{"id":21597,"date":"2015-07-03T00:40:11","date_gmt":"2015-07-02T16:40:11","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21597"},"modified":"2018-08-01T15:57:39","modified_gmt":"2018-08-01T07:57:39","slug":"%e3%80%90%e4%bc%8a%e6%b3%a2%e6%8b%89%e5%b0%88%e9%a1%8c%e3%80%91%e5%80%96%e5%ad%98%e4%b9%8b%e5%be%8c%ef%bc%9a%e4%bc%8a%e6%b3%a2%e6%8b%89%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e5%be%8c%e9%81%ba%e7%97%87","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21597","title":{"rendered":"\u3010\u4f0a\u6ce2\u62c9\u5c08\u984c\u3011\u5016\u5b58\u4e4b\u5f8c\uff1a\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u611f\u67d3\u5f8c\u907a\u75c7"},"content":{"rendered":"

\u25a0\u5728\u4f0a\u6ce2\u62c9\u75ab\u60c5\u7a0d\u7de9\u4e4b\u969b\uff0c\u6211\u5011\u5f9e\u4e2d\u5b78\u5230\u4e86\u4ec0\u9ebc\u5462\uff1f<\/strong><\/span><\/p>\n

\"\uff08\u5716\uff0f\u9054\u5fd7\u5f71\u50cf\uff0f\u7f8e\u806f\u793e\uff09\"
\uff08\u5716\uff0f\u9054\u5fd7\u5f71\u50cf\uff0f\u7f8e\u806f\u793e\uff09<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

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\u65e5\u524d\u7f8e\u570b\u75be\u75c5\u63a7\u5236\u8207\u9810\u9632\u4e2d\u5fc3\u63d0\u9192\u5927\u773e\uff0c\u5c31\u7b97\u8840\u6db2\u88e1\u5075\u6e2c\u4e0d\u5230\u4f0a\u6ce2\u62c9\u75c5\u6bd2\uff0c\u4f46\u5728\u5f88\u9577\u4e00\u6bb5\u6642\u9593\u5167\uff0c\u9084\u662f\u53ef\u4ee5\u5728\u7cbe\u6db2\u88e1\u6aa2\u6e2c\u5230\u75c5\u6bd2\uff0c\u4e26\u4e14\u53ef\u80fd\u900f\u904e\u6027\u884c\u70ba\u800c\u50b3\u67d3\u7d66\u5225\u4eba\u3002\u56e0\u6b64\uff0c\u7f8e\u570b\u75be\u75c5\u63a7\u5236\u8207\u9810\u9632\u4e2d\u5fc3\u5efa\u8b70\u5f9e\u66fe\u7d93\u88ab\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u611f\u67d3\u7684\u60a3\u8005\uff0c\u5728\u9084\u6c92\u6709\u66f4\u660e\u78ba\u7684\u6578\u64da\u8207\u5b9a\u8ad6\u524d\uff0c\u70ba\u4e86\u4fdd\u8b77\u81ea\u5df1\u7684\u4f34\u4fb6\uff0c\u6700\u597d\u7d42\u8eab\u4f7f\u7528\u4fdd\u96aa\u5957\u3002\u9664\u4e86\u9019\u9053\u8b66\u9418\uff0c\u5728The New England Journal of Medicine<\/em>\u4e0a\uff0c\u4e5f\u5831\u5c0e\u4e86\u4e00\u4f4d\u7f8e\u570b\u91ab\u751f\u5728\u5f9e\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u611f\u67d3\u5eb7\u5fa9\u4e4b\u5f8c\uff0c\u53c8\u56e0\u70ba\u5f8c\u907a\u75c7\u800c\u9032\u91ab\u9662\u7684\u6848\u4f8b\u3002<\/p>\n

