{"id":20490,"date":"2015-02-10T00:12:48","date_gmt":"2015-02-09T16:12:48","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=20490"},"modified":"2018-08-01T14:44:04","modified_gmt":"2018-08-01T06:44:04","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e9%80%b2%e5%b1%95%e3%80%91teixobactin%e6%9c%83%e6%98%af%e5%b0%8d%e6%8a%97%e7%b4%b0%e8%8f%8c%e7%9a%84%e7%b5%82%e6%a5%b5%e6%ad%a6%e5%99%a8%e5%97%8e%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=20490","title":{"rendered":"\u3010\u91ab\u5b78\u9032\u5c55\u3011Teixobactin\u6703\u662f\u5c0d\u6297\u7d30\u83cc\u7684\u7d42\u6975\u6b66\u5668\u55ce\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u5f9e\u5f17\u840a\u660e\u57281928\u5e74\u7684\u5149\u68cd\u7bc0\u90a3\u4e00\u5929\u65e9\u6668\uff0c\u8e0f\u9032\u5be6\u9a57\u5ba4\u7684\u90a3\u4e00\u523b\uff0c\u4eba\u8207\u7d30\u83cc\u7684\u6230\u722d\u5c31\u9032\u5165\u4e86\u53e6\u4e00\u500b\u968e\u6bb5\u3002\u6297\u751f\u7d20\uff08antibiotics\uff09\u7684\u767c\u73fe\uff0c\u4f7f\u4eba\u5011\u77e5\u9053\uff0c\u5927\u81ea\u7136\u860a\u85cf\u8457\u7121\u7aae\u7121\u76e1\u7684\u8cc7\u6e90\u7b49\u8457\u6211\u5011\u53bb\u958b\u767c\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_20527\" aria-describedby=\"caption-attachment-20527\" style=\"width: 440px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-20527 size-full\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/02\/1531231.jpg\" alt=\"iChip\u3002\u5716C\u70ba\u88dd\u7f6e\u7684\u5206\u89e3\u5716\u3002\u5716\u7247\u4f86\u6e90\uff1aAEM\u3002\" width=\"440\" height=\"212\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/02\/1531231.jpg 440w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/02\/1531231-300x144.jpg 300w\" sizes=\"(max-width: 440px) 100vw, 440px\" \/><figcaption id=\"caption-attachment-20527\" class=\"wp-caption-text\">iChip\u3002\u5716C\u70ba\u88dd\u7f6e\u7684\u5206\u89e3\u5716\u3002\u5716\u7247\u4f86\u6e90\uff1aAEM\u3002<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u5f9e\u90a3\u6642\u958b\u59cb\uff0c\u8a31\u591a\u7814\u7a76\u8005\u52aa\u529b\u5730\u7531\u7d30\u83cc\u8207\u771f\u83cc\u4e2d\u5c0b\u627e\u65b0\u7684\u6297\u751f\u7d20\uff1b\u800c\u96a8\u8457\u5316\u5b78\u5408\u6210\u7684\u6280\u8853\u63d0\u5347\uff0c\u79d1\u5b78\u5bb6\u5011\u4e5f\u5c07\u73fe\u6709\u7684\u6297\u751f\u7d20\u7684\u7d50\u69cb\u4ee5\u5316\u5b78\u65b9\u5f0f\u4fee\u98fe\uff0c\u7522\u751f\u65b0\u7684\u6297\u751f\u7d20\u3002<\/p>\n<p>\u4f46\u662f\uff0c\u7d30\u83cc\u5011\u5f88\u5feb\u7684\u5c31\u767c\u5c55\u51fa\u4e86\u5c0d\u6297\u751f\u7d20\u7684\u6297\u85e5\u6027\uff08antibiotics