{"id":21309,"date":"2015-05-15T00:33:14","date_gmt":"2015-05-14T16:33:14","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21309"},"modified":"2018-08-01T15:41:56","modified_gmt":"2018-08-01T07:41:56","slug":"%e3%80%90%e5%85%8d%e7%96%ab%e5%ad%b8%e3%80%91%e5%85%8d%e7%96%ab%e7%b3%bb%e7%b5%b1%e7%9a%84%e9%a3%a2%e9%a4%93%e9%81%8a%e6%88%b2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21309","title":{"rendered":"\u3010\u514d\u75ab\u5b78\u3011\u514d\u75ab\u7cfb\u7d71\u7684\u98e2\u9913\u904a\u6232"},"content":{"rendered":"

\u25a0\u300c\u9913\u4e00\u4e0b\uff01\u8b93\u4f60\u7684\u514d\u75ab\u7cfb\u7d71\u66f4\u5065\u5eb7\u300d\u9019\u807d\u8d77\u4f86\u50cf\u662f\u8a50\u9a19\u96c6\u5718\u7684\u5ee3\u544a\u53f0\u8a5e\uff0c\u537b\u6108\u4f86\u6108\u591a\u7814\u7a76\u986f\u793a\u5076\u723e\u8b93\u81ea\u5df1\u9951\u9913\u4e00\u4e0b\uff0c\u6216\u8a31\u5c0d\u514d\u75ab\u7cfb\u7d71\u7684\u6c70\u820a\u63db\u65b0\u4f86\u8aaa\u4e0d\u662f\u58de\u4e8b\u3002<\/strong><\/span><\/p>\n

\"\u5716\u7247\u4f86\u6e90\uff5cShutterstock\u3000by<\/a>
\u5716\u7247\u4f86\u6e90\uff5cShutterstock\u3000by crolique<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u5728\u71df\u990a\u904e\u5269\u6210\u70ba\u73fe\u4ee3\u4eba\u7169\u60f1\u7684\u4e8c\u5341\u4e00\u4e16\u7d00\uff0c\u8a31\u591a\u7814\u7a76\u90fd\u7d1b\u7d1b\u63a2\u8a0e\u904e\u91cf\u7684\u5361\u8def\u91cc\u651d\u53d6\uff0c \u5c0d\u5065\u5eb7\u6240\u9020\u6210\u7684\u5f71\u97ff\uff1b\u514d\u75ab\u5b78\u4f3c\u4e4e\u4e5f\u4e0d\u610f\u5916\u5730\u8ddf\u4e0a\u4e86\u9019\u80a1\u98a8\u6f6e\u3002\u518d\u52a0\u4e0a\uff0c\u8a31\u591a\u80a5\u80d6\u6240\u5f15\u8d77\u7684\u4ee3\u8b1d\u75c7\u5019\u7fa4\u76f8\u95dc\u75be\u75c5\uff0c\u4e5f\u90fd\u6f38\u6f38\u88ab\u8a8d\u77e5\u70ba\u662f\u4e00\u7a2e\u8eab\u9ad4\u5167\u8f15\u5fae\u7684\u6162\u6027\u767c\u708e\u53cd\u61c9\u3002\u4f7f\u5f97\u514d\u75ab\u6a5f\u5236\u5728\u5176\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272\u76ca\u767c\u5f15\u8d77\u95dc\u6ce8\u3002<\/p>\n

