{"id":18686,"date":"2014-08-11T03:31:12","date_gmt":"2014-08-10T19:31:12","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=18686"},"modified":"2017-03-31T23:16:54","modified_gmt":"2017-03-31T15:16:54","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e6%96%b0%e7%9f%a5%e3%80%91%e7%87%83%e8%84%82%e6%96%b0%e5%a6%99%e6%96%b9-%e6%a3%95%e5%8c%96%e8%84%82%e8%82%aa","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=18686","title":{"rendered":"\u3010\u91ab\u5b78\u65b0\u77e5\u3011\u71c3\u8102\u65b0\u5999\u65b9----\u68d5\u5316\u8102\u80aa"},"content":{"rendered":"

\u25a0\u70ba\u4e86\u6e1b\u80a5\uff0c\u4eba\u4eba\u7121\u6240\u4e0d\u7528\u5176\u6975\uff0c\u5c31\u662f\u8981\u7529\u6389\u4e00\u8eab\u7684\u80a5\u6cb9\uff0c\u8981\u662f\u6709\u66f4\u8f15\u9b06\u7684\u6e1b\u80a5\u65b9\u6cd5\u8a72\u6709\u591a\u597d\uff0c\u4f8b\u5982\u6162\u8d70\u6642\u8b93\u8eab\u9ad4\u4ee5\u70ba\u662f\u5728\u5feb\u8dd1\uff0c\u9032\u800c\u71c3\u71d2\u66f4\u591a\u8102\u80aa\u3002\u96d6\u7136\u73fe\u4eca\u4ecd\u6c92\u8fa6\u6cd5\u6539\u8b8a\u4eba\u9ad4\u7684\u8102\u80aa\u71c3\u71d2\u901f\u5ea6\uff0c\u4f46\u5c0f\u9f20\u5be6\u9a57\u8b49\u5be6\u9019\u9084\u662f\u6709\u53ef\u80fd\u767c\u751f\u7684\u3002\u5169\u7d44\u7814\u7a76\u5718\u968a\u8868\u793a\uff0c\u555f\u52d5\u8102\u80aa\u5167\u7684\u514d\u75ab\u7cfb\u7d71\uff0c\u80fd\u4f7f\u8102\u80aa\u7684\u985e\u578b\u5f9e\u5132\u5b58\u71b1\u91cf\u8b8a\u6210\u71c3\u71d2\u71b1\u91cf\uff0c\u9084\u80fd\u5e6b\u52a9\u6cbb\u7642\u904e\u5ea6\u80a5\u80d6\u548c\u7f79\u60a3\u7cd6\u5c3f\u75c5\u7684\u60a3\u8005\u3002<\/strong><\/span><\/p>\n

\"RT_news_jun06_bikemouse\"\u4f5c\u8005\uff5c<\/strong>Jennifer Couzin-Frankel
\n<\/a>\u7de8\u8b6f\uff5c<\/strong>\u6797\u6021\u5fb7<\/p>\n

\u8102\u80aa\u7684\u985e\u578b\u6709\u5169\u7a2e\uff1a\u767d\u8272\u548c\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u3002\u6210\u5e74\u4eba\u9ad4\u5167\u7684\u8102\u80aa\u5e7e\u4e4e\u90fd\u5c6c\u65bc\u767d\u8272\u8102\u80aa\u7d44\u7e54(white adipose tissue)\uff1b\u800c\u68d5\u8272\u8102\u80aa\u7d44\u7e54(brown adipose tissue)\uff0c\u591a\u898b\u65bc\u5b30\u5152\u9ad4\u5167\uff0c\u6703\u96a8\u8457\u5e74\u9f61\u589e\u9577\u6f38\u6f38\u6d88\u5931\uff1b\u5176\u4e3b\u8981\u529f\u80fd\u662f\u79a6\u5bd2\uff0c\u5728\u5927\u591a\u6578\u51ac\u7720\u7684\u52d5\u7269\u9ad4\u5167\u53ef\u898b\u3002\u5be6\u9a57\u767c\u73fe\uff0c\u66dd\u9732\u65bc\u5bd2\u51b7\u4e0b\u7684\u5c0f\u9f20\uff0c\u5176\u90e8\u5206\u767d\u8272\u8102\u80aa\u6703\u77ed\u66ab\u8b8a\u6210\u68d5\u8272\uff0c\u521d\u671f\u7684\u4eba\u9ad4\u7814\u7a76\u4e5f\u6709\u985e\u4f3c\u60c5\u6cc1\uff0c\u8102\u80aa\u68d5\u5316(browning)\u6703\u5f62\u6210\u7c73\u8272\u8102\u80aa(beige fat)\u3001\u71c3\u71d2\u8102\u80aa\u4e26\u7522\u751f\u71b1\u80fd\u3002\u52a0\u5dde\u5927\u5b78(University of California)\u7684\u751f\u7406\u5b78\u5bb6Ajay Chawla\u8868\u793a\uff0c\u76ee\u524d\u53ea\u77e5\u9053\u5bd2\u51b7\u80fd\u8a98\u767c\u68d5\u8272\u6216\u7c73\u8272\u8102\u80aa\u5f62\u6210\uff0c\u5e0c\u671b\u80fd\u4e86\u89e3\u5176\u4e2d\u539f\u7406\uff0c\u88fd\u9020\u5176\u4ed6\u8a98\u56e0\u68d5\u5316\u8102\u80aa\u3002<\/p>\n

