{"id":20240,"date":"2015-01-30T00:05:32","date_gmt":"2015-01-29T16:05:32","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=20240"},"modified":"2018-08-01T14:33:34","modified_gmt":"2018-08-01T06:33:34","slug":"%e3%80%90%e7%b9%bd%e7%b4%9b%e7%94%9f%e6%85%8b%e3%80%91%e8%b2%aa%e6%9d%af%e5%8d%83%e8%90%ac%e5%b9%b4%ef%bc%8d%ef%bc%8d%e7%8c%bf%e4%be%86%e6%98%af%e6%8b%9cadh4%e6%89%80%e8%b3%9c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=20240","title":{"rendered":"\u3010\u7e7d\u7d1b\u751f\u614b\u3011\u8caa\u676f\u5343\u842c\u5e74\uff0d\uff0d\u300c\u733f\u300d\u4f86\u662f\u62dcADH4\u6240\u8cdc"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u4e09\u4e94\u597d\u53cb\u76f8\u805a\u4f86\u559d\u500b\u5e7e\u676f\uff0c\u5c0d\u4e00\u4e9b\u4eba\u4f86\u8aaa\u53ef\u4ee5\u653e\u9b06\u548c\u8212\u58d3\uff0c\u4f46\u662f\u9ec3\u6e6f\u4e0b\u809a\u5f8c\u7684\u8822\u4e8b\u548c\u61be\u4e8b\u5728\u6211\u5011\u793e\u6703\u4e0a\u4e5f\u4e0d\u7b97\u5c11\u3002\u6211\u5011\u662f\u4ec0\u9ebc\u6642\u5019\u8caa\u98f2\u676f\u4e2d\u7269\u7684\uff1f\u4e00\u9805\u7814\u7a76\u767c\u73fe\uff0c\u53ef\u80fd\u767c\u751f\u5728\u4e00\u5343\u842c\u5e74\u524d\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_20243\" aria-describedby=\"caption-attachment-20243\" style=\"width: 470px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-20243\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/01\/Shizhao.jpg\" alt=\"Shizhao\" width=\"470\" height=\"353\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/01\/Shizhao.jpg 553w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/01\/Shizhao-300x225.jpg 300w\" sizes=\"(max-width: 470px) 100vw, 470px\" \/><figcaption id=\"caption-attachment-20243\" class=\"wp-caption-text\">Photo credit: Shizhao, CC BY-SA 1.0<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u9ec3\u8c9e\u7965<\/p>\n<p>\u4eba\u985e\u4e4b\u6240\u4ee5\u80fd\u5920\u4ee3\u8b1d\u9152\u7cbe\uff0c\u8981\u62dc\u9152\u7cbe\u812b\u9176ADH4\u6240\u8cdc\u3002\u96d6\u7136\u6240\u6709\u9748\u9577\u985e\u90fd\u6709ADH4\uff0c\u53ef\u662f\u4e0d\u898b\u5f97\u90fd\u7ba1\u7528\uff0c\u72d0\u7334\u548c\u72d2\u72d2\u7684ADH4\u5c31\u4e0d\u592a\u884c\u3002\u79d1\u5b78\u5bb6\u904e\u53bb\u4e0d\u6e05\u695a\u9ad8\u6548\u7684ADH4\u662f\u4ec0\u9ebc\u6642\u5019\u6f14\u5316\u51fa\u4f86\u7684\uff0c\u6709\u4eba\u731c\u6e2c\u53ef\u80fd\u662f\u4e5d\u5343\u5e74\u524d\u4eba\u985e\u958b\u59cb\u767c\u9175\u98df\u7269\u7684\u6642\u5019\u3002<\/p>\n<p>\u4eba\u985e\u5df2\u77e5\u6700\u65e9\u7684\u91c0\u9152\u8a18\u9304\uff0c\u662f\u767c\u73fe\u65bc\u4e2d\u570b\u6cb3\u5357\u7701\u6f2f\u6cb3\u5e02\u821e\u967d\u7e23\u5317\u821e\u6e21\u93ae\u897f\u53571.5\u516c\u91cc\u7684\u8cc8\u6e56\u6751\u7684\u65b0\u77f3\u5668\u6642\u4ee3\u6587\u5316\u907a\u5740\u3002\u8003\u53e4\u5316\u5b78\u5bb6\u5c0d\u8cc8\u6e56\u907a\u5740\u63a1\u96c6\u5230\u7684\u90e8\u5206\u9676\u7247\u767c\u73fe\u4e86\u4e00\u4e9b\u6b98\u7559\u7269\u4e2d\u542b\u6709\u4e00\u7a2e\u9152\u985e\u98f2\u6599\u7684\u6c89\u6fb1\u7269\uff0c\u5176\u5316\u5b78\u6210\u5206\u8207\u73fe\u4ee3\u7a3b\u7c73\u3001\u7c73\u9152\u3001\u8461\u8404\u9152\u3001\u8702\u881f\u3001\u8461\u8404\uff08\u6216\u5c71\u6942\uff09\u7684\u4e39\u5be7\u9178\uff0c\u4ee5\u53ca\u4e00\u4e9b\u53e4\u4ee3\u548c\u73fe\u4ee3\u8349\u85e5\u6240\u542b\u7684\u67d0\u4e9b\u5316\u5b78\u6210\u5206\u76f8\u540c\uff0c\u76ee\u524d\u4e16\u754c\u4e0a\u767c\u73fe\u6700\u65e9\u91c0\u9020\u9152\u985e\u7684\u8a18\u9304\u3002<!