{"id":21483,"date":"2015-06-12T00:01:19","date_gmt":"2015-06-11T16:01:19","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21483"},"modified":"2018-08-01T15:48:08","modified_gmt":"2018-08-01T07:48:08","slug":"%e3%80%90%e5%85%8d%e7%96%ab%e7%a0%94%e7%a9%b6%e3%80%91%e4%bd%a0%e5%b0%8d%e9%a3%9f%e7%89%a9%e9%81%8e%e6%95%8f%e5%97%8e%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21483","title":{"rendered":"\u3010\u514d\u75ab\u7814\u7a76\u3011\u4f60\u5c0d\u98df\u7269\u904e\u654f\u55ce\uff1f"},"content":{"rendered":"

\u25a0\u6642\u81f3\u4eca\u65e5\uff0c\u4ee4\u514d\u75ab\u5b78\u5bb6\u982d\u75db\u53c8\u56f0\u64fe\u7684\u554f\u984c\u4e4b\u4e00\uff0c\u9435\u5b9a\u662f\u5c11\u4e0d\u4e86\u6108\u4f86\u6108\u591a\u7684\u4eba\u5c0d\u98df\u7269\u904e\u654f\u9019\u4ef6\u4e8b\u3002\u4f60\u5c0d\u98df\u7269\u904e\u654f\u55ce\uff1f\u53c8\u6216\u66f4\u751a\u8005\uff0c\u4f60\u5c0d\u82b1\u751f\u904e\u654f\u55ce\uff1f<\/strong><\/span><\/p>\n

\"\u81e8\u5e8a\u8a66\u9a57\u7528\u7684"Bamba"
\u81e8\u5e8a\u8a66\u9a57\u7528\u7684\"Bamba\" \u4e5f\u662f\u4ee5\u8272\u5217\u6700\u66a2\u92b7\u7684\u5b30\u5152\u98df\u54c1\u3002\u5716\u7247\u4f86\u6e90\uff5c\u7dad\u57fa\u767e\u79d1<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u5c0d\u82b1\u751f\u904e\u654f\uff1f\u9019\u5728\u4e9e\u6d32\u6216\u8a31\u4e0d\u592a\u666e\u904d\uff0c\u4f46\u5728\u6b50\u7f8e\u537b\u662f\u65e5\u76ca\u56b4\u91cd\u7684\u554f\u984c\u3002\u4f46\u4e0d\u53ea\u662f\u82b1\u751f\uff0c\u5c0d\u98df\u7269\u904e\u654f\u7684\u5b69\u7ae5\u6bd4\u4f8b\u9010\u5e74\u6500\u5347\u30022000\u5e74\u6642\uff0c\u7f8e\u570b\u5152\u79d1\u5b78\u6703(American Academy of Pediatrics)\u5728Pediatrics<\/em>\u671f\u520a\u4e0a\uff0c\u5efa\u8b70\u4e09\u6b72\u4ee5\u4e0b\u7684\u5b69\u5b50\u82e5\u662f\u5c0d\u82b1\u751f\u904e\u654f\u7684\u9ad8\u5371\u96aa\u7fa4\uff0c\u5c31\u4e0d\u8981\u63a5\u89f8\u4efb\u4f55\u82b1\u751f\u88fd\u54c1\u3002\u800c\u300c\u9ad8\u5371\u96aa\u7fa4\u300d\u7684\u6307\u6a19\uff0c\u5305\u62ec\u66fe\u7d93\u51fa\u73fe\u904e\u6fd5\u75b9(eczema)\u3001\u76ae\u819a\u7d05\u75b9\u8207\u6c23\u5598\u7b49\u75c7\u72c0\u3002\u4f462008\u5e74\u6642\uff0c\u8a72\u5b78\u6703\u6b63\u5f0f\u5ba3\u544a\u4e4b\u524d\u7684\u9632\u5835\u7b56\u7565\uff0c\u6c92\u7528\u3002<\/p>\n

