{"id":18884,"date":"2014-08-21T02:30:25","date_gmt":"2014-08-20T18:30:25","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=18884"},"modified":"2017-07-25T11:34:40","modified_gmt":"2017-07-25T03:34:40","slug":"%e3%80%90%e7%94%9f%e7%90%86%e7%a7%91%e5%ad%b8%e3%80%91%e5%81%a5%e5%ba%b7%e7%9a%84%e5%a4%9c%e8%b2%93%e5%ad%90%e5%9c%a8%e6%9c%aa%e4%be%86%e6%98%af%e5%90%a6%e5%8f%af%e8%83%bd%e5%91%a2%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=18884","title":{"rendered":"\u3010\u751f\u7406\u79d1\u5b78\u3011\u672a\u4f86\u662f\u5426\u53ef\u80fd\u6709\u5065\u5eb7\u7684\u591c\u8c93\u5b50\u5462\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0CASE PRESS\u7684\u8b80\u8005\u5011\u662f\u5426\u6709\u4eba\u662f\u591c\u8c93\u5b50\u5462\uff1f\u91ab\u751f\u5e38\u8aaa\u7576\u591c\u8c93\u5b50\u5c0d\u8eab\u9ad4\u4e0d\u597d\uff0c\u90a3\u9ebc\u672a\u4f86\u6709\u6c92\u6709\u53ef\u80fd\u900f\u904e\u67d0\u4e9b\u65b9\u6cd5\u7576\u300c\u5065\u5eb7\u7684\u591c\u8c93\u5b50\u300d\u5462\uff1f<\/strong><\/span><\/p>\n<figure id=\"attachment_18886\" aria-describedby=\"caption-attachment-18886\" style=\"width: 470px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-18886\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/140813132041-large.jpg\" alt=\"140813132041-large\" width=\"470\" height=\"313\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/140813132041-large.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/140813132041-large-300x199.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/140813132041-large-600x400.jpg 600w\" sizes=\"(max-width: 470px) 100vw, 470px\" \/><figcaption id=\"caption-attachment-18886\" class=\"wp-caption-text\">Credit: \u00a9 DigitalGenetics \/ Fotolia<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong>\u8449\u7da0\u8212<\/p>\n<p>\u5927\u5bb6\u61c9\u8a72\u90fd\u6709\u71ac\u591c\u7684\u7d93\u9a57\u5427\uff01\u7531\u65bc\u6211\u5011\u4e26\u975e\u591c\u884c\u52d5\u7269\uff0c\u6240\u4ee5\u71ac\u591c\u5c0d\u6211\u5011\u90fd\u662f\u5f88\u8f9b\u82e6\u7684\u7d93\u9a57\uff0c\u800c\u7531\u7814\u7a76\u53ef\u77e5\uff0c\u8f2a\u73ed\u5de5\u4f5c\u8005\u66f4\u6703\u56e0\u70ba\u665d\u591c\u985b\u5012\u800c\u7522\u751f\u8a31\u591a\u554f\u984c\uff1a\u5305\u62ec\u5fc3\u81df\u75c5\u3001\u80a5\u80d6\u4ee5\u53ca\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u7b49\u75be\u75c5\uff0c\u76ee\u524d\u90fd\u88ab\u8a8d\u70ba\u8207\u8f2a\u73ed\u5de5\u4f5c\u6709\u95dc\u3002<\/p>\n<p>\u7136\u800c\uff0c\u8f2