{"id":18907,"date":"2014-08-18T02:47:20","date_gmt":"2014-08-17T18:47:20","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=18907"},"modified":"2017-07-25T11:39:47","modified_gmt":"2017-07-25T03:39:47","slug":"%e3%80%90%e6%99%82%e4%ba%8b%e7%84%a6%e9%bb%9e%e3%80%91%e4%bc%8a%e6%b3%a2%e6%8b%89%e7%97%85%e6%af%92%e7%9a%84%e9%86%ab%e7%99%82%e7%8f%be%e6%b3%81","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=18907","title":{"rendered":"\u3010\u6642\u4e8b\u7126\u9ede\u3011\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7684\u91ab\u7642\u73fe\u6cc1"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u8d8a\u6f14\u8d8a\u70c8\uff0c\u60c5\u6cc1\u4f3c\u4e4e\u96e3\u4ee5\u6536\u62fe\u3002\u4e0d\u904e\u6709\u6d88\u606f\u6307\u51fa\u660e(2015)\u5e74\u53ef\u80fd\u5c31\u6709\u75ab\u82d7\u4f9b\u7b2c\u4e00\u7dda\u91ab\u8b77\u4eba\u54e1\u4f7f\u7528\uff0c\u767c\u5c55\u60c5\u6cc1\u7a76\u7adf\u662f\u5982\u4f55\u5462\uff1f<\/strong><\/span><\/p>\n<figure id=\"attachment_18908\" aria-describedby=\"caption-attachment-18908\" style=\"width: 400px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-18908\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/266a1200-0239-0132-6fe7-0add9426c766-1024x768.jpg\" alt=\"266a1200-0239-0132-6fe7-0add9426c766\" width=\"400\" height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/266a1200-0239-0132-6fe7-0add9426c766-1024x768.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/266a1200-0239-0132-6fe7-0add9426c766-300x225.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/266a1200-0239-0132-6fe7-0add9426c766-800x600.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/266a1200-0239-0132-6fe7-0add9426c766-600x450.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/266a1200-0239-0132-6fe7-0add9426c766.jpg 1200w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><figcaption id=\"caption-attachment-18908\" class=\"wp-caption-text\">Ebola in Guinea (flickr Euro Comm DG ECHO)<\/figcaption><\/figure>\n<p><strong><strong>\u4f5c\u8005\uff5c<\/strong>Judy Stone<br \/>\n<\/strong><strong>\u7de8\u8b6f\uff5c<\/strong>\u9ad8\u82f1\u54f2<\/p>\n<p>\u4f0a\u6ce2\u62c9\u75ab\u60c5\u7684\u91ab\u7642\u6d88\u606f\u4e00\u5915\u6578\u8b8a\u3002\u6c11\u773e\u6700\u65e9\u63a5\u6536\u5230\u7684\u8a0a\u606f\uff0c\u662f\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u65e2\u7121\u89e3\u85e5\u4e5f\u7121\u75ab\u82d7\uff0c\u53ea\u80fd\u9760\u8f14\u52a9\u7642\u6cd5\u6e1b\u4f4e\u81f4\u6b7b\u7387\uff1b\u5f8c\u4f86\u6211\u5011\u53c8\u807d\u8aaa\u7f8e\u570b\u53ef\u80fd\u7814\u767c\u51fa\u67d0\u7a2e\u75ab\u82d7\uff0c\u660e\u5e74\u5c31\u53ef\u4ee5\u767c\u653e\u7d66\u5728\u975e\u6d32\u611f\u67d3\u5340\u9032\u884c\u9632\u75ab\u5de5\u4f5c\u7684\u7b2c\u4e00\u7dda\u4eba\u54e1\u3002<\/p>\n<p>\u9019\u6d88\u606f\u4e0d\u77e5\u9053\u662f\u4e0d\u662f\u67d0\u7a2e\u82ad\u6a02\uff0c\u56e0\u70ba\u85e5\u7269\u6216\u75ab\u82d7\u4e00\u822c\u4f86\u8aaa\uff0c\u5f9e\u7814\u767c\u5