{"id":21131,"date":"2015-04-17T00:30:44","date_gmt":"2015-04-16T16:30:44","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=21131"},"modified":"2018-08-01T15:36:42","modified_gmt":"2018-08-01T07:36:42","slug":"%e3%80%90%e9%a3%9f%e5%93%81%e5%ae%89%e5%85%a8%e3%80%91%e5%90%83%e5%88%b0%e8%82%9a%e5%ad%90%e8%a3%a1%e7%9a%84%e4%b9%b3%e5%8c%96%e5%8a%91","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=21131","title":{"rendered":"\u3010\u98df\u54c1\u5b89\u5168\u3011\u5403\u5230\u809a\u5b50\u88e1\u7684\u4e73\u5316\u5291"},"content":{"rendered":"

\u25a0\u5e38\u88ab\u7528\u65bc\u98df\u54c1\u4e2d\u7684\u4e73\u5316\u5291\uff0c\u771f\u7684\u597d\u7528\u53c8\u7121\u5bb3\u55ce\uff1f<\/strong><\/span><\/p>\n

\"\u5716\u7247\u4f86\u6e90\uff1awikipedia\"
\u5716\u7247\u4f86\u6e90\uff1awikipedia<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n

\u4e73\u5316\u5291\u662f\u5f88\u5e38\u898b\u7684\u98df\u54c1\u6dfb\u52a0\u5291\uff0c\u8209\u51e1\u597d\u5403\u7684\u9eb5\u5305\u3001\u86cb\u7cd5\u3001\u51b0\u6dc7\u6dcb\uff0c\u4f3c\u4e4e\u7e3d\u5c11\u4e0d\u4e86\u4e73\u5316\u5291\u3002\u4e73\u5316\u5291\u662f\u4e00\u7a2e\u754c\u9762\u6d3b\u6027\u5291\uff0c\u5b83\u540c\u6642\u5177\u6709\u300c\u89aa\u6c34\u7aef\u300d\u8ddf\u300c\u89aa\u6cb9\u7aef\u300d\uff0c\u53ef\u4ee5\u628a\u672c\u4f86\u4e0d\u4e92\u6eb6\u7684\u6cb9\u8ddf\u6c34\u5f62\u6210\u7a69\u5b9a\u7684\u6df7\u5408\u6db2\u3002\u56e0\u6b64\uff0c\u7576\u98df\u54c1\u88fd\u4f5c\u904e\u7a0b\u9700\u8981\u5c07\u6cb9\u8207\u6c34\u5747\u52fb\u6df7\u5408\u5728\u4e00\u8d77\u7684\u6642\u5019\uff0c\u5c31\u53ef\u4ee5\u52a0\u5165\u4e73\u5316\u5291\u3002<\/p>\n