\u70ba\u4ec0\u9ebc\u9632\u5835\u7b56\u7565\u6c92\u7528\u5462\uff1f\u5176\u4e2d\u4e00\u500b\u5047\u8aaa\u662f\uff0c\u5c31\u7b97\u907f\u514d\u651d\u53d6\u4e86\u6703\u5f15\u8d77\u904e\u654f\u7684\u98df\u7269\uff0c\u4f46\u662f\u900f\u904e\u76ae\u819a\uff0c\u4e5f\u6709\u53ef\u80fd\u6703\u63a5\u89f8\u5230\u6240\u884d\u751f\u51fa\u4f86\u7684\u904e\u654f\u539f\u3002\u52a0\u4e0a\u8a31\u591a\u98df\u7269\u904e\u654f\u7684\u5b69\u5b50\u4e5f\u6709\u76ae\u819a\u4e0a\u7684\u91ab\u7642\u554f\u984c\uff0c\u4f7f\u5176\u76ae\u819a\u505a\u70ba\u7b2c\u4e00\u5c64\u4fdd\u8b77\u969c\u7919\u7684\u529f\u80fd\u4e5f\u6e1b\u5f31\u8a31\u591a\u3002\u800c\u53e6\u4e00\u500b\u79d1\u5b78\u5bb6\u6216\u8a31\u6bd4\u8f03\u4e86\u89e3\u7684\u5047\u8aaa\uff0c\u4e3b\u5f35\u6b63\u56e0\u70ba\u5b8c\u5168\u907f\u514d\u651d\u5165\u53ef\u80fd\u5f15\u8d77\u7684\u904e\u654f\u98df\u7269\uff0c\u800c\u7121\u6cd5\u767c\u5c55\u51fa\u5c0d\u98df\u7269\u904e\u654f\u539f\u7684\u53e3\u670d\u514d\u75ab\u8010\u53d7\u6027(Oral tolerance)\u3002<\/p>\n

\u4ee5\u8001\u9f20\u5be6\u9a57\u4f86\u8aaa\uff0c\u8b93\u8001\u9f20\u55ae\u6b21\u5403\u4e0b\u9ad8\u5291\u91cf\u7684\u67d0\u7a2e\u86cb\u767d\u6297\u539f\uff0c\u6703\u5e6b\u52a9\u9ad4\u5167\u514d\u75ab\u7d30\u80de\u767c\u5c55\u51fa\u5c0d\u8a72\u7a2e\u6297\u539f\u7684\u8010\u53d7\u6027\uff0c\u800c\u4e0d\u6703\u5f15\u8d77\u904e\u654f\u53cd\u61c9\u3002\u5728\u91ab\u5b78\u81e8\u5e8a\u4e0a\uff0c\u652f\u6301\u9019\u9805\u5047\u8aaa\u7684\u7814\u7a76\u5831\u5c0e\u4e5f\u591a\u5982\u904e\u6c5f\u4e4b\u9bfd\u3002\u800c\u6700\u6709\u8da3\u7684\u7814\u7a76\uff0c\u5927\u6982\u662f\u85c9\u7531\u6bd4\u8f03\u4e0d\u540c\u570b\u5bb6\u56e0\u70ba\u98f2\u98df\u8207\u80b2\u5152\u7fd2\u6163\u7684\u4e0d\u540c\uff0c\u4f86\u63a2\u8a0e\u6587\u5316\u8207\u74b0\u5883\u56e0\u7d20\u5c0d\u5c0f\u5152\u904e\u654f\u767c\u751f\u6bd4\u4f8b\u7684\u5f71\u97ff\u3002<\/p>\n

