{"id":21208,"date":"2015-05-08T00:17:42","date_gmt":"2015-05-07T16:17:42","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21208"},"modified":"2018-08-01T15:42:37","modified_gmt":"2018-08-01T07:42:37","slug":"%e3%80%90%e9%86%ab%e7%99%82%e7%a0%94%e7%a9%b6%e3%80%91%e4%bc%8a%e6%b3%a2%e6%8b%89%e7%97%85%e6%af%92%e5%8f%af%e8%83%bd%e6%b2%92%e5%82%b3%e8%aa%aa%e4%b8%ad%e6%bc%94%e5%8c%96%e8%bf%85%e9%80%9f%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21208","title":{"rendered":"\u3010\u4f0a\u6ce2\u62c9\u5c08\u984c\u3011\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u53ef\u80fd\u6c92\u50b3\u8aaa\u4e2d\u6f14\u5316\u8fc5\u901f\uff1f"},"content":{"rendered":"

\u25a0\u897f\u975e\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u75ab\u60c5\u5df2\u611f\u67d3\u4e86\u8d85\u904e\u5169\u842c\u4eba\uff0c\u4e26\u4e14\u9020\u6210\u81f3\u5c11\u4e0a\u842c\u4eba\u55aa\u547d\u3002\u4e0d\u904e\u4e00\u500b\u53ef\u80fd\u7684\u597d\u6d88\u606f\u662f\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u4e26\u6c92\u6709\u6f14\u5316\u5f97\u6bd4\u4e4b\u524d\u63a8\u6e2c\u7684\u8fc5\u901f\uff0c\u6216\u8a31\u53ef\u4ee5\u7de9\u548c\u75ab\u82d7\u548c\u85e5\u7269\u6703\u8fc5\u901f\u5931\u6548\u7684\u6182\u616e\u3002<\/strong><\/span><\/p>\n

\"Photo
Photo credit: CDC Global, CC BY 2.0<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u9ec3\u8c9e\u7965<\/p>\n

\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u8086\u8650\u897f\u975e\uff0c\u5927\u591a\u6578\u60a3\u8005\u5206\u5e03\u5728\u8cf4\u6bd4\u4e9e\u3001\u7345\u5b50\u5c71\u5171\u548c\u570b\u548c\u5e7e\u5167\u4e9e\uff0c\u8a31\u591a\u975e\u6d32\u4ee5\u5916\u7684\u570b\u5bb6\u4e5f\u5982\u81e8\u5927\u6575\u3002\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7a76\u7adf\u6703\u4e0d\u6703\u7a81\u8b8a\u6210\u812b\u97c1\u91ce\u99ac\u4f86\u8086\u8650\u66f4\u591a\u4eba\u5462\uff1f\u5982\u679c\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u4f86\u52e2\u6d36\u6d36\uff0c\u6703\u4e0d\u6703\u9020\u6210\u5168\u7403\u6027\u7684\u4eba\u9593\u60b2\u5287\u5462\uff1f<\/p>\n

\u75c5\u6bd2\u7684\u8fc5\u901f\u4e14\u591a\u8b8a\u7684\u6f14\u5316\uff0c\u5411\u4f86\u662f\u91ab\u5b78\u7684\u96e3\u984c\u3002\u53bb\u5e74\u7684\u4e00\u7bc7\u300a\u79d1\u5b78\u300b\uff08Science<\/em>\uff09\u7684\u8ad6\u6587\uff0c\u7f8e\u570b\u528d\u6a4b\u535a\u5fb7\u7814\u7a76\u6240\u7684\u8a08\u7b97\u907a\u50b3\u5b78\u5bb6Pardis Sabeti\u7b49\u4eba\u5229\u7528\u4f86\u81ea\u7345\u5b50\u5c71\u5171\u548c\u570b\u768499\u500b\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u57fa\u56e0\u9ad4\uff0c\u9451\u5b9a\u51fa\u75c5\u6bd2\u5f9e\u5e7e\u5167\u4e9e\u50b3\u64ad\u5230\u7345\u5b50\u5c71\u5171\u548c\u570b\u7684\u50b3\u64ad\u93c8\u3002\u4ed6\u5011\u4e5f\u767c\u73fe\u897f\u975e\u7684\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u5e36\u6709\u4e0a\u767e\u500b\u6771\u908a\u7684\u75c5\u6bd2\u6240\u672a\u6709\u7a81\u8b8a\uff0c\u5176\u4e2d\u4e0d\u5c11\u53ef\u80fd\u6703\u6539\u8b8a\u75c5\u6bd2\u7684\u86cb\u767d\u8cea\u3002\u4ed6\u5011\u9084\u4f30\u8a08\u75c5\u6bd2\u5728\u75ab\u60c5\u7206\u767c\u6642\u7684\u6f14\u5316\u901f\u7387\u4e5f\u52a0\u500d\u3002\u4ed6\u5011\u8a8d\u70ba\u5929\u64c7\u628a\u8b93\u75c5\u6bd2\u6f14\u5316\u8f03\u7de9\u6162\u7684\u56e0\u7d20\u5254\u9664\u4e86\uff0c\u4f7f\u5f97\u5b83\u5011\u5feb\u901f\u6f14\u5316\u3002<\/p>\n

