{"id":18057,"date":"2014-06-12T05:28:19","date_gmt":"2014-06-11T21:28:19","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=18057"},"modified":"2017-07-25T11:56:02","modified_gmt":"2017-07-25T03:56:02","slug":"%e3%80%90%e5%85%8d%e7%96%ab%e5%af%a6%e9%a9%97%e3%80%91%e7%94%9f%e7%97%85%ef%bc%8c%e5%a4%9a%e7%9d%a1%e8%a6%ba%e5%b0%b1%e5%b0%8d%e4%ba%86%ef%bc%81","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=18057","title":{"rendered":"\u3010\u514d\u75ab\u5be6\u9a57\u3011\u751f\u75c5\uff0c\u591a\u7761\u89ba\u5c31\u5c0d\u4e86\uff01"},"content":{"rendered":"

\u25a0\u7576\u4eba\u751f\u75c5\u7684\u6642\u5019\uff0c\u70ba\u4e86\u80fd\u5920\u76e1\u5feb\u5730\u6062\u5fa9\u5065\u5eb7\uff0c\u5f88\u81ea\u7136\u5730\u6703\u60f3\u8981\u591a\u7761\u9ede\u89ba\u3002\u7f8e\u570b\u8cd3\u5dde\u5927\u5b78\u88f4\u96f7\u723e\u66fc\u91ab\u5b78\u9662 (Perelman School of Medicine) \u7684\u7814\u7a76\u4eba\u54e1\u767c\u73fe\u5728\u679c\u8805\u8eab\u4e0a\uff0c\u751f\u75c5\u5f8c\u591a\u7761\u89ba\u5177\u6709\u660e\u78ba\u7684\u76ee\u7684\uff0c\u85c9\u6b64\u53ef\u4ee5\u589e\u5f37\u514d\u75ab\u53cd\u61c9\u4ee5\u5c0d\u6297\u75c5\u83cc\u800c\u6062\u5fa9\u5065\u5eb7\u3002\u9019\u4e9b\u7814\u7a76\u5c07\u5206\u5225\u520a\u767b\u57282014\u5e74\u4e94\u6708\u53ca\u516d\u6708\u51fa\u7248\u7684\u300a\u7761\u7720\u300b(SLEEP<\/em>) \u96dc\u8a8c\u3002<\/strong><\/span><\/p>\n

\"140421211312-large\"<\/a>
Male fruit fly (Drosophila melanogaster) on a blade of grass (stock image).<\/figcaption><\/figure>\n

\u7de8\u8b6f\uff5c<\/strong>\u9ec3\u4f73\u6b23<\/p>\n

\u7761\u7720\u8207\u65e5\u9031\u795e\u7d93\u751f\u7269\u5b78\u4e2d\u5fc3\u7684\u7814\u7a76\u54e1 Julie Williams\u535a\u58eb\u63d0\u5230\uff1a\u300c\u7576\u4f60\u751f\u75c5\u6642\uff0c\u4f60\u81ea\u7136\u6703\u60f3\u8981\u597d\u597d\u5730\u7761\u4e00\u89ba\u3002\u8a31\u591a\u7684\u7814\u7a76\u5de5\u4f5c\u5229\u7528\u7761\u7720\u525d\u596a\u4f86\u4e86\u89e3\u7761\u7720\u662f\u5426\u6709\u52a9\u65bc\u8eab\u9ad4\u6062\u5fa9\u5065\u5eb7\u3002\u4e0d\u904e\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u652f\u6301\u591a\u7761\u4e00\u9ede\u53ef\u4ee5\u5e6b\u52a9\u6211\u5011\u5fa9\u5143\u7684\u5be6\u9a57\u8b49\u64da\u537b\u662f\u76f8\u7576\u7a00\u5c11\u3002\u65bc\u662f\u6211\u5011\u6c7a\u5b9a\u7528\u679c\u8805\u4f86\u56de\u7b54\u9019\u500b\u554f\u984c\u3002\u300dWilliams\u535a\u58eb\u8207\u53e6\u4e00\u4f4d\u535a\u58eb\u5f8c\u7814\u7a76\u54e1Tzu-Hsing Kuo\u535a\u58eb\u5171\u540c\u5408\u4f5c\uff0c\u4ed6\u5011\u9032\u884c\u4e86\u5169\u9805\u76f8\u95dc\u7684\u7814\u7a76\uff0c\u4f86\u6aa2\u6e2c\u7761\u7720\u5c0d\u65bc\u88ab\u75c5\u83cc\u611f\u67d3\u5f8c\u7684\u5eb7\u5fa9\u548c\u751f\u5b58\u7684\u5f71\u97ff\u3002<\/p>\n