\u5728\u4e2d\u6771\uff0c\u56e0\u70ba\u5c0d\u82b1\u751f\u7b49\u5805\u679c\u98df\u54c1\u7684\u63a5\u89f8\u5f88\u65e9\uff0c\u5e7c\u7ae5\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6bd4\u4f8b\u6bd4\u82f1\u7f8e\u570b\u5bb6\u8981\u4f4e\u5f97\u8a31\u591a\u30022008\u5e74\u6642\uff0cGeorge Du Toit\u6bd4\u8f03\u4ee5\u8272\u5217\u5883\u5167\u7684\u7336\u592a\u4eba\u5c0f\u5b69\uff0c\u8207\u65b0\u79fb\u6c11\u81f3\u82f1\u570b\u7684\u7336\u592a\u4eba\u5c0f\u5b69\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6bd4\u4f8b\uff1b\u7b97\u662f\u7b2c\u4e00\u500b\u5728\u59a5\u5584\u63a7\u5236\u57fa\u56e0\u8207\u7a2e\u65cf\u7b49\u8b8a\u56e0\uff0c\u800c\u80fd\u5c08\u4e00\u63a2\u8a0e\u6587\u5316\u5dee\u7570\u8207\u74b0\u5883\u5c0d\u5c0f\u5152\u98df\u7269\u904e\u654f\u7684\u5f71\u97ff\u3002
\n\u5be6\u9a57\u7d50\u679c\u986f\u793a\uff0c\u5728\u4ee5\u8272\u5217\u5883\u5167\u990a\u5927\u76844657\u500b\u7336\u592a\u4eba\u5b69\u5b50\u88e1\uff0c\u53ea\u67098\u4f4d\u5c0d\u82b1\u751f\u904e\u654f\uff08\u7d040.47%\uff09\uff0c\u4f46\u662f3943\u500b\u5728\u82f1\u570b\u9577\u5927\u7684\u65b0\u79fb\u6c11\u7336\u592a\u4eba\u5b69\u5b50\uff0c\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6bd4\u4f8b\u5247\u9ad8\u90542%\uff0c \u800c\u4e14\u5c0d\u5176\u4ed6\u5805\u679c\u985e\u4e5f\u6709\u8f03\u9ad8\u7684\u904e\u654f\u6bd4\u4f8b\u3002\u5c31\u7b97\u53ea\u770b\u6709\u6fd5\u75b9\u75c5\u53f2\u7684\u300c\u9ad8\u5371\u96aa\u7fa4\u300d\u5b69\u5b50\uff0c\u5728\u82f1\u570b\u9577\u5927\u7684\u67096.5%\u5c0d\u82b1\u751f\u904e\u654f\uff0c\u4f46\u5728\u4ee5\u8272\u5217\u9577\u5927\u7684\u537b\u53ea\u67090.8%\u3002\u6709\u8da3\u7684\u662f\uff0c\u5982\u679c\u6bd4\u8f03\u9019\u4e9b\u5b69\u5b50\u5c0d\u96de\u86cb\u6216\u725b\u5976\u904e\u654f\u7684\u6bd4\u4f8b\uff0c\u5247\u90fd\u5dee\u4e0d\u591a\uff0c\u986f\u793a\u98f2\u98df\u7fd2\u6163\u7684\u78ba\u5c0d\u98df\u7269\u904e\u654f\u6709\u56e0\u679c\u95dc\u4fc2\u7684\u5f71\u97ff\u3002\u9032\u4e00\u6b65\u5206\u6790\u767c\u73fe\uff0c\u5728\u4ee5\u8272\u5217\u7684\u7236\u6bcd\u89aa\u7fd2\u6163\u975e\u5e38\u65e9\u7d66\u4e88\u5b30\u5152\u82b1\u751f\u985e\u98df\u54c1\uff0c\u800c\u4e14\u901a\u5e38\u5728\u56db\u500b\u6708\u7684\u6642\u5019\u3002\u6108\u65e9\u958b\u59cb\u7d66\u5b30\u5152\u5403\u82b1\u751f\u98df\u54c1\uff0c\u4f3c\u4e4e\u548c\u964d\u4f4e\u5b69\u7ae5\u767c\u751f\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6bd4\u4f8b\u5728\u7d71\u8a08\u4e0a\u6709\u986f\u8457\u76f8\u95dc\u3002<\/p>\n