230\u901a\u904e\u5404\u7a2e\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\uff0c\u5f97\u8981\u82b1\u4e0a\u597d\u5e7e\u5e74\u7684\u6642\u9593\u3002\u5982\u679c\u6d88\u606f\u5c6c\u5be6\uff0c\u53ea\u6709\u4e0b\u9762\u5169\u7a2e\u53ef\u80fd\u6027\uff1a\u4e00\u7a2e\u60c5\u6cc1\u662f\u56e0\u70ba\u8981\u53d6\u5f97\u6709\u6548\u7684\u81e8\u5e8a\u8cc7\u6599\u592a\u904e\u56f0\u96e3\uff0c\u56e0\u6b64\u6709\u95dc\u7576\u5c40\u7279\u8a31\u5728\u53d7\u6e2c\u8005\u5b8c\u6210\u7b2c\u4e00\u968e\u6bb5\u7684\u4eba\u9ad4\u5b89\u5168\u6027\u8a66\u9a57\u4e4b\u5f8c\uff0c\u5c31\u76f4\u63a5\u63a1\u7528\u52d5\u7269\u5be6\u9a57\u7372\u5f97\u7684\u8a66\u9a57\u8cc7\u6599\uff1b\u53e6\u4e00\u7a2e\u60c5\u6cc1\u5c31\u662f\u6b7b\u99ac\u7576\u6d3b\u99ac\u91ab\uff0c\u6c92\u5225\u7684\u9078\u64c7\u6642\u52a0\u6e1b\u63a1\u7528\u3002<!--more--><\/p>\n<p>\u76ee\u524d\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u6709\u4e09\u7a2e\u53ef\u80fd\u7684\u65b0\u7642\u6cd5\uff1a<\/p>\n<p>1. Tekmira \u85e5\u5ee0\u7814\u767c\u7684 RNA \u5e72\u64fe\u85e5\u7269\uff0c\u76ee\u524d\u5df2\u5728\u9032\u884c\u7b2c\u4e00\u968e\u6bb5\u7684\u4eba\u9ad4\u8a66\u9a57\u3002\u4e0d\u904e\u9019\u7a2e\u85e5\u7269\u6709\u91cb\u653e\u51fa\u7d30\u80de\u6fc0\u7d20\u7684\u7591\u616e\uff0c\u53ef\u80fd\u6703\u5c0d\u7528\u85e5\u8005\u7522\u751f\u5668\u5b98\u8870\u7aed\u7684\u56b4\u91cd\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\u76ee\u524d\u66ab\u7de9\u9032\u884c\u9032\u4e00\u6b65\u8a66\u9a57\u3002<\/p>\n<p>2. BioCryst \u85e5\u5ee0\u7814\u767c\u7684\u6838\u82f7\u578b\u85e5\u7269\uff0c\u53ef\u7528\u4f86\u904f\u6b62\u75c5\u6bd2\u7e41\u6b96\uff0c\u76ee\u524d\u4ecd\u5728\u52d5\u7269\u8a66\u9a57\u968e\u6bb5\u3002\u7f8e\u570b\u653f\u5e9c\u4e5f\u6709\u53c3\u8207\u7814\u767c\uff0c\u4ee5\u505a\u70ba\u5c0d\u6297\u751f\u5316\u6050\u6016\u653b\u64ca\u7684\u624b\u6bb5\u3002<\/p>\n<p>3. MAPP \u85e5\u5ee0\u7814\u767c\u7684\u55ae\u682a\u6297\u9ad4\uff0c\u53ef\u7528\u4f86\u963b\u6b62\u75c5\u6bd2\u9032\u5165\u7d30\u80de\u3002\u9019\u7a2e\u85e5\u7269\u5728\u52d5\u7269\u8a66\u9a57\u4e2d\u8868\u73fe\u4e0d\u932f\uff0c\u751a\u81f3\u5728\u75c7\u72c0\u51fa\u73fe\u5f8c 48 \u5c0f\u6642\u624d\u9032\u884c\u65bd\u6253\uff0c\u4e5f\u80fd\u7522\u751f\u4e00\u5b9a\u7684\u6548\u679c\uff0c\u518d\u52a0\u4e0a\u7528\u4f86\u751f\u7522\u6297\u9ad4\u7684\u690d\u682a\uff0c\u53ea\u9700\u6578\u500b\u661f\u671f\u5c31\u80fd\u9032\u884c\u8655\u7406\uff0c\u88fd\u9020\u51fa\u85e5\u7269\uff0c\u61c9\u4ed8\u75ab\u60c5\u9700\u6c42\u7684\u80fd\u529b\u76f8\u7576\u5f37\u3002\u5169\u4f4d\u67d3\u75c5\u7684\u7f8e\u570b\u50b3\u6559\u58eb\uff0c\u64da\u50b3\u63a5\u53d7\u65bd\u6253\u7684\u5c31\u662f\u9019\u7a2e\u85e5\u7269\u3002<\/p>\n<p>\u5176\u5be6\u9664\u4e86\u9019\u4e9b\u9084\u5728\u8a66\u9a57\u968e\u6bb5\u7684\u65b0\u7642\u6cd5\u4ee5\u5916\uff0c\u50b3\u7d71\u7684\u8840\u6e05\u7642\u6cd5\uff08\u4e5f\u5c31\u662f\u5f9e\u525b\u5fa9\u539f\u7684\u75c5\u4eba\u8eab\u4e0a\u53d6\u5f97\u8840\u6e05\uff0c\u65bd\u6253\u5728\u9700\u8981\u6cbb\u7642\u7684\u75c5\u4eba\u8eab\u4e0a\uff09\u9084\u662f\u76f8\u7576\u7ba1\u7528\u7684\uff0c\u81f3\u5c11\u5728 