\u5728\u7b2c\u4e00\u4efd\u7814\u7a76\u5831\u544a\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u63a1\u7528\u50b3\u7d71\u7684\u65b9\u6cd5\uff0c\u4e5f\u5c31\u662f\u5148\u8b93\u679c\u8805\u4e0d\u7761\u89ba\u4e00\u6bb5\u6642\u9593\uff0c\u7136\u5f8c\u518d\u6ce8\u5c04\u75c5\u83cc (Serratia marcescens<\/em>\u00a0orPseudomonas aeruginosa<\/em>\u00a0) \u5230\u679c\u8805\u9ad4\u5167\u9032\u884c\u611f\u67d3\u3002\u4e8b\u5148\u88ab\u525d\u596a\u7761\u7720\u7684\u679c\u8805\u53ca\u672a\u5be6\u65bd\u7761\u7720\u525d\u596a\u7684\u5c0d\u7167\u7d44\uff0c\u5747\u5728\u88ab\u75c5\u83cc\u611f\u67d3\u5f8c\u660e\u986f\u5730\u589e\u9577\u7761\u7720\u6642\u9593\uff0c\u5be6\u9a57\u4eba\u54e1\u5c07\u9019\u6a23\u7684\u884c\u70ba\u7a31\u4e4b\u70ba\u300c\u6025\u6027\u7761\u7720\u53cd\u61c9 (acute sleep response)\u3002\u300d<\/p>\n

\u4e0d\u904e\u5be6\u9a57\u7684\u7d50\u679c\u51fa\u4e4e\u610f\u6599\u4e4b\u5916\uff0c\u4e8b\u5148\u88ab\u525d\u596a\u7761\u7720\u7684\u679c\u8805\u5728\u88ab\u611f\u67d3\u5f8c\u7684\u5b58\u6d3b\u7387\u5c45\u7136\u6bd4\u8f03\u9ad8\u3002\u7814\u7a76\u4eba\u54e1\u8868\u793a\uff1a\u300c\u7260\u5011\u78ba\u5be6\u6bd4\u6c92\u6709\u7d93\u6b77\u7761\u7720\u525d\u596a\u7684\u5c0d\u7167\u7d44\u679c\u8805\u6d3b\u5f97\u6642\u9593\u66f4\u9577\u3002\u300d\u66f4\u9032\u4e00\u6b65\u767c\u73fe\uff0c\u4e8b\u524d\u6709\u88ab\u525d\u596a\u7761\u7720\u7684\u679c\u8805\u6bd4\u5c0d\u7167\u7d44\u5728\u611f\u67d3\u4e4b\u5f8c\u7761\u89ba\u7684\u6642\u9593\u66f4\u9577\u3002\u679c\u8805\u7761\u5f97\u8d8a\u4e45\u4e5f\u5c31\u6d3b\u5f97\u8d8a\u9577\uff0c\u53cd\u4e4b\u5982\u679c\u5728\u679c\u8805\u88ab\u611f\u67d3\u4e4b\u5f8c\u63a5\u8457\u5c31\u4e0d\u8b93\u7260\u5011\u7761\u89ba\uff0c\u5176\u5b58\u6d3b\u7387\u5c31\u6703\u660e\u986f\u5730\u4e0b\u964d\u3002\u56e0\u6b64\uff0c\u95dc\u9375\u5728\u65bc\u611f\u67d3\u4e4b\u5f8c\u7260\u5011\u5fc5\u9808\u6709\u4e00\u6bb5\u66f4\u9577\u7684\u7761\u7720\u6642\u9593\uff0c\u9664\u6b64\u4e4b\u5916\u9032\u884c\u7761\u7720\u525d\u596a\u7684\u8655\u7406\u53cd\u800c\u6703\u8b93\u7260\u5011\u66f4\u70ba\u5065\u58ef\u3002<\/p>\n