\u5728\u4e8c\u5341\u4e16\u7d00\u4e2d\u4e4b\u5f8c\uff0c\u80a5\u80d6\u3001\u4ee3\u8b1d\u75c7\u5019\u7fa4\u3001\u767c\u708e\u6027\u8178\u9053\u75be\u75c5(Inflammatory bowel diseases)\u7b49\uff0c\u4f3c\u4e4e\u6210\u4e86\u73fe\u4ee3\u4eba\u7cbe\u7dfb\u98f2\u98df\u4e0b\u7684\u7169\u60f1\u3002 \u975e\u907a\u50b3\u56e0\u7d20\uff08\u4f8b\u5982\u98f2\u98df\uff09\u88ab\u8a8d\u70ba\u662f\u8a98\u767c\u4ee3\u8b1d\u75c7\u5019\u7fa4\uff0c\u6216\u662f\u8178\u9053\u708e\u75c7\u7684\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\uff0c\u800c\u8a31\u591a\u52a0\u5de5\u98df\u54c1\u4e5f\u90fd\u4e0d\u53ef\u907f\u514d\u7684\u9700\u8981\u6dfb\u52a0\u4e73\u5316\u5291\u3002\u7f8e\u570b\u98df\u54c1\u8207\u85e5\u54c1\u7ba1\u7406\u5c40(FDA)\u5c07\u4e73\u5316\u5291\u6b78\u985e\u5728\u300c\u4e00\u822c\u4f7f\u7528\u4e0a\u8a8d\u70ba\u662f\u5b89\u5168\u7121\u865e\u300d(generally regarded as safe)\u7684\u6a19\u7ae0\u5e95\u4e0b\uff0c\u4e26\u5141\u8a31\u4e73\u5316\u5291\u5728\u98df\u54c1\u4e2d\u7684\u6dfb\u52a0\u91cf\u6700\u9ad8\u53ef\u9054\u767e\u5206\u4e4b\u4e00\u3002\u96d6\u7136\u4e73\u5316\u5291\u88ab\u5ee3\u6cdb\u61c9\u7528\u5728\u98df\u54c1\u88fd\u9020\uff0c\u5b89\u5168\u6027\u4e5f\u88abFDA\u8a8d\u8b49\uff0c\u4f46\u96a8\u8457\u8fd1\u5e7e\u5e74\u4f86\u5927\u5bb6\u5c0d\u98df\u54c1\u5b89\u5168\u554f\u984c\u6108\u4f86\u6108\u7559\u5fc3\u8207\u6ce8\u610f\uff0c\u5305\u62ec\u4e73\u5316\u5291\u5728\u5167\u7684\u5e38\u898b\u98df\u54c1\u6dfb\u52a0\u7269\u662f\u4e0d\u662f\u771f\u5982\u6211\u5011\u6240\u9810\u60f3\u7684\u90a3\u9ebc\u300c\u5b89\u5168\u300d\uff0c\u4e5f\u6210\u4e86\u79d1\u5b78\u5bb6\u5011\u95dc\u5fc3\u7684\u7814\u7a76\u8ab2\u984c\u3002<\/p>\n

\u6700\u8fd1\u5728\u300a\u81ea\u7136\u300b\u671f\u520a\u4e0a\uff0c\u7f8e\u570b\u55ac\u6cbb\u4e9e\u5dde\u7acb\u5927\u5b78\u7684Andrew Gewirtz\u535a\u58eb\u548c\u4ed6\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\u5982\u679c\u5728\u5c0f\u9f20\u7684\u98f2\u7528\u6c34\u4e2d\u647b\u5165\u4e73\u5316\u5291\uff0c\u6703\u5c0e\u81f4\u5c0f\u9f20\u7f79\u60a3\u8f15\u5ea6\u7684\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\u8207\u4ee3\u8b1d\u75c7\u5019\u7fa4\u3002\u4ed6\u5011\u6e2c\u8a66\u4e86\u5169\u7a2e\u5e38\u898b\u7684\u4e73\u5316\u5291\uff1a\u7fa7\u7532\u57fa\u7e96\u7dad\u7d20(Carboxymethyl Cellulose\uff0c\u7c21\u7a31CMC)\u548c\u805a\u5c71\u68a8\u9187\u916f(polysorbate 80\uff0c\u7c21\u7a31P80)\u3002\u4e0d\u8ad6\u5c07CMC\u6216\u662fP80\u647b\u5165\u5c0f\u9f20\u98f2\u7528\u6c34\u4e2d\u6216\u662f\u56fa\u9ad4\u98df\u7269\u5167\uff0c\u90fd\u6703\u5f15\u8d77\u985e\u4f3c\u75c7\u72c0\u3002\u800c\u9019\u4e9b\u75c7\u72c0\u4f3c\u4e4e\u8ddf\u8178\u9053\u5fae\u751f\u7269\u7fa4\u843d\u8207\u8178\u9053\u4e0a\u76ae\u7d30\u80de\u4e4b\u9593\u7684\u4fdd\u8b77\u7db2\u300c\u9ecf\u819c\u5c64\u300d\u8b8a\u8584\uff0c\u800c\u4f7f\u5f97\u300c\u8178\u9053\u7d50\u69cb\u5c4f\u969c\u300d\u5e73\u8861\u88ab\u7834\u58de\u6709\u95dc\u3002<\/p>\n

