ab\u81e8\u5e8a\u800c\u8a00\uff0c\u537b\u662f\u5c1a\u672a\u88ab\u6838\u53ef\u4f7f\u7528\u7684\u85e5\u7269\u3002\u800c\u4e14\uff0c\u4ee4\u4eba\u6cc4\u6c23\u7684\u662f\uff0c\u56e0\u70batetrandrine\u6240\u6291\u5236\u7684\u662f\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u611f\u67d3\u7d30\u80de\u7684\u6700\u521d\u74b0\u7bc0\uff0c\u5728\u5c0f\u9f20\u8eab\u4e0a\u767c\u73fe\uff0c\u85e5\u7269\u6709\u6548\u7684\u9ec3\u91d1\u6642\u9593\u975e\u5e38\u77ed\u66ab\u3002\u5c31\u7b97\u53ea\u662f\u5ef6\u9072\u4e86\u4e00\u5929\u624d\u958b\u59cb\u6295\u8207\u85e5\u7269\uff0c\u4fdd\u8b77\u6548\u679c\u5c31\u5927\u5927\u964d\u4f4e\u4e86\u3002\u56e0\u6b64\uff0ctetrandrine\u6216\u8a31\u4e5f\u4e0d\u9069\u7528\u65bc\u4ee5\u5176\u70ba\u4e3b\u653b\u85e5\u7269\u7684\u55ae\u4e00\u7642\u6cd5\uff0c\u800c\u6bd4\u8f03\u9069\u5408\u8ddf\u5176\u4ed6\u85e5\u7269\u642d\u914d\u4e00\u8d77\u4f7f\u7528\u7684\u6cbb\u7642\u7b56\u7565\u3002\u4f46\u662f\uff0c\u4eba\u9ad4\u7684\u9069\u7528\u5291\u91cf\uff0c\u5f9e\u8001\u9f20\u8eab\u4e0a\u7684\u5be6\u9a57\u7d50\u679c\u8a72\u5982\u4f55\u8f49\u79fb\u5230\u4eba\u985e\u8eab\u4e0a\uff0c\u7b49\u7b49\u8af8\u591a\u8b70\u984c\u90fd\u9084\u9700\u8981\u66f4\u591a\u79d1\u5b78\u8b49\u64da\u7684\u4f50\u8b49\u8207\u652f\u6301\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a\u00a0<\/strong><\/p>\n

    \n
  1. Falzarano D, Feldmann H. Delineating Ebola entry. Science.<\/em> 2015 Feb 27;347(6225):947-8. doi: 10.1126\/science.aaa8121.<\/li>\n
  2. Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science<\/em>. 2015 Feb 27;347(6225):995-8. doi: 10.1126\/science.1258758.<\/li>\n
  3. Jae LT, Brummelkamp TR. Emerging intracellular receptors for hemorrhagic fever viruses. Trends Microbiol.<\/em> 2015 May 21. pii: S0966-842X(15)00100-6. doi: 10.1016\/j.tim.2015.04.006. [Epub ahead of print]<\/li>\n
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    --<\/span><\/strong>
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     <\/p>\n

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