{"id":20867,"date":"2015-02-25T08:16:18","date_gmt":"2015-02-25T00:16:18","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=20867"},"modified":"2018-08-01T14:43:05","modified_gmt":"2018-08-01T06:43:05","slug":"%e3%80%90%e5%9c%8b%e9%9a%9b%e5%9c%9f%e5%a3%a4%e5%b9%b4%e5%b0%88%e9%a1%8c%e3%80%91%e5%85%ac%e6%b0%91%e7%a7%91%e5%ad%b8%e9%bd%8a%e5%bf%83%e5%90%88%e5%8a%9b%e5%9c%a8%e5%9c%9f%e8%a3%a1%e6%b7%98%e9%87%91-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=20867","title":{"rendered":"\u3010\u570b\u969b\u571f\u58e4\u5e74\u5c08\u984c\u3011\u516c\u6c11\u79d1\u5b78\u9f4a\u5fc3\u5408\u529b\u5728\u571f\u88e1\u6dd8\u91d1\uff0d\uff0d\u958b\u767c\u65b0\u85e5\u65b0\u904b\u52d5"},"content":{"rendered":"

\u25a0\u571f\u58e4\u88e1\u6709\u8a31\u591a\u6709\u8da3\u7684\u5fae\u751f\u7269DNA\uff0c\u900f\u904e\u516c\u6c11\u79d1\u5b78\u5bb6\u7684\u529b\u91cf\uff0c\u672a\u4f86\u53ef\u80fd\u6703\u767c\u73fe\u66f4\u591a\u6709\u7528\u7684\u65b0\u85e5\uff01<\/strong><\/span><\/p>\n

\"(Photo
(Photo : Oregon Department of Transportation)<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u9ec3\u8c9e\u7965<\/p>\n

\u751f\u7269\u591a\u6a23\u6027\u4e4b\u7236\uff0c\u54c8\u4f5b\u6f14\u5316\u751f\u7269\u5b78\u5bb6\u611b\u5fb7\u83ef\uff0e\u5a01\u723e\u905c\uff08E. O. Wilson\uff09\u662f\u4e16\u754c\u879e\u87fb\u7684\u6b0a\u5a01\uff0c\u4ed6\u5728\u81ea\u50b3\u300a\u5927\u81ea\u7136\u7684\u7375\u4eba\uff1a\u535a\u7269\u5b78\u5bb6\u5a01\u723e\u68ee\u300b\uff08Naturalist<\/em>\uff09\u8868\u793a\uff0c\u5982\u679c\u4ed6\u9084\u80fd\u518d\u9078\u64c7\u7814\u7a76\u7684\u5c0d\u8c61\uff0c\u4ed6\u53ef\u80fd\u6703\u9078\u64c7\u7814\u7a76\u571f\u58de\u88e1\u7684\u5fae\u751f\u7269\uff0c\u96d6\u7136\u5b83\u5011\u901a\u5e38\u4e0d\u53d7\u95dc\u6ce8\uff0c\u53ef\u662f\u751f\u7269\u591a\u6a23\u6027\u537b\u66f4\u52a0\u8c50\u5bcc\uff01<\/p>\n

\u85c9\u8457DNA\u5b9a\u5e8f\u6280\u8853\u7684\u9032\u6b65\uff0c\u4ee5\u53ca\u7db2\u8def\u7684\u4fbf\u5229\uff0c\u79d1\u5b78\u5bb6\u7d42\u65bc\u80fd\u5920\u958b\u59cb\u597d\u597d\u77ad\u89e3\u571f\u58e4\u88e1\u597d\u5e7e\u4e4e\u7121\u7aae\u7684\u5fae\u751f\u7269\u4e86\uff01\u7f8e\u570b\u6d1b\u514b\u83f2\u52d2\u5927\u5b78\u7684\u5fae\u751f\u7269\u5b78\u5bb6Sean Brady\u7b49\u4eba\u7372\u5f97\u4f86\u81ea\u4e94\u5927\u6d32\u7684\u516c\u6c11\u79d1\u5b78\u5bb6\u7684\u5354\u52a9\uff0c\u53c3\u8207\u4e86\u4ed6\u5011\u7684\u300cDrugs from Dirt<\/a>\u300d\u7684\u8a08\u756b\uff0c\u8b93\u4ed6\u5011\u5171\u6536\u96c6\u4e86185\u4efd\u571f\u58e4\u6a23\u672c\u4e26\u4e14\u5f9e\u4e2d\u8403\u53d6\u4e86DNA\u4f5c\u5206\u6790\u3002<\/p>\n