\u9019\u4f4d\u91ab\u751f\u5e74\u7d04\u56db\u5341\uff0c\u53bb\u5e74\u5728\u7345\u5b50\u5c71\u5354\u52a9\u4f0a\u6ce2\u62c9\u9632\u75ab\u6cbb\u7642\u5de5\u4f5c\u6642\u88ab\u611f\u67d3\uff0c\u5728\u51fa\u73fe\u81e8\u5e8a\u75c7\u72c0\u7684\u56db\u5929\u4e4b\u5f8c\u9001\u56de\u7f8e\u570b\u63a5\u53d7\u6cbb\u7642\u3002\u7576\u6642\u9664\u4e86\u652f\u6301\u6027\u7642\u6cd5\u5916\uff0c\u9084\u63a5\u53d7\u4e86\u5be6\u9a57\u4e2d\u7684\u6297\u75c5\u6bd2\u85e5\u7269\u5c0f\u5e72\u64feRNA(small interfering RNA) TKM-100802\uff0c\u8207\u5eb7\u5fa9\u8005\u8840\u6e05\u7684\u6cbb\u7642\u3002\u6cbb\u7642\u671f\u9593\u56e0\u70ba\u591a\u91cd\u5668\u5b98\u8870\u7aed\u7684\u539f\u56e0\uff0c\u6709\u6bb5\u6642\u9593\u4f9d\u8cf4\u547c\u5438\u5668\u8207\u8840\u6db2\u900f\u6790\uff1b\u62d4\u7ba1\u5f8c\u6709\u884c\u52d5\u969c\u7919\uff0c\u8207\u7cbe\u795e\u72c0\u614b\u6539\u8b8a\u3002\u4f46\u5728\u63a5\u53d7\u6cbb\u7642\u56db\u5341\u591a\u5929\u4e4b\u5f8c\uff0c\u591a\u6b21\u7684\u8840\u6db2\u8207\u5c3f\u6db2\u6aa2\u9ad4\u4e2d\u90fd\u6aa2\u6e2c\u4e0d\u5230\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u91cf\uff0c\u75c5\u4eba\u7cbe\u795e\u72c0\u614b\u4e5f\u986f\u8457\u597d\u8f49\uff0c\u4f46\u4ecd\u6709\u8f15\u5fae\u7684\u8868\u9054\u6027\u5931\u8a9e\u75c7\uff0c\u4e5f\u5f88\u5bb9\u6613\u75b2\u52de\u3002\u51fa\u9662\u7576\u5929\uff0c\u75c5\u4eba\u7cbe\u6db2\u6aa2\u9ad4\u4e2d\u53ef\u4ee5\u6aa2\u6e2c\u5230\u75c5\u6bd2\u91cf\uff0c\u4e5f\u80fd\u5206\u6790\u57f9\u990a\u51fa\u75c5\u6bd2\uff0c\u4f46\u9019\u5728\u611f\u67d3\u5eb7\u5fa9\u8005\u4e2d\u6975\u70ba\u5e38\u898b\u3002<\/p>\n

\u51fa\u9662\u4e4b\u5f8c\uff0c\u9019\u4f4d\u91ab\u751f\u6062\u5fa9\u826f\u597d\uff0c\u4f46\u4e00\u500b\u6708\u5f8c\u958b\u59cb\u51fa\u73fe\u807d\u89ba\u9000\u5316\uff0c\u95dc\u7bc0\u8207\u808c\u8089\u75bc\u75db\u7684\u4e0d\u9069\u3002\u5176\u4e2d\u6700\u4ee4\u91ab\u751f\u64d4\u5fc3\u7684\u662f\u4ed6\u5de6\u773c\u7684\u75c7\u72c0\uff1a\u7d05\u816b\u767c\u708e\uff0c\u754f\u5149\u75bc\u75db\uff0c\u773c\u58d3\u9ad8\uff0c\u800c\u4e14\u8996\u529b\u4e5f\u65e5\u6f38\u6a21\u7cca\u3002\u6c42\u8a3a\u4e4b\u5f8c\uff0c\u88ab\u8a3a\u65b7\u51fa\u662f\u8461\u8404\u819c\u708e(uveitis)\u3002\u8461\u8404\u819c\u4ecb\u65bc\u773c\u775b\u6700\u5916\u5c64\u7684\u978f\u819c\u8207\u6700\u5167\u5c64\u7684\u8996\u7db2\u819c\u4e4b\u9593\uff0c\u5176\u5167\u542b\u7684\u8840\u7ba1\u4f9b\u61c9\u4e86\u5927\u90e8\u5206\u773c\u90e8\u7d44\u7e54\u6240\u9700\u7684\u8840\u6d41\u8207\u71df\u990a\u3002\u5f8c\u4f86\uff0c\u91ab\u7642\u5718\u968a\u5047\u8a2d\u53ef\u80fd\u662f\u4e4b\u524d\u7684\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u611f\u67d3\u9020\u6210\u75c5\u60a3\u7684\u514d\u75ab\u529b\u4e0b\u964d\uff0c\u800c\u4f7f\u5176\u4ed6\u75c5\u6bd2\u6709\u53ef\u8d81\u4e4b\u6a5f\u800c\u9020\u6210\u773c\u90e8\u611f\u67d3\u3002\u65bc\u662f\u4ed6\u5011\u5f9e\u773c\u775b\u524d\u623f\u63a1\u53d6\u6c34\u6f3e\u6db2\u6aa2\u9ad4\u9001\u53bb\u5316\u9a57\uff0c\u6c92\u60f3\u5230\u6aa2\u6e2c\u5831\u544a\u51fa\u4f86\u5f8c\uff0c\u767c\u73fe\u90a3\u767b\u5802\u5165\u5ba4\u7684\u5c31\u662f\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u3002<\/p>\n