\"sn-diabetes\"
\u5169\u7d44\u7814\u7a76\u5718\u968a\u63d0\u51fa\u5169\u7a2e\u300c\u68d5\u5316\u300d(browning)\u5c0f\u9f20\u8102\u80aa\u7684\u8fa6\u6cd5\uff0c\u53ef\u589e\u52a0\u5361\u8def\u91cc\u7684\u6d88\u8017\u3002\u4e0a\u5716\u70ba\u6b63\u5b50\u65b7\u5c64\u6383\u63cf(PET scan)\uff0c\u7da0\u8272\u5340\u584a\u70ba\u68d5\u8272\u8102\u80aa\uff0c\u7d05\u8272\u5247\u662f\u4ee3\u8b1d\u8f03\u65fa\u76db\u7684\u90e8\u5206\u3002<\/figcaption><\/figure>\n

\u7814\u7a76\u5718\u968a\u63a8\u8ad6\uff0c\u5bd2\u51b7\u6703\u6d3b\u5316\u767d\u8272\u8102\u80aa\u5167\u7684\u514d\u75ab\u7d30\u80de---\u5de8\u566c\u7d30\u80de(macrophage)\u3002\u7814\u7a76\u4eba\u54e1\u4f7f\u7f3a\u4e4f\u767d\u7d30\u80de\u4ecb\u7d204(interleukin- 4, IL-4)\u548c13\u7684\u5c0f\u9f20\u66b4\u9732\u65bc\u5bd2\u51b7\u4e2d\uff0c\u6b64\u7a2e\u4ecb\u7d20\u70ba\u4e00\u7a2e\u86cb\u767d\u8cea\uff0c\u53ef\u8a98\u767c\u5de8\u566c\u7d30\u80de\u3002\u5be6\u9a57\u7d50\u679c\u986f\u793a\uff0c\u6bd4\u8d77\u6b63\u5e38\u5c0f\u9f20\uff0c\u9019\u4e9b\u5c0f\u9f20\u771f\u7684\u7522\u751f\u8f03\u5c11\u7684\u7c73\u8272\u8102\u80aa\uff0c\u8b49\u5be6\u5de8\u566c\u7d30\u80de\u548c\u68d5\u5316\u53cd\u61c9\u6709\u5bc6\u5207\u7684\u95dc\u4fc2\u3002<\/p>\n

