{"id":19957,"date":"2014-12-24T00:35:48","date_gmt":"2014-12-23T16:35:48","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=19957"},"modified":"2017-03-31T23:16:30","modified_gmt":"2017-03-31T15:16:30","slug":"%e3%80%90%e6%99%82%e4%ba%8b%e7%84%a6%e9%bb%9e%e3%80%91%e4%bc%8a%e6%b3%a2%e6%8b%89%e7%97%85%e6%af%92%e7%9a%84%e5%85%8d%e7%96%ab%e5%8f%8d%e6%87%89","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=19957","title":{"rendered":"\u3010\u4f0a\u6ce2\u62c9\u5c08\u984c\u3011\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7684\u514d\u75ab\u53cd\u61c9"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u5c0d\u6297\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7684\u611f\u67d3\u6700\u7d42\u9084\u662f\u5f97\u9760\u75c5\u4eba\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u4f46\uff0c\u4f60\u66fe\u7d93\u597d\u5947\u904e\u6700\u5148\u958b\u59cb\u6642\uff0c\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u662f\u5982\u4f55\u9003\u812b\u514d\u75ab\u7cfb\u7d71\u7684\u5929\u7f85\u5730\u7db2\u55ce\uff1f<\/strong><\/span><\/p>\n<figure id=\"attachment_19958\" aria-describedby=\"caption-attachment-19958\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-19958\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_ebola-897x1024.png\" alt=\"\u51fa\u8655\uff1aOpenclipart\" width=\"300\" height=\"342\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_ebola-897x1024.png 897w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_ebola-262x300.png 262w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-19958\" class=\"wp-caption-text\">\u51fa\u8655\uff1aOpenclipart<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u99f1\u5b9b\u7433<\/p>\n<p>\u4eca\u5e74\uff0c\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u5728\u897f\u975e\u7206\u767c\u53f2\u7121\u524d\u4f8b\u7684\u75ab\u60c5\uff0c\u898f\u6a21\u4e4b\u5927\u4f7f\u5f97\u4eba\u5fc3\u60f6\u60f6\u3002\u5728\u65b0\u805e\u5a92\u9ad4\u8207\u5c08\u5bb6\u53e3\u4e2d\uff0c\u6211\u5011\u5e38\u807d\u5230\u5831\u5c0e\u6307\u51fa\uff0c\u73fe\u5728\u91ab\u5b78\u91dd\u5c0d\u4f0a\u6ce2\u62c9\u611f\u67d3\u7684\u60a3\u8005\uff0c\u591a\u534a\u662f\u7d66\u4e88\u652f\u6301\u6027\u7642\u6cd5\uff0c\u85c9\u7531\u88dc\u5145\u60a3\u8005\u96fb\u89e3\u8cea\u8207\u6c34\u5206\u7b49\uff0c\u8b93\u60a3\u8005\u53ef\u4ee5\u5229\u7528\u672c\u8eab\u7684\u514d\u75ab\u7cfb\u7d71\u6230\u52dd\u75c5\u6bd2\u3002\u7136\u800c\uff0c\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u8207\u514d\u75ab\u7cfb\u7d71\u4e4b\u9593\u7684\u6230\u722d\uff0c\u7a76\u7adf\u662f\u5982\u4f55\u5728\u4f60\u6b7b\u6211\u6d3b\u9593\u5206\u51fa\u52dd\u8ca