\u7d66\u56db\u500b\u6708\u7684\u5b30\u5152\u5403\u82b1\u751f\uff01 \u96e3\u9053\u4e0d\u6703\u564e\u6b7b\u55ce\uff1f\u539f\u4f86\u4ee5\u8272\u5217\u6709\u7a2e\u8d85\u7d1a\u66a2\u92b7\u7684\u5b30\u5152\u98df\u54c1\uff1a\u82b1\u751f\u53e3\u5473\u7684Bamba\uff01\u6839\u64da\u7dad\u57fa\u767e\u79d1\uff0c\u5f9e1964\u958b\u59cb\u8ca9\u552e\u4ee5\u4f86\uff0cBamba\u92b7\u552e\u6578\u5b57\u4e00\u76f4\u5c45\u9ad8\u4e0d\u4e0b\uff0c\u5927\u6982\u5360\u4ee5\u8272\u5217\u96f6\u5634\u5e02\u5834\u92b7\u552e\u7684\u56db\u5206\u4e4b\u4e00\u3002\u4e00\u5305Bamba\u5927\u6982\u670928g\uff0c\u5176\u4e2d\u6709\u5927\u7d04\u4e00\u534a\u662f\u82b1\u751f\u86cb\u767d\u8cea\u3002 George Du Toit\u7684\u7814\u7a76\u5f88\u6709\u8da3\uff0c\u4f46\u7576\u7136\u9700\u8981\u66f4\u56b4\u8b39\u7684\u7814\u7a76\u4f86\u52a0\u4ee5\u8b49\u5be6\u3002\u800c\u6700\u65b0\u7684\u7814\u7a76\u7d50\u679c\uff0c\u6b63\u767c\u8868\u65bcThe New England Journal of Medicine<\/em>\u671f\u520a\u4e0a\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u5047\u8a2d\uff0c\u5982\u679c\u5b30\u5152\u70ba\u5c0d\u82b1\u751f\u904e\u654f\u7684\u9ad8\u5371\u96aa\u7fa4\uff0c\u5247\u5728\u5341\u4e00\u500b\u6708\u5927\u4e4b\u524d\u9935\u98df\u82b1\u751f\u70ba\u539f\u6599\u7684\u5b30\u5152\u98df\u54c1\uff0c\u53ef\u4ee5\u964d\u4f4e\u65e5\u5f8c\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6bd4\u7387\u3002\u4ed6\u5011\u5728\u82f1\u570b\u5883\u5167\u627e\u4f86640\u500b\u56db\u5230\u5341\u4e00\u500b\u6708\u5c0d\u82b1\u751f\u904e\u654f\u70ba\u9ad8\u5371\u96aa\u7fa4\u7684\u5b30\u5152\uff0c\u9019\u4e9b\u5b30\u5152\u56e0\u70ba\u66fe\u7d93\u51fa\u73fe\u6fd5\u75b9\uff0c\u6216\u662f\u5c0d\u96de\u86cb\u904e\u654f\uff0c\u56e0\u6b64\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6a5f\u7387\u6bd4\u5176\u4ed6\u5b69\u5b50\u8981\u9ad8\u5f88\u591a\u3002\u4ed6\u5011\u63a5\u8457\u5c0d\u52a0\u5165\u8a66\u9a57\u7684\u5b69\u5b50\u9032\u884c\u76ae\u819a\u8cbc\u5e03\u6e2c\u8a66\u3002\u5927\u7d04\u6709\u4e00\u767e\u4f4d\u5b30\u5152\u5728\u76ae\u819a\u8cbc\u5e03\u6e2c\u8a66\u4e2d\u51fa\u73fe\u8f15\u5fae\u7684\u82b1\u751f\u904e\u654f\u53cd\u61c9\u3002\u70ba\u4e86\u5b89\u5168\u8d77\u898b\uff0c\u7814\u7a76\u4eba\u54e1\u5148\u914c\u91cf\u7d66\u4e88\u9019\u4e9b\u76ae\u819a\u8cbc\u5e03\u6e2c\u8a66\u967d\u6027\u7684\u5b30\u5152Bamba\uff0c\u4f86\u78ba\u8a8d\u4ed6\u5011\u662f\u4e0d\u662f\u53ef\u4ee5\u63a5\u53d7\u82b1\u751f\u98df\u54c1\u3002\u5176\u4e2d\u670922\u500b\u5b30\u5152\u56e0\u70ba\u904e\u654f\u53cd\u61c9\u592a\u5287\u70c8\u800c\u7121\u6cd5\u7e7c\u7e8c\u53c3\u52a0\u3002\u7136\u5f8c\uff0c\u7814\u7a76\u4eba\u54e1\u96a8\u6a5f\u628a\u76ae\u819a\u8cbc\u5e03\u6e2c\u8a66\u967d\u6027\u8207\u9670\u6027\u7684\u5b30\u5152\uff0c\u96a8\u6a5f\u5404\u5206\u70ba\u5169\u7d44\u3002\u7d66\u5176\u4e2d\u4e00\u7d44\u5403\u82b1\u751f\u53e3\u5473\u7684Bamba\uff0c\u53e6\u5916\u4e00\u7d44\u5247\u5b8c\u5168\u4e0d\u63a5\u89f8\u4efb\u4f55\u82b1\u751f\u7522\u54c1\u3002\u8a66\u9a57\u9032\u884c\u4e86\u4e94\u5e74\uff0c\u7136\u5f8c\u5c0d\u9019\u4e9b\u5b69\u5b50\u6aa2\u6e2c\u9ad4\u5167\u5c0d\u82b1\u751f\u6297\u539f\u7684IgE\u514d\u75ab\u7403\u86cb\u767d\u53cd\u61c9\u3002<\/p>\n