\"\u88ab\u611f\u67d3\u4e4b\u5f8c<\/a>
\u88ab\u611f\u67d3\u4e4b\u5f8c \u75c5\u6bd2\u6703\u9020\u6210\u773c\u775b\u8b8a\u8272(http:\/\/www.eyecenter.emory.edu\/press_releases\/pr_retina_45.htm)<\/figcaption><\/figure>\n

\u9019\u4f4d\u7f8e\u570b\u91ab\u751f\u5eb7\u5fa9\u5f8c\u7684\u75c7\u72c0\uff0c\u8ddf\u76ee\u524d\u81e8\u5e8a\u4e0a\u5176\u4ed6\u60bb\u5b58\u8005\u5e38\u51fa\u73fe\u7684\u5f8c\u907a\u75c7\u75c7\u72c0\u6975\u70ba\u985e\u4f3c\u3002\u90a3\u70ba\u4ec0\u9ebc\u75c5\u6bd2\u6703\u85cf\u533f\u5230\u773c\u90e8\u53bb\u5462\uff1f<\/p>\n

\u7814\u7a76\u4eba\u54e1\u63a8\u4f30\uff0c\u9019\u53ef\u80fd\u8ddf\u5373\u4f7f\u75c5\u4eba\u5eb7\u5fa9\u5f8c\u7684\u597d\u5e7e\u500b\u6708\u5167\uff0c\u5728\u7cbe\u6db2\u88e1\u9084\u80fd\u5920\u6aa2\u6e2c\u51fa\u75c5\u6bd2\u662f\u985e\u4f3c\u7684\u6a5f\u5236\u3002\u773c\u7403\u8ddf\u776a\u4e38\u90fd\u662f\u514d\u75ab\u7d30\u80de\u4e0d\u592a\u53bb\u4e5f\u56e0\u70ba\u7279\u6b8a\u7684\u8840\u7ba1\u969c\u853d\u800c\u7121\u6cd5\u53bb\u5de1\u5b88\u7684\u7279\u5225\u5340\u57df\uff0c\u6545\u88ab\u7a31\u4f5c\u514d\u75ab\u8c41\u514d\u5340(immune privilege)\u3002\u7576\u514d\u75ab\u7cfb\u7d71\u628a\u9ad4\u5167\u7684\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u90fd\u8d95\u76e1\u6bba\u7d55\uff0c\u91ab\u7642\u6aa2\u6e2c\u90fd\u5075\u6e2c\u4e0d\u5230\u75c5\u6bd2\u91cf\u6642\uff0c\u85cf\u533f\u5230\u773c\u7403\u8207\u776a\u4e38\u9019\u4e9b\u514d\u75ab\u8c41\u514d\u5340\u7684\u75c5\u6bd2\uff0c\u9003\u907f\u4e86\u628a\u95dc\uff0c\u773c\u7403\u8207\u776a\u4e38\u5c31\u6210\u4e86\u75c5\u6bd2\u8907\u88fd\u7684\u6eab\u5e8a\u4e86\u3002\u4f46\u8ddf\u7cbe\u6db2\u5167\u9084\u6b98\u5b58\u7684\u75c5\u6bd2\u4e0d\u540c\uff0c\u96d6\u7136\u5728\u773c\u775b\u6c34\u6f3e\u6db2\u4e2d\u6aa2\u6e2c\u51fa\u75c5\u6bd2\uff0c\u4f46\u773c\u6dda\u3001\u773c\u775b\u8868\u9762\uff0c\u5247\u90fd\u6c92\u6709\u767c\u73fe\u75c5\u6bd2\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong>
\n1. Varkey JB, et al. Persistence of Ebola Virus in Ocular Fluid during Convalescence. N Engl J Med<\/em>. 2015 May 7.
\n2. After Nearly Claiming His Life, Ebola Lurked in a Doctor\u2019s Eye<\/a> The New York Times.<\/em> 2015 May 7.\u00a0
\n<\/a>3. Kraft CS, et al. The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States. Clin Infect Dis<\/em>. 2015 Apr 22. pii: civ334.
\n4. Zhou R, Caspi RR. Ocular immune privilege. F1000 Biol Rep.<\/em> 2010 Jan 18;2. pii: 3. doi: 10.3410\/B2-3.<\/p>\n

--<\/span><\/strong>
\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n

 <\/p>\n

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