{"id":21449,"date":"2015-05-21T00:06:34","date_gmt":"2015-05-20T16:06:34","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21449"},"modified":"2018-08-01T15:41:31","modified_gmt":"2018-08-01T07:41:31","slug":"%e3%80%90%e7%b4%b0%e8%83%9e%e5%a5%a7%e5%a6%99%e3%80%91%e8%a2%ab%e7%b6%81%e6%9e%b6%e7%9a%84%e7%b2%92%e7%b7%9a%e9%ab%94","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21449","title":{"rendered":"\u3010\u7d30\u80de\u5967\u5999\u3011\u88ab\u7d81\u67b6\u7684\u7c92\u7dda\u9ad4"},"content":{"rendered":"<figure id=\"attachment_21450\" aria-describedby=\"caption-attachment-21450\" style=\"width: 400px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-21450 size-full\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/nrm1697-f2.jpg\" alt=\"\u7c92\u7dda\u9ad4\u5206\u88c2\u7684\u6a21\u578b\u3002\u5716\u7247\u4f86\u6e90\uff1aNature\" width=\"400\" height=\"452\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/nrm1697-f2.jpg 400w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/nrm1697-f2-265x300.jpg 265w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><figcaption id=\"caption-attachment-21450\" class=\"wp-caption-text\">\u7c92\u7dda\u9ad4\u5206\u88c2\u7684\u6a21\u578b\u3002\u5716\u7247\u4f86\u6e90\uff1aNature<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u6211\u5011\u7e3d\u662f\u628a\u7d30\u80de\u4e2d\u7684\u7c92\u7dda\u9ad4\u60f3\u50cf\u6210\u4e00\u9846\u9846\u7368\u7acb\u7684\u80de\u5668\uff0c\u4f46\u662f\u79d1\u5b78\u5bb6\u5011\u5728\u591a\u5e74\u524d\u4fbf\u5df2\u77e5\u9053\uff0c\u540c\u4e00\u7d30\u80de\u4e2d\u7684\u7c92\u7dda\u9ad4\u5011\uff0c\u5f7c\u6b64\u4e4b\u9593\u662f\u6709\u806f\u7e6b\u7684\u3002\u5728\u7d30\u80de\u4e2d\uff0c\u7c92\u7dda\u9ad4\u7d93\u7531\u819c\u7684\u9023\u7d50\uff0c\u69cb\u6210\u4e00\u500b\u7db2\u72c0\u7684\u69cb\u9020\uff1b\u9019\u6a23\u7684\u69cb\u9020\u88ab\u7a31\u70ba\u300c\u7c92\u7dda\u9ad4\u7db2\u7d61\u300d(mitochondrial network)\u3002\u6709\u610f\u601d\u7684\u662f\uff0c\u79d1\u5b78\u5bb6\u5011\u767c\u73fe\uff0c\u5728\u8a31\u591a\u7a2e\u985e\u7684\u764c\u75c7\u7d30\u80de\u4e2d\uff0c\u7c92\u7dda\u9ad4\u7db2\u7d61\u4e0d\u898b\u4e86\u3002\u53d6\u800c\u4ee3\u4e4b\u7684\u662f\u500b\u5225\u7684\u7c92\u7dda\u9ad4\uff1b\u9019\u6a23\u7684\u73fe\u8c61\u7a31\u70ba\u300c\u7c92\u7dda\u9ad4\u7834\u788e\u5316\u300d(mitochondrial