\u65e2\u7136\u5982\u6b64\uff0c\u90a3\u9ebc\u5982\u679c\u7d66\u4e88\u8212\u9069\u6eab\u5ea6\u4e0b\u5065\u5eb7\u7684\u5c0f\u9f20\u767d\u7d30\u80de\u4ecb\u7d204\uff0c\u5c31\u80fd\u7522\u751f\u66f4\u591a\u7c73\u8272\u8102\u80aa\u56c9\uff1fChawla\u7684\u7814\u7a76\u5718\u968a\u8868\u793a\u7b54\u6848\u662f\u80af\u5b9a\u7684\uff01\u7d66\u4e88\u651d\u6c0f30\u5ea6\u4e0b\u7684\u52d5\u7269\u767d\u7d30\u80de\u4ecb\u7d204\u5f8c\uff0c\u8868\u73fe\u65bc\u7c73\u8272\u8102\u80aa\u4e2d\u5e6b\u52a9\u8eab\u9ad4\u7522\u751f\u71b1\u91cf\u7684\u86cb\u767d\u8ceaUCP1\uff0c\u6578\u91cf\u589e\u52a0\u4e8615\u500d\uff0c\u80fd\u91cf\u6d88\u8017\u4e5f\u589e\u52a0\u4e8615%-20%\uff0c\u5c31\u50cf\u8655\u65bc\u5bd2\u51b7\u7684\u60c5\u6cc1\u3002<\/p>\n

\u54c8\u4f5b\u91ab\u5b78\u9662\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662(Dana-Farber Cancer Institute)\u7684\u7d30\u80de\u751f\u7269\u5b78\u5bb6\u66a8\u751f\u7269\u5316\u5b78\u5bb6Bruce Spiegelman\u548cRajesh Rao\u4e5f\u8457\u624b\u7814\u7a76\u5c0f\u9f20\u8102\u80aa\u68d5\u5316\u7684\u53cd\u61c9\uff0c\u4ed6\u5011\u767c\u73fe\u7576\u53e6\u4e00\u7a2e\u86cb\u767d\u8ceaPGC-1\u8868\u73fe\u65bc\u808c\u8089\u7d44\u7e54\u4e2d\u6642\uff0c\u80fd\u8a98\u767c\u8102\u80aa\u7d44\u7e54\u68d5\u5316\u3002\u6b64\u5916\uff0c\u66f4\u6709\u4e00\u7a2e\u57fa\u56e0\u6703\u5728\u86cb\u767d\u8ceaPGC-1\u51fa\u73fe\u6642\u6d3b\u5316\uff0c\u80fd\u76f4\u63a5\u5f71\u97ff\u8102\u80aa\u68d5\u5316\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u8aaa\u660e\uff0c\u6b64\u7a2e\u57fa\u56e0\u6703\u88fd\u9020Metrnl(meteorin-like)\u6fc0\u7d20\uff0c\u5728\u904b\u52d5\u5f8c\u6216\u5bd2\u51b7\u7684\u72c0\u614b\u4e0b\u65bc\u808c\u8089\u4e2d\u7522\u751f\uff0c\u80fd\u8a98\u767c\u5c0f\u9f20\u7684\u8102\u80aa\u68d5\u5316\u3002\u4f7f\u7528\u57fa\u56e0\u7642\u6cd5\u7684\u5c0f\u9f20\uff0cMetrnl\u589e\u52a0\u5f8c\uff0c\u5176\u8461\u8404\u7cd6\u8010\u53d7\u5ea6(glucose tolerance)\u8b8a\u597d\u4e14\u9ad4\u91cd\u7565\u964d\uff0c\u8868\u793a\u9019\u7a2e\u7642\u6cd5\u80fd\u6539\u5584\u7cd6\u5c3f\u75c5\uff1b\u4e5f\u6703\u589e\u52a0\u67d0\u4e9b\u985e\u578b\u7684\u5de8\u566c\u7d30\u80de\u548c\u8102\u80aa\u7d44\u7e54\u5167\u767d\u4ecb\u7d204\u7684\u6578\u91cf\u3002\u7814\u7a76\u4eba\u54e1\u9084\u505a\u4e86\u53e6\u4e00\u9805\u5be6\u9a57\uff0c\u7d66\u4e88\u5c0f\u9f20\u80fd\u4e2d\u548cMetrnl\u7684\u6297\u9ad4(antibody)\uff0c\u767c\u73fe\u66b4\u9732\u5728\u5bd2\u51b7\u4e0b\u7684\u5c0f\u9f20\u7121\u6cd5\u6b63\u5e38\u7684\u6d3b\u5316\u5de8\u566c\u7d30\u80de\u57fa\u56e0\u4ee5\u68d5\u5316\u8102\u80aa\u3002<\/p>\n