0\u5462\uff1f\u53c8\uff0c\u5982\u679c\u6211\u5011\u5c0d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u9003\u8eb2\u514d\u75ab\u53cd\u61c9\u7684\u6a5f\u5236\u6709\u66f4\u52a0\u6e05\u695a\u5730\u77ad\u89e3\uff0c\u662f\u4e0d\u662f\u53ef\u4ee5\u5728\u65b0\u85e5\u8a2d\u8a08\u8207\u958b\u767c\u4e0a\uff0c\u7d66\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u8fce\u982d\u75db\u64ca\u5462\uff1f<\/p>\n<p>\u5728\u8a0e\u8ad6\u4e0a\u9762\u5169\u500b\u554f\u984c\u4e4b\u524d\uff0c\u8b93\u6211\u5011\u5148\u4f86\u77ad\u89e3\u4e00\u4e0b\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u5427\uff01\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u57281976\u5e74\u7684\u6642\u5019\uff0c\u88ab\u6b78\u985e\u65bc\u7dda\u72c0\u75c5\u6bd2\u7684\u4e00\u7a2e\uff1b\u7dda\u72c0\u75c5\u6bd2\u79d1\u9664\u4e86\u4f0a\u6ce2\u62c9\u75c5\u6bd2\uff0c\u9084\u5305\u62ec1967\u5e74\u88ab\u767c\u73fe\u7684\u99ac\u5821\u75c5\u6bd2\u3002\u76ee\u524d\u7814\u7a76\u767c\u73fe\uff0c\u52d5\u7269\u5728\u611f\u67d3\u7dda\u72c0\u75c5\u6bd2\u7684\u6700\u521d\u5e7e\u5929\uff0c\u6700\u5148\u88ab\u611f\u67d3\u7684\u5bbf\u4e3b\u7d30\u80de\u591a\u70ba\u53c3\u8207\u5148\u5929\u514d\u75ab\u53cd\u61c9\u7684\u514d\u75ab\u7d30\u80de\uff0c\u5305\u62ec\u6a39\u7a81\u7d30\u80de\u3001\u55ae\u6838\u7d30\u80de\u8207\u5de8\u55dc\u7d30\u80de\u3002\u4f46\u7dda\u72c0\u75c5\u6bd2\u80fd\u611f\u67d3\u7684\u7d30\u80de\u7a2e\u985e\u6975\u70ba\u5ee3\u6cdb\uff0c\u56e0\u6b64\u5728\u75c5\u6bd2\u611f\u67d3\u7684\u75c5\u7a0b\u5f8c\u671f\uff0c\u9664\u4e86\u514d\u75ab\u7d30\u80de\uff0c\u4e5f\u5f88\u5bb9\u6613\u5728\u5176\u4ed6\u7a2e\u7d30\u80de\uff08\u4f8b\u5982\u809d\u81df\u7d30\u80de\uff09\u767c\u73fe\u75c5\u6bd2\u8e64\u8de1\u3002<!--more--><\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_virus-03.jpg\"><img decoding=\"async\" class=\"alignright wp-image-19964\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_virus-03-757x1024.jpg\" alt=\"141123_Fig_virus-03\" width=\"300\" height=\"406\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_virus-03-757x1024.jpg 757w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_virus-03-221x300.jpg 221w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_virus-03-800x1082.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_virus-03.jpg 