{"id":19080,"date":"2014-09-23T01:58:57","date_gmt":"2014-09-22T17:58:57","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=19080"},"modified":"2017-07-25T11:22:12","modified_gmt":"2017-07-25T03:22:12","slug":"%e3%80%90%e5%be%ae%e7%94%9f%e7%89%a9%e3%80%91%e7%82%ba%e4%bb%80%e9%ba%bc%e9%85%b5%e6%af%8d%e8%8f%8c%e4%b8%8d%e6%83%b3%e7%99%bc%e9%85%b5%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=19080","title":{"rendered":"\u3010\u5fae\u751f\u7269\u3011\u70ba\u4ec0\u9ebc\u9175\u6bcd\u83cc\u4e0d\u60f3\u767c\u9175\uff1f"},"content":{"rendered":"

\u25a0\u91c0\u9152\u7684\u4eba\u5927\u6982\u90fd\u66fe\u9047\u4e0a\u4e00\u7a2e\u72c0\u6cc1\uff1a\u9175\u6bcd\u83cc\u4e0d\u77e5\u9053\u70ba\u4ec0\u9ebc\u4e0d\u9032\u884c\u767c\u9175\u4f5c\u7528\uff0c\u65bc\u662f\u540c\u6a23\u5728\u9152\u6db2\u4e2d\u7684\u7d30\u83cc\u4fbf\u958b\u59cb\u5927\u91cf\u751f\u9577\u3002\u9019\u500b\u73fe\u8c61\u7a31\u70ba\u300c\u767c\u9175\u505c\u6eef\u300d\uff08stuck fermentation\uff09\uff0c\u5c0d\u65bc\u696d\u8005\u61c9\u8a72\u662f\u4e00\u7a2e\u975e\u5e38\u60f1\u4eba\u7684\u72c0\u6cc1\u3002\u7562\u7adf\uff0c\u6211\u5011\u5e0c\u671b\u9175\u6bcd\u83cc\u53ef\u4ee5\u300c\u4e56\u4e56\u7684\u300d\u767c\u9175\uff0c\u4f46\u662f\u7260\u537b\u4e0d\u77e5\u9053\u70ba\u4ec0\u9ebc\u7f77\u5de5\u4e86\u3002<\/strong><\/span><\/p>\n

\"Mthomebrew_crushed_grapes\"
\u91c0\u9152\u6700\u6015\u767c\u9175\u505c\u6eef\uff0c\u900f\u904e\u79d1\u5b78\u7814\u7a76\uff0c\u73fe\u5728\u79d1\u5b78\u5bb6\u5011\u5efa\u8b70 \u696d\u8005\uff0c\u53ef\u4ee5\u5728\u58d3\u788e\u8461\u8404\u7684\u6642\u5019\u5c31\u6dfb\u52a0\u4e8c\u6c27\u5316\u786b\u4f86\u6bba\u83cc\uff0c \u63d0\u9ad8\u767c\u9175\u6210\u529f\u7684\u6a5f\u7387\u3002\u5716\u7247\u4f86\u6e90\uff1a\u7dad\u57fa\u767e\u79d1\u3002<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n

\u901a\u5e38\u696d\u8005\u9047\u5230\u9019\u6a23\u7684\u72c0\u6cc1\uff0c\u5c31\u53ea\u80fd\u5920\u628a\u9019\u5806\u767c\u9175\u5931\u6557\u7684\u3001\u81ed\u9178\u7684\u9152\u6db2\u5012\u6389\u3001\u8655\u7406\u6389\u3002\u4f46\u662f\uff0c\u5c0d\u65bc\u79d1\u5b78\u5bb6\u4f86\u8aaa\uff0c\u9019\u537b\u662f\u4e00\u500b\u6709\u8da3\u7684\u73fe\u8c61\u3002<\/p>\n