\u5728\u6b63\u5e38\u751f\u7406\u72c0\u6cc1\u4e0b\uff0c\u8178\u9053\u7684\u9ecf\u819c\u5c64\u53ef\u4ee5\u4f5c\u70ba\u4e00\u9053\u6709\u6548\u7684\u5c4f\u969c\uff0c\u9632\u6b62\u8178\u9053\u83cc\u53e2\u76f4\u63a5\u63a5\u89f8\u5230\u8178\u9053\u4e0a\u76ae\u7d30\u80de\u3002\u5e73\u5747\u800c\u8a00\uff0c\u8178\u9053\u9ecf\u819c\u5c64\u53ef\u4ee5\u5c07\u9019\u4e9b\u8178\u9053\u7d30\u83cc\u9694\u7d55\u5728\u4e0a\u76ae\u7d30\u80de25 \u5fae\u7c73\u4e4b\u5916\u3002\u800c\u4e14\u5728\u4e0a\u76ae\u7d30\u80de10\u5fae\u7c73\u7684\u8ddd\u96e2\u4ee5\u5167\uff0c\u751a\u81f3\u53ef\u4ee5\u7a31\u4f5c\u662f\u8178\u9053\u83cc\u53e2\u7684\u300c\u8d85\u7d1a\u7981\u5340\u300d\uff0c\u5728\u986f\u5fae\u93e1\u5e95\u4e0b\u5e7e\u4e4e\u4e0d\u6703\u89c0\u5bdf\u5230\u7d30\u83cc\u3002<\/p>\n

