{"id":21493,"date":"2015-06-04T00:22:53","date_gmt":"2015-06-03T16:22:53","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21493"},"modified":"2018-08-01T15:52:05","modified_gmt":"2018-08-01T07:52:05","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e8%a7%a3%e7%a2%bc%e7%98%a7%e5%8e%9f%e8%9f%b2plasmodium-falciparum%e5%b0%8d%e9%9d%92%e8%92%bf%e7%b4%a0%e7%9a%84%e6%8a%97%e6%80%a7","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21493","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u89e3\u78bc\u7627\u539f\u87f2(Plasmodium falciparum)\u5c0d\u9752\u84bf\u7d20\u7684\u6297\u6027"},"content":{"rendered":"<figure id=\"attachment_21499\" aria-describedby=\"caption-attachment-21499\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-21499\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/blood-158837_640.png\" alt=\"\u5716\u7247\u4f86\u6e90\uff5cpixabay.com\" width=\"300\" height=\"296\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/blood-158837_640.png 640w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/blood-158837_640-300x296.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/blood-158837_640-600x593.png 600w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-21499\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff5cpixabay.com<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u7627\u75be\u53ef\u80fd\u662f\u4eba\u985e\u6700\u65e9\u7684\u50b3\u67d3\u75c5\u4e4b\u4e00\uff0c\u6bb7\u5546\u6642\u671f(3500B.C.)\u7684\u7532\u9aa8\u6587\u4e0a\u5c31\u6709\u300c\u7627\u300d\u9019\u500b\u5b57\u3002<\/p>\n<p>\u4e0d\u53ea\u5728\u4e2d\u570b\uff0c\u6b50\u6d32\u4e5f\u5f88\u65e9\u5c31\u77e5\u9053\u7627\u75be\u3002\u53e4\u4ee3\u7684\u4eba\u7e3d\u4ee5\u70ba\u751f\u75c5\u662f\u56e0\u70ba\u63a5\u89f8\u5230\u4e0d\u65b0\u9bae\u7684\u7a7a\u6c23\uff0c\u9ec3\u5e1d\u5167\u7d93\u8a8d\u70ba\u7627\u75be\u662f\u300c\u7634\u6c23\u300d\uff0c\u6b50\u6d32\u5c07\u7627\u75be\u7a31\u70bamalaria\uff0c\u610f\u601d\u662fmala aria\uff0c\u4e5f\u5c31\u662f\u6c61\u6fc1\u7684\u7a7a\u6c23\u3002\u7576\u7136\uff0c\u5c07\u7627\u75be\u8207\u6c61\u6fc1\u7a7a\u6c23\u4f5c\u95dc\u9023\uff0c\u53ef\u80fd\u4e5f\u662f\u56e0\u70ba\u6cbc\u6fa4\u9644\u8fd1\u7627\u75be\u7684\u76db\u884c\u7387\u7e3d\u662f\u5c45\u9ad8\u4e0d\u4e0b\u5427\uff01<\/p>\n<p>\u5230\u4e86\u5341\u4e03\u4e16\u7d00\uff0c\u6b50\u6d32\u4eba\u5728\u5357\u7f8e\u6d32\u767c\u73fe\u4e86\u91d1\u96de\u7d0d(cinchona)\u53ef\u4ee5\u6cbb\u7627\u75be\uff0c\u7d42\u65bc\u4f7f\u5f97\u9019\u500b\u75be\u75c5\u4e0d\u518d\u4ee4\u4eba\u805e\u98a8\u55aa\u81bd\uff1b\u4f46\u7576\u6642\u7531\u65bc\u91d1\u96de\u7d0d\u6a39\u76ae\u50f9\u683c\u6975\u9ad8\uff0c\u4e00\u958b\u59cb\u7627\u75be\u7684\u6cbb\u7642\u9084\u53ea\u662f\u300c\u597d\u91ce\u4eba\u300d\u7684\u5c08\u5229\u3002<\/p>\n<p>\u5