{"id":17132,"date":"2014-03-24T06:54:12","date_gmt":"2014-03-23T22:54:12","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=17132"},"modified":"2017-07-27T10:24:11","modified_gmt":"2017-07-27T02:24:11","slug":"%e3%80%90%e6%99%82%e4%ba%8b%e5%b0%88%e9%a1%8c%e3%80%91%e6%b5%81%e6%84%9f%e8%88%87%e7%a6%bd%e6%b5%81%e6%84%9f%e5%b0%88%e9%a1%8c%e5%a0%b1%e5%b0%8e%e4%b8%8a","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=17132","title":{"rendered":"\u3010\u5c08\u984c\u5831\u5c0e\u3011\u6d41\u611f\u8207\u79bd\u6d41\u611f(\u4e0a)"},"content":{"rendered":"

\u25a0<\/b>\u4f55\u8b02\u6d41\u611f\u8207\u79bd\u6d41\u611f\uff1a\u6bcf\u5e74\u51ac\u5b63\u7684\u5b63\u7bc0\u6027\u6d41\u884c\u6027\u611f\u5192\uff0c\u56e0\u70ba\u5927\u591a\u6578\u4eba\u5177\u6709\u514d\u75ab\u529b\uff0c\u591a\u6578\u6d41\u611f\u75c5\u6bd2\u5c0d\u4eba\u7684\u81f4\u75c5\u6027\u4f4e\uff0c\u4e14\u4e8b\u524d\u4e5f\u80fd\u63a5\u7a2e\u75ab\u82d7\uff0c\u5065\u5eb7\u8005\u5927\u591a\u50c5\u6703\u51fa\u73fe\u8f15\u5fae\u7684\u75c7\u72c0\uff0c\u75c7\u72c0\u8f03\u70ba\u56b4\u91cd\u901a\u5e38\u662f\u5e74\u5e7c\u6216\u5e74\u9577\u8005\u3002<\/strong><\/span><\/p>\n

\u4f5c\u8005\uff5c<\/strong>\u8303\u59dc\u6587\u69ae\u00a0<\/b><\/p>\n

\"2013041814223937064\"<\/a>
\u5716\u7247\u4f86\u6e90\uff5cwww.apdnews.com<\/figcaption><\/figure>\n

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\u79bd\u6d41\u611f\u75c5\u6bd2\u7684\u64f4\u6563<\/b><\/p>\n

\u539f\u672c\u79bd\u6d41\u611f\u75c5\u6bd2\u56e0\u50b3\u64ad\u5c0d\u8c61\u9650\u65bc\u9ce5\u79bd\u985e\uff0c\u4e00\u822c\u8a8d\u70ba\u4e0d\u6703\u50b3\u67d3\u7d66\u4eba\u3002\u5176\u539f\u56e0\u662f\u79bd\u6d41\u611f\u75c5\u6bd2\u6703\u8fa8\u8b58\u9ce5\u79bd\u985e\u7d30\u80de\u8868\u9762\u7684\u7279\u5b9a\u53d7\u5668\uff0c\u800c\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u4eba\u5f8c\uff0c\u5247\u8fa8\u8b58\u4eba\u985e\u7d30\u80de\u8868\u9762\u7684\u7279\u5b9a\u53d7\u5668\uff0c\u518d\u5165\u4fb5\u81f3\u7d30\u80de\u5167\uff0c\u5169\u53d7\u5668\u7279\u5fb5\u4e26\u4e0d\u76f8\u540c\uff0c\u56e0\u6b64\u4e00\u822c\u9ce5\u79bd\u985e\u7684\u79bd\u6d41\u611f\u75c5\u6bd2\u4e0d\u6703\u50b3\u67d3\u7d66\u4eba[1]\u3002<\/p>\n

