{"id":21568,"date":"2015-05-28T00:58:26","date_gmt":"2015-05-27T16:58:26","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21568"},"modified":"2018-08-01T15:40:45","modified_gmt":"2018-08-01T07:40:45","slug":"%e3%80%90%e7%94%9f%e7%89%a9%e5%80%ab%e7%90%86%e3%80%91%e4%b8%ad%e5%9c%8b%e7%a7%91%e5%ad%b8%e5%ae%b6%e6%94%b9%e9%80%a0%e4%ba%ba%e9%a1%9e%e8%83%9a%e8%83%8e%e5%bc%95%e7%99%bc%e7%9a%84%e7%88%ad%e8%ad%b0","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21568","title":{"rendered":"\u3010\u751f\u7269\u502b\u7406\u3011\u4e2d\u570b\u79d1\u5b78\u5bb6\u6539\u9020\u4eba\u985e\u80da\u80ce\u5f15\u767c\u7684\u722d\u8b70"},"content":{"rendered":"

\u25a02015\u5e74\u7684\u56db\u6708\u5341\u516b\u65e5\uff0c\u6709\u4e00\u7bc7\u6587\u7ae0\u6084\u6084\u5730\u51fa\u73fe\u5728\u00a0Protein Cell\u00a0<\/em>\u9019\u672c\u671f\u520a\u4e0a\u3002\u8aaa\u6084\u6084\uff0c\u5176\u5be6\u4e5f\u4e0d\u5168\u7136\uff1b\u6839\u64da\u901a\u4fe1\u4f5c\u8005\u3001\u5ee3\u5dde\u4e2d\u5c71\u5927\u5b78\u7684\u9ec3\u8ecd\u5c31\u526f\u6559\u6388\u8aaa\uff0c\u4ed6\u5011\u66fe\u6295\u7a3f\u5230\u300a\u81ea\u7136\u300b\u8207\u300a\u79d1\u5b78\u300b\u9019\u5169\u672c\u671f\u520a\uff0c\u4f46\u662f\u90fd\u88ab\u4ee5\u9055\u53cd\u751f\u7269\u502b\u7406\u7684\u7406\u7531\u62d2\u7d55\u4e86\u3002\u7a76\u7adf\u662f\u4ec0\u9ebc\u7814\u7a76\u5462\uff1f\u7b54\u6848\u662f\u300c\u57fa\u56e0\u7de8\u8f2f\u300d(gene editing)\u3002\u57fa\u56e0\u7de8\u8f2f\u5df2\u7d93\u4e0d\u662f\u65b0\u9bae\u4e8b\uff0c\u690d\u7269<\/span><\/a>\u90fd\u5df2\u7d93\u5728\u505a\u4e86\uff1b\u4f46\u65b0\u9bae\u7684\u662f\uff0c\u9ec3\u8001\u5e2b\u7684\u7814\u7a76\u5718\u968a\u4f7f\u7528\u4e86\u4eba\u985e\u80da\u80ce\u3002<\/strong><\/span><\/p>\n

\"\u03b2-\u7403\u86cb\u767d\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\"
\u03b2-\u7403\u86cb\u767d\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n