\u4ed6\u5011\u7684\u76ee\u6a19\u662f\u5728\u5f9e\u4e16\u754c\u5404\u5730\u7684\u571f\u58e4\u88e1\u5c0b\u627e\u6709\u8da3\u7684\u5fae\u751f\u7269DNA\uff0c\u8a66\u5716\u5f9e\u4e2d\u5c0b\u627e\u80fd\u5920\u88fd\u9020\u65b0\u6297\u751f\u7d20\u6216\u6297\u764c\u85e5\u7269\u7684\u5fae\u751f\u7269\u3002\u4ed6\u5011\u6709\u5927\u7d04\u56db\u5206\u4e4b\u4e00\u7684\u6a23\u672c\u662f\u4f86\u81ea\u516c\u6c11\u79d1\u5b78\u5bb6\uff0c\u5982\u679c\u6c92\u6709\u5f8c\u8005\u7684\u53c3\u8207\uff0c\u9019\u500b\u8a08\u756b\u7684\u8cbb\u7528\u5c07\u6703\u6975\u5176\u6602\u8cb4\uff0c\u55ae\u55ae\u65c5\u8cbb\u5c31\u6703\u53eb\u4eba\u5403\u4e0d\u6d88\uff0c\u66f4\u752d\u63d0\u6642\u9593\u6210\u672c\u3002\u4e16\u754c\u5404\u5730\u7684\u516c\u6c11\u79d1\u5b78\u5bb6\uff0c\u53ea\u9700\u8981\u6316\u4e00\u4e9b\u571f\u88dd\u5728\u5851\u81a0\u888b\u90f5\u5bc4\u7d66\u4ed6\u5011\u3002\u571f\u58e4\u7684\u63a1\u6a23\u5730\u9ede\u6709\u6d77\u7058\u3001\u68ee\u6797\u3001\u6c99\u6f20\u3001\u6d1e\u7a74\u3001\u5cf6\u5dbc\u548c\u6eab\u6cc9\u7b49\u7b49\u3002<\/p>\n

\u6211\u5011\u904e\u53bb\u50c5\u77ad\u89e3\u7d30\u83cc\u751f\u7522\u7684\u6210\u5343\u4e0a\u842c\u7a2e\u5316\u5408\u7269\u7684\u4e00\u5c0f\u90e8\u5206\u800c\u5df2\uff0c\u56e0\u70ba\u53ea\u6709\u6975\u5c11\u91cf\u571f\u58e4\u7d30\u83cc\u80fd\u5920\u5728\u5be6\u9a57\u5ba4\u88e1\u57f9\u990a\uff0c\u4ed6\u5011\u5e0c\u671b\u80fd\u5f9e\u4e16\u754c\u5404\u5730\u7684\u571f\u58e4\u6a23\u672c\u4e2d\u767c\u73fe\u5be6\u9a57\u5ba4\u524d\u6240\u672a\u6709\u7684\u5316\u5408\u7269\u3002\u96d6\u7136\u96e2\u4e0a\u5343\u500b\u571f\u58e4\u6a23\u672c\u7684\u7406\u60f3\u4ecd\u6709\u8ddd\u96e2\uff0c\u53ef\u662f\u4ed6\u5011\u5df2\u7d93\u6709\u4e86\u4ee4\u4eba\u9a5a\u559c\u7684\u767c\u73fe\u3002\u4ed6\u5011\u767c\u73fe\u4f86\u81ea\u7f8e\u570b\u65b0\u58a8\u897f\u54e5\u5dde\u767c\u73fe\u4e86\u80fd\u5920\u88fd\u9020\u300c\u4f9d\u6ce2\u7e2e\u9ef4\u7d20\u300d\uff08epoxomicin\uff09\u985e\u4f3c\u7684\u5206\u5b50\u7684\u57fa\u56e0\u3002\u4f9d\u6ce2\u7e2e\u9ef4\u7d20\u662f\u9078\u64c7\u6027\u86cb\u767d\u9176\u6291\u5236\u5291\uff0c\u6709\u6297\u767c\u708e\u7684\u6d3b\u6027\u3002<\/p>\n