resistance\uff09\u3002\u6709\u4e9b\u7d30\u83cc\u7522\u751f\u9175\u7d20\u5206\u89e3\u6297\u751f\u7d20\uff08\u5982\u03b2-lactamase\u4e4b\u65bc\u9752\u9ef4\u7d20\uff09\u3001\u6709\u4e9b\u7d30\u83cc\u6539\u8b8a\u81ea\u5df1\u7684\u7279\u5b9a\u80de\u5668\uff08\u5982\u6838\u7cd6\u9ad4\uff09\u7684\u7d50\u69cb\u3001\u6709\u4e9b\u7d30\u83cc\u4e7e\u8106\u62cb\u68c4\u88ab\u6297\u751f\u7d20\u6291\u5236\u7684\u4ee3\u8b1d\u9014\u5f91\uff08\u5982\u8449\u9178\u7684\u5408\u6210\uff09...\u53cd\u6b63\u300c\u751f\u547d\u50f9\u66f4\u9ad8\u300d\uff0c\u6240\u4ee5\u53ea\u8981\u80fd\u6d3b\u8457\uff0c\u5c0d\u7d30\u83cc\u4f86\u8aaa\u5176\u4ed6\u4e8b\u60c5\u90fd\u662f\u5c0f\u83dc\u4e00\u789f\u3002<\/p>\n<p>\u65bc\u662f\u79d1\u5b78\u5bb6\u5011\u52aa\u529b\u5c0b\u627e\u66f4\u591a\u7684\u6297\u751f\u7d20\u3002\u4f46\u662f\u96a8\u8457\u6642\u9593\u904e\u53bb\uff0c\u627e\u5c0b\u65b0\u7684\u6297\u751f\u7d20\u8d8a\u4f86\u8d8a\u56f0\u96e3\u4e86\uff1b\u4e8b\u5be6\u4e0a\uff0c1980\u5e74\u4ee3\u958b\u59cb\uff0c\u518d\u4e5f\u6c92\u6709\u627e\u5230\u65b0\u7684\u3001\u53ef\u4ee5\u7528\u7684\u6297\u751f\u7d20\u4e86\u3002<!--more--><\/p>\n<p>\u65b0\u7684\u6297\u751f\u7d20\u627e\u4e0d\u5230\uff0c\u820a\u7684\u6297\u751f\u7d20\u4e0d\u65b7\u5730\u6709\u7d30\u83cc\u767c\u5c55\u51fa\u5c0d\u5b83\u5011\u7684\u6297\u85e5\u6027\u3002\u5728<a href=\"http:\/\/www.who.int\/mediacentre\/news\/releases\/2014\/amr-report\/en\/\" target=\"_blank\" rel=\"noopener noreferrer\">2014\u5e74\u7684WHO\u5831\u544a<\/a>\u4e2d\uff081\uff09\uff0c\u5206\u6790\u4e86\u4e00\u767e\u4e00\u5341\u56db\u500b\u570b\u5bb6\u7684\u6578\u64da\uff0c\u96c6\u4e2d\u5728\u6703\u5c0e\u81f4\u6557\u8840\u75c7\u3001\u80ba\u708e\u3001\u8179\u7009\u3001\u6ccc\u5c3f\u9053\u611f\u67d3\u53ca\u6dcb\u75c5\u7684\u4e03\u7a2e\u4e0d\u540c\u7d30\u83cc\uff0c\u767c\u73fe\u5168\u7403\u90fd\u51fa\u73fe\u7d30\u83cc\u6297\u85e5\u6027\u554f\u984c\uff0c\u800c\u4e14\u90fd\u6709\u7528\u5230\u6700\u5f8c\u4e00\u7dda\u6297\u751f\u7d20\u7684\u60c5\u6cc1\u3002<\/p>\n<p>\u7d30\u83cc\u6297\u85e5\u6027\uff0c\u5c0d\u65bc\u56e0\u70ba\u6b63\u5728\u9032\u884c\u5316\u7642\u3001\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u6cbb\u7642\u3001\u5fc3\u81df\u7e5e\u9053\u624b\u8853\u3001\u5668\u5b98\/\u9aa8\u9ad3\u79fb\u690d\u4ee5\u53ca\u6d17\u814e\u7684\u75c5\u4eba\u7279\u5225\u4e0d\u5229\u3002\u9019\u4e9b\u75c5\u4eba\u53ef\u80fd\u56e0\u70ba\u7642\u7a0b\u9700\u8981\u800c\u5fc5\u9700\u6291\u5236\u514d\u75ab\u4f5c\u7528\u3001\u6216\u8005\u56e0\u70ba\u624b\u8853\u7684\u8907\u96dc\u6027\u5bb9\u6613\u53d7\u5230\u611f\u67d3\u3001\u6216\u8005\u56e0\u70