--more--><\/p>\n<p>\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5dde\u8056\u5854\u83f2\u5b78\u9662\u7684Matthew Carrigan\u7b49\u4eba\uff0c\u6210\u529f\u5730\u6536\u96c6\u4e8628\u7a2e\u54fa\u4e73\u985e\u5305\u62ec17\u7a2e\u73fe\u751f\u9748\u9577\u985e\u7684ADH4\u4e26\u4e14\u5b9a\u4e86\u5e8f\u5217\uff0c\u4ed6\u5011\u5229\u7528\u90a3\u4e9b\u86cb\u767d\u8cea\u5e8f\u5217\u4f86\u63a8\u6572\u51fa\u4e0d\u540c\u9748\u9577\u985eADH4\u7684\u7956\u5148\u4e4b\u5e8f\u5217\uff0c\u63a5\u8457\u4ed6\u5011\u88fd\u9020\u51fa\u90a3\u4e9b\u539f\u59cb\u7248\u7684ADH4\uff0c\u4f86\u6e2c\u8a66\u5b83\u5011\u4ee3\u8b1d\u9152\u7cbe\u7684\u6548\u7387\u3002\u4ed6\u5011\u767c\u73fe\uff0c\u9748\u9577\u985e\u4e03\u5343\u842c\u5e74\u524d\u6700\u53e4\u8001\u7684ADH4\u4e5f\u4e0d\u600e\u9ebc\u884c\uff0c\u4ee3\u8b1d\u9152\u7cbe\u7684\u901f\u7387\u76f8\u7576\u7de9\u6162\u3002\u53ef\u662f\u5230\u4e86\u4eba\u985e\u3001\u9ed1\u7329\u7329\u53ca\u5927\u7329\u7329\u5728\u4e00\u5343\u842c\u5e74\u524d\u7684\u5171\u540c\u7956\u5148\uff0c\u53ef\u80fd\u5c31\u6f14\u5316\u51fa\u6548\u7387\u76f8\u7576\u4e0d\u932f\u7684ADH4\uff0c\u4ee3\u8b1d\u9152\u7cbe\u7684\u901f\u7387\u5feb\u4e8640\u500d\uff01<\/p>\n<p>\u5728\u90a3\u6642\u5019\uff0c\u4e2d\u65b0\u4e16\u665a\u671f\u5730\u7403\u74b0\u5883\u8b8a\u51b7\uff0c\u6211\u5011\u7684\u9748\u9577\u985e\u7956\u5148\u88ab\u8feb\u958b\u59cb\u5230\u5730\u4e0a\u5c0b\u627e\u98df\u7269\uff0c\u9019\u610f\u5473\u8457\u6211\u5011\u7684\u7956\u5148\u4e0d\u4f46\u5403\u6a39\u4e0a\u525b\u6210\u719f\u7684\u679c\u5b50\uff0c\u4e5f\u64bf\u5730\u4e0a\u719f\u900f\u7684\u4f86\u5403\u3002\u90a3\u4e9b\u5f9e\u6a39\u4e0a\u6389\u4e0b\u4f86\u7684\u679c\u5b50\u53ef\u80fd\u5df2\u7d93\u767c\u9175\u4e86\uff0c\u90e8\u5206\u7cd6\u7cbe\u5df2\u8f49\u5316\u6210\u9152\u7cbe\u3002\u5982\u679c\u6c92\u6709\u6548\u7387\u8f03\u9ad8\u7684ADH4\uff0c\u9152\u7cbe\u5728\u8840\u6db2\u4e2d\u7684\u6fc3\u5ea6\u6703\u5347\u9ad8\u5230\u8b93\u733f\u9189\u5012\uff0c\u7522\u751f\u7a81\u8b8a\u80fd\u5920\u8f03\u5feb\u5730\u4ee3\u8b1d\u9152\u7cbe\u7684\u500b\u9ad4\u5c31\u76f8\u5c0d\u8f03\u6709\u512a\u52e2\uff0c\u56e0\u70ba\u7260\u5011\u80fd\u5920\u8d81\u5176\u4ed6\u540c\u4f34\u9189\u5012\u4e0d\u7701\u733f\u4e8b\u6642\uff0c\u7e7c\u7e8c\u8993\u98df\u4e26\u4e14\u634d\u885b\u5730\u76e4\u3002<\/p>\n<p>\u4ed6\u5011\u4e5f\u8a8d\u70ba\uff0c\u9019\u4e5f\u662f\u70ba\u4f55\u6211\u5011\u4eba\u985e\u6703\u55dc\u9152\uff0c\u56e0\u70ba\u9152\u7cbe\u7684\u5b58\u5728\u4e5f\u4ee3\u8868\u4e86\u98df\u7269\u7684\u4f86\u6e90\u3002\u904e\u53bb\u55ae\u5f9e\u767c\u9175\u7684\u679c\u5b50\u651d\u53d6\uff0c\u4e26\u4e0d\u5bb9\u6613\u8b93\u4eba\u651d\u53d6\u904e\u91cf\u9152\u7cbe\uff0c\u6240\u4ee5\u6211\u5011\u53ef\u4ee5\u958b\u61f7\u66a2\u5403\u767c\u9175\u7684\u679c\u5b50\uff0c\u53ef\u662f\u9019\u500b\u55dc\u9152\u7684\u504f\u597d\u5728\u73fe\u4ee3\u793e\u6703\u537b\u6703\u8b93\u6211\u5011\u5bb9\u6613\u98f2\u9152\u904e\u91cf\u3002<\/p>\n<p>\u9019\u500b\u767c\u73fe\uff0c\u6216\u8a31\u4e5f\u80fd\u5920\u89e3\u91cb\uff0c\u70ba\u4f55\u6709\u4e9b\u9748\u9577\u985e\u5982\u9ed1\u7329\u7329\u548c\u5927\u7329\u7329\u6f14\u5316\u51fa\u5728\u5730\u4e0a\u751f\u6d3b\uff0c\u56e0\u70ba\u8f03\u5f37\u7684ADH4\uff0c\u8b93\u7260\u5011\u80fd\u5920\u5403\u5f9e\u5730\u4e0a\u64bf\u4f86\u7684\u767c\u9175\u679c\u5b50\uff0c\u800c\u4ecd\u751f\u6d3b\u5728\u6a39\u4e0a\u7684\u7d05\u6bdb\u7329\u7329\u7684ADH4\u5c31\u4ecd\u4e0d\u592a\u884c\u3002<\/p>\n<p><strong>\u53c3\u8003\u4f86\u6e90\uff1a<\/strong><br \/>\n1.Sarah C. P. Williams. <a href=\"http:\/\/news.sciencemag.org\/biology\/2014\/12\/ability-consume-alcohol-may-have-shaped-primate-evolution\uff3f\" target=\"_blank\" rel=\"noopener noreferrer\">Ability to consume alcohol may have shaped primate evolution<\/a>. Science News. 1 December 2014.<br \/>\n2.Liam Corless.\u00a0 <a href=\"http:\/\/www.mirror.co.uk\/news\/world-news\/alcohol-been-part-diet-1000-4729344\" target=\"_blank\" rel=\"noopener noreferrer\">Alcohol has been part of our diet for 1000 TIMES longer than it was previously thought.Mirror. <\/a>Dec 01, 2014<br \/>\n3.MELISSA HEALY. <a href=\"http:\/\/www.latimes.com\/science\/la-sci-sn-human-ancestors-alcohol-20141201-story.html\" target=\"_blank\" rel=\"noopener noreferrer\">Human ancestors developed a taste for alcohol 10 million years ago.<\/a> Los Angeles Times.\u00a0 1 December 2014.<br \/>\n4.Carl Engelking.<a href=\"http:\/\/blogs.discovermagazine.com\/d-brief\/2014\/12\/01\/human-ancestors-were-consuming-alcohol-10-million-years-ago\/\" target=\"_blank\" rel=\"noopener noreferrer\"> Human Ancestors Were Consuming Alcohol 10 Million Years Ago.<\/a> DIscovery. December 1, 2014.<br \/>\n5.Sarah Knapton. <a href=\"http:\/\/www.telegraph.co.uk\/science\/science-news\/11266265\/Booze-culture-may-date-back-10-million-years-say-scientists.html\" target=\"_blank\" rel=\"noopener noreferrer\">Booze culture may date back 10 million years, say scientists.<\/a>\u00a0 The Telegraph. 01 Dec 2014.<\/p>\n<p><strong>\u539f\u5b78\u8853\u8ad6\u6587\uff1a<\/strong><br \/>\nCarrigan MA, et al. Hominids adapted to metabolize ethanol long before human-directed fermentation. doi: 10.1073\/pnas.1404167111<br \/>\n<span style=\"color: #333399;\"><strong>--<br \/>\n\u4f5c\u8005\uff1a\u9ec3\u8c9e\u7965 \u73fe\u65bc\u53f0\u7063\u4e2d\u592e\u7814\u7a76\u9662\u751f\u7269\u591a\u6a23\u6027\u7814\u7a76\u4e2d\u5fc3\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2 \u751f\u7269\u5b78\u7814\u7a76\u3002\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4e09\u4e94\u597d\u53cb\u76f8\u805a\u4f86\u559d\u500b\u5e7e\u676f\uff0c\u5c0d\u4e00\u4e9b\u4eba\u4f86\u8aaa\u53ef<\/p>\n","protected":false},"author":20,"featured_media":28733,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,26],"tags":[1610,1609,124,1611,1448,481,1590],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/01\/Shizhao-1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/20240"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20240"}],"version-history":[{"count":10,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/20240\/revisions"}],"predecessor-version":[{"id":32122,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/20240\/revisions\/32122"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/28733"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}