\u4f46\u662f\u5728\u986f\u5fae\u93e1\u4e0b\u89c0\u5bdf\u98f2\u7528\u6c34\u5167\u542b\u6709\u4e73\u5316\u5291\u7684\u5c0f\u9f20\u7684\u8178\u9053\u7d50\u69cb\u6642\uff0c\u537b\u53ef\u4ee5\u767c\u73fe\u9019\u4e9b\u5c0f\u9f20\u7684\u8178\u9053\u9ecf\u819c\u5c64\u539a\u5ea6\u6bd4\u63a7\u5236\u7d44\u6e1b\u5c11\u4e86\u4e00\u534a\uff0c\u800c\u4e14\u8178\u9053\u5167\u7684\u7d30\u83cc\u4e5f\u53ef\u4ee5\u300c\u6df1\u5165\u300d\u5230\u66f4\u63a5\u8fd1\u8178\u9053\u4e0a\u76ae\u7d30\u80de\u7684\u7981\u5340\u5167\u3002Gewirtz\u535a\u58eb\u9032\u4e00\u6b65\u5206\u6790\u9019\u4e9b\u5c0f\u9f20\u7684\u8178\u9053\u83cc\u843d\u7d44\u6210\u5f8c\uff0c\u767c\u73fe\u4e73\u5316\u5291CMC\u8207P80\u90fd\u6703\u986f\u8457\u6539\u8b8a\u5c0f\u9f20\u8178\u9053\u83cc\u843d\u7684\u83cc\u7a2e\u7d44\u6210\u3002\u800c\u4e14\u9019\u4e9b\u5c0f\u9f20\u7684\u7cde\u4fbf\u88e1\uff0c\u90fd\u6aa2\u9a57\u51fa\u589e\u91cf\u7684\u7d30\u83cc\u5167\u6bd2\u7d20\u8102\u591a\u91a3\u9ad4(lipopolysaccharide\uff0c\u7c21\u7a31LPS)\u548c\u97ad\u6bdb\u86cb\u767d(flagellin)\uff0c\u800c\u9019\u5169\u7a2e\u7d30\u83cc\u7d44\u6210\u55ae\u5143\u90fd\u5bb9\u6613\u5f15\u8d77\u8178\u9053\u767c\u708e\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u5c0f\u9f20\u98f2\u7528\u6c34\u6216\u56fa\u9ad4\u98df\u7269\u5167\u5982\u679c\u542b\u6709\u4e73\u5316\u5291\uff0c\u4e0d\u50c5\u6703\u7834\u58de\u3001\u964d\u89e3\u5177\u6709\u4fdd\u8b77\u4f5c\u7528\u7684\u8178\u9053\u9ecf\u819c\u5c64\uff0c\u9084\u6703\u6dd8\u6c70\u8178\u9053\u7684\u76ca\u751f\u83cc\u53e2\uff0c\u800c\u5c07\u5bb9\u6613\u5f15\u8d77\u8178\u9053\u767c\u708e\u53cd\u61c9\u7684\u83cc\u7a2e\u300c\u5f15\u72fc\u5165\u5ba4\u300d\uff0c\u5c0e\u81f4\u9019\u4e9b\u5c0f\u9f20\u51fa\u73fe\u4ee3\u8b1d\u75c7\u5019\u7fa4\u7684\u75c7\u72c0\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u96d6\u7136\u5728\u98f2\u7528\u6c34\u6216\u662f\u98df\u7269\u4e2d\u6dfb\u52a0\u4e73\u5316\u5291\u80fd\u5920\u5f15\u8d77\u8a31\u591a\u4e0d\u540c\u54c1\u7a2e\u7684\u5c0f\u9f20\u51fa\u73fe\u4ee5\u4e0a\u75c7\u72c0\uff0c\u4f46\u662f\u88ab\u990a\u5728\u7279\u5225\u5be6\u9a57\u52d5\u7269\u4e2d\u5fc3\uff0c\u8178\u9053\u5167\u6c92\u6709\u7d30\u83cc\u83cc\u53e2\u7684\u300c\u7121\u83cc\u8001\u9f20\u300d(germ free\uff09\uff0c\u5176\u9ecf\u819c\u5c64\u539a\u5ea6\u7d72\u6beb\u4e0d\u6703\u53d7\u5230\u4e73\u5316\u5291\u7684\u5f71\u97ff\u3002\u9019\u986f\u793a\u6dfb\u52a0\u81f3\u6c34\u3001\u98df\u7269\u4e2d\u7684\u4e73\u5316\u5291\u4e0d\u662f\u76f4\u63a5\u4f5c\u7528\u5728\u9ecf\u819c\u5c64\u4e0a\u800c\u5c0e\u81f4\u9ecf\u819c\u5c64\u539a\u5ea6\u8b8a\u8584\uff0c\u800c\u662f\u85c9\u7531\u6539\u8b8a\u8178\u9053\u83cc\u53e2\u7d44\u6210\uff0c\u9032\u800c\u9593\u63a5\u5f71\u97ff\u5230\u9ecf\u819c\u5c64\u7684\u539a\u5ea6\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5373\u4f7f\u7528\u9060\u4f4e\u65bcFDA\u6838\u53ef\u8a08\u91cf\u7684\u4e73\u5316\u5291CMC\u6216P80\u542b\u91cf\uff0cGewirtz\u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\u4ecd\u7136\u53ef\u4ee5\u767c\u73fe\u5c0f\u9f20\u51fa\u73fe\u9019\u4e9b\u75c5\u72c0\u3002\u96d6\u7136\u4e73\u5316\u5291\u7684\u98df\u54c1\u5b89\u5168\u554f\u984c\u9084\u9700\u8981\u5f8c\u7e8c\u7814\u7a76\u7684\u4f50\u8b49\uff0c\u4ee5\u53ca\u66f4\u8a73\u76e1\u7684\u7814\u7a76\uff0c\u4f86\u8b49\u660e\u5be6\u9a57\u7d50\u679c\u4e0d\u53ea\u662f\u4e00\u65b9\u4e4b\u8a00\u3002\u800c\u4e14\uff0c\u5927\u81ea\u7136\u4e2d\u4e5f\u6709\u8a31\u591a\u5929\u7136\u7684\u4e73\u5316\u5291\uff0c\u9019\u4e9b\u5929\u7136\u4e73\u5316\u5291\u662f\u4e0d\u662f\u4e5f\u6703\u50cf\u5be6\u9a57\u4e2d\u6240\u88ab\u6aa2\u6e2c\u7684CMC\u3001P80\u4e73\u5316\u5291\u4e00\u6a23\uff0c\u9020\u6210\u4ee3\u8b1d\u75c7\u5019\u7fa4\u7684\u96b1\u6182\u5462\uff1f<\/p>\n