\u4f46\u662f\u6aa2\u8996\u904e\u53bb\u4e16\u754c\u4e0a\u6240\u767c\u751f\u7684\u6578\u8d77\u4eba\u611f\u67d3\u79bd\u6d41\u611f\u7684\u75c5\u4f8b\uff0c\u5176\u539f\u56e0\u96d6\u5c1a\u672a\u660e\u78ba\u3002\u63a8\u6e2c\u96d6\u53d7\u5668\u7279\u5fb5\u76f8\u7570\uff0c\u4f46\u75c5\u6bd2\u8207\u53d7\u5668\u9593\u4ecd\u4e0d\u5177\u975e\u5e38\u56b4\u5bc6\u7684\u5c08\u4e00\u6027\uff0c\u82e5\u5927\u91cf\u75c5\u6bd2\u9032\u5165\u9ad4\u5167\uff0c\u5373\u4f7f\u53d7\u5668\u6709\u5c08\u4e00\u6027\uff0c\u4e5f\u53ef\u80fd\u51fa\u73fe\u90e8\u5206\u7d30\u80de\u67d3\u4e0a\u75c5\u6bd2\u3002\u63db\u8a00\u4e4b\uff0c\u80fd\u7406\u89e3\u70ba\u4f55\u79bd\u6d41\u611f\u75c5\u60a3\u5927\u591a\u662f\u66b4\u9732\u65bc\u5177\u6709\u5927\u91cf\u75c5\u6bd2\u5834\u6240\u7684\u9ce5\u79bd\u985e\u5f9e\u4e8b\u8005\uff0c\u53ef\u80fd\u662f\u63a5\u89f8\u5230\u5177\u9ad8\u6fc3\u5ea6\u75c5\u6bd2\u7684\u9ce5\u79bd\u6216\u6392\u6cc4\u7269\u7b49[1]\u3002<\/p>\n

1997\u5e74\u9999\u6e2f\u51fa\u73feH5N1\u79bd\u6d41\u611f\u75c5\u6bd2\u4ee5\u4f86\uff0c\u4e9e\u6d32\u5730\u5340\u9678\u7e8c\u767c\u751f\u4eba\u611f\u67d3H5N1\u7684\u75c5\u4f8b\uff0c\u7d93\u7814\u7a76\u767c\u73fe\u662f\u4eba\u985e\u80ba\u6ce1\u4e0a\u76ae\u7d30\u80de\u53d7\u5230\u611f\u67d3\u3002\u4e4b\u5f8c\u7814\u7a76\u8a73\u7d30\u89e3\u6790\u4eba\u985e\u9f3b\u9ecf\u819c\u3001\u9f3b\u8154\u3001\u6c23\u7ba1\u3001\u7d30\u652f\u6c23\u7ba1\u3001\u53ca\u80ba\u6ce1\u4e0a\u76ae\u7684\u7d44\u7e54\uff0c\u767c\u73fe\u4eba\u985e\u7684\u7d42\u7aef\u7d30\u652f\u6c23\u7ba1(terminal bronchiole)\u8207\u80ba\u6ce1\u4e0a\u76ae\u7d30\u80de\u5177\u6709\u80fd\u63a5\u53d7\u79bd\u6d41\u611f\u75c5\u6bd2\u7684\u53d7\u5668\u3002\u56e0\u8a72\u5340\u57df\u5728\u80ba\u90e8\u6df1\u8655\uff0c\u9664\u66b4\u9732\u5728\u5927\u91cf\u79bd\u6d41\u611f\u75c5\u6bd2\u7684\u5834\u5408\u5916\uff0c\u75c5\u6bd2\u4e0d\u6613\u5f9e\u9ce5\u79bd\u50b3\u67d3\u5230\u4eba\uff0c\u4e14\u4e00\u822c\u4e5f\u8a8d\u70ba\u4e0d\u6613\u51fa\u73fe\u4eba\u50b3\u4eba\u7684\u60c5\u5f62[4]\u3002<\/p>\n

\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0c\u79bd\u6d41\u611f\u75c5\u6bd2\u53ef\u80fd\u4e26\u975e\u55ae\u4e00\u65b9\u5411\u5f9e\u91ce\u751f\u9ce5\u985e\u50b3\u67d3\u81f3\u5bb6\u79bd\u985e\uff0c\u4ee5\u53ca\u5728\u4e0d\u540c\u7a2e\u985e\u5bbf\u4e3b\u4ee5\u4e0d\u540c\u901f\u7387\u9032\u884c\u6f14\u5316\uff0c\u9019\u4e9b\u767c\u73fe\u53ef\u80fd\u6539\u8b8a\u4eba\u985e\u539f\u6709\u7684\u5065\u5eb7\u98a8\u96aa\u7684\u8a55\u4f30\u8207\u75ab\u82d7\u767c\u5c55\u7b56\u7565[2][3]\u3002<\/p>\n