\u7136\u800c\uff0c\u300c\u9913\u51fa\u5065\u5eb7\u300d\u7684\u8ad6\u8abf\u5c0d\u9ad4\u5167\u540c\u6642\u990a\u4e86\u995e\u9b3c\u8207\u611b\u5403\u9b3c\u7684\u6211\u4f86\u8aaa\uff0c\u6cf0\u534a\u662f\u8033\u908a\u98a8\uff0c\u7e3d\u89ba\u5f97\u90a3\u662fBMI\u8d85\u91cd\u5230\u96e2\u8b5c\u7684\u4eba\u624d\u8981\u64d4\u5fc3\u7684\u4e8b\u3002\u53bb\u5e74\u590f\u5929\uff0c\u5357\u52a0\u5dde\u5927\u5b78Valter Longo\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\uff0c\u5728\u00a0Cancer Stem Cell\u00a0<\/em>\u4e0a\u767c\u8868\u4e00\u7bc7\u95dc\u65bc\u9069\u5ea6\u9951\u9913\u53ef\u4ee5\u91cd\u5851\u514d\u75ab\u7cfb\u7d71\u5e74\u8f15\u8207\u6d3b\u529b\u7684\u6587\u7ae0\u3002\u4ed6\u5011\u5728\u7b2c\u4e00\u968e\u6bb5\u7684\u81e8\u5e8a\u8a66\u9a57\u4e0a\uff0c\u767c\u73fe\u968e\u6bb5\u6027\u7684\u9951\u9913\u5faa\u74b0\uff0c\u5c0d\u9020\u8840\u5e79\u7d30\u80de(Hematopoietic stem cells)\u4f86\u8aaa\u50cf\u662f\u4e00\u500b\u6253\u958b\u4e86\u4e00\u500b\u795e\u5947\u7684\u958b\u95dc\uff0c\u6703\u56e0\u6b64\u6539\u8b8a\u9020\u8840\u5e79\u7d30\u80de\u7684\u8a0a\u606f\u50b3\u5c0e\u8def\u5f91\uff0c\u8b93\u9019\u4e9b\u5e79\u7d30\u80de\u5f9e\u4f11\u7720\u72c0\u614b\u8f49\u800c\u52e4\u596e\u52aa\u529b\u5730\u9032\u884c\u518d\u751f\u3002<\/p>\n

\u7b2c\u4e00\u968e\u6bb5\u81e8\u5e8a\u8a66\u9a57\u627e\u4f86\u6b63\u5728\u9032\u884c\u5316\u5b78\u7642\u6cd5\u7684\u764c\u75c7\u75c5\u4eba\uff0c\u8b93\u4ed6\u5011\u5728\u63a5\u53d7\u5316\u7642\u7684\u524d\u5169\u5929\u6642\uff0c\u958b\u59cb\u7981\u98df\uff0c\u53ea\u80fd\u5920\u559d\u6c34\uff0c\u7136\u5f8c\u63a5\u4e0b\u4f86\u7684\u5341\u4e8c\u5929\u53ef\u4ee5\u6b63\u5e38\u98f2\u98df\u3002\u7136\u5f8c\uff0c\u4ee5\u6bcf\u5169\u500b\u79ae\u62dc\u7981\u98df\u5169\u5929\u7684\u6b65\u8abf\uff0c\u5b8c\u6210\u70ba\u671f\u5341\u4e8c\u500b\u79ae\u62dc\u7684\u8a66\u9a57\u8a08\u5283\u3002Longo\u535a\u58eb\u7684\u5718\u968a\u767c\u73fe\uff0c\u9031\u671f\u6027\u5730\u7981\u98df\u53ef\u4ee5\u8b93\u75c5\u4eba\u5728\u5316\u7642\u904e\u7a0b\u4e2d\uff0c\u4fdd\u8b77\u9020\u8840\u5e79\u7d30\u80de\u6bd4\u8f03\u4e0d\u6703\u53d7\u5230\u640d\u50b7\uff0c\u4e26\u4e14\u4fc3\u9032\u9020\u8840\u5e79\u7d30\u80de\u7684\u518d\u751f\u80fd\u529b\u3002\u4ed6\u5011\u6240\u63d0\u51fa\u4f86\u7684\u5047\u8aaa\u662f\uff0c\u7981\u98df\u904e\u7a0b\u6703\u4f7f\u5f97\u9020\u8840\u5e79\u7d30\u80de\u5167\u7684PKA\u86cb\u767d\u6fc0\u9176(Protein kinase A)\u8868\u73fe\u91cf\u4e0b\u964d\u3002\u800cPKA\u5728\u9020\u8840\u5e79\u7d30\u80de\u7684\u518d\u751f\u662f\u500b\u81f3\u95dc\u91cd\u5927\u7684\u89d2\u8272\uff1aPKA\u7684\u8868\u73fe\u5fc5\u9808\u88ab\u95dc\u6389\uff0c\u5e79\u7d30\u80de\u624d\u6703\u5f9e\u4f11\u7720\u4e2d\u88ab\u559a\u9192\u800c\u91cd\u62fe\u300c\u518d\u751f\u300d\u7684\u5de5\u4f5c\u4efb\u52d9\u3002\u4ed6\u5011\u4e5f\u5728\u8001\u9f20\u8eab\u4e0a\u89c0\u5bdf\u5230\u985e\u4f3c\u7684\u73fe\u8c61\uff0c\u4e26\u5728\u53e6\u4e00\u500b\u7368\u7acb\u7684\u5c0f\u578b\u8a66\u9a57\u4e2d\uff0c\u8b93\u75c5\u4eba\u6539\u70ba\u7981\u98df72\u5c0f\u6642\uff0c\u4e5f\u6709\u540c\u6a23\u7684\u7d50\u679c\u3002<\/p>\n