\u53ef\u662f\u5728\u6700\u65b0\u4e00\u7bc7\u300a\u79d1\u5b78\u300b\uff08Science<\/em>\uff09\u8ad6\u6587\u4e2d\uff0c\u7f8e\u570b\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u570b\u5bb6\u904e\u654f\u548c\u50b3\u67d3\u75be\u75c5\u7814\u7a76\u6240\u75c5\u6bd2\u5be6\u9a57\u5ba4\u7684\u4e3b\u4efbHeinz Feldmann\u7b49\u4eba\uff0c\u767c\u8868\u4e86\u99ac\u5229\u53bb\u5e74\u5341\u6708\u548c\u5341\u4e00\u6708\u6d41\u884c\u7684\u75c5\u6bd2\u4e4b\u5e8f\u5217\uff0c\u4ed6\u5011\u767c\u73fe\u75c5\u6bd2\u7684\u6f14\u5316\u901f\u7387\u53ea\u6709Sabeti\u7b49\u4eba\u63a8\u4f30\u7684\u5927\u6982\u4e00\u534a\u3002\u82f1\u570b\u66fc\u5fb9\u65af\u7279\u7684\u7814\u7a76\u5c0f\u59d0\u5c07\u6703\u767c\u8868\u5728\u671f\u520a\u300a\u75c5\u6bd2\u5b78\u300b\uff08Virology<\/em>\uff09\u7684\u8ad6\u6587\u4e5f\u6307\u51fa\uff0c\u7345\u5b50\u5c71\u5171\u548c\u570b\u6d41\u884c\u7684\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7a81\u8b8a\u53ef\u80fd\u4e26\u672a\u5c0d\u86cb\u767d\u8cea\u9020\u6210\u91cd\u5927\u6539\u8b8a\u3002<\/p>\n

Sabeti\u5ba3\u7a31\uff0c\u9019\u500b\u65b0\u7814\u7a76\u7d50\u679c\u4e26\u6c92\u6709\u8207\u4ed6\u5011\u7684\u4e92\u76f8\u885d\u7a81\uff0c\u56e0\u70ba\u8a08\u7b97\u96d9\u65b9\u4f30\u8a08\u6f14\u5316\u7684\u65b9\u6cd5\u6709\u7570\u3002\u540c\u6642\u4e5f\u6709\u6f14\u5316\u907a\u50b3\u5b78\u5bb6\u8a8d\u70ba\uff0c\u75c5\u6bd2\u7684\u7a81\u8b8a\u591a\u5be1\u4e26\u4e0d\u662f\u91cd\u9ede\uff0c\u56e0\u70ba\u5c0f\u7a81\u8b8a\u4e5f\u53ef\u80fd\u9020\u6210\u56b4\u91cd\u7684\u5f8c\u679c\u3002\u79d1\u5b78\u5bb6\u4e0d\u53ef\u80fd\u55ae\u55ae\u5f9eDNA\u5e8f\u5217\uff0c\u78ba\u8a8d\u51fa\u75c5\u6bd2\u7a81\u8b8a\u7684\u5be6\u969b\u751f\u7269\u6548\u61c9\uff0c\u6240\u4ee5\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u8a8d\u6709\u5f85\u9032\u4e00\u6b65\u7684\u5be6\u9a57\u9a57\u8b49\u3002<\/p>\n

\u5018\u82e5\u4ed6\u5011\u7684\u767c\u73fe\u5c6c\u5be6\uff0c\u90a3\u9ebc\u5c0d\u75ab\u82d7\u548c\u85e5\u7269\u7684\u7814\u767c\u662f\u500b\u597d\u6d88\u606f\uff0c\u56e0\u70ba\u9019\u4e9b\u7814\u767c\u662f\u5229\u7528\u5df2\u6d41\u884c\u7684\u75c5\u6bd2\u9032\u884c\u7684\uff0c\u5982\u679c\u75c5\u6bd2\u6f14\u5316\u8fc5\u901f\uff0c\u90a3\u9ebc\u75ab\u82d7\u548c\u85e5\u7269\u7684\u6642\u6548\u5c31\u5927\u5927\u53d7\u9650\u3002<\/p>\n

\u539f\u5b78\u8853\u8ad6\u6587\uff1a
\nGire, S. K. et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science 345, 1369\u20131372 (2014).
\nHoenen, T. et al. Mutation rate and genotype variation of Ebola virus from Mali case sequences. Science http:\/\/dx.doi.org\/10.1126\/science.aaa5646 (2015).
\nOlabode, A. S., Jiang, X., Robertson, D. L. & Lovell, S. C. Ebola virus is evolving but not changing: no evidence for functional change in EBOV from 1976 to the 2014 outbreak. Preprint at http:\/\/dx.doi.org\/10.1101\/014480 (2015).<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a
\n1. Ewen Callaway. Ebola\u2019s fast evolution questioned.<\/a> NATURE | NEWS. 26 March 2015.
\n2. PAM BELLUCK. Ebola Virus in Latest Outbreak Does Not Show Unusual Mutations, Study Finds.<\/a> New York Times. MARCH 26, 2015<\/p>\n

--<\/strong><\/span>
\u4f5c\u8005\uff1a\u9ec3\u8c9e\u7965 \u73fe\u65bc\u53f0\u7063\u4e2d\u592e\u7814\u7a76\u9662\u751f\u7269\u591a\u6a23\u6027\u7814\u7a76\u4e2d\u5fc3\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2 \u751f\u7269\u5b78\u7814\u7a76\u3002\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u25a0\u897f\u975e\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u75ab\u60c5\u5df2\u611f\u67d3\u4e86\u8d85\u904e\u5169\u842c\u4eba\uff0c<\/p>\n","protected":false},"author":20,"featured_media":21965,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1921,1361,57,714,1192,864,1590],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/01\/EBOLA-S.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21208"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21208"}],"version-history":[{"count":7,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21208\/revisions"}],"predecessor-version":[{"id":32238,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21208\/revisions\/32238"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/21965"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21208"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}