230\u4e86\u91d1\u96de\u7d0d\u6a39\u958b\u59cb\u5728\u5370\u5c3c\u8207\u5370\u5ea6\u5927\u91cf\u683d\u7a2e\u6642\uff0c\u7d42\u65bc\u5927\u90e8\u5206\u7684\u4eba\u53ef\u4ee5\u5f97\u5230\u5b83\u3002\u91d1\u96de\u7d0d\u7684\u6709\u6548\u6210\u5206\u662f\u594e\u5be7(quinine)\uff0c\u5b83\u4e0d\u4f46\u5177\u6709\u89e3\u71b1\u7684\u6548\u679c\uff0c\u9084\u53ef\u4ee5\u6291\u5236\u7627\u539f\u87f2\u4ee3\u8b1d\u6b63\u9435\u8840\u7d05\u7d20(ferriprotoporphyrin IX)\uff0c\u7531\u65bc\u7627\u539f\u87f2\u4ee5\u8840\u7d05\u86cb\u767d(hemoglobulin)\u70ba\u98df\u6642\uff0c\u91cb\u653e\u51fa\u6b63\u9435\u8840\u7d05\u7d20\uff1b\u6b63\u9435\u8840\u7d05\u7d20\u6703\u7522\u751f\u81ea\u7531\u57fa(reactive oxygen species)\uff0c\u7834\u58de\u7627\u539f\u87f2\u7684\u7d30\u80de\u819c\uff1b\u56e0\u6b64\u7627\u539f\u87f2\u6703\u4ee5\u5b83\u7684\u6eb6\u5c0f\u9ad4\u4e2d\u7684\u8840\u7d05\u7d20\u805a\u5408\u9176(heme polymerase)\u5c07\u6b63\u9435\u8840\u7d05\u7d20\u4ee3\u8b1d\u70ba\u4e0d\u5177\u6709\u6bd2\u6027\u7684\u7627\u75be\u8272\u7d20(hemazoin)\u3002\u7576\u6b63\u9435\u8840\u7d05\u7d20\u7684\u4ee3\u8b1d\u88ab\u594e\u5be7\u6291\u5236\u6642\uff0c\u7627\u539f\u87f2\u5c31\u6703\u56e0\u70ba\u906d\u5230\u81ea\u7531\u57fa\u7834\u58de\u7d30\u80de\u819c\u800c\u6b7b\u3002<!--more--><\/p>\n<figure id=\"attachment_21494\" aria-describedby=\"caption-attachment-21494\" style=\"width: 352px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-21494\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/352px-Quinine.svg_.png\" alt=\"\u594e\u5be7\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\" width=\"352\" height=\"235\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/352px-Quinine.svg_.png 352w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/352px-Quinine.svg_-300x200.png 300w\" sizes=\"(max-width: 352px) 100vw, 352px\" \/><figcaption id=\"caption-attachment-21494\" class=\"wp-caption-text\">\u594e\u5be7\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p>\u5230\u4e86\u4e8c\u6b21\u4e16\u754c\u5927\u6230\uff0c\u722a\u54c7\u88ab\u65e5\u672c\u4f54\u9818\u4fc3\u6210\u4e86\u6c2f\u594e(chloroquine)\u7684\u767c\u660e\uff1b\u6230\u5f8c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u5c55\u958b\u6839\u6cbb\u7627\u75be\u884c\u52d5\uff0c\u5305\u62ec\u4f7f\u7528\u868a\u5e33\u3001\u4ee5\u67f4\u6cb9\u8986\u84cb\u6c34\u6e9d\u8868\u9762\u4f7f\u5b51\u5b53\u7a92\u606f\u3001\u5674\u6d12DDT\u6ec5\u868a\u4ee5\u53ca\u5ee3\u6cdb\u5730\u4f7f\u7528\u6c2f\u594e\u6cbb\u7642\u7627\u75be\u3002\u4f46\u6839\u6cbb\u884c\u52d5\u6700\u5f8c\u5c0e\u81f4\u4e86\u6297DDT\u7684\u7627\u868a\u4ee5\u53ca\u6297\u6c2f\u594e\u7684\u7627\u539f\u87f2\u51fa\u73fe\u3002<\/p>\n<p>\u76f4\u52301967\u5e74\u767c\u73fe\u9752\u84bf\uff08\u53c8\u540d\u9ec3\u82b1\u84bf\uff0c<em>Artemisia