a\u73ed\u5de5\u4f5c\u6240\u7522\u751f\u7684\u554f\u984c\uff0c\u6211\u5011\u5728\u8de8\u591a\u500b\u6642\u5340\u65c5\u884c\u6642\u4e5f\u6703\u767c\u751f\u3002\u7576\u6211\u5011\u7531\u53f0\u7063\u642d\u98db\u6a5f\u5230\u7f8e\u570b\u6642\uff0c\u90fd\u7d93\u6b77\u904e\u6240\u8b02\u7684\u300c\u8abf\u6642\u5dee\u300d\u7684\u904e\u7a0b\uff1a\u7c21\u55ae\u8aaa\u5c31\u662f\u8981\u4ee5\u665d\u4f5c\u591c\u3002\u4e00\u958b\u59cb\u90fd\u6703\u5f88\u96e3\u53d7\uff0c\u5927\u5bb6\u7761\u5f97\u6b63\u9999\u7684\u6642\u5019\u4f60\u537b\u4e86\u7121\u7761\u610f\uff0c\u7b49\u5230\u5927\u5bb6\u7cbe\u795e\u6296\u64fb\u7684\u6642\u5019\u63db\u4f60\u660f\u660f\u6b32\u7761...<!--more--><\/p>\n<p>\u4f46\u662f\u65e2\u7136\u53eb\u505a\u300c\u8abf\u6642\u5dee\u300d\uff0c\u4e5f\u5c31\u662f\u8aaa\u9019\u500b\u73fe\u8c61\u662f\u53ef\u4ee5\u6539\u8b8a\u7684\u3002\u901a\u5e38\u5c11\u5247\u4e00\u5169\u5929\uff0c\u591a\u5247\u4e00\u9031\uff0c\u5c31\u53ef\u4ee5\u8b93\u6211\u5011\u7684\u4f5c\u606f\u8207\u7576\u5730\u5b8c\u5168\u4e00\u81f4\u4e86\u3002\u70ba\u4ec0\u9ebc\u53ef\u4ee5\u9019\u6a23\u8abf\u6574\u5462\uff1f<\/p>\n<p>\u904e\u53bb\u7684\u7814\u7a76\u8b93\u6211\u5011\u4e86\u89e3\uff0c\u6211\u5011\u7684\u8166\u4e2d\u6709\u6240\u8b02\u7684\u300c\u8996\u4ea4\u53c9\u4e0a\u6838\u300d\uff08suprachiasmatic nucleus\uff0cSCN\uff09\u64d4\u4efb\u300c\u4e3b\u6642\u9418\u300d\uff08master clock\uff09\u3002\u8996\u4ea4\u53c9\u4e0a\u6838\u4f4d\u65bc\u4e0b\u8996\u4e18\uff0c\u7531\u5169\u842c\u500b\u795e\u7d93\u5143\u7d44\u6210\u3002\u96d6\u7136\u5927\u8166\u795e\u7d93\u5143\u4e4b\u9593\u90fd\u6709\u5f88\u591a\u3001\u5f88\u7dca\u5bc6\u7684\u806f\u7e6b\uff0c\u4f46\u662f\u4f4d\u65bc\u8996\u4ea4\u53c9\u4e0a\u6838\u7684\u9019\u4e9b\u795e\u7d93\u5143\u4e4b\u9593\u7684\u806f\u7e6b\uff0c\u6bd4\u4e00\u822c\u5927\u8166\u795e\u7d93\u5143\u4e4b\u9593\u7684\u806f\u7e6b\u66f4\u591a\u4e5f\u66f4\u7dca\u5bc6\u3002<\/p>\n<figure id=\"attachment_18885\" aria-describedby=\"caption-attachment-18885\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-18885\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/Circadian_rhythm_labeled.jpg\" alt=\"\u65e5\u5149\u3001\u8996\u4ea4\u53c9\u4e0a\u6838\u3001\u8207\u751f\u7269\u6642\u9418\u4e4b\u9593\u7684\u95dc\u4fc2\u3002 \u5716\u7247\u4f86\u6e90\uff1a\u7dad\u57fa\u767e\u79d1\" width=\"400\" height=\"267\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/Circadian_rhythm_labeled.jpg 400w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/Circadian_rhythm_labeled-300x200.