\u8cd3\u5dde\u5927\u5b78(University of Pennsylvania)\u7684\u5206\u5b50\u4ee3\u8b1d\u5b78(molecular metabolism)\u5c08\u5bb6Patrick Seale\u8868\u793a\uff0c\u9019\u7a2e\u8a98\u767c\u68d5\u8272\u6216\u7c73\u8272\u8102\u80aa\u7684\u65b9\u5f0f\u662f\u524d\u6240\u672a\u898b\u7684\uff0c\u50c5\u9700\u7d66\u4e88\u52d5\u7269\u86cb\u767d\u8cea\u5c31\u80fd\u8a98\u767c\u68d5\u5316\uff0c\u5be6\u5728\u975e\u5e38\u632f\u596e\u4eba\u5fc3\u3002\u4e14\u6b64\u7a2e\u65b9\u5f0f\u5341\u5206\u5b89\u5168\u6709\u6548\uff0c\u4e5f\u53ef\u7528\u65bc\u6cbb\u7642\u7cd6\u5c3f\u75c5\u548c\u904e\u5ea6\u80a5\u80d6\u7684\u60a3\u8005\u3002<\/p>\n

\u52a0\u5dde\u5927\u5b78(University of California)\u5c08\u7814\u5206\u5b50\u4ee3\u8b1d\u7684Peter Tontonoz\u535a\u58eb\u4e5f\u8aaa\uff0c\u80fd\u4ee5\u85e5\u7406\u5b78\u7684\u89d2\u5ea6\u4f86\u300c\u64cd\u63a7\u300d\u4eba\u7684\u80fd\u91cf\u6d88\u8017\u5f88\u767c\u4eba\u6df1\u7701\uff0c\u8b93\u4eba\u91cd\u65b0\u601d\u8003\u6cbb\u7642\u904e\u5ea6\u80a5\u80d6\u7684\u65b9\u5f0f\u3002\u96d6\u7136\u73fe\u4eca\u4ecd\u4e0d\u6e05\u695a\u6b64\u6a5f\u5236\u5982\u4f55\u5728\u4eba\u9ad4\u5167\u904b\u4f5c\uff0c\u4f46\u67d0\u4e9b\u79d1\u5b78\u5bb6\u5df2\u7d93\u8e8d\u8e8d\u6b32\u8a66\uff0c\u4f8b\u5982Spiegelman\u5df2\u6210\u7acb\u4e86\u751f\u6280\u516c\u53f8Ember Therapeutics\uff0c\u5e0c\u671b\u80fd\u5728\u4e0d\u4e45\u5f8c\u5c07\u5176\u6210\u679c\u5546\u54c1\u5316\u3002<\/p>\n

--\u5ef6\u4f38\u95b1\u8b80\uff1a<\/strong>
\n \u3010\u65e5\u5e38\u751f\u6d3b\u3011\u5c0f\u5b69\u9577\u671f\u7761\u7720\u4e0d\u8db3\uff0c\u5bb9\u6613\u5c0e\u81f4\u80a5\u80d6<\/strong><\/a>
\n \u3010\u795e\u7d93\u79d1\u5b78\u3011\u300c\u98e2\u9913\u795e\u7d93\u5143\u300d\u8b93\u4f60\u98df\u617e\u5927\u767c<\/strong><\/a>
\n \u3010\u98f2\u98df\u5065\u5eb7\u3011\u6539\u8b8a\u5403\u98ef\u6642\u9593\u53ef\u6709\u6548\u964d\u4f4e\u809d\u8102\u80aa\u56e4\u7a4d<\/strong><\/a>
\n--
\n\u7814\u7a76\u51fa\u8655\uff1aA New Way to Burn Calories<\/a><\/strong><\/span>
\n\u8b6f\u8005\uff1a\u6797\u6021\u5fb7 \u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u7de8\u8b6f\u3002<\/strong><\/strong><\/span>
\n\u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u25a0\u70ba\u4e86\u6e1b\u80a5\uff0c\u4eba\u4eba\u7121\u6240\u4e0d\u7528\u5176\u6975\uff0c\u5c31\u662f\u8981\u7529\u6389<\/p>\n","protected":false},"author":20,"featured_media":18687,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[756,1356,593,1355],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/07\/RT_news_jun06_bikemouse1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18686"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18686"}],"version-history":[{"count":7,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18686\/revisions"}],"predecessor-version":[{"id":18695,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18686\/revisions\/18695"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/18687"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}