{"id":20492,"date":"2015-02-06T00:14:46","date_gmt":"2015-02-05T16:14:46","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=20492"},"modified":"2018-08-01T14:44:15","modified_gmt":"2018-08-01T06:44:15","slug":"%e3%80%90%e7%94%9f%e7%89%a9%e7%b4%b0%e8%83%9e%e3%80%91%e8%bd%89%e8%ad%af%ef%bc%88translation%ef%bc%89%e4%b8%89%e5%8a%8d%e5%ae%a2%e5%8f%af%e4%bb%a5%e6%b2%92%e5%88%b0%e9%bd%8a%ef%bc%8c%e8%9b%8b%e7%99%bd","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=20492","title":{"rendered":"\u3010\u751f\u7269\u7d30\u80de\u3011\u8f49\u8b6f\uff08translation\uff09\u4e09\u528d\u5ba2\u53ef\u4ee5\u6c92\u5230\u9f4a\uff0c\u86cb\u767d\u8cea\u4f9d\u820a\u5f62\u6210\uff1f"},"content":{"rendered":"
\"\u8f49\u8b6f\u4f5c\u7528\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\"
\u8f49\u8b6f\u4f5c\u7528\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n

\u5f9e\u4e2d\u5b78\u7684\u751f\u7269\u5b78\u958b\u59cb\uff0c\u5927\u5bb6\u90fd\u77e5\u9053\uff0c\u7d30\u80de\u5408\u6210\u86cb\u767d\u8cea\u5fc5\u9700\u8981\u7d93\u904e\u8f49\u8b6f\uff08translation\uff09\u4f5c\u7528\uff0c\u800c\u8f49\u8b6f\u4f5c\u7528\u4e0d\u53ef\u6216\u7f3a\u7684\u4e09\u528d\u5ba2\u662f\uff1a\u6838\u7cd6\u9ad4\uff08ribosome\uff09\u3001\u4fe1\u606fRNA\uff08messenger RNA\uff0cmRNA\uff09\u8207\u8f49\u79fbRNA\uff08transfer RNA\uff0ctRNA\uff09\u3002<\/p>\n

\u5728\u4e0a\u5927\u5b78\u4ee5\u524d\uff0c\u5927\u5bb6\u5c0d\u65bcDNA\u8907\u88fd\uff08DNA replication\uff09\u3001\u4fe1\u606fRNA\u7684\u5408\u6210\uff08\u8f49\u9304\u4f5c\u7528\uff0ctranscription\uff09\u8207\u8f49\u8b6f\u4f5c\u7528\u4e09\u8005\u4e4b\u9593\u7684\u95dc\u4fc2\u61c9\u8a72\u90fd\u4e86\u7136\u65bc\u80f8\uff1b\u800c\u5927\u5bb6\u4e5f\u77e5\u9053DNA\u8907\u88fd\u5b58\u5728\u8457\u6821\u6b63\uff08proofreading\uff09\u7684\u529f\u80fd\uff1a\u7576\u932f\u8aa4\u7684\u53bb\u6c27\u6838\u7cd6\u6838\u82f7\u9178\uff08nucleotide\uff09\u88ab\u52a0\u5230DNA\u7684\u672b\u7aef\u6642\uff0cDNA\u8907\u88fd\u6a5f\u5668\u6703\u5c07\u9019\u500b\u932f\u8aa4\u7684\u53bb\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u6c34\u89e3\u3001\u518d\u91cd\u65b0\u53cd\u61c9\uff0c\u76f4\u5230\u6b63\u78ba\u7684\u53bb\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u88ab\u52a0\u5165\u70ba\u6b62\u3002<\/p>\n

\u800c\u8f49\u9304\u4f5c\u7528\u7684\u6821\u6b63\u6a5f\u5236\uff0c\u6c92\u6709DNA\u8907\u88fd\u90a3\u6a23\u7cbe\u78ba\uff1b\u4f46\u662f\uff0c\u86cb\u767d\u8cea\u7684\u5408\u6210\u6709\u6821\u6b63\u6a5f\u5236\u55ce\uff1f<\/p>\n

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\u4f86\u81ea\u7336\u4ed6\u5927\u5b78\uff08University of Utah\uff09\u8207\u52a0\u5927\u820a\u91d1\u5c71\u5206\u6821\uff08University of California, San Francisco\uff09\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u5176\u4e2d\u7684\u4e00\u500b\u672a\u77e5\u529f\u80fd\u86cb\u767d\u8ceaRqc2p\u7684\u795e\u79d8\u529f\u80fd\u3002<\/p>\n

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\"\u4e19\u6c28\u9178\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\"
\u4e19\u6c28\u9178\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n
\"\u8607\u6c28\u9178\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\"
\u8607\u6c28\u9178\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n

