{"id":21657,"date":"2015-06-25T00:48:43","date_gmt":"2015-06-24T16:48:43","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21657"},"modified":"2018-08-01T15:47:18","modified_gmt":"2018-08-01T07:47:18","slug":"%e3%80%90%e7%94%9f%e7%90%86%e7%8f%be%e8%b1%a1%e3%80%91%e6%a3%95%e8%89%b2%e8%84%82%e8%82%aa%e8%aa%aa%ef%bc%9a%e3%80%8c%e7%86%ac%e5%a4%9c%e4%bd%bf%e4%ba%ba%e8%83%96%ef%bc%81%e3%80%8d","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21657","title":{"rendered":"\u3010\u751f\u7406\u73fe\u8c61\u3011\u68d5\u8272\u8102\u80aa\u8aaa\uff1a\u300c\u71ac\u591c\u4f7f\u4eba\u80d6\uff01\u300d"},"content":{"rendered":"
\"UCP1\uff08\u4e0b\u65b9\u7d2b\u8272\u6a62\u5713\uff09\u7684\u4f5c\u7528\u6a5f\u5236\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\"
UCP1\uff08\u4e0b\u65b9\u7d2b\u8272\u6a62\u5713\uff09\u7684\u4f5c\u7528\u6a5f\u5236\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n

\u665d\u591c\u985b\u5012\u7684\u751f\u6d3b\u6703\u4f7f\u4ee3\u8b1d\u7d0a\u4e82\u5df2\u7d93\u4e0d\u662f\u65b0\u805e\u4e86\uff01\u76f8\u95dc\u7684\u7814\u7a76\u767c\u73fe\uff0c\u8f2a\u73ed\u5de5\u4f5c\u8005\u7d93\u5e38\u56e0\u70ba\u751f\u7406\u6642\u9418\u53d7\u5f71\u97ff\uff0c\u5c0e\u81f4\u4ee3\u8b1d\u7d0a\u4e82\uff0c\u6700\u5f8c\u9020\u6210\u80a5\u80d6\u3001\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u3002\u800c\u5f71\u97ff\u751f\u7406\u6642\u9418\u6700\u5927\u7684\u56e0\u7d20\u662f\u5149\u3002\u4e00\u9805\u7531\u725b\u6d25\u5927\u5b78\u7814\u7a76\u5718\u968a\u57282014\u5e74\u767c\u8868\u7684\u5927\u578b\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u591c\u9593\u5149\u7167\u8207\u80a5\u80d6\u4e4b\u9593\u5448\u73fe\u76f8\u95dc(\u53c31)\uff1b\u800c\u751f\u7406\u6642\u9418\u57fa\u56e0\u7f3a\u640d\u7684\u5c0f\u9f20\uff0c\u51fa\u73fe\u80a5\u80d6\u8207\u80f0\u5cf6\u7d20\u963b\u6297(insulin resistance)(\u53c32)\u3002\u4f46\u662f\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u7a76\u7adf\u591c\u9593\u5149\u7167\u5982\u4f55\u5c0e\u81f4\u80a5\u80d6\u7684\u6a5f\u5236\uff0c\u9084\u4e0d\u6e05\u695a\u3002<\/p>\n

\u68d5\u8272\u8102\u80aa\u7d44\u7e54(brown fat tissue)\u662f\u4eba\u9ad4\u4e2d\u6d88\u8017\u5927\u91cf\u80fd\u91cf\u7684\u7d44\u7e54\u4e4b\u4e00\u3002\u900f\u904e\u5b83\u7684\u7c92\u7dda\u9ad4\uff0c\u68d5\u8272\u8102\u80aa\u5c07\u539f\u672c\u71c3\u71d2\u4e09\u9178\u7518\u6cb9\u916f(TG\uff0ctriglycerides)\u6240\u7522\u751f\u7684\u80fd\u91cf\u5168\u90e8\u8f49\u63db\u70ba\u71b1\u80fd\u3001\u9032\u884c\u6240\u8b02\u7684\u300c\u4e0d\u767c\u6296\u7522\u71b1\u300d\u4f86\u8abf\u7bc0\u9ad4\u6eab\u3002<\/p>\n