1995 \u5e74\u7206\u767c\u7684\u4f0a\u6ce2\u62c9\u75ab\u60c5\u4e2d\uff0c\u5c31\u7372\u5f97\u9084\u7b97\u4e0d\u932f\u7684\u6210\u6548\u3002\u88fd\u4f5c\u8840\u6e05\u7684\u6280\u8853\u76f8\u5c0d\u4f86\u8aaa\u4e26\u4e0d\u7b97\u9ad8\uff0c\u8981\u61c9\u4ed8\u76ee\u524d\u897f\u975e\u7684\u75ab\u60c5\uff0c\u4ecd\u7136\u76f8\u7576\u503c\u5f97\u63a1\u7528\u3002<\/p>\n<p>\u81f3\u65bc\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7684\u75ab\u82d7\uff0c\u76ee\u524d\u4ecd\u5728\u7814\u767c\u4e2d\u3002\u75ab\u82d7\u96e3\u7522\u7684\u539f\u56e0\u6709\u5f88\u591a\u662f\u8001\u554f\u984c\uff0c\u6bd4\u65b9\u8aaa\u662f\u8981\u505a\u6210\u6d3b\u6027\u6e1b\u6bd2\u75ab\u82d7\u9084\u662f\u6b7b\u75c5\u6bd2\u75ab\u82d7\uff08\u6d3b\u6027\u6e1b\u6bd2\u75ab\u82d7\u6548\u529b\u8f03\u5f37\uff0c\u4f46\u5bb9\u6613\u7522\u751f\u526f\u4f5c\u7528\uff09\uff0c\u8a72\u5982\u4f55\u5224\u5b9a\u75ab\u82d7\u662f\u5426\u6709\u6548\uff08\u7576\u75ab\u60c5\u7206\u767c\u6642\uff0c\u4f60\u9858\u610f\u6210\u70ba\u4e0d\u65bd\u6253\u75ab\u82d7\u7684\u300c\u63a7\u5236\u7d44\u300d\u55ce\uff1f\u5373\u4f7f\u75ab\u82d7\u6709\u6c92\u6709\u6548\u90fd\u9084\u4e0d\u78ba\u5b9a\uff09\uff0c\u4ee5\u53ca\u8a72\u5982\u4f55\u4f7f\u7576\u5730\u6c11\u773e\u540c\u610f\u65bd\u6253\u75ab\u82d7\uff08\u75ab\u5340\u6c11\u773e\u666e\u904d\u4e0d\u4fe1\u4efb\u73fe\u4ee3\u91ab\u7642\uff09\u3002\u56e0\u6b64\u82e5\u662f\u771f\u7684\u7814\u767c\u51fa\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u7684\u75ab\u82d7\uff0c\u6700\u6709\u53ef\u80fd\u9078\u64c7\u6027\u5730\u65bd\u6253\u5728\u611f\u67d3\u8005\u9031\u906d\u7684\u4eba\u5011\u8eab\u4e0a\uff08\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u74b0\u5f62\u63a5\u7a2e\uff09\uff0c\u4ee5\u53ca\u8b93\u7b2c\u4e00\u7dda\u7684\u91ab\u7642\u7167\u8b77\u4eba\u54e1\u512a\u5148\u63a5\u7a2e\uff0c\u4ee5\u6700\u6709\u6548\u7387\u7684\u65b9\u5f0f\u9810\u9632\u611f\u67d3\u3002<\/p>\n<p>\u4e0d\u904e\u7814\u767c\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u75ab\u82d7\u6700\u9ebb\u7169\u7684\u554f\u984c\uff0c\u5728\u65bc\u75ab\u60c5\u767c\u751f\u7684\u6b21\u6578\u4e26\u4e0d\u983b\u7e41\uff0c\u53c8\u96c6\u4e2d\u767c\u751f\u5728\u975e\u6d32\uff0c\u7f8e\u570b\u7684\u5927\u85e5\u5ee0\u89ba\u5f97\u7121\u5229\u53ef\u5716\uff0c\u5c31\u6c92\u6709\u52d5\u529b\u6295\u8cc7\u5728\u5fc5\u8981\u7684\u7814\u767c\u5de5\u4f5c\u4e0a\u3002\u8af7\u523a\u7684\u662f\u9019\u7a2e\u4ee5\u5229\u76ca\u70ba\u672c\u7684\u52d5\u6a5f\uff0c\u537b\u4f7f\u5f97\u7531\u8afe\u83ef\u85e5\u5ee0\u7814\u767c\uff0c\u5728\u6b50\u6d32\u96a8\u8655\u53ef\u5f97\u7684\u6d41\u884c\u6027\u8166\u810a\u9ad3\u819c\u708e\u75ab\u82d7 Bexsero \uff0c\u4e26\u672a\u5728\u7f8e\u570b\u7533\u8acb\u4e0a\u5e02\uff08\u56e0\u70ba\u8afe\u83ef\u85e5\u5ee0\u8a8d\u70ba\u7f8e\u570b\u6700\u591a\u53ea\u6703\u7206\u767c\u96f6\u661f\u75ab\u60c5\uff0c\u7533\u8acb\u4e0a\u5e02\u4e0d\u6577\u6210\u672c\uff09\uff0c\u5c0e\u81f4\u666e\u6797\u65af\u9813\u4ee5\u53ca\u8056\u5854\u82ad\u82ad\u62c9\u5730\u5340\u5728\u53bb\u5e74\u7206\u767c\u50b3\u67d3\u75ab\u60c5\u3002\u5982\u679c\u7f8e\u570b\u7e7c\u7e8c\u7528\u9019\u7a2e\u81ea\u6383\u9580\u524d\u96ea\u7684\u614b\u5ea6\u9032\u884c\u9632\u75ab\u7814\u767c\u5de5\u4f5c\uff0c\u842c\u4e00\u75ab\u60c5\u7a81\u7834\u822a\u7a7a\u7ba1\u5236\u62b5\u9054\u7f8e\u570b\uff0c\u5c07\u6703\u5f97\u4e0d\u511f\u5931\u3002<\/p>\n<p>\u7121\u8ad6\u5c0d\u6297\u4f0a\u6ce2\u62c9\u7684\u7642\u6cd5\u6216\u75ab\u82d7\u7814\u767c\u9032\u5c55\u5982\u4f55\uff0c\u6211\u5011\u90fd\u4e0d\u8a72\u5ffd\u7565\u8f14\u52a9\u6027\u91ab\u7642\u7167\u8b77\u7684\u91cd\u8981\u6027\u3002\u4ee5\u6557\u8840\u75c7\u70ba\u4f8b\uff0c\u7121\u8ad6\u4f60\u4f7f\u7528\u54ea\u4e00\u7a2e\u85e5\u5291\uff0c\u9810\u4f30\u6b7b\u4ea1\u7387\u5927\u7d04\u90fd\u5728 50% \u5de6\u53f3\uff1b\u4e0d\u904e\u5018\u82e5\u60a3\u8005\u6709\u63a5\u53d7\u5b8c\u5584\u7684\u8f14\u52a9\u6027\u91ab\u7642\u7167\u8b77\uff0c\u6b7b\u4ea1\u7387\u4fbf\u53ef\u9a5f\u964d\u5230 10% ~ 15% \u3002\u82e5\u662f\u80fd\u5920\u70ba\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u60a3\u8005\u63d0\u4f9b\u76f8\u540c\u7684\u5b8c\u5584\u7167\u8b77\uff0c\u5373\u4f7f\u6c92\u6709\u4efb\u4f55\u65b0\u85e5\u6216\u75ab\u82d7\u53ef\u7528\uff0c\u90fd\u53ef\u4ee5\u5927\u5927\u6e1b\u5c11\u751f\u547d\u7684\u640d\u5931\u3002<br \/>\n<strong>--<br \/>\n\u7814\u7a76\u51fa\u8655\uff1a<a href=\"http:\/\/blogs.scientificamerican.com\/molecules-to-medicine\/2014\/08\/05\/ebola-and-priorities-in-drug-development\/\" target=\"_blank\" rel=\"noopener noreferrer\">Ebola and Priorities in Drug Development<\/a><\/strong><br \/>\n<span style=\"color: #333399;\"><strong> \u8b6f\u8005\uff1a\u9ad8\u82f1\u54f2 \u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u7de8\u8b6f\u3002<\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong> \u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u4f0a\u6ce2\u62c9\u75c5\u6bd2\u8d8a\u6f14\u8d8a\u70c8\uff0c\u60c5\u6cc1\u4f3c\u4e4e\u96e3\u4ee5\u6536\u62fe\u3002<\/p>\n","protected":false},"author":20,"featured_media":18908,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1386,1921,1128,1387,714],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/266a1200-0239-0132-6fe7-0add9426c766.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18907"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18907"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18907\/revisions"}],"predecessor-version":[{"id":28799,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18907\/revisions\/28799"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/18908"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18907"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18907"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}