\u7761\u7720\u525d\u596a\u6703\u589e\u52a0NF-\u03baB\u8f49\u9304\u56e0\u5b50Relish\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u9019\u500b\u57fa\u56e0\u5c0d\u65bc\u8eab\u9ad4\u5c0d\u6297\u75c5\u83cc\u7684\u611f\u67d3\u662f\u76f8\u7576\u91cd\u8981\u7684\u3002\u5982\u679c\u7f3a\u4e4fRelish\u57fa\u56e0\u7684\u7a81\u8b8a\u679c\u8805\u4e0d\u6703\u7522\u751f\u6025\u6027\u7761\u7720\u53cd\u61c9\uff0c\u4e26\u4e14\u5f88\u5bb9\u6613\u53d7\u5230\u611f\u67d3\u800c\u6b7b\u4ea1\u3002\u4f46\u662f\u7814\u7a76\u767c\u73fe\uff0c\u5728\u75c5\u83cc\u611f\u67d3\u4e4b\u524d\u5148\u5c0d\u9019\u7a2e\u7f3a\u5c11Relish\u57fa\u56e0\u7684\u7a81\u8b8a\u679c\u8805\u5be6\u65bd\u7761\u7720\u525d\u596a\uff0c\u7260\u5011\u5728\u611f\u67d3\u5f8c\u4ecd\u6703\u7761\u5f97\u66f4\u4e45\u800c\u4e14\u5b58\u6d3b\u7387\u4e5f\u6703\u63d0\u9ad8\u3002\u7814\u7a76\u4eba\u54e1\u63a5\u8457\u6aa2\u9a57\u540c\u6642\u7f3a\u5c11\u5169\u7a2eNF-\u03baB\u8f49\u9304\u56e0\u5b50 (Relish\u53caDif) \u7684\u7a81\u8b8a\u679c\u8805\u3002\u5169\u500b\u57fa\u56e0\u540c\u6642\u7f3a\u5931\u7684\u679c\u8805\uff0c\u4e8b\u524d\u7684\u7761\u7720\u525d\u596a\u8655\u7406\u4e26\u4e0d\u6703\u589e\u9577\u6025\u6027\u7761\u7720\u53cd\u61c9\uff0c\u800c\u4e14\u6b7b\u4ea1\u7387\u8ddf\u5c0d\u7167\u7d44\u76f8\u540c\uff0c\u7260\u5011\u5728\u53d7\u5230\u75c5\u83cc\u611f\u5f8c\u7684\u5e7e\u500b\u5c0f\u6642\u5167\u5747\u5feb\u901f\u5730\u6b7b\u4ea1\u3002\u7c21\u8a00\u4e4b\uff0c\u611f\u67d3\u5f8c\u7684\u5ef6\u9577\u7761\u7720\u6709\u52a9\u65bc\u63d0\u9ad8\u5b58\u6d3b\u7387\u3002<\/p>\n