fragmentation)\u3002\u7c92\u7dda\u9ad4\u7834\u788e\u5316\u5f71\u97ff\u5230\u5b83\u672c\u8eab\u7684\u529f\u80fd\uff0c\u9020\u6210\u764c\u7d30\u80de\u66f4\u52a0\u4f9d\u8cf4\u91a3\u89e3\u4f5c\u7528(glycolysis)\uff0c\u800c\u9019\u6a23\u7684\u764c\u7d30\u80de\u4e5f\u88ab\u767c\u73fe\u662f\u66f4\u52a0\u60e1\u6027\u7684\u3002<\/p>\n<p>\u7c92\u7dda\u9ad4\u7834\u788e\u5316\u662f\u600e\u9ebc\u767c\u751f\u7684\u5462\uff1f\u904e\u53bb\u7684\u7814\u7a76\u767c\u73fe\uff0c\u5728\u67d0\u4e9b\u764c\u7d30\u80de\u4e2d\u7684\u7c92\u7dda\u9ad4\u6703\u52a0\u901f\u5206\u88c2\uff0c\u5c0e\u81f4\u7c92\u7dda\u9ad4\u7834\u788e\u5316\u3002\u7576\u764c\u7d30\u80de\u7684\u7c92\u7dda\u9ad4\u5206\u88c2\u88ab\u6291\u5236\u4ee5\u5f8c\uff0c\u764c\u7d30\u80de\u5206\u88c2\u7684\u901f\u5ea6\u4e5f\u96a8\u4e4b\u964d\u4f4e\uff0c\u540c\u6642\u7d30\u80de\u51cb\u4ea1\u7684\u901f\u5ea6\u4e5f\u4e0a\u5347\u4e86\u3002<!--more--><\/p>\n<p>\u53ef\u662f\uff0c\u7a76\u7adf\u662f\u4ec0\u9ebc\u5c0e\u81f4\u7c92\u7dda\u9ad4\u52a0\u901f\u5206\u88c2\uff1f\u8b93\u6211\u5011\u5148\u4f86\u770b\u4e00\u4e0b\u4e0a\u9762\u9019\u500b\u5716\uff1a\u539f\u4f86\u7c92\u7dda\u9ad4\u5206\u88c2\u9700\u8981Drp1\u86cb\u767d\u5148\u88ab\u53ec\u559a\u5230\u7c92\u7dda\u9ad4\u819c\u4e0a\uff0c\u63a5\u4e0b\u4f86\u7684\u78f7\u9178\u5316\u4f7fDrp1\u7d44\u6210\u4e00\u500b\u74b0\u72c0\u69cb\u9020\uff0c\u7136\u5f8c\u74b0\u72c0\u69cb\u9020\u6536\u7e2e...\u7c92\u7dda\u9ad4\u4fbf\u4e00\u5206\u70ba\u4e8c\u4e86\uff01\u904e\u53bb\u7684\u7814\u7a76\u767c\u73fe\uff0cRalGEF-Ral\u9014\u5f91\u53ef\u4ee5\u7d93\u7531\u53ec\u559a\u4ee5\u53ca\u78f7\u9178\u5316(phosphorylation)Drp1\u86cb\u767d\uff0c\u4f7f\u7c92\u7dda\u9ad4\u52a0\u901f\u5206\u88c2\u3002<\/p>\n<p>\u7531\u65bcRalGEF-Ral\u9014\u5f91\u4f4d\u65bcRas\u86cb\u767d\u4e0b\u6e38\uff0c\u9019\u500b\u767c\u73fe\u4f7f\u5f97\u79d1\u5b78\u5bb6\u5011\u61f7\u7591\uff0c\u662f\u5426\u9019\u5c31\u662f\u764c\u5316\u7684Ras\u86cb\u767d(oncogenic Ras)\u4e4b\u6240\u4ee5\u4ee5\u80fd\u5920\u8b93\u764c\u7d30\u80de\u60e1\u6027\u5316\u7684\u624b\u6bb5\u4e4b\u4e00\u5462\uff1f<\/p>\n<p>\u6700\u8fd1\uff0c\u7dad\u5409\u5c3c\u4e9e\u5927\u5b78(University of Virginia)\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u539f\u4f86\u764c\u5316Ras\u86cb\u767d\u771f\u7684\u53ef\u4ee5\u5f71\u97ff\u7c92\u7dda\u9ad4\u5206\u88c2\uff0c\u4f7f\u5f97\u7c92\u7dda\u9ad4\u7834\u788e\u5316\uff1b\u800c\u764c\u5316Ras\u86cb\u767d\u5c31\u662f\u900f\u904eRalGEF-Ral\u9014\u5f91\u4f86\u6307\u63eeDrp1\u7684\u78f7\u9178\u5316\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u7576Ras\u86cb\u767d\u764c\u5316\u5f8c\uff0c\u5b83\u7d93\u7531\u6307\u63ee\u4e00\u7cfb\u5217\u7684\u86cb\u767d\u8cea\uff0c\u6700\u5f8c\u8b93Drp1\u6d3b\u6027\u4e0a\u6607\uff08\u78f7\u9178\u5316\uff09\uff1b\u63a5\u8457\u7c92\u7dda\u9ad4\u56e0\u70ba\u52a0\u901f\u5206\u88c2\u800c\u5931\u53bb\u8017\u6c27\u4ee3\u8b1d\u65b9\u9762\u7684\u529f\u80fd\uff0c\u7522\u751f\u764c\u7d30\u80de\u559c\u611b\u7684\u74b0\u5883...