{"id":19876,"date":"2014-12-16T00:25:37","date_gmt":"2014-12-15T16:25:37","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=19876"},"modified":"2018-11-21T09:41:06","modified_gmt":"2018-11-21T01:41:06","slug":"%e3%80%90%e5%9f%ba%e5%9b%a0%e6%8f%ad%e5%af%86%e3%80%91%e5%8e%9f%e4%be%86%e5%90%8c%e6%80%a7%e6%88%80%e7%9c%9f%e7%9a%84%e8%83%bd%e9%81%ba%e5%82%b3%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=19876","title":{"rendered":"\u539f\u4f86\u540c\u6027\u6200\u771f\u7684\u80fd\u907a\u50b3\uff1f"},"content":{"rendered":"

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\"Ludovic
Ludovic Bertron, CC BY 2.0<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u9ec3\u8c9e\u7965<\/p>\n

2014\u5e7410\u6708\u6709\u8d85\u904e6\u842c5\u5343\u4eba\u53c3\u52a0\u5df2\u9081\u5165\u7b2c13\u5c46\u3001\u4e3b\u984c\u662f\u300c\u64c1\u62b1\u6027\uff0f\u5225\u2027\u8a8d\u540c\u5dee\u7570\u300d\u7684\u81fa\u7063\u540c\u5fd7\u904a\u884c\uff0c\u9664\u4e86\u540c\u6027\u6200\u65cf\u7fa4\u4e0a\u8857\uff0c\u4e0d\u5c11\u7570\u6027\u6200\u4e5f\u767c\u8072\u529b\u633a\u540c\u6027\u5a5a\u59fb\uff0c\u4f7f\u81fa\u7063\u540c\u5fd7\u904a\u884c\u6210\u70ba\u4e9e\u6d32\u898f\u6a21\u6700\u5927\u7684\u722d\u53d6\u540c\u5fd7\u6b0a\u76ca\u6d3b\u52d5\u3002<\/p>\n

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\u5176\u5be6\uff0c\u5eff\u5e74\u524d\u7f8e\u570b\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u7684Deam Hamer\u65e9\u57281993\u5e74\u5c31\u5728\u300a\u79d1\u5b78\u300b\uff08Science<\/em>\uff09\u767c\u8868\u4e86\u8ad6\u6587\u6307\u51faX\u67d3\u8272\u9ad4\u4e0a\u7684Xq28\u4f4d\u7f6e\u542b\u6709\u5f71\u97ff\u6027\u5411\u7684\u57fa\u56e0\uff0c\u53ef\u662f\u5728\u5b78\u754c\u537b\u5f15\u8d77\u4e0d\u5c11\u722d\u8ad6\uff0c\u800c\u4e14\u6709\u5b78\u8005\u5ba3\u7a31\u7121\u6cd5\u518d\u73fe\u5176\u7d50\u679c\uff1b\u7b2c\u516b\u5c0d\u67d3\u8272\u9ad4\u76848q12\u4e5f\u65e9\u5df2\u88abHamer\u7b49\u4eba\u767c\u73fe\u548c\u6027\u5411\u6c7a\u5b9a\u6709\u95dc\uff0c\u9996\u5148\u767c\u8868\u57282005\u5e74\u7684\u300a\u4eba\u985e\u907a\u50b3\u5b78\u300b\uff08Human Genetics<\/em>\uff09\u671f\u520a\u3002Hamer\u73fe\u5df2\u5f9eNIH\u9000\u4f11\u4e26\u4e14\u6295\u8eab\u88fd\u4f5c\u8a18\u9304\u7247\u3002<\/p>\n

\u9019\u500b\u6700\u65b0\u7684\u7814\u7a76\u767c\u8868\u5728\u300a\u5fc3\u7406\u91ab\u5b78\u300b\uff08Psychological Medicine<\/em>\uff09\u671f\u520a\uff0c\u7f8e\u570b\u897f\u5317\u5927\u5b78\u7684J. Michael Bailey\u548c\u5317\u5cb8\u5927\u5b78\u91ab\u7642\u7cfb\u7d71\u7684Alan Sanders\u7b49\u4eba\u6536\u96c6\u4e86\u4f86\u81ea384\u500b\u5bb6\u5ead\u7684409\u5c0d\u540c\u6027\u6200\u5144\u5f1f\u7684\u8840\u6db2\u548c\u553e\u6db2\u6a23\u672c\uff0c\u76f8\u8f03Hamer\u7b49\u4eba\u7814\u7a76\u4e2d\u768438\u5c0d\u5144\u5f1f\uff0c\u4f7f\u7528\u7684\u4eba\u6578\u5927\u5e45\u589e\u52a0\uff0c\u6240\u4ee5\u7d71\u8a08\u4e0a\u66f4\u70ba\u6709\u529b\u3002<\/p>\n