\u56e0\u70ba\uff0c\u9175\u6bcd\u83cc\u88e1\u9762\u6709\u500b\u6a5f\u5236\uff0c\u7a31\u70ba\u300c\u8461\u8404\u7cd6\u6291\u5236\u4f5c\u7528\u300d\uff08glucose repression\uff09\u3002\u9019\u500b\u6a5f\u5236\uff0c\u4f7f\u5f97\u9175\u6bcd\u83cc\u5728\u6709\u8461\u8404\u7cd6\u5b58\u5728\u7684\u6642\u5019\uff0c\u53ea\u6703\u5229\u7528\u8461\u8404\u7cd6\uff1b\u800c\u5728\u53ea\u6709\u8461\u8404\u7cd6\u7684\u72c0\u6cc1\u4e0b\uff0c\u53c8\u4e0d\u63d0\u4f9b\u6c27\u6c23\u6642\uff0c\u9175\u6bcd\u83cc\u70ba\u4e86\u751f\u5b58\u4e0b\u53bb\uff0c\u4fbf\u6703\u5c07\u4e19\u916e\u9178\uff08pyruvate\uff0c\u8461\u8404\u7cd6\u7684\u4ee3\u8b1d\u7522\u7269\uff09\u9084\u539f\uff0c\u7522\u751f\u4e59\u9187\uff08ethanol\uff09\u8207\u4e8c\u6c27\u5316\u78b3\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u767c\u9175\u4f5c\u7528\uff08fermentation\uff09\u3002<\/p>\n

\u4f46\u662f\uff0c\u5728\u767c\u9175\u505c\u6eef\u7684\u72c0\u6cc1\u4e0b\uff0c\u9175\u6bcd\u83cc\u4e0d\u53d7\u5230\u8461\u8404\u7cd6\u6291\u5236\u4f5c\u7528\u7684\u5f71\u97ff\uff1b\u96d6\u7136\u8461\u8404\u7cd6\u5b58\u5728\uff0c\u4f46\u662f\u9175\u6bcd\u83cc\u8f49\u800c\u5229\u7528\u5176\u4ed6\u78b3\u6e90\u3002\u5728\u9019\u6a23\u7684\u72c0\u6cc1\u4e0b\uff0c\u96d6\u7136\u9175\u6bcd\u83cc\u7167\u5e38\u751f\u9577\uff0c\u4f46\u662f\u4e26\u672a\u9032\u884c\u767c\u9175\u4f5c\u7528\uff0c\u800c\u5176\u4ed6\u7684\u7d30\u83cc\u4e5f\u8ddf\u8457\u4e00\u8d77\u751f\u9577\uff0c\u65bc\u662f\u767c\u9175\u5c31\u5931\u6557\u4e86\u3002<\/p>\n

\u79d1\u5b78\u5bb6\u5011\u7814\u7a76\u5f8c\uff0c\u767c\u73fe\u9019\u500b\u767c\u9175\u505c\u6eef\u7684\u73fe\u8c61\uff0c\u662f\u56e0\u70ba\u9175\u6bcd\u83cc\u88e1\u9762\u7684\u4e00\u500b\u7a31\u70ba[GAR+<\/em>]\u7684\u666e\u5229\u6602\u86cb\u767d\uff08prion\uff09\u6240\u5c0e\u81f4\u3002\u300cGAR\u300d\u7684\u610f\u601d\u662f\u300c\u5c0d\u8461\u8404\u7cd6\u6291\u5236\u4f5c\u7528\u6709\u62b5\u6297\u529b\u300d\uff08resistant to glucose-associated repression\uff09\u7684\u610f\u601d\uff0c\u800c\u5927\u5beb\u4ee5\u53ca\u65b9\u5f62\u62ec\u865f\uff0c\u5247\u4ee3\u8868\u4e86\u5b83\u662f\u986f\u6027\u4ee5\u53ca\u975e\u5b5f\u5fb7\u723e\u907a\u50b3\u3002<\/p>\n