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48\u5c0f\u6642\u5f8c\uff0c\u5927\u7d04\u670980%\u7684\u80da\u80ce\u5b58\u6d3b\uff1b\u5728\u9019\u4e9b\u5b58\u6d3b\u4e0b\u4f86\u7684\u80da\u80ce\u4e2d\uff0c\u7814\u7a76\u5718\u968a\u4ed4\u7d30\u5730\u6aa2\u9a57\u4e86\u5176\u4e2d\u768454\u500b\uff0c\u767c\u73fe\u53ea\u670928\u500b\u7de8\u8f2f\u6210\u529f\uff08\u7d04\u70ba52%\uff09\u3002\u4f46\u662f\u7814\u7a76\u5718\u968a\u4e5f\u767c\u73fe\uff0c\u5728\u901928\u500b\u80da\u80ce\u88e1\uff0c\u9084\u5b58\u5728\u8457\u4e0d\u80fd\u5141\u8a31\u7684\u72c0\u6cc1\uff1a\u5176\u4ed6\u4f4d\u9ede\u7684\u7a81\u8b8a(off-target cleavage)\u3002\u800c\u4e14\uff0c\u9019\u4e9b\u7a81\u8b8a\u4e26\u4e0d\u50c5\u9650\u65bc\u8207\u03b2-\u7403\u86cb\u767d\u57fa\u56e0\u76f8\u4f3c\u5ea6\u751a\u9ad8\u7684\u03b4-\u7403\u86cb\u767d\u57fa\u56e0(HBD)\u800c\u5df2\uff0c\u4e5f\u5305\u62ec\u4e86\u5176\u4ed6\u7684\u5340\u57df\u3002\u96d6\u7136\u7814\u7a76\u5718\u968a\u4e8b\u5148\u5df2\u7d93\u5728\u4eba\u985e\u7684293T\u7d30\u80de\u682a\u4e2d\u6e2c\u8a66\u904e\u3001\u4e26\u6311\u9078\u4e86\u4e00\u500b\u5728293T\u7d30\u80de\u682a\u4e2d\u6c92\u6709\u767c\u751f\u5176\u4ed6\u4f4d\u9ede\u7a81\u8b8a\u7684\u4f4d\u7f6e\uff0c\u4f86\u9032\u884c\u57fa\u56e0\u7de8\u8f2f\uff1b\u7d50\u679c\u7a81\u8b8a\u9084\u662f\u767c\u751f\u4e86\u3002<\/p>\n

\u7531\u65bc\u7de8\u8f2f\u6210\u529f\u7387\u4e0d\u9ad8\uff0c\u52a0\u4e0a\u767c\u751f\u4e86\u5176\u4ed6\u4f4d\u7f6e\u7684\u7a81\u8b8a\uff0c\u56e0\u6b64\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff0c\u8981\u5c07CRISPR\/Cas9\u7684\u6280\u8853\u61c9\u7528\u5728\u4eba\u7684\u57fa\u56e0\u7de8\u8f2f\u4e0a\u9084\u592a\u65e9\u3002\u9ec3\u8001\u5e2b\u5728\u63a5\u53d7\u300a\u81ea\u7136\u300b\u96dc\u8a8c\u7684\u65b0\u805e\u5718\u968a\u8a2a\u554f\u6642\u4e5f\u63d0\u5230\uff0c\u8981\u61c9\u7528\u5728\u4eba\u8eab\u4e0a\uff0c\u4e00\u5b9a\u8981\u767e\u5206\u4e4b\u767e\u624d\u884c\u3002<\/p>\n

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\n<\/strong>\u4e2d\u570b\u79d1\u5b78\u5bb6\u7de8\u8f2f\u4eba\u985e\u80da\u80ce\u9707\u9a5a\u4e16\u754c\uff01\uff08\u6bcf\u65e5\u96fb\u8a0a\u5831\uff09
\n<\/strong>\u4e2d\u570b\u79d1\u5b78\u5bb6\u7de8\u8f2f\u4eba\u985e\u80da\u80ce\u5f15\u767c\u6050\u61fc\uff08\u4eca\u65e5\u7f8e\u570b\u5831\uff09<\/strong><\/p>\n

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\u53c3\u8003\u6587\u737b\uff1a<\/strong>
\n1. Puping Liang, Yanwen Xu, Xiya Zhang, Chenhui Ding, Rui Huang, Zhen Zhang, Jie Lv, Xiaowei Xie, Yuxi Chen, Yujing Li, Ying Sun, Yaofu Bai, Zhou Songyang, Wenbin Ma, Canquan Zhou, Junjiu Huang. 2015.\u00a0CRISPR\/Cas9-mediated gene editing in human tripronuclear zygotes<\/a>.\u00a0Protein Cell<\/em>. 6(5):363-372.
\n2. David Cyranoski and Sara Reardon. 2015\/4\/22.\u00a0Chinese scientists genetically modify human embryos<\/a>. Nature News.
\n3. \u8af8\u5e73 2015\/4\/24\u3002\u4e2d\u5c71\u5927\u5b78\u9ec4\u8ecd\u5c31\u526f\u6559\u6388\u7684\u4eba\u985e\u80da\u80ce\u57fa\u56e0\u4fee\u98fe\u5f15\u722d\u8b70<\/a>\uff08\u9644\u539f\u6587\uff09\u3002
\n4. Sara Reardon and Nature magazine. 2015\/4\/29.\u00a0Ban DNA Editing Human Embryos, NIH Says<\/a>. Scientific American.<\/p>\n

--<\/strong><\/span>
\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

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