annua<\/em>\uff09\u53ef\u4ee5\u6cbb\u7642\u7627\u75be\uff0c\u4e26\u7531\u9752\u84bf\u4e2d\u5206\u96e2\u51fa\u9752\u84bf\u7d20(artemisinin)\uff0c\u7627\u75be\u7684\u6cbb\u7642\u624d\u53c8\u91cd\u7372\u66d9\u5149\uff1b\u4f46\u8fd1\u5e74\u4f86\u6297\u9752\u84bf\u7d20\u7684\u7627\u539f\u87f2\u65bc\u4e2d\u5357\u534a\u5cf6\u51fa\u73fe\uff0c\u4f7f\u7627\u75be\u7684\u6cbb\u7642\u53c8\u8499\u4e0a\u4e00\u5c64\u6697\u5f71\u3002\u96d6\u7136\u8fd1\u5e74\u4f86\u7627\u75be\u7684\u6cbb\u7642\u6709\u9577\u8db3\u7684\u9032\u6b65\uff0c\u7f79\u60a3\u7627\u75be\u7684\u4eba\u6578\u8207\u6b7b\u65bc\u7627\u75be\u7684\u4eba\u6578\u90fd\u5728\u4e0b\u964d\u4e2d\uff0c\u4f462013\u5e74\u5168\u4e16\u754c\u4ecd\u6709\u7d04\u4e00\u5104\u4e5d\u5343\u516b\u767e\u842c\u4eba\u7f79\u60a3\u7627\u75be\uff1b\u5176\u4e2d\u5927\u7d04\u6709\u4e94\u5341\u516b\u842c\u56db\u5343\u4eba\u6b7b\u4ea1\u3002\u5176\u4e2d82%\u7684\u60a3\u8005\u820790%\u7684\u6b7b\u4ea1\u767c\u751f\u5728\u975e\u6d32\uff0c\u5c0d\u65bc\u5c0f\u5b69\u8207\u61f7\u5b55\u7684\u5a66\u5973\u5f71\u97ff\u6975\u5927\u3002\u56e0\u6b64\uff0c\u4e16\u754c\u5404\u570b\u7684\u79d1\u5b78\u5bb6\u7121\u4e0d\u536f\u8db3\u4e86\u52c1\u60f3\u627e\u5230\u66f4\u597d\u7684\u6cbb\u7642\u65b9\u6cd5\u3002\u6709\u4e9b\u79d1\u5b78\u5bb6\u52aa\u529b\u958b\u767c\u7627\u75be\u7684\u75ab\u82d7\uff0c\u6709\u4e9b\u5247\u60f3\u8981\u627e\u51fa\u70ba\u4f55\u7627\u539f\u87f2\u6703\u767c\u5c55\u51fa\u5c0d\u9752\u84bf\u7d20\u7684\u6297\u6027\uff0c\u5e0c\u671b\u80fd\u6291\u5236\u5b83\u3002<\/p>\n<figure id=\"attachment_21495\" aria-describedby=\"caption-attachment-21495\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-21495\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/Life_Cycle_of_the_Malaria_Parasite.jpg\" alt=\"\u7627\u539f\u87f2\u7684\u751f\u547d\u9031\u671f\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\" width=\"500\" height=\"493\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/Life_Cycle_of_the_Malaria_Parasite.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/Life_Cycle_of_the_Malaria_Parasite-300x295.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/Life_Cycle_of_the_Malaria_Parasite-800x789.jpg 800w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-21495\" class=\"wp-caption-text\">\u7627\u539f\u87f2\u7684\u751f\u547d\u9031\u671f\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p>\u70ba\u4ec0\u9ebc\u5462\uff1f\u539f\u4f86\u9752\u84bf\u7d20\u4f5c\u7528\u5728\u7627\u539f\u87f2\u5165\u4fb5\u7d05\u8840\u7403\u7684\u65e9\u671f\uff08\u898b\u4e0a\u5716\u5de6\u5c0f\u5708\uff09\uff0c\u56e0\u6b64\u9752\u84bf\u7d20\u5c0d\u65bc\u7627\u75be\u7684\u6cbb\u7642\u4ee5\u53ca\u75c5\u4eba\u7684\u5065\u5eb7\u7dad\u8b77\u4e0a\u662f\u76f8\u5c0d\u512a\u65bc\u594e\u5be7\u6216\u6c2f\u594e\u7684\u3002<\/p>\n<p>\u4e0d\u904e\uff0c\u8981\u7814\u7a76\u6297\u6027\u7684\u7522\u751f\uff0c\u4e00\u5b9a\u8981\u5148\u4e86\u89e3\u7a76\u7adf\u9752\u84bf\u7d20\u662f\u5982\u4f55\u6d88\u6ec5\u7627\u539f\u87f2\u3002\u57282012\u5e74\uff0c\u8056\u6bcd\u5927\u5b78(University