ba\u672c\u8eab\u7684\u5065\u5eb7\u72c0\u6cc1\u5f71\u97ff\u5230\u514d\u75ab\u529f\u80fd\uff0c\u7576\u767c\u751f\u611f\u67d3\u66f4\u9700\u8981\u6709\u6548\u7684\u6297\u751f\u7d20\u4f86\u6cbb\u7642\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u7d30\u83cc\u6297\u85e5\u6027\u554f\u984c\u5c0d\u65bc\u767c\u5c55\u4e2d\u570b\u5bb6\u4e5f\u6975\u70ba\u4e0d\u5229\u3002\u9019\u4e9b\u570b\u5bb6\u6216\u8a31\u91ab\u7642\u8cc7\u6e90\u539f\u672c\u5c31\u5df2\u4e0d\u8db3\uff0c\u6297\u85e5\u6027\u7684\u767c\u5c55\u9020\u6210\u5fc5\u9700\u4f7f\u7528\u7b2c\u4e09\u7dda\u3001\u7b2c\u56db\u7dda\u7684\u6297\u751f\u7d20\uff0c\u9019\u4e9b\u85e5\u54c1\u90fd\u6975\u70ba\u6602\u8cb4\uff0c\u4e26\u975e\u4e00\u822c\u6c11\u773e\u6240\u80fd\u8ca0\u64d4\uff1b\u4f46\u767c\u5c55\u4e2d\u570b\u5bb6\u5f80\u5f80\u7f3a\u4e4f\uff08\u6216\u50c5\u6709\u804a\u5099\u4e00\u683c\u7684\uff09\u91ab\u7642\u4fdd\u96aa\uff0c\u5e38\u4f7f\u5f97\u6c11\u773e\u56e0\u70ba\u7121\u529b\u8ca0\u64d4\u800c\u653e\u68c4\u6cbb\u7642\u3002<\/p>\n<p>\u7576\u7136\uff0c\u79d1\u5b78\u5bb6\u5011\u4e26\u672a\u653e\u68c4\u5c0b\u627e\u65b0\u7684\u6297\u751f\u7d20\u7684\u60f3\u6cd5\u3002\u4f46\u662f\u6700\u5927\u5b97\u7684\u6297\u751f\u7d20\u7684\u4f86\u6e90\u662f\u4f86\u81ea\u65bc\u5fae\u751f\u7269\uff08\u7d30\u83cc\u8207\u771f\u83cc\uff09\uff0c\u800c\u81ea\u7136\u754c\u6709\u975e\u5e38\u591a\u7684\u5fae\u751f\u7269\uff0c\u56e0\u70ba\u6211\u5011\u5c0d\u65bc\u57f9\u990a\u4ed6\u5011\u7684\u77e5\u8b58\u4e0d\u8db3\uff0c\u662f\u7121\u6cd5\u88ab\u6211\u5011\u57f9\u990a\u51fa\u4f86\u7684\u3002\u800c\u7121\u6cd5\u57f9\u990a\u9019\u4e9b\u5fae\u751f\u7269\uff0c\u4ee3\u8868\u4e86\u6211\u5011\u6c92\u6709\u6a5f\u6703\u53bb\u4e86\u89e3\u9019\u4e9b\u5fae\u751f\u7269\u88e1\u9762\u6709\u591a\u5c11\u53ef\u7528\u7684\u8cc7\u6e90\u3002<\/p>\n<p>\u57282002\u5e74\uff0cKim Lewis\u8207Slava Epstein\u767c\u660e\u4e86\u4e00\u500b\u65b0\u6280\u8853\uff1aiChip\uff08i\u662fisolation[\u9694\u96e2]\u7684\u610f\u601d\uff09\uff082\uff09\u3002iChip\u7684\u539f\u7406\u662f\uff1a\u5c07\u653e\u5728\u53ef\u6ef2\u900f\u819c\u4e4b\u9593\u7684\u571f\u58e4\u6a23\u672c\uff08\u88e1\u9762\u542b\u6709\u8a31\u8a31\u591a\u591a\u7684\u5fae\u751f\u7269\uff09\uff0c\u653e\u56de\u571f\u58e4\u4e2d\u57f9\u990a\uff1b\u5982\u6b64\u4e00\u4f86\uff0c\u5468\u570d\u571f\u58e4\u4e2d\u7684\u5fae\u751f\u7269\u7121\u6cd5\u9032\u5165iChip\u6c61\u67d3\u6211\u5011\u7684\u6a23\u672c\uff0c\u4f46\u4ed6\u5011\u6240\u7522\u751f\u7684\u5c0f\u5206\u5b50\u4ee3\u8b1d\u7269\u537b\u53ef\u4ee5\u6ef2\u900f\u9032\u5982iChip\uff0c\u5354\u52a9\u9019\u4e9b\u5fae\u751f\u7269\u7684\u751f\u9577\u3002\u7576\u9019\u4e9b\u5fae\u751f\u7269\u9069\u61c9\u4e86\u9019\u6a23\u534a\u4eba\u5de5\u7684\u74b0\u5883\u5f8c\uff0c\u4fbf\u6703\u8b8a\u5f97\u6bd4\u8f03\u5bb9\u6613\u57f9\u990a\u4e86\u3002<\/p>\n<p>\u7814\u7a76\u5718\u968a\u5229\u7528iChip\u5728Losee