\u7576\u6642\uff0cLongo\u7684\u7814\u7a76\u7d05\u6975\u534a\u908a\u5929\uff0c\u4f46\u5c0d\u611b\u5403\u5982\u6211\u7684\u597d\u80c3\u53e3\uff0c\u4e5f\u50c5\u50c5\u662f\u9694\u9774\u6414\u7662\u3002\u7e3d\u89ba\u5f97\u7981\u98df\u767c\u751f\u5728\u9020\u8840\u5e79\u7d30\u80de\u88e1\u4e4b\u65bc\u514d\u75ab\u7d30\u80de\u7684\u4e8b\uff0c\u50cf\u662f\u6211\u5728\u5abd\u5abd\u809a\u5b50\u88e1\u6642\u807d\u904e\u7684\u83ab\u672d\u7279\u80ce\u6559\u97f3\u6a02\u3002\u9019\u4e00\u5207\uff0c\u90fd\u597d\u9059\u9060\u554a\u3002\u76f4\u5230\u6700\u8fd1\uff0c\u300c\u9913\u4e00\u4e0b\uff0c\u8b93\u4f60\u514d\u75ab\u7cfb\u7d71\u66f4\u5065\u5eb7\uff01\u300d\u7684\u985e\u4f3c\u8ad6\u8abf\u53c8\u518d\u6b21\u6d6e\u4e0a\u6aaf\u9762\u3002\u9019\u6b21\uff0c\u662f\u8036\u9b6f\u5927\u5b78Dixit\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\uff0c\u767c\u8868\u5728\u00a0Nature Medicine\u00a0<\/em>\u7684\u6587\u7ae0\u3002\u9019\u7bc7\u6587\u7ae0\u5c31\u66f4\u6709\u8da3\u4e86\uff0c\u4ed6\u5011\u767c\u73fe\u7981\u98df\u6642\u7684\u4ee3\u8b1d\u7522\u7269\u03b2-\u7fa5\u4e01\u9178\u9e7d(\u03b2-hydroxybutyrate)\uff0c\u53ef\u4ee5\u6291\u5236NLRP3\u767c\u708e\u5c0f\u9ad4(inflammasome)\u7684\u6d3b\u5316\uff0c\u9032\u800c\u964d\u4f4eNLRP3\u6240\u5f15\u8d77\u7684\u75be\u75c5\u3002<\/p>\n