1048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>\u5728\u611f\u67d3\u521d\u671f\u7684\u6642\u5019\uff0c\u88ab\u611f\u67d3\u7684\u6a39\u7a81\u7d30\u80de\u3001\u55ae\u6838\u7d30\u80de\u8207\u5de8\u55dc\u7d30\u80de\u4e2d\uff0c\u5e72\u64fe\u7d20\u7684\u5206\u6ccc\u90fd\u88ab\u767c\u73fe\u660e\u986f\u964d\u4f4e\u3002\u5e72\u64fe\u7d20\u662f\u7d30\u80de\u5728\u88ab\u75c5\u6bd2\u611f\u67d3\u6642\u5f88\u91cd\u8981\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u5b83\u6709\u9ede\u50cf\u662f\u7d30\u80de\u5167\u7684119\u6c42\u6551\u5c08\u7dda\u3002\u5e72\u64fe\u7d20\u7684\u5206\u6ccc\u53ef\u4ee5\u8b93\u88ab\u611f\u67d3\u7684\u7d30\u80de\u5feb\u901f\u6b66\u88dd\uff0c\u6d3b\u5316\u4e26\u8868\u73fe\u4e0a\u767e\u7a2e\u5c0d\u6297\u75c5\u6bd2\u7684\u57fa\u56e0\uff08\u901a\u5e38\u88ab\u7d71\u7a31\u70ba\u5e72\u64fe\u7d20\u8a98\u5c0e\u57fa\u56e0\uff09\uff0c\u8b93\u500b\u9ad4\u9032\u5165\u5c0d\u6297\u75c5\u6bd2\u611f\u67d3\u7684\u7dca\u6025\u72c0\u614b\u3002\u800c\u4fc3\u4f7f\u9019\u7dca\u6025\u5c08\u7dda\u80fd\u5920\u5feb\u901f\u53cd\u61c9\u7684\u6700\u5927\u529f\u81e3\u662fSTAT1\u548cSTAT2\u9019\u5169\u500b\u86cb\u767d\u8cea\u7684\u78f7\u9178\u5316\u8207\u6838\u8f49\u79fb\u3002<\/p>\n<p>\u5927\u90e8\u4efd\u7684\u86cb\u767d\u8cea\u6216\u8f49\u9304\u56e0\u5b50\u8981\u9032\u5165\u7d30\u80de\u6838\uff0c\u5fc5\u9808\u4ef0\u8cf4\u6838\u8f49\u904b\u86cb\u767d\u3002\u6838\u8f49\u904b\u86cb\u767d\u900f\u904e\u8fa8\u8b58\u4e00\u6bb5\u7279\u5b9a\u7684\u8a0a\u606f\u5e8f\u5217\uff0c\u80fd\u5920\u5c07\u86cb\u767d\u8cea\u5f9e\u7d30\u80de\u8cea\u8f49\u79fb\u81f3\u7d30\u80de\u6838\u3002\u6709\u8da3\u7684\u662f\uff0cSTAT1\u4e26\u4e0d\u5177\u6709\u9019\u6bb5\u5e38\u898b\u7684\u8a0a\u606f\u5e8f\u5217\uff1b\u5b83\u5011\u901a\u5e38\u5728\u78f7\u9178\u5316\u4e4b\u5f8c\u5169\u5169\u7d50\u5c0d\uff0c\u4e26\u5728\u7d50\u4f34\u6210\u96d9\u5076\u9ad4\u4e4b\u5f8c\uff0c\u5f62\u6210\u4e00\u7d44\u7279\u5225\u7684\u6838\u8f49\u79fb\u8a0a\u606f\u5e8f\u5217\uff0c\u9032\u800c\u80fd\u5920\u88ab\u6838\u8f49\u79fb\u86cb\u767d\u5bb6\u65cf\u4e2d\u7684KPNA1\u3001KPNA5\u4ee5\u53caKPNA6\u6240\u8fa8\u8b58\uff0c\u800c\u88ab\u8f49\u79fb\u5230\u7d30\u80de\u6838\u4e2d\uff0c\u6d3b\u5316\u5e72\u64fe\u7d20\u8a98\u5c0e\u57fa\u56e0\u7684\u8868\u9054\uff0c\u800c\u958b\u555f\u62b5\u6297\u75c5\u6bd2\u7684\u4e00\u9023\u4e32\u53cd\u61c9\u3002STAT1\u7684\u6838\u8f49\u79fb\u5e8f\u5217\u5982\u6b64\u8207\u773e\u4e0d\u540c\u662f\u6709\u512a\u52e2\u7684\uff0c\u7d30\u80de\u53ef\u4ee5\u85c9\u6b64\u5340\u5206\u6d3b\u5316\u524d\u7684STAT1\u55ae\u9ad4\u4ee5\u53ca\u88ab\u6d3b\u5316\u5f8c\u7684\u96d9\u5076\u9ad4\u3002\u66f4\u6709\u751a\u8005\uff0c\u56e0\u70ba\u6838\u8f49\u79fb\u86cb\u767d\u5229\u7528\u4e0d\u540c\u7684\u86cb\u767d\u8cea\u5340\u57df\u4f86\u8fa8\u8b58\u5e38\u898b\u7684\u6838\u8f49\u79fb\u5e8f\u5217\u3001\u6216STAT1\u7279\u6709\u7684\u6838\u8f49\u79fb\u5e8f\u5217\uff0c\u6838\u8f49\u79fb\u86cb\u767d\u56e0\u800c\u53ef\u4ee5\u540c\u6642\u904b\u8f38STAT1\u548c\u5176\u4ed6\u86cb\u767d\u8cea\u9032\u5165\u5230\u7d30\u80de\u6838\u4e2d\uff0c\u800c\u4e0d\u6703\u8b93STAT1\u5fc5\u9808\u548c\u5176\u4ed6\u4e5f\u8981\u9032\u5165\u7d30\u80de\u6838\u7684\u86cb\u767d\u8cea\u7af6\u722d\u300c\u5165\u53e3\u300d\uff0c\u800c\u5f71\u97ff\u5230STAT1\u9019\u689d\u7dca\u6025\u5c08\u7dda\u7684\u8a0a\u606f\u50b3\u905e\u3002<img