\u9019\u662f\u600e\u9ebc\u767c\u751f\u7684\u5462\uff1f\u539f\u672c\u7c92\u7dda\u9ad4\u9032\u884c\u7d30\u80de\u547c\u5438(cellular respiration)\u7684\u76ee\u7684\u662f\u7522\u751f\u80fd\u91cf(ATP)\uff0c\u4f46\u7531\u65bc\u68d5\u8272\u8102\u80aa\u4e2d\u7684\u7c92\u7dda\u9ad4\u591a\u4e86UCP1\u86cb\u767d\u3002(uncoupling protein 1\uff0c\u53c8\u7a31\u70bathermogenin\uff0c\u5de6\u5716\u7d2b\u8272\u6a62\u5713)<\/p>\n

UCP1\u5c07\u96fb\u5b50\u50b3\u905e\u93c8\u6240\u904b\u9001\u7684\u3001\u539f\u672c\u8981\u7528\u65bc\u7522\u751fATP\u7684\u6c2b\u96e2\u5b50\u76f4\u63a5\u9001\u56de\u7c92\u7dda\u9ad4\u57fa\u8cea\uff08mitochondrial matrix\uff0c\u7c73\u8272\u5340\u584a\uff09\uff0c\u65bc\u662f\u6c2b\u96e2\u5b50\u4e2d\u6240\u542b\u7684\u80fd\u91cf\u5168\u90e8\u8f49\u63db\u70ba\u71b1\u80fd\uff0c\u6210\u70ba\u6211\u5011\u7684\u9ad4\u6eab\u7684\u4e00\u90e8\u4efd\u3002<\/p>\n

\u7531\u65bc\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u6d88\u8017\u76f8\u7576\u591a\u7684\u80fd\u91cf\uff0c\u800c\u904e\u53bb\u53c8\u767c\u73fe\u4ea4\u611f\u795e\u7d93(sympatheic nervous system)\u9023\u7d50\u5230\u68d5\u8272\u8102\u80aa\u7d44\u7e54\uff1b\u65bc\u662f\u5728\u8377\u862d\u7684\u7814\u7a76\u5718\u968a\u4fbf\u6c7a\u5b9a\u4f86\u770b\u770b\u904e\u591a\u7684\u5149\u7167\u662f\u5426\u6703\u5f71\u97ff\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7684\u6d3b\u6027(\u53c33)\u3002<\/p>\n

\u4ed6\u5011\u5c07\u5c0f\u9f20\u5206\u6210\u4e09\u7d44\uff0c\u7b2c\u4e00\u7d44\u662f\u767d\u5929\u9ed1\u591c\u540412\u5c0f\u6642\uff1b\u7b2c\u4e8c\u7d44\u662f16\u5c0f\u6642\u5149\u7167\u30018\u5c0f\u6642\u9ed1\u591c\uff1b\u7b2c\u4e09\u7d44\u5247\u662f24\u5c0f\u6642\u5149\u7167\u3002\u7d50\u679c\u767c\u73fe\uff0c\u96d6\u7136\u4e09\u7d44\u5403\u4e00\u6a23\u7684\u98df\u7269\u3001\u9ad4\u91cd\u4e5f\u90fd\u5dee\u4e0d\u591a\uff0c\u4f46\u662f24\u5c0f\u6642\u5149\u7167\u7d44\u7684\u767d\u8272\u8102\u80aa\u91cf\uff08\u4ee5gWAT\uff0c\u6027\u817a\u767d\u8272\u8102\u80aa\u7d44\u7e54\uff0c\u4f86\u8a08\u7b97\uff09\u6bd412\u5c0f\u6642\u7d44\u7684\u591a\u4e86\u5169\u6210\uff0816\u5c0f\u6642\u7d44\u7684\u767d\u8272\u8102\u80aa\u91cf\u5247\u4ecb\u65bc\u5169\u8005\u4e4b\u9593\uff09\u3002<\/p>\n