\u4ec0\u9ebc\u662fNLRP3\u767c\u708e\u5c0f\u9ad4\u5462\uff1fNLRP3\u767c\u708e\u5c0f\u9ad4\u662f\u7d30\u80de\u5167\u7684\u4e00\u7a2e\u86cb\u767d\u8cea\u805a\u5408\u9ad4\uff0c\u662f\u5c6c\u65bc\u5148\u5929\u6027\u514d\u75ab\u7cfb\u7d71\u88e1\u7684\u91cd\u8981\u6230\u5c07\u3002\u53ef\u4ee5\u5075\u6e2c\u4f86\u81ea\u75c5\u539f\u83cc\u3001\u74b0\u5883\u6216\u662f\u6211\u5011\u81ea\u5df1\u672c\u8eab\u6703\u5f15\u8d77\u767c\u708e\u53cd\u61c9\u7684\u56e0\u5b50\u3002\u9019\u4e9b\u767c\u708e\u56e0\u5b50\u901a\u5e38\u88ab\u7d71\u7a31\u70baDAMPs(damage-associated molecular patterns)\uff0c\u5e38\u898b\u7684\u4f8b\u5b50\u50cf\u662f\u7d30\u83cc\u6bd2\u7d20\u3001\u904e\u91cf\u7684\u8461\u8404\u7cd6\u3001\u795e\u7d93\u91af\u80fa\u3001\u81bd\u56fa\u9187\u7d50\u6676\u7b49\u3002<\/p>\n

NLRP3\u767c\u708e\u5c0f\u9ad4\u7684\u6d3b\u5316\uff0c\u6703\u555f\u52d5\u4e0b\u6e38\u8a0a\u606f\u50b3\u5c0e\u86cb\u767d\u8cea\u7684\u6d3b\u6027\uff0c\u800c\u4f7f\u4e00\u4e9b\u6703\u4fc3\u9032\u767c\u708e\u53cd\u61c9\u7684\u7d30\u80de\u6fc0\u7d20\u88ab\u91cb\u653e\u51fa\u4f86\uff08\u5305\u62ecIL-1\u03b2\u548cIL-18\uff09\u3002\u800cNLRP3\u767c\u708e\u5c0f\u9ad4\u4e5f\u88ab\u767c\u73fe\u548c\u8a31\u591a\u8907\u96dc\u7684\u75be\u75c5\u90fd\u63ea\u626f\u4e0d\u6e05\u3002\u4f8b\u5982\uff1a\u963f\u8332\u6d77\u9ed8\u75c7\u3001\u80a5\u80d6\u3001\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u751a\u81f3\u662f\u8001\u5316\u8207\u4e00\u4e9b\u809d\u814e\u75be\u75c5\u3002\u901a\u5e38\u81e8\u5e8a\u4e0a\u5728\u6cbb\u7642NLRP3\u767c\u708e\u5c0f\u9ad4\u76f8\u95dc\u75be\u75c5\u7684\u6642\u5019\uff0c\u90fd\u662f\u7528IL-1\u7576\u4f5c\u85e5\u7269\u6cbb\u7642\u7684\u6a19\u9776\u3002\u4e0d\u8ad6\u662f\u4f7f\u7528IL-1\u53d7\u9ad4\u7684\u62ee\u6297\u5291Anakinra\uff0c\u6216\u662f\u80fd\u4e2d\u548c\u6389IL-1\u03b2\u7684\u6297\u9ad4Canakinumab\u7b49\u7b49\uff0c\u90fd\u6709\u4e00\u5b9a\u7684\u6548\u679c\u3002<\/p>\n