decoding=\"async\" class=\"aligncenter wp-image-19962\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_mechanism-02-1024x672.jpg\" alt=\"141123_Fig_mechanism-02\" width=\"699\" height=\"459\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_mechanism-02-1024x672.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/12\/141123_Fig_mechanism-02-300x196.jpg 300w\" sizes=\"(max-width: 699px) 100vw, 699px\" \/><\/p>\n<p>\u800c\u56de\u5230\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u8207\u514d\u75ab\u7d30\u80de\u7684\u6df7\u6230\uff1a\u6700\u8fd1\u5728\u8056\u8def\u6613\u83ef\u76db\u9813\u5927\u5b78\uff0c\u7531Amarasinghe\u535a\u58eb\u6240\u5e36\u9818\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u6240\u8868\u73fe\u7684\u4e00\u500b\u86cb\u767d\u8ceaVP24\uff0c\u6703\u548cKPNA1\u3001KPNA5\u4ee5\u53caKPNA6\u7d50\u5408\uff0c\u9032\u800c\u963b\u7919\u78f7\u9178\u5316\u7684STAT1\u96d9\u5076\u9ad4\u9032\u5165\u7d30\u80de\u6838\u3002\u7559\u6eef\u5728\u7d30\u80de\u8cea\u4e2d\u7684STAT1\u6c92\u6709\u8fa6\u6cd5\u6d3b\u5316\u4e0b\u6e38\u57fa\u56e0\uff0c\u65bc\u662f\u6297\u75c5\u6bd2\u53cd\u61c9\u5c31\u53d7\u5230\u6291\u5236\u3002\u8a72\u7814\u7a76\u5718\u968a\u900f\u904e\u7d50\u6676\u5be6\u9a57\uff0c\u8b49\u660eVP24\u4ee5\u6975\u9ad8\u7684\u5c08\u4e00\u6027\u7d50\u5408\u4e0aKPNA5\u7684\u78b3\u7aef\u3002\u7d50\u6676\u7d50\u69cb\u4e5f\u63ed\u9732VP24\u6240\u7d50\u5408\u4e0a\u7684KPNA5\u529f\u80fd\u5340\u584a\uff0c\u548c\u5176\u4ed6\u5e38\u898b\u6838\u8f49\u79fb\u5e8f\u5217\u6240\u7d50\u5408\u4e0a\u7684\u529f\u80fd\u5340\u584a\u4e0d\u4e00\u6a23\u3002\u56e0\u6b64\u7576\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u900f\u904eVP24\u6291\u5236KPNA5\u8f49\u904bSTAT1\u9032\u5165\u7d30\u80de\u6838\u6642\uff0c\u5176\u4ed6\u9700\u8981\u88ab\u79fb\u52d5\u5230\u7d30\u80de\u6838\u5167\u7684\u86cb\u767d\u8cea\u8f49\u904b\u529f\u80fd\u4e26\u4e0d\u6703\u53d7\u5230\u5f71\u97ff\u3002\u63db\u8a00\u4e4b\uff0c\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u80fd\u5920\u5feb\u3001\u72e0\u3001\u6e96\u5730\u8b93STAT1\u7dca\u6025\u5c08\u7dda\u5931\u53bb\u529f\u80fd\uff0c\u537b\u7121\u7919\u5176\u4ed6\u86cb\u767d\u8cea\u7684\u7d30\u80de\u6838\u8f49\u904b\uff0c\u4e5f\u5c31\u53ef\u4ee5\u8b93\u7d30\u80de\u9664\u4e86\u6297\u75c5\u6bd2\u53cd\u61c9\u4e4b\u5916\u7684\u5176\u4ed6\u751f\u7406\u529f\u80fd\u7dad\u6301\u6b63\u5e38\uff0c\u800c\u4e0d\u6703\u653e\u706b\u4e0d\u6210\uff0c\u9084\u4f5c\u7e6d\u81ea\u7e1b\u7684\u71d2\u5230\u81ea\u5df1\u3002<br \/>\n\u5728\u4e86\u89e3\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u5982\u4f55\u5728\u611f\u67d3\u7d30\u80de\u4e4b\u5f8c\u963b\u65b7\u5e72\u64fe\u7d20\u8a0a\u606f\u50b3\u905e\u4e4b\u5f8c\uff0c\u4e0d\u50c5\u89e3\u7b54\u4e86\u70ba\u4ec0\u9ebc\u5e72\u64fe\u7d20\u6cbb\u7642\u5c0d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u611f\u67d3\u7684\u7d30\u80de\u7121\u6548\uff0c\u4e5f\u70ba\u65b0\u85e5\u958b\u767c\u63d0\u4f9b\u53e6\u4e00\u500b\u5d84\u65b0\u7684\u601d\u7dad\u89d2\u5ea6\u3002\u8a72\u7814\u7a76\u5718\u968a\u4e5f\u6b63\u5728\u627e\u5c0b\u80fd\u5920\u6291\u5236VP24\u6d3b\u6027\u7684\u65b9\u6cd5\u3002\u96d6\u7136\u5f9e\u57fa\u790e\u7814\u7a76\u5230\u81e8\u5e8a\u904b\u7528\u662f\u4e00\u689d\u6f2b\u6f2b\u9577\u8def\uff0c\u4f46\u5e0c\u671b\u5728\u5c0d\u6297\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u4e0a\uff0c\u9019\u53c8\u662f\u53e6\u4e00\u500b\u6eff\u61f7\u5e0c\u671b\u7684\u958b\u59cb\u3002<\/p>\n<p><strong>\u539f\u5b78\u8853\u8ad6\u6587\uff1a<\/strong><br \/>\nXu, W. et al. Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. <em>Cell Host Microbe<\/em>. 2014 Aug 13;16(2):187-200. doi: 10.1016\/j.chom.2014.07.008.<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><br \/>\nDaugherty, MD. et al. How a virus blocks a cellular emergency access lane to the nucleus, STAT!<em>Cell Host Microbe<\/em>. 2014 Aug 13;16(2):150-2. doi: 10.1016\/j.chom.2014.07.013.<br \/>\nMohamadzadeh, M. el al. How Ebola and Marburg viruses battle the immune system.<em>Nat Rev Immunol<\/em>. 2007 Jul;7(7):556-67.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u5c0d\u6297\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7684\u611f\u67d3\u6700\u7d42\u9084\u662f\u5f97\u9760\u75c5\u4eba\u7684<\/p>\n","protected":false},"author":20,"featured_media":21965,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1386,1921,702,1192,1573],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2015\/01\/EBOLA-S.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/19957"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19957"}],"version-history":[{"count":11,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/19957\/revisions"}],"predecessor-version":[{"id":26218,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/19957\/revisions\/26218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/21965"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}