\u4f46\u662f\uff0c\u7a76\u7adf\u70ba\u4ec0\u9ebc\u9175\u6bcd\u83cc\u8981\u9032\u5165\u767c\u9175\u505c\u6eef\u5462\uff1f\u7562\u7adf\u8461\u8404\u7cd6\u6291\u5236\u4f5c\u7528\u4e4b\u6240\u4ee5\u6703\u5b58\u5728\uff0c\u662f\u5fae\u751f\u7269\u5011\u70ba\u4e86\u751f\u5b58\u6240\u7522\u751f\u7684\u6709\u5229\u6a5f\u5236\u3002\u5b83\u53ef\u4ee5\u8b93\u5fae\u751f\u7269\u5728\u6700\u597d\u7528\u7684\u98df\u7269\uff08\u8461\u8404\u7cd6\uff09\u5b58\u5728\u6642\uff0c\u512a\u5148\u5229\u7528\u8461\u8404\u7cd6\uff0c\u7b49\u5230\u8461\u8404\u7cd6\u8017\u76e1\u6642\uff0c\u518d\u8f49\u800c\u5229\u7528\u5176\u4ed6\u7684\u78b3\u6c34\u5316\u5408\u7269\u3002\u512a\u5148\u5229\u7528\u8461\u8404\u7cd6\uff0c\u5c0d\u751f\u5b58\u7af6\u722d\u662f\u6709\u5229\u7684\uff1b\u9019\u53ef\u4ee5\u5f9e\u767c\u9175\u505c\u6eef\u7684\u57f9\u990a\u6db2\u4e2d\u770b\u51fa\u4f86\u3002\u767c\u9175\u6210\u529f\u7684\u57f9\u990a\u6db2\u4e2d\uff0c\u7d55\u5927\u90e8\u5206\u7684\u5fae\u751f\u7269\u90fd\u662f\u9175\u6bcd\u83cc\uff1b\u800c\u767c\u9175\u505c\u6eef\u7684\u57f9\u990a\u6db2\u4e2d\uff0c\u4e0d\u50c5\u6709\u9175\u6bcd\u83cc\uff0c\u4e5f\u6709\u5927\u91cf\u7684\u7d30\u83cc\u3002\u6240\u4ee5\uff0c\u70ba\u4ec0\u9ebc\u9175\u6bcd\u83cc\u8981\u9019\u6a23\u505a\u5462\uff1f<\/p>\n

\u6700\u8fd1\u7684\u7814\u7a76\u767c\u73fe\uff0c\u539f\u4f86\u7576\u67d0\u4e9b\u7279\u5b9a\u7a2e\u985e\u7684\u7d30\u83cc\uff08\u5982\u8461\u8404\u7403\u83cc\u00a0Staphyloccus gallinarium<\/em>\uff09\u4e5f\u5b58\u5728\u65bc\u57f9\u990a\u6db2\u4e2d\u7684\u6642\u5019\uff0c\u9019\u4e9b\u7d30\u83cc\u6703\u900f\u904e\u8ddf\u9175\u6bcd\u83cc\u7684\u4e92\u52d5\uff0c\u4f7f\u5f97\u9175\u6bcd\u83cc\u7684[GAR+<\/em>]\u666e\u5229\u6602\u86cb\u767d\u88ab\u5f15\u767c\u51fa\u4f86\uff1b\u63a5\u8457\u9175\u6bcd\u83cc\u5c31\u4e0d\u518d\u5c08\u5fc3\u5229\u7528\u8461\u8404\u7cd6\uff0c\u8f49\u800c\u5229\u7528\u5176\u4ed6\u78b3\u6c34\u5316\u5408\u7269\u3002<\/p>\n

\u800c\u7576\u9175\u6bcd\u83cc\u4e0d\u518d\u5c08\u5fc3\u5229\u7528\u8461\u8404\u7cd6\u6642\uff0c\u767c\u9175\u4f5c\u7528\u5c31\u4e0d\u6703\u5927\u91cf\u767c\u751f\uff0c\u65bc\u662f\u57f9\u990a\u6db2\u5167\u7684\u9152\u7cbe\u6fc3\u5ea6\uff0c\u4fbf\u4e0d\u6703\u5982\u6b63\u5e38\u767c\u9175\u9032\u884c\u6642\u7684\u5feb\u901f\u4e0a\u6607\uff0c\u4e5f\u4e0d\u6703\u63d0\u9ad8\u5230\u7d30\u83cc\u7121\u6cd5\u5fcd\u53d7\u7684\u6fc3\u5ea6\u3002\u9019\u9ebc\u4e00\u4f86\uff0c\u7d30\u83cc\u5f97\u5230\u4e00\u500b\u8f03\u597d\u7684\u751f\u9577\u74b0\u5883\uff0c\u800c\u9175\u6bcd\u83cc\u9084\u662f\u53ef\u4ee5\u751f\u9577\uff0c\u4f3c\u4e4e\u5927\u5bb6\u662f\u7686\u5927\u6b61\u559c\u4e86--\u9664\u4e86\u91c0\u9152\u696d\u8005\u4ee5\u5916\u3002<\/p>\n