\u8b80\u8005\u53ef\u80fd\u6703\u8aaa\uff0c\u6703\u4e0d\u670324\u5c0f\u6642\u7d44\u7684\u8001\u9f20\u5403\u5f97\u6bd4\u5225\u4eba\u591a\uff1f\u4e8b\u5be6\u4e0a\uff0c\u7814\u7a76\u5718\u968a\u767c\u73fe24\u5c0f\u6642\u7d44\u7684\u8001\u9f20\uff0c\u6d3b\u52d5\u529b\u6bd4\u5176\u4ed6\u5169\u7d44\u8981\u5dee\uff0c\u5403\u5f97\u4e5f\u6bd4\u5176\u4ed6\u5169\u7d44\u5c11\u3002\u6240\u4ee5\uff0c\u9019\u4e00\u7d44\u7684\u8001\u9f20\u7684\u767d\u8272\u8102\u80aa\u6bd4\u5225\u4eba\u591a\uff0c\u4e26\u4e0d\u662f\u56e0\u70ba\u5403\u5f97\u591a\u7684\u95dc\u4fc2\u3002<\/p>\n

\u800c\u7814\u7a76\u5718\u968a\u9032\u4e00\u6b65\u4f7f\u7528\u540c\u4f4d\u7d20\u6a19\u5b9a\u7684\u8102\u80aa\uff08\u6cb9\u9178\uff0coleate\uff09\u8207\u8461\u8404\u7cd6\u4f86\u89c0\u5bdf\u68d5\u8272\u8102\u80aa\u7684\u6d3b\u6027\u3002\u7d50\u679c\u767c\u73fe\uff0c24\u5c0f\u6642\u7d44\u7684\u8001\u9f20\uff0c\u5728\u5e7e\u500b\u4e0d\u540c\u90e8\u4f4d\u7684\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u90fd\u51fa\u73fe\u4e86\u8102\u80aa\u8207\u8461\u8404\u7cd6\u651d\u53d6\u964d\u4f4e\u7684\u73fe\u8c61\uff1b\u4f46\u662f\u7260\u5011\u7684\u809d\u3001\u5fc3\u8207\u808c\u8089\u5c0d\u9019\u4e9b\u990a\u5206\u7684\u651d\u53d6\u4e26\u6c92\u6709\u964d\u4f4e\u3002<\/p>\n

\u5728\u66f4\u9032\u4e00\u6b65\u7684\u5be6\u9a57\u4e2d\uff0c\u7814\u7a76\u5718\u968a\u767c\u73fe\u572824\u5c0f\u6642\u5149\u7167\u7d44\u7684\u8001\u9f20\uff0c\u7260\u5011\u7684\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u5408\u6210\u6b63\u814e\u4e0a\u817a\u7d20(norepinephrine)\u7684\u80fd\u529b\u4e0b\u964d\u4e86\u3002\u7531\u65bc\u4ea4\u611f\u795e\u7d93\u4e3b\u8981\u662f\u900f\u904e\u814e\u4e0a\u817a\u7d20\u4f86\u8abf\u7bc0\u7d44\u7e54\u7684\u6d3b\u6027\uff0c\u56e0\u6b64\u7814\u7a76\u5718\u968a\u53c8\u505a\u4e86\u4e00\u4ef6\u4e8b\uff1a\u5c07\u9023\u5f80\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7684\u4ea4\u611f\u795e\u7d93\u5207\u9664\u3002<\/p>\n