of Notre Dame)\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\u4e00\u500b\u5c0f\u5c0f\u7684\u5206\u5b50\uff0c\u78f7\u8102\u9170\u808c\u9187-3-\u78f7\u9178(PI3P,\u00a0phosphatidylinositol-3-phosphate)\u7adf\u7136\u53ef\u80fd\u662f\u5c0e\u81f4\u6297\u85e5\u6027\u7684\u95dc\u9375\u3002<\/p>\n<figure id=\"attachment_21497\" aria-describedby=\"caption-attachment-21497\" style=\"width: 226px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21497\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/226px-Phosphatidylinositol-3-phosphate.svg_.png\" alt=\"PI3P\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\" width=\"226\" height=\"435\" \/><figcaption id=\"caption-attachment-21497\" class=\"wp-caption-text\">PI3P\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p>\u539f\u4f86PI3P\u5e6b\u52a9\u7627\u539f\u87f2\u5c07\u5206\u6ccc\u9ad4(secretome)\u904b\u8f38\u5230\u7d30\u80de\u8868\u9762\u3002\u5982\u6b64\u4e00\u4f86\uff0c\u7627\u539f\u87f2\u4fbf\u53ef\u4ee5\u611f\u67d3\u66f4\u591a\u7d05\u8840\u7403\u3002\u800c\u7627\u539f\u87f2\u7684PI3P\u662f\u7531\u78f7\u8102\u9170\u808c\u9187-3-\u6fc0\u9176(PI3K\uff0cphorphatidylinositol-3-kinase)\u5408\u6210\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u6709\u4e00\u500b\u7a31\u70baPfKelch\u7684\u86cb\u767d\u8cea\u53ef\u4ee5\u6291\u5236PI3K\u7684\u6d3b\u6027\u3002\u7576PfKelch\u8207PI3K\u7d50\u5408\u5f8c\uff0cPI3K\u5c31\u6703\u88ab\u52a0\u4e0a\u4e00\u9023\u4e32\u7684\u6cdb\u7d20(ubiquitin)\uff0c\u7136\u5f8c\u88ab\u9001\u53bb\u5206\u89e3\u3002<\/p>\n<p>\u7576PfKelch\u86cb\u767d\u7684\u7b2c580\u500b\u6c28\u57fa\u9178\u56e0\u7a81\u8b8a\u7531\u534a\u80f1\u6c28\u9178(cysteine)\u8b8a\u70ba\u916a\u6c28\u9178(tyrosine)\u6642\uff0c\u5b83\u8207PI3K\u7684\u7d50\u5408\u529b\u8b8a\u5f31\uff0c\u65bc\u662f\u8f03\u5c11\u7684PI3K\u6703\u88ab\u5206\u89e3\uff0c\u9020\u6210PI3P\u7684\u7522\u91cf\u4e0a\u6607\uff0c\u65bc\u662f\u7627\u539f\u87f2\u5c31\u51fa\u73fe\u4e86\u5c0d\u9752\u84bf\u7d20\u7684\u6297\u6027\u4e86\uff01\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u53ea\u8981\u8b93\u7627\u539f\u87f2\u7684PI3P\u589e\u52a0\uff0c\u5373\u4f7fPI3K\u7684\u6d3b\u6027\u6c92\u6709\u4e0a\u6607\uff0c\u7627\u539f\u87f2\u5c0d\u9752\u84bf\u7d20\u7684\u6297\u6027\u9084\u662f\u4e0a\u6607\u4e86\u3002\u7576PI3P\u4e0a\u66072.5\u500d\u6642\uff0c\u7627\u539f\u87f2\u5c0d\u9752\u84bf\u7d20\u7684\u6297\u6027\u589e\u52a0\u4e86\u5341\u500d\u3002<\/p>\n<p>\u9019\u500b\u767c\u73fe\uff0c\u61c9\u8a72\u53ef\u4ee5\u5e6b\u52a9\u79d1\u5b78\u5bb6\u