\u63a5\u8457\u4ed6\u5011\u5229\u7528\u55ae\u6838\u82f7\u9178\u591a\u5f62\u6027\uff08single nucleotide polymorphisms\uff0cSNPs\uff09\u4f5c\u70ba\u907a\u50b3\u6a19\u8a18\u4f86\u5c0b\u627e\u9019\u4e9b\u7537\u540c\u6027\u6200\u7684\u5171\u540c\u907a\u50b3\u7279\u5fb5\uff0c\u5229\u7528\u5168\u57fa\u56e0\u9ad4\u95dc\u806f\u7814\u7a76\uff08genome-wide association studies\uff0cGWAS\uff09\u7684\u65b9\u6cd5\u4f86\u5f9e\u5168\u57fa\u56e0\u9ad4\u4e2d\u5c0b\u627e\u548c\u540c\u6027\u6200\u6709\u95dc\u7684SNPs\u3002<\/p>\n

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\u96d6\u7136\u9019\u500b\u767c\u73fe\u5f88\u91cd\u8981\uff0c\u4f46\u662f\u540c\u6027\u6200\u5f88\u6709\u53ef\u80fd\u662f\u591a\u57fa\u56e0\u907a\u50b3\uff0c\u800c\u4e14\u9084\u662f\u6703\u53d7\u5230\u74b0\u5883\u7684\u5f71\u97ff\uff0c\u4f8b\u5982\u6709\u79d1\u5b78\u5bb6\u5c31\u8a8d\u70ba\u6bcd\u89aa\u7684\u5b50\u5bae\u74b0\u5883\u6703\u5f71\u97ff\u80ce\u5152\u7684\u8868\u89c0\u907a\u50b3\uff08epigenetics\uff09\u800c\u6c7a\u5b9a\u6027\u5411\uff0c\u6240\u4ee5\u5373\u4f7f\u771f\u7684\u9451\u5b9a\u51fa\u540c\u6027\u6200\u7684\u57fa\u56e0\uff0c\u90a3\u4e9b\u57fa\u56e0\u60f3\u5fc5\u4e5f\u53ea\u626e\u6f14\u4e00\u90e8\u5206\u7684\u89d2\u8272\u3002<\/p>\n

\u7136\u800c\uff0c\u5982\u679c\u771f\u7684\u5b58\u5728\u80fd\u5920\u5f71\u97ff\u6027\u5411\u7684\u57fa\u56e0\uff0c\u90a3\u9ebc\u6027\u5411\u662f\u5426\u5c31\u50cf\u8eab\u9ad8\u3001\u667a\u5546\u3001\u9762\u8c8c\u3001\u819a\u8272\u7b49\u751f\u7269\u7279\u5fb5\u4e00\u6a23\u6709\u90e8\u5206\u662f\u907a\u50b3\u4f86\u7684\uff1f\u5982\u679c\u8aaa\u4e00\u500b\u4eba\u4e0d\u61c9\u56e0\u5176\u5148\u5929\u5148\u5929\u907a\u50b3\u4f86\u7684\u7279\u5fb5\u53d7\u5230\u6b67\u8996\uff0c\u90a3\u9ebc\u5c0d\u540c\u6027\u6200\u7684\u5404\u7a2e\u6b67\u8996\u548c\u8aa4\u89e3\u9084\u6703\u6709\u9053\u7406\u4e86\u55ce\uff1f<\/p>\n

\u53c3\u8003\u4f86\u6e90\uff1a<\/strong>
\nAndy Coghlan. Largest study of gay brothers homes in on 'gay genes'.<\/a> New Scientist. 17 November 2014.
\nChris Weller. The Red Herring 'Gay Gene,' And How Sexuality Is More Than Just Genetics.<\/a> Medical Daily. Nov 17, 2014.
\nKelly Servick. Study of gay brothers may confirm X chromosome link to homosexuality.<\/a> Science News. 17 November 2014.<\/p>\n

\u539f\u5b78\u8853\u8ad6\u6587\uff1a<\/strong>
\nHamer DH, Hu S, Magnuson VL, Hu N, Pattatucci AM.  A linkage between DNA markers on the X chromosome and male sexual orientation. Science. 1993 Jul 16;261(5119):321-7.
\nMustanski BS, et al. A genomewide scan of male sexual orientation. Hum Genet. 2005 Mar;116(4):272-8. Epub 2005 Jan 12.
\nSanders AR, et al. Genome-wide scan demonstrates significant linkage for male sexual orientation. Psychol Med. 2014 Nov 17:1-10. [Epub ahead of print]
\n--<\/strong><\/span>
\n \u4f5c\u8005\uff1a\u9ec3\u8c9e\u7965 \u73fe\u65bc\u53f0\u7063\u4e2d\u592e\u7814\u7a76\u9662\u751f\u7269\u591a\u6a23\u6027\u7814\u7a76\u4e2d\u5fc3\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u5f9e\u4e8b\u9ce5\u985e\u7684\u6f14\u5316\u907a\u50b3\u5b78\u3001\u57fa\u56e0\u9ad4\u5b78\u53ca\u6f14\u5316\u767c\u80b2 \u751f\u7269\u5b78\u7814\u7a76\u3002\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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