Dixit\u535a\u58eb\u6240\u6307\u5c0e\u7684\u7814\u7a76\u5718\u968a\u60f3\u8981\u627e\u51fa\u6709\u6c92\u6709\u5167\u751f\u6027\u7684\u8a0a\u606f\u50b3\u5c0e\u6a5f\u5236\uff0c\u53ef\u4ee5\u628a\u4e0d\u5b89\u5206\u7684NLRP3\u767c\u708e\u5c0f\u9ad4\u53bb\u6d3b\u5316\uff0c\u7d50\u679c\u4ed6\u5011\u767c\u73fe\u03b2-\u7fa5\u4e01\u9178\u9e7d\u53ef\u4ee5\u5c0d\u6297NLRP3\u767c\u708e\u5c0f\u9ad4\u6240\u5f15\u8d77\u7684\u767c\u708e\u53cd\u61c9\u3002\u03b2-\u7fa5\u4e01\u9178\u9e7d\u662f\u4e00\u7a2e\u916e\u9ad4\uff0c\u7531\u809d\u81df\u88fd\u9020\u7522\u751f\uff0c\u4e3b\u8981\u662f\u7576\u6211\u5011\u5728\u7981\u98df\u3001\u6216\u98f2\u98df\u651d\u53d6\u4ee5\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u70ba\u4e3b\u6642\u3001\u6216\u662f\u9032\u884c\u9ad8\u5f37\u5ea6\u904b\u52d5\u6642\uff0c\u7d30\u80de\u6240\u9700\u80fd\u91cf\u7684\u5099\u6848\u4f86\u6e90\u3002\u4ed6\u5011\u767c\u73fe\u03b2-\u7fa5\u4e01\u9178\u9e7d\u6703\u5c08\u4e00\u6027\u7684\u6291\u5236NLRP3\u767c\u708e\u5c0f\u9ad4\u8abf\u63a7\u767c\u708e\u53cd\u61c9\u7684\u8a0a\u606f\u50b3\u5c0e\u9014\u5f91\uff0c\u800c\u4e0d\u662f\u56e0\u70ba\u7981\u98df\u6240\u8abf\u63a7\u7684\u76f8\u95dc\u751f\u7406\u53cd\u61c9\u7684\u9023\u5e36\u53cd\u61c9\uff0c\u6240\u4ee5\u4e5f\u8ddf\u53d7\u5230\u6291\u5236\u7684\u91a3\u89e3\u4f5c\u7528\u7121\u95dc\u3002<\/p>\n

\u4e0d\u904e\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0d\u8ad6\u7981\u98df\u662f\u4e0d\u662f\u80fd\u5920\u900f\u904e\u5fae\u8abf\u9ad4\u5167\u4ee3\u8b1d\u53cd\u61c9\u4f86\u91cd\u5851\u514d\u75ab\u7cfb\u7d71\uff0c\u5be6\u9a57\u4e2d\u7684\u8a2d\u8a08\u8207\u5be6\u9a57\u4eba\u54e1\u7684\u5047\u8aaa\u8ad6\u9ede\uff0c\u90fd\u662f\u300c\u5076\u4e00\u70ba\u4e4b\u300d\u7684\u5169\u4e09\u5929\u968e\u6bb5\u6027\u7981\u98df\uff0c\u800c\u4e14\u662f\u5728\u4e0d\u6703\u5f15\u8d77\u71df\u990a\u4e0d\u826f\u7684\u5927\u524d\u63d0\u4e0b\u9032\u884c\u5594\uff01<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Cheng CW, et al. Prolonged fasting reduces IGF-1\/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell<\/em>. 2014 Jun 5;14(6):810-23. doi: 10.1016\/j.stem.2014.04.014.<\/li>\n
  2. Hine C, Mitchell JR. Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging. Cell Stem Cell<\/em>. 2014 Jun 5;14(6):704-5. doi: 10.1016\/j.stem.2014.05.016.<\/li>\n
  3. Youm YH, et al. The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med.<\/em> 2015 Mar;21(3):263-9. doi: 10.1038\/nm.3804.<\/li>\n
  4. Kugelberg E. Inflammasome: Starving inflammation. Nat Rev Immunol<\/em>. 2015 Apr;15(4):199. doi: 10.1038\/nri3832. Epub 2015 Mar 6.<\/li>\n
  5. Peart KN. Anti-inflammatory mechanism of dieting and fasting revealed. http:\/\/news.yale.edu\/2015\/02\/16\/anti-inflammatory-mechanism-dieting-and-fasting-revealed<\/li>\n<\/ol>\n

    --<\/span><\/strong>
    \u4f5c\u8005\uff1a\u99f1\u5b9b\u7433\u3000\u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/span><\/strong><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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