\u56e0\u6b64\uff0c\u79d1\u5b78\u5bb6\u5efa\u8b70\u91c0\u9152\u696d\u8005\uff0c\u5982\u679c\u60f3\u8981\u6709\u6548\u5730\u6291\u5236\u9019\u4e9b\u7d30\u83cc\u751f\u9577\uff0c\u53ef\u4ee5\u5728\u58d3\u788e\u8461\u8404\u6642\u5c31\u52a0\u5165\u4e8c\u6c27\u5316\u786b\uff08SO2\uff0c\u8461\u8404\u9152\u91c0\u9020\u4e2d\u6700\u5e38\u4f7f\u7528\u7684\u6bba\u83cc\u85e5\u5291\uff0c\u901a\u5e38\u5728\u767c\u9175\u524d\u4ee5\u53ca\u767c\u9175\u7d50\u675f\u5f8c\u52a0\u5165\uff09\u4f86\u6bba\u83cc\uff0c\u964d\u4f4e\u5176\u4ed6\u7684\u7d30\u83cc\u8207\u9175\u6bcd\u83cc\u300c\u804a\u5929\u300d\u7684\u6a5f\u6703\uff0c\u61c9\u8a72\u5c31\u53ef\u4ee5\u6e1b\u5c11\u767c\u9175\u505c\u6eef\u73fe\u8c61\u7684\u767c\u751f\u4e86\u3002<\/p>\n

\u81f3\u65bc\u9019\u500b\u73fe\u8c61\uff0c\u7a76\u7adf\u5c0d\u9175\u6bcd\u83cc\u672c\u8eab\u6709\u6c92\u6709\u76ca\u8655\u5462\uff1f\u7814\u7a76\u767c\u73fe\uff0c[GAR+<\/em>]\u7684\u9175\u6bcd\u83cc\uff0c\u6bd4\u539f\u4f86\u7684\u9175\u6bcd\u83cc\u66f4\u80fd\u5920\u8010\u9152\u7cbe\uff0c\u4e5f\u66f4\u80fd\u5920\u5728\u990a\u5206\u4e0d\u8db3\uff08\u4f4e\u6c28\u57fa\u9178\uff09\u7684\u74b0\u5883\u4e0b\u751f\u5b58\uff0c\u6240\u4ee5\uff0c\u90a3\u4e9b\u7d30\u83cc\u8ddf\u9175\u6bcd\u83cc\u9054\u6210\u7684\u5354\u5b9a\u4e26\u4e0d\u662f\u640d\u4eba\u5229\u5df1\uff0c\u800c\u662f\u4e92\u5229\u5171\u751f\u5462\uff01<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/strong>
\nJessica C.S. Brown and Susan Lindquist. 2009.\u00a0A heritable switch in carbon source utilization driven by an unusual yeast prion<\/a>. Genes &amp; Dev. 23: 2320-2332
\nDaniel F. Jarosz, Jessica C.S. Brown, Gordon A. Walker, Manoshi S. Datta, W. Lloyd Ung, Alex K. Lancaster, Assaf Rotem, Amelia Chang, Gregory A. Newby, David A. Weitz, Linda F. Bissonemail, Susan Lindquist. 2014.\u00a0Cross-Kingdom Chemical Communication Drives a Heritable, Mutually Beneficial Prion-Based Transformation of Metabolism<\/a>. \u00a0Cell. 158\uff085\uff09\uff1a1083\u20131093.
\nDaniel F. Jarosz, Alex K. Lancaster, Jessica C.S. Brown, Susan Lindquist. 2014.\u00a0An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists.<\/a>\u00a0Cell. 158(5)\uff1a1072\u20131082.<\/p>\n

--
\n\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/span><\/strong>
\n \u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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