\u5207\u9664\u4ee5\u5f8c\u7684\u8001\u9f20\u9ad4\u91cd\u4e0a\u6607\u4e86\u3001\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7684\u6d3b\u6027\u4e0b\u964d\u4e86\uff0c\u4f46\u6709\u610f\u601d\u7684\u4e8b\u60c5\u662f\uff0c\u5373\u4f7f\u7d66\u7260\u501124\u5c0f\u6642\u5149\u7167\uff0c\u5207\u9664\u4ea4\u611f\u795e\u7d93\u7684\u8001\u9f20\u7684\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7684\u6d3b\u6027\u4e26\u6c92\u6709\u518d\u9032\u4e00\u6b65\u964d\u4f4e\u3002\u9019\u986f\u793a\u4e86\uff0c\u5149\u7167\u5c0d\u65bc\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u6d3b\u6027\u7684\u5f71\u97ff\uff0c\u662f\u900f\u904e\u4ea4\u611f\u795e\u7d93\u7cfb\u7d71\u4f86\u8abf\u7bc0\u7684\u3002<\/p>\n

\u770b\u5230\u9019\u88e1\uff0c\u8b80\u8005\u670b\u53cb\u53ef\u80fd\u6703\u89ba\u5f97\uff0c\u597d\uff0c\u6211\u5011\u77e5\u9053\u5149\u7167\u6703\u5f71\u97ff\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7684\u6d3b\u6027\uff0c\u9032\u800c\u4f7f\u6211\u5011\u80a5\u80d6\u3001\u751a\u81f3\u767c\u5c55\u51fa\u5730\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\uff1b\u4f46\u5c0d\u65bc\u8f2a\u73ed\u5de5\u4f5c\u8005\u4f86\u8aaa\uff0c\u4e0a\u73ed\u600e\u9ebc\u53ef\u80fd\u4e0d\u958b\u71c8\u5462\uff1f\u6240\u4ee5\u9019\u6a23\u7684\u7814\u7a76\u5c0d\u4ed6\u5011\u4f86\u8aaa\u53c8\u6709\u4ec0\u9ebc\u7528\uff1f<\/p>\n

\u6216\u8a31\u5c0d\u65bc\u8f2a\u73ed\u5de5\u4f5c\u8005\u4f86\u8aaa\uff0c\u662f\u771f\u7684\u7121\u53ef\u5948\u4f55\uff08\u9664\u975e\u653e\u68c4\u5de5\u4f5c\uff09\uff1b\u4f46\u5982\u679c\u55ae\u8003\u616e\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7684\u8a71\uff0c\u4f3c\u4e4e\u5c07\u5de5\u4f5c\u74b0\u5883\u7684\u6eab\u5ea6\u8abf\u4f4e<\/a>\uff0c\u5c0d\u65bc\u63d0\u9ad8\u5b83\u7684\u6d3b\u6027\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7684\u5e6b\u52a9\u3002\u800c\u5c0d\u65bc\u4e00\u822c\u4eba\u4f86\u8aaa\uff0c\u9019\u500b\u7814\u7a76\u7d50\u679c\u610f\u5473\u8457\u7761\u89ba\u7684\u6642\u5019\u4e0d\u958b\u71c8\uff0c\u53ef\u4ee5\u7dad\u6301\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u7684\u6d3b\u6027\uff0c\u5c0d\u6211\u5011\u7684\u5065\u5eb7\u662f\u6709\u76ca\u7684\uff0c\u4e0d\u662f\u55ce\uff1f<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a
\n<\/strong>1. Emily McFadden et. al. 2014.\u00a0The Relationship Between Obesity and Exposure to Light at Night: Cross-Sectional Analyses of Over 100,000 Women in the Breakthrough Generations Study<\/a>. American Journal of Epidemoiolgy. doi: 10.1093\/aje\/kwu117
\n2. F.W. Turek et. al. 2005.\u00a0Obesity and metabolic syndrome in circadian Clock mutant mice<\/a>. Science. 308\uff085724\uff09\uff1a1043-1045.
\n3. Sander Kooijman et. al., 2015.\u00a0Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity<\/a>. Proc. Natl. Acad. Sci. USA. doi: 10.1073\/pnas.1504239112<\/p>\n

--<\/strong><\/span>
\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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