H5N1<\/b>\u8207H7N9\u7684\u5dee\u7570<\/b><\/p>\n

\u570b\u969b\u7378\u75ab\u4e8b\u52d9\u5c40(OIE)\u5c07\u75c5\u6bd2\u611f\u67d3\u6700\u5c118\u96bb4~8\u9031\u5927\u7684\u96de\u96bb\uff0c10\u5929\u4ee5\u5167\u51fa\u73fe75%\u4ee5\u4e0a\u7684\u81f4\u6b7b\u7387\u5b9a\u7fa9\u70ba\u300c\u9ad8\u75c5\u539f\u6027\u300d[1]\u3002\u5c0d\u9ce5\u79bd\u985e\u800c\u8a00\uff0cH5N1\u79bd\u6d41\u611f\u75c5\u6bd2\u5c6c\u65bc\u9ad8\u75c5\u539f\u6027\uff0c\u5230\u76ee\u524d\u70ba\u6b62\u768415\u5e74\u9593\uff0c\u4eba\u611f\u67d3H5N1\u6709\u8d85\u904e600\u75c5\u4f8b\u4ee5\u4e0a\uff0c\u4ecd\u6301\u7e8c\u9ad8\u9054\u7d0460%\u7684\u6b7b\u4ea1\u7387\u3002\u4f46\u56e0\u70ba\u9ce5\u79bd\u611f\u67d3H5N1\u5f8c\u5e7e\u4e4e100%\u51fa\u73fe\u75c5\u7665\uff0c\u80fd\u85c9\u7531\u75c5\u79bd\u5168\u90e8\u64b2\u6bba\uff0c\u4f86\u907f\u514d\u50b3\u67d3\u64f4\u5927[5]\u3002<\/p>\n

\u76f8\u5c0d\u5730\uff0cH7N9\u79bd\u6d41\u611f\u75c5\u6bd2\u7684\u75c5\u539f\u6027\u9060\u6bd4H5N1\u79bd\u6d41\u611f\u75c5\u6bd2\u70ba\u4f4e\uff0c\u88ab\u8a8d\u70ba\u662f\u5065\u5eb7\u7684\u9ce5\u79bd\uff0c\u4e5f\u6709\u51fa\u73feH7N9\u75c5\u6bd2\u88ab\u6aa2\u51fa\u7684\u73fe\u8c61\u3002\u56e0\u6b64\u5be6\u52d9\u9762\u8f03\u96e3\u63a1\u7528\u767c\u73fe\u75c5\u79bd\u5c31\u5168\u9762\u64b2\u6bba\u7684\u63aa\u65bd\uff0c\u5f62\u6210\u75c5\u6bd2\u8f03\u6613\u50b3\u64ad\u7684\u60c5\u52e2\u3002\u76ee\u524d\u5c0d\u65bcH7N9\u79bd\u6d41\u611f\u75c5\u6bd2\u7684\u611f\u67d3\u6027\u3001\u75c5\u539f\u6027\u3001\u4ee5\u53ca\u56b4\u91cd\u7a0b\u5ea6\u7b49\u5373\u4f7f\u4ecd\u6709\u4e0d\u78ba\u5b9a\u6027\uff0c\u4f46\u4eba\u611f\u67d3\u7684\u6b7b\u4ea1\u7387\u9ad8\u9054\u7d0420%\uff0c\u5404\u570b\u75be\u75c5\u7ba1\u5236\u55ae\u4f4d\u8a8d\u70ba\u4ecd\u6709\u5fc5\u8981\u63a1\u53d6\u9ad8\u898f\u683c\u7684\u9632\u75ab\u63aa\u65bd[5]\u3002<\/p>\n

\u767c\u73feH10N8\u65b0\u578b\u79bd\u6d41\u611f\u75c5\u6bd2<\/b><\/p>\n

\u6839\u64da\u79bd\u6d41\u611f\u6700\u65b0\u75ab\u60c5\uff0c\u79d1\u5b78\u5bb6\u6700\u8fd1\u767c\u73fe\u65b0\u51fa\u73fe\u7684H10N8\u65b0\u578b\u75c5\u6bd2\uff0c\u5df2\u6f14\u5316\u51fa\u4e00\u4e9b\u57fa\u56e0\u7279\u5fb5\uff0c\u4e5f\u8a31\u80fd\u5728\u4eba\u985e\u66f4\u6709\u6548\u7387\u5730\u8907\u88fd\u8a72\u75c5\u6bd2\u30022014\u5e741\u6708\u4e0b\u65ec\u4e2d\u570b\u5df2\u51fa\u73fe\u4eba\u611f\u67d3H10N8\u65b0\u578b\u75c5\u6bd2\u7684\u7b2c\u4e8c\u75c5\u4f8b\uff0c\u5f15\u767c\u5404\u754c\u9ad8\u5ea6\u95dc\u6ce8\uff0c\u56e0\u70ba\u5c07\u4f86\u8a72H10N8\u65b0\u578b\u75c5\u6bd2\u53ef\u80fd\u7e7c\u7e8c\u64f4\u6563\uff0c\u66f4\u591a\u4eba\u53d7\u5230\u611f\u67d3[6]\u3002<\/p>\n