\u5728\u7b2c\u4e8c\u500b\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u5229\u7528\u907a\u50b3\u5b78\u5de5\u5177\u4f86\u64cd\u63a7\u7761\u7720\u3002\u7814\u7a76\u4eba\u54e1\u4f7f\u7528RU486\u85e5\u7269\u53bb\u8a98\u5c0e\u96e2\u5b50\u901a\u9053\u7684\u8868\u73fe\uff0c\u6539\u8b8a\u679c\u8805\u5927\u8166\u8548\u72c0\u9ad4\u5167\u795e\u7d93\u5143\u7684\u6d3b\u52d5\uff0c\u7e7c\u800c\u8abf\u7bc0\u7761\u7720\u6a21\u5f0f\u3002\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u5982\u679c\u5728\u611f\u67d3\u524d\u8b93\u679c\u8805\u591a\u7761\u9577\u9054\u5169\u5929\u7684\u6642\u9593\uff0c\u5c0d\u65bc\u611f\u67d3\u5f8c\u7684\u5b58\u6d3b\u7387\u6703\u986f\u8457\u5730\u63d0\u9ad8\u3002\u7761\u5f97\u6bd4\u8f03\u591a\u7684\u679c\u8805\u5176\u8eab\u9ad4\u4e5f\u80fd\u66f4\u5feb\u66f4\u6709\u6548\u5730\u6e05\u9664\u9ad4\u5167\u7684\u7d30\u83cc\u3002\u9019\u9805\u7814\u7a76\u7d50\u679c\u518d\u6b21\u8b49\u5be6\u5ef6\u9577\u7761\u7720\u6642\u9593\u6709\u52a9\u65bc\u514d\u75ab\u7cfb\u7d71\u7684\u63d0\u5347\u800c\u589e\u5f37\u6297\u83cc\u80fd\u529b\u53ca\u88ab\u611f\u67d3\u5f8c\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56e0\u70ba\u54fa\u4e73\u52d5\u7269\u4e5f\u540c\u6a23\u5177\u5099NF-\u03baB\u7684\u8a0a\u606f\u50b3\u5c0e\u9014\u5f91\uff0c\u76f8\u5c0d\u7c21\u55ae\u7684\u679c\u8805\u7cfb\u7d71\u4fbf\u6210\u70ba\u63a2\u7d22\u7761\u7720\u57fa\u672c\u529f\u80fd\u4e00\u500b\u7406\u60f3\u7684\u6a21\u5f0f\u7269\u7a2e\u3002\u65e9\u572840\u5e74\u524d\u79d1\u5b78\u5bb6\u5c31\u61f7\u7591\u7761\u7720\u8207\u514d\u75ab\u4e4b\u9593\u5b58\u5728\u8457\u76f4\u63a5\u7684\u95dc\u4fc2\uff0c\u73fe\u5728\u8cd3\u5dde\u5927\u5b78\u7684\u7814\u7a76\u4eba\u54e1\u5229\u7528\u679c\u8805\u7684\u7814\u7a76\u5c07\u554f\u984c\u7d66\u7c21\u55ae\u5316\uff0c\u800c\u4e14\u6709\u6a5f\u6703\u89e3\u958b\u8abf\u63a7\u9019\u4e9b\u8a0a\u606f\u50b3\u5c0e\u9014\u5f91\u7684\u5206\u5b50\u6a5f\u5236\u53ca\u57fa\u56e0\uff0c\u53cd\u89c0\u8981\u5728\u9ad8\u7b49\u52d5\u7269\u4e0a\u9032\u884c\u985e\u4f3c\u7684\u7814\u7a76\u662f\u76f8\u5c0d\u56f0\u96e3\u7684\u3002<\/p>\n

\u9019\u500b\u7814\u7a76\u63d0\u4f9b\u5168\u65b0\u7684\u8b49\u64da\u8b49\u660e\u7761\u7720\u7684\u529f\u80fd\u76f4\u63a5\u5f71\u97ff\u514d\u75ab\u80fd\u529b\u4ee5\u53ca\u5176\u4e2d\u76f8\u95dc\u7684\u5206\u5b50\u6a5f\u5236\u3002\u7d66\u6211\u5011\u5e36\u4f86\u6700\u70ba\u95dc\u9375\u7684\u8a0a\u606f\u5c31\u662f\uff1a\u7576\u4f60\u751f\u75c5\u6642\uff0c\u591a\u7761\u89ba\u5c31\u5c0d\u4e86\uff01<\/p>\n

\u539f\u59cb\u8ad6\u6587
\n1.Kuo TH, Williams JA. Acute sleep deprivation enhances post-infection sleep and promotes survival during bacterial infection in Drosophila<\/em>. SLEEP 2014;37(5):859-869.
\n2.Excess Sleep Promotes Survival during a Bacterial Infection in Drosophila.<\/em><\/p>\n

--
\n\u7814\u7a76\u51fa\u8655\uff1aSleeping away infection: Researchers find link between sleep, immune function in fruitflies<\/a><\/strong>
\n \u8b6f\u8005\uff1a\u9ec3\u4f73\u6b23 \u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u7de8\u8b6f\u3002<\/strong><\/span>
\n \u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u25a0\u7576\u4eba\u751f\u75c5\u7684\u6642\u5019\uff0c\u70ba\u4e86\u80fd\u5920\u76e1\u5feb\u5730\u6062\u5fa9\u5065\u5eb7<\/p>\n","protected":false},"author":20,"featured_media":18058,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,791,1025],"tags":[702,444,1295,1296],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/06\/140421211312-large.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18057"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18057"}],"version-history":[{"count":6,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18057\/revisions"}],"predecessor-version":[{"id":28823,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/18057\/revisions\/28823"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/18058"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}