\u65bc\u662f\uff0c\u764c\u7d30\u80de\u958b\u59cb\u6063\u610f\u751f\u9577\uff0c\u800c\u4e0d\u5e78\u7684\u75c5\u4eba\u5c31\u7cdf\u7cd5\u6975\u4e86\uff01<\/p>\n<p>\u4e0d\u904e\uff0c\u5728\u6240\u6709\u7684\u764c\u75c7\u88e1\uff0cRas\u86cb\u767d\u764c\u5316\u7684\u767c\u751f\u662f\u5426\u662f\u4e00\u7a2e\u975e\u5e38\u666e\u904d\u7684\u73fe\u8c61\u5462\uff1f\u96d6\u7136Ras\u86cb\u767d\u764c\u5316\u5728\u6240\u6709\u7684\u764c\u75c7\u4e2d\u767c\u751f\u7387\u53ea\u670930%\uff1b\u4f46\u662f\u5728\u80f0\u81df\u764c(pancreatic ductal adenocarcinoma)\u4e2d\uff0cRas\u86cb\u767d\u764c\u5316\u7684\u767c\u751f\u7387\u537b\u670990%\uff01\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u96d6\u7136\u8981\u7d93\u7531\u8655\u7406\u764c\u5316\u7684Ras\u86cb\u767d\u4f86\u6cbb\u7642\u764c\u75c7\u5f88\u56f0\u96e3\uff0c\u4f46\u537b\u53ef\u4ee5\u5f9eDrp1\u86cb\u767d\u4e0b\u624b\u3002\u5728\u5927\u9f20\u5be6\u9a57\u4e2d\uff0c\u7814\u7a76\u5718\u968a\u82e5\u5c07Drp1\u7684\u8868\u73fe\u91cf\u964d\u4f4e\uff0c\u4fbf\u53ef\u4ee5\u4f7f\u816b\u7624\u7684\u9ad4\u7a4d\u8207\u91cd\u91cf\u90fd\u6e1b\u5c11\uff1b\u56e0\u6b64\uff0c\u9019\u500b\u767c\u73fe\u6216\u8a31\u70ba\u80f0\u81df\u764c\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u4e00\u7dda\u751f\u6a5f\uff0c\u7562\u7adf\u80f0\u81df\u764c\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u4ecd\u7136\u662f\u4e94\u5e74\u5b58\u6d3b\u7387\u76f8\u5c0d\u6975\u4f4e\u7684\u764c\u75c7\u5462\uff01<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong><br \/>\n1. 2015\/4\/6.\u00a0<a href=\"http:\/\/www.sciencedaily.com\/releases\/2015\/04\/150406101035.htm\" target=\"_blank\" rel=\"noopener noreferrer\">Common cancers highjack powerhouses of cells<\/a>. Science Daily.<br \/>\n2. Jennifer A. Kashatus et al. 2015.\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1097276515000039\" target=\"_blank\" rel=\"noopener noreferrer\">Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth<\/a>. Molecular Cell,57:537-551.<\/p>\n<p style=\"color: #000000;\"><span style=\"color: #333399;\"><strong>--<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong>\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u64b0\u6587\uff5c\u8449\u7da0\u8212 \u6211\u5011\u7e3d\u662f\u628a\u7d30\u80de\u4e2d\u7684\u7c92\u7dda\u9ad4\u60f3<\/p>\n","protected":false},"author":20,"featured_media":21450,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,26],"tags":[1866,1868,1867,1865,727,1543],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/05\/nrm1697-f2.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21449"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21449"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21449\/revisions"}],"predecessor-version":[{"id":32228,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21449\/revisions\/32228"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/21450"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}