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><figcaption id=\"caption-attachment-18885\" class=\"wp-caption-text\">\u65e5\u5149\u3001\u8996\u4ea4\u53c9\u4e0a\u6838\u3001\u8207\u751f\u7269\u6642\u9418\u4e4b\u9593\u7684\u95dc\u4fc2\u3002<br \/>\u5716\u7247\u4f86\u6e90\uff1a\u7dad\u57fa\u767e\u79d1<\/figcaption><\/figure>\n<p>\u7d93\u7531\u8996\u89ba\u8ff4\u8def\uff08vision circuits\uff09\u8f38\u5165\u665d\u591c\u5faa\u74b0\u7684\u898f\u5f8b\uff0c\u63d0\u4f9b\u7d66\u8996\u4ea4\u53c9\u4e0a\u6838\uff0c\u7136\u5f8c\u518d\u7531\u8996\u4ea4\u53c9\u4e0a\u6838\u4f86\u7dad\u6301\u6211\u5011\u6bcf\u5929\u7684\u4f5c\u606f\u898f\u5f8b\u3002\u7576\u6211\u5011\u9032\u884c\u6a6b\u8de8\u591a\u500b\u6642\u5340\u7684\u65c5\u884c\u6642\uff0c\u7531\u65bc\u5728\u982d\u5e7e\u5929\uff0c\u8996\u4ea4\u53c9\u4e0a\u6838\u7684\u795e\u7d93\u5143\u53ea\u7d04\u6709\u7565\u5c11\u65bc\u4e00\u534a\u53ef\u4ee5\u88ab\u8996\u89ba\u8ff4\u8def\u6240\u8f38\u5165\u7684\u65e5\u5149\u4fe1\u606f\u7d66\u300c\u91cd\u8a2d\u300d\uff08reset\uff09\uff0c\u9020\u6210\u6211\u5011\u767c\u751f\u9700\u8981\u300c\u8abf\u6642\u5dee\u300d\u7684\u72c0\u6cc1\u3002\u70ba\u4ec0\u9ebc\u8abf\u6642\u5dee\u6703\u9019\u9ebc\u6162\u5462\uff1f\u4e3b\u8981\u662f\u56e0\u70ba\u8996\u4ea4\u53c9\u4e0a\u6838\u7684\u795e\u7d93\u5143\u4e4b\u9593\u7684\u7dca\u5bc6\u806f\u7e6b\uff0c\u9020\u6210\u96d6\u7136\u65e5\u5149\u53ef\u4ee5\u300c\u91cd\u8a2d\u300d\u9019\u4e9b\u795e\u7d93\u5143\uff0c\u4f46\u662f\u300c\u91cd\u8a2d\u300d\u7684\u901f\u5ea6\u537b\u76f8\u7576\u7de9\u6162\u3002<\/p>\n<p>\u9019\u5c31\u8b93\u79d1\u5b78\u5bb6\u5011\u60f3\u5230\uff0c\u5982\u679c\u9019\u500b\u91cd\u8a2d\u7684\u52d5\u4f5c\u53ef\u4ee5\u5feb\u4e00\u9ede\uff0c\u6216\u8005\u5982\u679c\u6211\u5011\u53ef\u4ee5\u627e\u5230\u91cd\u8a2d\u7684\u95dc\u9375\uff0c\u8a2d\u8a08\u4ec0\u9ebc\u85e5\u7269\u53ef\u4ee5\u5f71\u97ff\u9019\u500b\u91cd\u8a2d\u7684\u95dc\u9375\uff0c\u5982\u6b64\u4e00\u4f86\uff0c\u6216\u8a31\u5728\u672a\u4f86\u53ef\u4ee5\u6709\u300c\u5065\u5eb7\u7684\u591c\u8c93\u5b50\u300d\u4e5f\u4e0d\u4e00\u5b9a\uff1f\u6709\u53ef\u80fd\u55ce\uff1f<\/p>\n<p>\u6700\u8fd1\uff0c\u5728\u6c99\u514b\u7814\u7a76\u6240\uff08The Salk