\u4f86\u81ea\u5df4\u897f\u7684\u571f\u58e4\uff0c\u53ef\u80fd\u542b\u6709\u4e00\u500b\u80fd\u5920\u88fd\u9020\u4e00\u7a2e\u6297\u764c\u85e5\u7269\u300c\u535a\u4f86\u9ef4\u7d20\u300d\uff08\u53c8\u540d\u535a\u840a\u9ef4\u7d20\u3001\u722d\u5149\u9ef4\u7d20\uff0cbleomycin\uff09\u985e\u4f3c\u6210\u4efd\u7684\u57fa\u56e0\u3002\u535a\u4f86\u9ef4\u7d20\u662f\u4e00\u7a2e\u7531\u8f2a\u679d\u93c8\u9ef4\u83cc\uff08Streptomyces verticillus<\/em>\uff09\u7522\u751f\u7684\u7cd6\u80bd\u985e\u6297\u751f\u7d20\uff0c\u4e2d\u6587\u5546\u54c1\u540d\u70ba\u300c\u64b2\u985e\u60e1\u6ce8\u5c04\u5291\u300d\uff0c\u901a\u904e\u8207DNA\u7d50\u5408\u5f15\u8d77\u6838\u9178\u93c8\u65b7\u88c2\u800c\u8d77\u4f5c\u7528\u3002\u535a\u4f86\u9ef4\u7d20\u4e3b\u8981\u88ab\u7528\u65bc\u6cbb\u7642\u970d\u5947\u91d1\u6c0f\u6dcb\u5df4\u7624\u3001\u9c57\u72c0\u7d30\u80de\u764c\u548c\u777e\u4e38\u764c\uff0c\u540c\u6642\u4e5f\u88ab\u5916\u7528\u65bc\u75a3\uff0c\u53ca\u7528\u65bc\u80f8\u819c\u7c98\u9023\u8853\uff1b\u4f86\u81ea\u7f8e\u570b\u897f\u5357\u90e8\u7684\u571f\u58e4\uff0c\u5247\u53ef\u80fd\u542b\u6709\u88fd\u9020\u985e\u4f3c\u300c\u7acb\u798f\u9ef4\u7d20\u300d\uff08rifamycin\uff09\u7684\u57fa\u56e0\uff0c\u53ef\u80fd\u53ef\u4ee5\u6cbb\u7642\u6297\u85e5\u6027\u7d50\u6838\u5206\u679d\u687f\u83cc\u5f15\u8d77\u7684\u5c0d\u591a\u7a2e\u85e5\u7269\u6297\u85e5\u6027\u4e4b\u6162\u6027\u80ba\u7d50\u6838\u3002<\/p>\n

\u5c31\u5728\u4e0d\u4e45\u4e4b\u524d\uff0c\u7f8e\u570b\u6ce2\u58eb\u9813\u6771\u5317\u5927\u5b78\u7684Kim Lewis\u7b49\u4eba\u5229\u7528\u4e86\u65b0\u6280\u8853\u6210\u529f\u5f9e\u571f\u58e4\u88e1\u57f9\u990a\u51fa\u80fd\u7522\u751f\u65b0\u6297\u751f\u7d20Teixobactin\u7684\u7d30\u83ccEleftheria terrae<\/em>\uff0c\u662f\u9019\u5345\u5e74\u4f86\u9996\u5ea6\u767c\u73fe\u7684\u65b0\u6297\u751f\u7d20\uff01\u76f8\u4fe1\u571f\u58e4\u5fae\u751f\u7269\u80af\u5b9a\u9084\u6703\u5e36\u7d66\u6211\u5011\u66f4\u591a\u66f4\u9810\u60f3\u4e0d\u5230\u7684\u9a5a\u559c\uff01<\/p>\n

\u5e0c\u671b\u4e00\u8d77\u5171\u8944\u76db\u8209\u7684\u670b\u53cb\uff0c\u8acb\u5230\u4ed6\u5011\u7684\u7db2\u7ad9\u300c Drug from Dirt<\/a>\u300d\u586b\u5beb\u8cc7\u6599\uff0c\u5982\u679c\u6709\u9700\u8981\uff0c\u4ed6\u5011\u6703\u806f\u7d61\u60a8\uff0c\u544a\u8a34\u60a8\u8981\u5982\u4f55\u63a1\u6a23\u548c\u5bc4\u9001\u6a23\u672c\u3002<\/p>\n

\u539f\u5b78\u8853\u8ad6\u6587\uff1a<\/strong>
\nCharlop-Powers Z, et al. Chemical-biogeographic survey of secondary metabolism in soil. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3757-62. doi: 10.1073\/pnas.1318021111. Epub 2014 Feb 18.
\nCharlop-Powers Z, et al. Global biogeographic sampling of bacterial secondary metabolism. Elife. 2015 Jan 20;4. doi: 10.7554\/eLife.05048. [Epub ahead of print]<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong>
\nPenny Sarchet. Citizen scientists sift soil for new antibiotics.<\/a> New Scientist.com. 20 January 2015.
\nMichelle Roberts. Drugs in dirt: Scientists appeal for help. <\/a>BBC News. 20 January 2015.
\nBrian Stallard. Searching Soil for an Antibiotic Savior.<\/a> Nature World News. Jan 20, 2015.
\nDrugs from dirt: Scientists develop first global roadmap for drug discovery.<\/a> Phys.org. Jan 20, 2015.
\nSearching for drugs in dirt, researchers call on citizen scientists.<\/a> Phys.org. May 19, 2014.<\/p>\n

--<\/strong><\/span>
\n \u4f5c\u8005\uff1a\u9ec3\u8c9e\u7965 \u73fe\u65bc\u53f0\u7063\u4e2d\u592e\u7814\u7a76\u9662\u751f\u7269\u591a\u6a23\u6027\u7814\u7a76\u4e2d\u5fc3\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2 \u751f\u7269\u5b78\u7814\u7a76\u3002\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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