\u79bd\u6d41\u611f\u75c5\u60a3\u7684\u6cbb\u7642<\/b><\/p>\n

\u76ee\u524d\u5c0d\u65bc\u4eba\u985e\u611f\u67d3H5N1\u6216H7N9\u79bd\u6d41\u611f\u75c5\u6bd2\u7684\u6cbb\u7642\u65b9\u5f0f\uff0c\u75c5\u60a3\u57fa\u672c\u4e0a\u90fd\u662f\u63a1\u53d6\u767c\u75c5\u65e9\u671f\u7d66\u4e88\u300c\u6297\u6d41\u611f\u75c5\u6bd2\u85e5\u5291\u300d\uff0c\u5982\u514b\u6d41\u611f(Oseltamivir)\uff0c\u4ee5\u6291\u5236\u6216\u6e1b\u7de9\u75c5\u6bd2\u4e2d\u6c92\u6709\u6297\u85e5\u6027\u4e4b\u75c5\u682a\u5728\u4eba\u9ad4\u7d30\u80de\u9593\u7684\u64f4\u6563[5]\u3002<\/p>\n

\u00a0<\/b>\u500b\u4eba\u5065\u5eb7\u7ba1\u7406<\/b><\/p>\n

\u56e0\u70ba\u79bd\u6d41\u611f\u75c5\u6bd2\u4e0d\u65b7\u7a81\u8b8a\u6216\u7522\u751f\u6297\u85e5\u6027\uff0c\u6bcf\u500b\u4eba\u61c9\u505a\u597d\u81ea\u4e3b\u5065\u5eb7\u7ba1\u7406\uff0c\u96a8\u6642\u89c0\u5bdf\u500b\u4eba\u5065\u5eb7\u75c7\u72c0\uff0c\u5982\u6709\u985e\u6d41\u611f\u75c5\u72c0\uff0c\u61c9\u5373\u523b\u6234\u53e3\u7f69\u53ca\u5c31\u91ab\u3002\u53e6\u5916\u65e5\u5e38\u751f\u6d3b\u61c9\u52e4\u6d17\u624b\u3001\u91cd\u885b\u751f\u3001\u4ee5\u53ca\u907f\u514d\u63a5\u89f8\u5177\u6709\u75c5\u6bd2\u5e36\u539f\u9ad8\u98a8\u96aa\u7684\u9ce5\u79bd\u985e[7]\u3002<\/p>\n

 <\/p>\n

\u63a8\u85a6\u95b1\u8b80\uff1a<\/strong>
\n[1] \u9ce5\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u95a2\u3059\u308bQ\uff06A
\n<\/a>[2] UA Study on Flu Evolution May Change Textbooks, History Books
\n<\/a>[3] A synchronized global sweep of the internal genes of modern avian influenza virus, 2014 \u00a0Nature, DOI: 10.1038\/nature13016<\/strong>
\n[4] Avian flu: Influenza virus receptors in the human airway, 2006\u00a0Nature, DOI: 10.1038\/440435a<\/strong>
\n[5] \u9ce5\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6A(H7N9)\u3078\u306e\u5bfe\u5fdc, \u65e5\u672c\u611f\u67d3\u75c7\u5b66\u4f1a<\/a>\u00a0<\/strong>
\n[6] New strain of 'deadly' bird flu<\/a>\u00a0<\/strong>
\n[7] \u885b\u751f\ufa1b\uf9dd\u90e8\u75be\u75c5\u7ba1\u5236\u7f72,\u50b3\u67d3\u75c5\u9632\u6cbb\u6838\u5fc3\u6559\u6750, H5N1\uf9ca\u611f<\/a>\u00a0<\/strong><\/p>\n

 
\n\u4f5c\u8005\uff1a\u8303\u59dc\u6587\u69ae \u81fa\u7063\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\uff0c\u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\u3002<\/strong><\/strong><\/span>
\n\u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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