Institute\uff09\u7684\u7814\u7a76\u5718\u968a\uff0c\u627e\u5230\u4e86Lhx1\u57fa\u56e0\uff0c\u6216\u8a31\u5c31\u662f\u9019\u500b\u554f\u984c\u7684\u7b54\u6848\u3002<\/p>\n<p>\u7814\u7a76\u5718\u968a\u5148\u5c07\u5c0f\u9f20\u7684\u665d\u591c\u7bc0\u5f8b\u5f04\u4e82\uff0c\u7136\u5f8c\u6bd4\u8f03\u8996\u4ea4\u53c9\u4e0a\u6838\u8207\u4e00\u822c\u7d44\u7e54\u7684\u57fa\u56e0\u8868\u73fe\uff0c\u627e\u51fa\u4e86213\u500b\u57fa\u56e0\u70ba\u8996\u4ea4\u53c9\u4e0a\u6838\u6240\u7368\u6709\uff1b\u63a5\u8457\uff0c\u518d\u7531\u9019213\u500b\u57fa\u56e0\u4e2d\uff0c\u627e\u5230\u4e8613\u500b\u8ca0\u8cac\u958b\u95dc\u5176\u4ed6\u57fa\u56e0\u7684\u57fa\u56e0\u3002\u5728\u901913\u500b\u57fa\u56e0\u4e2d\uff0c\u53ea\u6709Lhx1\u53d7\u5230\u5149\u7684\u6291\u5236\u3002<\/p>\n<p>\u904e\u53bb\u53ea\u77e5\u9053Lhx1\u5c0d\u795e\u7d93\u5143\u7684\u767c\u80b2\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u6b64\u7f3a\u4e4fLhx1\u7684\u5c0f\u9f20\u7121\u6cd5\u5b58\u6d3b\uff1b\u4f46\u4e26\u4e0d\u77e5\u9053\u5b83\u8207\u751f\u7269\u6642\u9418\u76f8\u95dc\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u5718\u968a\u5148\u5728Lhx1\u8868\u73fe\u91cf\u964d\u4f4e\u7684\u5c0f\u9f20\u4e2d\u89c0\u5bdf\u4ed6\u5011\u7684\u8996\u795e\u7d93\u4e0a\u6838\u795e\u7d93\u5143\u7684\u6d3b\u52d5\u72c0\u6cc1\u3002\u4ed6\u5011\u767c\u73fe\uff0c\u7576Lhx1\u8868\u73fe\u91cf\u964d\u4f4e\u6642\uff0c\u96d6\u7136\u8996\u795e\u7d93\u4e0a\u6838\u7684\u795e\u7d93\u5143\u5011\u5404\u81ea\u4ecd\u7136\u5b58\u5728\u8457\u665d\u591c\u7bc0\u5f8b\uff0c\u4f46\u662f\u6574\u500b\u8996\u795e\u7d93\u4e0a\u6838\u537b\u5448\u73fe\u4e0d\u540c\u6b65\u7684\u72c0\u614b\u3002<\/p>\n<p>\u63a5\u8457\uff0c\u7814\u7a76\u5718\u968a\u5c07\u5c0f\u9f20\u5011\u7684\u4f5c\u606f\u79fb\u52d5\u516b\u5c0f\u6642\uff0c\u767c\u73fe\u964d\u4f4e\u6216\u4e0d\u8868\u73feLhx1\u7684\u5c0f\u9f20\uff0c\u53ef\u4ee5\u5f88\u8f15\u9b06\u7684\u9069\u61c9\u6642\u5dee\u3002\u9019\u4ee3\u8868\u4e86\uff0c\u5982\u679c\u53ef\u4ee5\u627e\u5230\u4eba\u985e\u7248\u672c\u7684Lhx1\uff0c\u4e26\u5728\u8de8\u6642\u5340\u65c5\u884c\u6642\uff0c\u9810\u5148\u4f7f\u7528\u85e5\u7269\u6539\u8b8aLhx1\u7684\u8868\u73fe\uff0c\u6216\u8a31\u6211\u5011\u4e5f\u53ef\u4ee5\u8f15\u9b06\u7684\u8abf\u6574\u6642\u5dee\u4e86\uff1f\uff01<\/p>\n<p>\u96d6\u7136\u9019\u500b\u60f3\u6cd5\u807d\u8d77\u4f86\u5f88\u68d2\uff0c\u4f46\u662f\u7531\u65bc\u8996\u795e\u7d93\u4e0a\u6838\u4f4d\u65bc\u4e0b\u8996\u4e18\u5167\uff0c\u4e5f\u5c31\u662f\u8aaa\uff0c\u9019\u500b\u85e5\u7269\u5fc5\u9700\u8981\u80fd\u5920\u901a\u904e\u8840\u8166\u969c\u58c1\uff08Blood-Brain Barrier\uff0cBBB\uff09\uff0c\u9019\u90e8\u5206\u5176\u5be6\u4e26\u4e0d\u5bb9\u6613\u5594\uff01<\/p>\n<p>\u4e0d\u904e\uff0c\u7531\u65bc\u964d\u4f4e\u6216\u4e0d\u8868\u73feLhx1\u7684\u5c0f\u9f20\uff0c\u540c\u6642\u4e5f\u6703\u5f71\u97ff\u53e6\u4e00\u500b\u57fa\u56e0\uff1aVip\uff08vasoactive