Rqc2p\u8207\u6838\u7cd6\u9ad4\u5728\u5c07\u4e19\u6c28\u9178\u8207\u8607\u6c28\u9178\u52a0\u5165\u6642\uff0c\u5b8c\u5168\u4e0d\u9700\u8981\u6709mRNA\u7684\u8173\u672c\uff1b\u9019\u8ddf\u6211\u5011\u4e00\u5411\u77e5\u9053\u7684\u8f49\u8b6f\u4f5c\u7528\u76f8\u9055\u80cc\u3002\u6211\u5011\u90fd\u77e5\u9053\u8f49\u8b6f\u4f5c\u7528\u6642\uff0c\u6838\u7cd6\u9ad4\u9700\u8981\u95b1\u8b80mRNA\u7684\u8173\u672c\uff0c\u624d\u80fd\u5c07\u6b63\u78ba\u7684\u6c28\u57fa\u9178\u4e00\u500b\u4e00\u500b\u52a0\u5165\u3002\u4f46\u662f\u7576\u932f\u8aa4\u7684\u6c28\u57fa\u9178\u88ab\u52a0\u5165\u6642\uff0cRqc2p\u537b\u53ef\u4ee5\u5728\u6c92\u6709mRNA\u7684\u72c0\u6cc1\u4e0b\uff0c\u5c07\u4e19\u6c28\u9178\u8207\u8607\u6c28\u9178\u91cd\u8907\u52a0\u5165\u3002<\/p>\n

\u4f46\u662f\uff0c\u70ba\u4ec0\u9ebcRqc2p\u8981\u6307\u63ee\u6838\u7cd6\u9ad4\u505a\u9019\u4ef6\u4e8b\u5462\uff1f<\/p>\n

\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff0c\u6216\u8a31Rqc2p\u505a\u9019\u4ef6\u4e8b\u6709\u5169\u500b\u76ee\u7684\uff1a\u5176\u4e2d\u4e4b\u4e00\u662f\u52a0\u901f\u9019\u500b\u505a\u58de\u4e86\u7684\u591a\u80bd\u93c8\u88ab\u5206\u89e3\uff1b\u53e6\u4e00\u500b\u539f\u56e0\u5247\u53ef\u80fd\u662f\uff0c\u6e2c\u8a66\u8f49\u8b6f\u6a5f\u5668\u662f\u5426\u4ecd\u53ef\u6b63\u5e38\u904b\u4f5c\u3002\u800c\u70ba\u4f55\u9078\u64c7\u4e86\u4e19\u6c28\u9178\u8207\u8607\u6c28\u9178\uff0c\u5247\u662f\u56e0\u70baRqc2p\u86cb\u767d\u5728\u8207\u6838\u7cd6\u9ad4\u7d50\u5408\u5f8c\uff0c\u672c\u4f86\u5c31\u6703\u8ddf\u9023\u63a5\u9019\u5169\u500b\u6c28\u57fa\u9178\u7684tRNA\u7d50\u5408\u3002<\/p>\n

\u9019\u500b\u7814\u7a76\u7d50\u679c\uff0c\u63a8\u7ffb\u4e86\u6559\u79d1\u66f8\u4e0a\u8aaa\u7684\u300c\u8f49\u8b6f\u4e00\u5b9a\u8981\u6709tRNA\u3001mRNA\u8207\u6838\u7cd6\u9ad4\u624d\u80fd\u9032\u884c\u300d\u7684\u7d50\u8ad6\u3002\u53ea\u80fd\u8aaa\uff0c\u751f\u7269\u7684\u4e16\u754c\u662f\u4e00\u500b\u4ee4\u4eba\u8b9a\u6b4e\u7684\u4e16\u754c\uff0c\u6211\u5011\u539f\u672c\u4ee5\u70ba\u53ea\u80fd\u4ee5DNA\u70ba\u8173\u672c\u8f49\u9304\u51faRNA\uff0c\u7d50\u679c\u57281970\u5e74\u7531Howard Temin\u8207David Baltimore\u63a8\u7ffb\u4e86\u9019\u500b\u60f3\u6cd5\uff1b\u73fe\u5728\u6211\u5011\u53c8\u767c\u73fe\u86cb\u767d\u8cea\u53ef\u4ee5\u5728\u6c92\u6709mRNA\u7684\u72c0\u6cc1\u4e0b\u5408\u6210\uff0c\u96d6\u7136\u53ea\u662f\u753120\u500b\u6c28\u57fa\u9178\u6240\u69cb\u6210\u7684\u591a\u80bd\u93c8\uff0c\u4f46\u9019\u4e5f\u5df2\u7d93\u8db3\u5920\u8b93\u6211\u5011\u60f3\u5230\u300c\u6709\u898f\u5247\u5c31\u6709\u4f8b\u5916\u300d\u9019\u53e5\u540d\u8a00\u4e86\uff01<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong>
\nPeter S. Shen, Joseph Park, Yidan Qin, Xueming Li, Krishna Parsawar, Matthew H. Larson, James Cox, Yifan Cheng, Alan M. Lambowitz, Jonathan S. Weissman, Onn Brandman, Adam Frost. 2015.\u00a0Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains<\/a>. Science. 347\uff086217\uff09\uff1a75-78 DOI: 10.1126\/science.1259724
\n--<\/strong><\/span>
\n \u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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