Ling\u535a\u58eb\u5bb6\u7684\u5f8c\u9662\u5206\u96e2\u51fa\u4e86\u8a31\u591a\u65b0\u7684\u83cc\u7a2e\u3002\u63a5\u8457\u4ed6\u5011\u62ff\u9019\u4e9b\u65b0\u83cc\u7a2e\u8207\u8072\u540d\u72fc\u7c4d\u7684\u91d1\u9ec3\u8461\u8404\u7403\u83cc\uff08<em>Staphylococcus aureus<\/em>\uff09\u5728\u57f9\u990a\u76bf\u4e0a\u6253\u5c0d\u6297\u8cfd\u3002\u6700\u5f8c\uff0c\u5176\u4e2d\u4e00\u7a2e\uff0c<em>Eleftheria terrae<\/em>\u5728\u5c0d\u6297\u8cfd\u4e2d\u52dd\u51fa\u3002<\/p>\n<p>\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u9019\u7a2e\u7d30\u83cc\u88fd\u9020\u7684\u6297\u751f\u7d20\uff0cteixobactin\uff0c\u4e0d\u50c5\u5c0d\u65bc\u91d1\u9ec3\u8461\u8404\u7403\u83cc\u975e\u5e38\u6709\u6548\uff0c\u5c0d\u5176\u4ed6\u5e7e\u7a2e\u4eba\u985e\u7684\u75c5\u539f\u4e5f\u975e\u5e38\u6709\u6548\uff083\uff09\uff1b\u5728\u521d\u671f\u6e2c\u8a66\u6642\uff0c\u7531\u65bc\u91d1\u9ec3\u8461\u8404\u7403\u83cc\u88ab\u6bba\u5f97\u5c4d\u6a6b\u904d\u91ce\u3001\u8840\u6d41\u6210\u6cb3\uff0c\u5230\u4e86\u7121\u83cc\u5016\u5b58\u7684\u5730\u6b65\uff0c\u9023\u7814\u7a76\u5718\u968a\u90fd\u4ee5\u70ba\u9019\u500b\u6771\u897f\u6216\u8a31\u4e0d\u904e\u662f\u53e6\u4e00\u500b\u300c\u6f02\u767d\u6c34\u300d\u7f77\u5566\uff01\u8981\u77e5\u9053\u6f02\u767d\u6c34\u6bba\u83cc\u4e5f\u5f88\u6709\u6548\uff0c\u4f46\u662f\u6f02\u767d\u6c34\u5c0d\u4eba\u4e5f\u6709\u5bb3\u3002\u4f46\u662f\u9032\u4e00\u6b65\u7684\u7814\u7a76\u767c\u73fe\uff0c\u7531\u65bc\u5b83\u5e72\u64fe\u4e86\u7d30\u83cc\u7d30\u80de\u58c1\u7684\u5408\u6210\uff0c\u56e0\u6b64\u5b83\u61c9\u8a72\u5c0d\u4eba\u7121\u5bb3\u3002<\/p>\n<figure id=\"attachment_20528\" aria-describedby=\"caption-attachment-20528\" style=\"width: 512px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-20528\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/02\/Teixobactin.svg_.png\" alt=\"teixobactin\u7684\u7d50\u69cb\u3002\u5716\u7247\u4f86\u6e90\uff1awiki\" width=\"512\" height=\"352\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/02\/Teixobactin.svg_.png 512w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/02\/Teixobactin.svg_-300x206.png 300w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><figcaption