intestinal peptide\uff09\u7684\u8868\u73fe\uff0c\u800cVip\u86cb\u767d\u5728\u5c0f\u9f20\u5be6\u9a57\u4e2d\u4e5f\u53ef\u4ee5\u4f7f\u8996\u795e\u7d93\u4e0a\u6838\u6062\u5fa9\u540c\u6b65\uff0c\u6216\u8a31\u53ef\u4ee5\u7d93\u7531\u5f71\u97ffVip\u4f86\u5f71\u97ff\u8996\u795e\u7d93\u4e0a\u6838\uff0c\u5f9e\u800c\u4f7f\u8de8\u6642\u5340\u65c5\u884c\u8005\u8207\u8f2a\u73ed\u5de5\u4f5c\u8005\u80fd\u5920\u66f4\u8f15\u9b06\u7684\u8abf\u6574\u6642\u5dee\uff1f\u9019\u807d\u4f86\u975e\u5e38\u6709\u8da3\uff0c\u4e0d\u904e\u7b46\u8005\u8a8d\u70ba\uff0c\u662f\u5426\u80fd\u7d93\u7531\u8abf\u6574\u300c\u4e3b\u6642\u9418\u300d\u800c\u9054\u6210\u8abf\u6574\u5168\u8eab\u4ee3\u8b1d\u7684\u76ee\u7684\uff0c\u53ef\u80fd\u9084\u9700\u8981\u9032\u4e00\u6b65\u7684\u8a55\u4f30\uff1b\u7576\u7136\uff0c\u5982\u679c\u771f\u7684\u53ef\u4ee5\uff0c\u5c0d\u65bc\u8f2a\u73ed\u5de5\u4f5c\u8005\u61c9\u8a72\u662f\u500b\u5f88\u5927\u7684\u798f\u97f3\uff0c\u7562\u7adf\u6c92\u6709\u4eba\u6703\u60f3\u8981\u56e0\u70ba\u4e0a\u591c\u73ed\u800c\u640d\u5931\u4e86\u5065\u5eb7\u4e0d\u662f\u55ce\uff1f<\/p>\n<p>\u53c3\u8003\u6587\u737b\uff1a2014\/8\/13\u00a0Single gene controls jet lag, study finds. Science Daily.<br \/>\n--<br \/>\n<strong><span style=\"color: #333399;\">\u4f5c\u8005\uff1a\u8449\u7da0\u8212\u3000\u6148\u6fdf\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u52a9\u7406\u6559\u6388\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u5beb\u4f5c\u3002<\/span><\/strong><br \/>\n<strong><span style=\"color: #333399;\"> \u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0CASE PRESS\u7684\u8b80\u8005\u5011\u662f\u5426\u6709\u4eba\u662f<\/p>\n","protected":false},"author":20,"featured_media":18886,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257,3293,791],"tags":[1384,1383,1085,1172],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/08\/140813132041-large.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18884"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18884"}],"version-history":[{"count":8,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18884\/revisions"}],"predecessor-version":[{"id":18906,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18884\/revisions\/18906"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/18886"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}