5011\u767c\u660e\u66f4\u597d\u7684\u6297\u7627\u75be\u85e5\u7269\uff1b\u800c\u6700\u8fd1\u54c8\u4f5b\u5927\u5b78\u8207\u9ebb\u7701\u7406\u5de5\u5b78\u9662\u7684\u7814\u7a76\u5718\u968a\u4e5f\u767c\u73fe\u7627\u539f\u87f2\u9700\u8981\u8840\u7403\u8868\u9762\u6297\u539fCD55\u8b93\u4ed6\u5011\u53ef\u4ee5\u611f\u67d3\u7d05\u8840\u7403\u3002\u6240\u6709\u7684\u9019\u4e9b\u767c\u73fe\uff0c\u662f\u5426\u986f\u793a\u4e86\u6211\u5011\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\u5c31\u53ef\u4ee5\u6210\u529f\u5730\u6839\u6cbb\u7627\u75be\u5462\uff1f\u5e0c\u671b\u5982\u6b64\u5566\uff01<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<br \/>\n<\/strong>1. \u856d\u5b5f\u82b3\u30022007\u3002\u89e3\u8b80\u7627\u75be\u64ca\u9000\u7627\u75be\uff1a\u767e\u5e74\u7701\u601d\u4e16\u7d00\u6311\u6230\u3002\u5408\u8a18\u3002<br \/>\n2. 2015\/4\/17.\u00a0<a href=\"http:\/\/www.sciencedaily.com\/releases\/2015\/04\/150417190001.htm\">Researchers make key malarial drug-resistence finding<\/a>. Science Daily.<br \/>\n3. S. Bhattacharjee et. al. 2012.\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S009286741101364X\">Endoplasmic reticulum PI3P lipid binding targets malaria proteins to the host cell<\/a>. Cell. 148. 201-212.<br \/>\n4. Alassane Mbengue et. al., 2015.\u00a0<a href=\"http:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature14412.html\">A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria<\/a>. Nature. doi:10.1038\/nature14412<br \/>\n5. E. S. Egan et. al. 2015.\u00a0<a href=\"http:\/\/dx.doi.org\/10.1126\/science.aaa3526\">A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion<\/a>. Science. 348 (6235): 711-714<br \/>\n6.\u00a0<a href=\"http:\/\/www.who.int\/entity\/malaria\/publications\/world_malaria_report_2014\/en\/index.html\">World Malaria Report 2014 Summary<\/a>.<\/p>\n<p><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br style=\"color: #000000;\" \/><span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u64b0\u6587\uff5c\u8449\u7da0\u8212 \u7627\u75be\u53ef\u80fd\u662f\u4eba\u985e\u6700\u65e9\u7684\u50b3\u67d3\u75c5<\/p>\n","protected":false},"author":20,"featured_media":21499,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1882,154,1884,1569,1883,1881,1885],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/blood-158837_640.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21493"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21493"}],"version-history":[{"count":7,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21493\/revisions"}],"predecessor-version":[{"id":32268,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21493\/revisions\/32268"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/21499"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}