\u96d6\u7136\uff0c\u8a31\u591a\u7684\u7591\u554f\u9084\u662f\u672a\u5b9a\u4e4b\u8ad6\uff0c\u5728\u4eba\u985e\u98f2\u98df\u4e2d\u5e38\u5e38\u88ab\u7528\u505a\u98df\u54c1\u6dfb\u52a0\u5291\u7684\u4e73\u5316\u5291\uff0c\u4e5f\u9700\u8981\u66f4\u9032\u4e00\u6b65\u7684\u7814\u7a76\uff0c\u4f86\u63a2\u8a0e\u4e73\u5316\u5291\u5c0d\u8178\u9053\u83cc\u53e2\u548c\u4eba\u9ad4\u5065\u5eb7\u7684\u6f5b\u5728\u5f71\u97ff\uff0c\u4ee5\u5e6b\u52a9\u76f8\u95dc\u55ae\u4f4d\u5728\u5236\u5b9a\u6e96\u5247\u898f\u7bc4\u7684\u6642\u5019\u80fd\u5920\u66f4\u52a0\u8b39\u614e\u5468\u5168\u3002\u4f46\u6216\u8a31\u4e0b\u6b21\u5634\u995e\u7684\u6642\u5019\uff0c\u60f3\u60f3Gewirtz\u535a\u58eb\u7684\u6182\u5fc3\u8207\u4ed6\u7684\u7814\u7a76\uff0c\u80fd\u8b93\u6211\u5011\u5403\u5f97\u66f4\u5065\u5eb7\u5427\uff01<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong>
\n1. Chassaing B. et al. (2015). Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature<\/em> 519, 92\u201396
\n2. Roberts, CL. et al. (2010). Translocation of Crohn\u2019s disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut<\/em> 59, 1331\u20131339
\n3. Swidsinski A. et al. (2009). Mucosal flora in Crohn\u2019s disease and ulcerative colitis - an overview. J. Physiol. Pharmacol<\/em>. 60 (Suppl 6). 61\u201371
\n4. Bordon Y. (2015) Food additives feed the fire. Nature Reviews Immunology <\/em>(Research Highlight). \u00a0doi:10.1038\/nri3833<\/p>\n

--<\/strong><\/span>
\u4f5c\u8005\uff1a\u99f1\u5b9b\u7433 \u7f8e\u570b\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff08Washington University in St. Louis\uff09\u514d\u75ab\u5b78\u535a\u58eb\uff0c\u5f9e\u4e8bT\u7d30\u80de\u767c\u80b2\u8207\u6d3b\u5316\u76f8\u95dc\u7684\u8a0a\u606f\u50b3\u5c0e\u7814\u7a76\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u25a0\u5e38\u88ab\u7528\u65bc\u98df\u54c1\u4e2d\u7684\u4e73\u5316\u5291\uff0c\u771f\u7684\u597d\u7528\u53c8\u7121\u5bb3<\/p>\n","protected":false},"author":20,"featured_media":21132,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,3293],"tags":[1763,1764,924,1573],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/03\/150306.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21131"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21131"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21131\/revisions"}],"predecessor-version":[{"id":32207,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21131\/revisions\/32207"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/21132"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21131"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21131"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}