id=\"caption-attachment-20528\" class=\"wp-caption-text\">teixobactin\u7684\u7d50\u69cb\u3002\u5716\u7247\u4f86\u6e90\uff1awiki<\/figcaption><\/figure>\n<p>\u76ee\u524dteixobactin\u6b63\u5728\u7b49\u5f85\u9032\u5165\u81e8\u5e8a\u6e2c\u8a66\u3002\u82e5\u81e8\u5e8a\u6e2c\u8a66\u901a\u904e\u4e86\uff08\u9084\u8981\u597d\u5e7e\u5e74\uff09\uff0c\u5b83\u662f\u5426\u6703\u6210\u70ba\u4eba\u985e\u5c0d\u6297\u7d30\u83cc\u7684\u7d42\u6975\u6b66\u5668\u5462\uff1f\u76ee\u524d\u5728\u5be6\u9a57\u5ba4\u4e2d\uff0c\u9084\u6c92\u6709\u770b\u5230\u75c5\u539f\u83cc\u5c0d\u5b83\u767c\u5c55\u51fa\u6297\u85e5\u6027\uff1b\u800c\u5b83\u7684\u6bba\u83cc\u6548\u679c\u662f\u6cdb\u53ef\u9ef4\u7d20\uff08vancomycin\uff09\u7684100\u500d\u3002\u7576\u7136\uff0cteixobactin\u53ea\u5c0d\u683c\u862d\u6c0f\u967d\u6027\u83cc\u6709\u6548\uff0c\u5c0d\u683c\u862d\u6c0f\u9670\u6027\u83cc\uff08\u5982\u6dcb\u7403\u83cc<em>Neisseria gonorrhoeae<\/em>\u76ee\u524d\u5df2\u7d93\u5230\u4e86\u5e7e\u4e4e\u7121\u85e5\u53ef\u91ab\u7684\u5730\u6b65\uff09\u5247\u4e0d\u5177\u6709\u85e5\u6548\u3002<\/p>\n<p>\u96d6\u7136\u7814\u7a76\u5718\u968a\u8a8d\u70bateixobactin\u61c9\u8a72\u662f\u5c0d\u6297\u683c\u862d\u6c0f\u967d\u6027\u83cc\uff08\u5c24\u5176\u662fMRSA\uff0c\u591a\u91cd\u6297\u85e5\u6027\u91d1\u9ec3\u8461\u8404\u7403\u83cc\uff09\u7684\u7d42\u6975\u6b66\u5668\uff0c\u4f46\u7b46\u8005\u4e26\u4e0d\u5982\u6b64\u6a02\u89c0\u3002\u7562\u7adf\uff0c\u5fae\u751f\u7269\u7684\u4e16\u754c\u539f\u672c\u5c31\u5b58\u5728\u8457\u4e92\u76f8\u5c0d\u6297\uff0c\u4ee5\u722d\u53d6\u751f\u5b58\u7a7a\u9593\u7684\u72c0\u6cc1\uff1b\u6297\u751f\u7d20\u4fbf\u662f\u7d30\u83cc\/\u771f\u83cc\u7528\u4f86\u5c0d\u6297\u5176\u4ed6\u5fae\u751f\u7269\u6240\u7522\u751f\u7684\u5316\u5b78\u6b66\u5668\u3002\u5982\u679cteixobactin\u771f\u7684\u5982\u6b64\u6709\u6548\uff0c\u571f\u58e4\u4e2d\u61c9\u8a72\u53ea\u6709\u5f88\u5c11\u7684\u5176\u4ed6\u683c\u862d\u6c0f\u967d\u6027\u83cc\u5b58\u6d3b\u624d\u662f\u5427\uff1f\u5728\u6211\u5011\u5c0d\u65bc\u672a\u4f86\u53ef\u80fd\u6709\u65b0\u6b66\u5668\u5c0d\u6297\u5fae\u751f\u7269\u611f\u67d3\u611f\u5230\u6b23\u6170\u4e4b\u6642\uff0c\u9084\u662f\u61c9\u8a72\u8981\u9075\u5b88<a href=\"http:\/\/www.who.int\/mediacentre\/news\/releases\/2014\/amr-report\/en\/\" target=\"_blank\" rel=\"noopener noreferrer\">WHO\u5831\u544a<\/a>\u4e2d\u7684\u4f7f\u7528\u6297\u751f\u7d20\u6e96\u5247\uff1a<\/p>\n<p>\u75c5\u4eba\u8981\uff1a<br \/>\n1. \u9075\u7167\u91ab\u5e2b\u8655\u65b9\u670d\u85e5\uff0c\u4e0d\u8981\u81ea\u884c\u8cfc\u85e5\u6216\u62ff\u5225\u4eba\u7684\u85e5\u4f86\u670d\u7528\uff1b<br \/>\n2. \u6cbb\u7642\u904e\u7a0b\uff0c\u5373\u4f7f\u89ba\u5f97\u75c7\u72c0\u6e1b\u7de9\u4e5f\u4e0d\u53ef\u81ea\u884c\u505c\u85e5\u3002<\/p>\n<p>\u91ab\u5e2b\u8981\uff1a<br \/>\n1. \u5207\u5be6\u4f5c\u597d\u611f\u67d3\u9810\u9632\uff0c\u6e1b\u5c11\u4f7f\u7528\u6297\u751f\u7d20\u7684\u6a5f\u6703\uff1b<br \/>\n2. \u53ea\u6709\u5728\u771f\u7684\u6709\u611f\u67d3\u6642\u624d\u958b\u7acb\u6297\u751f\u7d20\uff0c\u800c\u4e14\u8981\u958b\u5c0d\u75c7\u7684\u6297\u751f\u7d20\uff1b<\/p>\n<p>\u9019\u6a23\uff0c\u65b0\u7684\u300c\u7d42\u6975\u6b66\u5668\u300d\u624d\u6709\u53ef\u80fd\u771f\u7684\u300c\u7d42\u6975\u300d\uff1b\u6211\u5011\u4e5f\u624d\u4e0d\u6703\u56de\u523020\u4e16\u7d00\u4ee5\u524d\u7684\u5e74\u4ee3\uff0c\u90a3\u6642\u5019\uff0c\u4efb\u4f55\u7d30\u83cc\u611f\u67d3\u4fbf\u8db3\u4ee5\u81f4\u547d\uff0c\u9019\u6a23\u7684\u4e16\u754c\uff0c\u61c9\u8a72\u4e0d\u662f\u4efb\u4f55\u4eba\u6240\u671f\u671b\u56de\u53bb\u7684\u3002<\/p>\n<p><strong>\u53c3\u8003\u6587\u737b\uff1a<\/strong><br \/>\n1. 2014\/4\/30.<a href=\"http:\/\/www.who.int\/mediacentre\/news\/releases\/2014\/amr-report\/en\/\" target=\"_blank\" rel=\"noopener noreferrer\">WHO\u2019s first global report on antibiotic resistance reveals serious, worldwide threat to public health<\/a>.<br \/>\n2. D. Nichols, N. Cahoon, E. M. Trakhtenberg, L. Pham, A. Mehta1, A. Belanger, T. Kanigan, K. Lewis and S. S. Epstein. 2010.\u00a0<a href=\"http:\/\/aem.asm.org\/content\/76\/8\/2445.long\" target=\"_blank\" rel=\"noopener noreferrer\">Use of Ichip for High-Throughput In Situ Cultivation of \u201cUncultivable\u201d Microbial Species<\/a>.\u00a0<em>Appl. Environ. Microbiol<\/em>. 76\uff088\uff09\uff1a2445-2450.<br \/>\n3. 2015\/1\/7. Kelly Servick.\u00a0<a href=\"http:\/\/news.sciencemag.org\/biology\/2015\/01\/microbe-found-grassy-field-contains-powerful-antibiotic?rss=1\" target=\"_blank\" rel=\"noopener noreferrer\">Microbe found in grassy field contains powerful antibiotic<\/a>. Science<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u5f9e\u5f17\u840a\u660e\u57281928\u5e74\u7684\u5149\u68cd\u7bc0\u90a3\u4e00\u5929\u65e9\u6668<\/p>\n","protected":false},"author":20,"featured_media":20527,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1647,1643,1128,35,214,1543],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/02\/1531231.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/20490"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20490"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/20490\/revisions"}],"predecessor-version":[{"id":32162,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/20490\/revisions\/32162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/20527"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}