\u5728\u76ae\u819a\u8cbc\u5e03\u6e2c\u8a66\u70ba\u9670\u6027\u7684\u5b69\u5b50\u7fa4\u4e2d\uff0c\u5403Bamba\u7684\u53ea\u67091.9%\u51fa\u73fe\u5c0d\u82b1\u751f\u904e\u654f\u7684\u75c7\u72c0\uff0c\u800c\u5b8c\u5168\u4e0d\u78b0\u82b1\u751f\u88fd\u54c1\u7684\u5b69\u5b50\uff0c\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6bd4\u7387\u5247\u9ad8\u905413.7%\uff0c\u986f\u793a\u6108\u65e9\u958b\u59cb\u5403\u82b1\u751f\u88fd\u54c1\u7684\u78ba\u986f\u8457\u964d\u4f4e\u9ad8\u5371\u96aa\u7fa4\u7684\u5b69\u5b50\u65e5\u5f8c\u5c0d\u82b1\u751f\u904e\u654f\u7684\u6bd4\u4f8b\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5728\u76ae\u819a\u8cbc\u5e03\u6e2c\u8a66\u70ba\u967d\u6027\u7684\u5b69\u5b50\u7fa4\u4e2d\uff0c\u5403Bamba\u7684\u670910.6%\u51fa\u73fe\u5c0d\u82b1\u751f\u904e\u654f\u75c7\u72c0\uff0c\u4f46\u662f\u5b8c\u5168\u4e0d\u78b0\u82b1\u751f\u98df\u54c1\u7684\uff0c\u537b\u670935%\u5c0d\u82b1\u751f\u904e\u654f\uff01<\/p>\n

\u96d6\u7136\u9019\u9805\u7814\u7a76\u4ee5\u82b1\u751f\u904e\u654f\u70ba\u4e3b\uff0c\u4f46\u6216\u8a31\u80fd\u8b93\u79d1\u5b78\u754c\u91cd\u65b0\u601d\u8003\u4e00\u76f4\u4ee5\u4f86\u5949\u70ba\u572d\u81ec\u7684\u9632\u5835\u9003\u907f\u7b56\u7565\u7684\u5229\u5f0a\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a\u00a0<\/strong><\/p>\n

    \n
  1. Du Toit G, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol<\/em>. 2008. 122(5):984-91. doi:10.1016\/j.jaci.2008.08.039.<\/li>\n
  2. Sampson HA. Clinical practice. Peanut allergy. N Engl J Med.<\/em> 2002 Apr 25;346(17):1294-9. No abstract available.<\/li>\n
  3. Gruchalla RS, Sampson HA. Preventing peanut allergy through early consumption--ready for prime time? N Engl J Med.<\/em> 2015 Feb 26;372(9):875-7. doi: 10.1056\/NEJMe1500186. Epub 2015 Feb 23.<\/li>\n
  4. Bunyavanich S, et al. Peanut allergy prevalence among school-age children in a US cohort not selected for any disease. J Allergy Clin Immunol.<\/em> 2014 Sep;134(3):753-5. doi: 10.1016\/j.jaci.2014.05.050. Epub 2014 Jul 30.<\/li>\n
  5. American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics<\/em>. 2000 Aug;106(2 Pt 1):346-9.<\/li>\n
  6. Greer FR, et al. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics.<\/em> 2008 Jan;121(1):183-91. doi: 10.1542\/peds.2007-3022.<\/li>\n
  7. Du Toit G, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med<\/em>. 2015 Feb 26;372(9):803-13. doi: 10.1056\/NEJMoa1414850. Epub 2015 Feb 23<\/li>\n<\/ol>\n

    --<\/span><\/strong>
    \u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n

     <\/p>\n

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