{"id":17006,"date":"2014-03-26T06:05:21","date_gmt":"2014-03-25T22:05:21","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=17006"},"modified":"2017-07-27T10:23:39","modified_gmt":"2017-07-27T02:23:39","slug":"%e3%80%8c%e9%a3%a2%e9%a4%93%e7%a5%9e%e7%b6%93%e5%85%83%e3%80%8d%e8%ae%93%e4%bd%a0%e9%a3%9f%e6%85%be%e5%a4%a7%e7%99%bc","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=17006","title":{"rendered":"\u3010\u795e\u7d93\u79d1\u5b78\u3011\u300c\u98e2\u9913\u795e\u7d93\u5143\u300d\u8b93\u4f60\u98df\u617e\u5927\u767c"},"content":{"rendered":"<p><span style=\"color: #333399;\"><b><strong>\u25a0<\/strong>\u79d1\u5b78\u5bb6\u8fd1\u65e5\u767c\u73fe\uff0c\u8166\u4e2d\u6709\u63a7\u5236\u98df\u617e\u7684\u795e\u7d93\u5143\u3002\u6b64\u9805\u767c\u73fe\u53ef\u80fd\u6709\u52a9\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u3002<\/b><\/span><\/p>\n<p><strong>\u7de8\u8b6f\uff5c<\/strong>\u67ef\u5b97\u4f51<\/p>\n<figure id=\"attachment_17007\" aria-describedby=\"caption-attachment-17007\" style=\"width: 576px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/03\/140207132911-large.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\" wp-image-17007\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/03\/140207132911-large.jpg\" alt=\"140207132911-large\" width=\"576\" height=\"382\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/03\/140207132911-large.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/03\/140207132911-large-300x198.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/03\/140207132911-large-600x398.jpg 600w\" sizes=\"(max-width: 576px) 100vw, 576px\" \/><\/a><figcaption id=\"caption-attachment-17007\" class=\"wp-caption-text\">\u4ee5\u524d\u8a8d\u70ba\uff0c\u8166\u4e2d\u7684\u5ba4\u65c1\u6838\u80fd\u5e36\u4f86\u6eff\u8db3\u611f\uff0c\u4f46\u6700\u8fd1\u7814\u7a76\u4eba\u54e1\u767c\u73fe\uff0c\u5ba4\u65c1\u6838\u88e1\u982d\u7684\u523a\u9f20\u80bd\u795e\u7d93\u5143\uff0c\u53cd\u800c\u6703\u5f15\u8d77\u98e2\u9913\u611f\u3002\u9019\u9805\u65b0\u767c\u73fe\uff0c\u8b93\u4eba\u5011\u66f4\u4e86\u89e3\u795e\u7d93\u7db2\u7d61\u7684\u904b\u4f5c\u6a21\u5f0f\uff0c\u9032\u800c\u660e\u767d\u98df\u617e\u7522\u751f\u7684\u539f\u56e0\u3002<\/figcaption><\/figure>\n<p>\u4eba\u985e\u5403\u6771\u897f\uff0c\u70ba\u7684\u662f\u651d\u53d6\u71df\u990a\uff0c\u4f46\u6211\u5011\u4e4b\u6240\u4ee5\u60f3\u5403\u6771\u897f\uff0c\u537b\u662f\u53d7\u80c3\u90e8\u7684\u98e2\u9913\u611f\u9a45\u4f7f\uff0c\u624d\u4e0d\u5f97\u4e0d\u52d5\u624b\u7ffb\u51b0\u7bb1\uff0c\u6216\u56db\u8655\u627e\u98df\u7269\u5403\u3002\u96d6\u8aaa\u98e2\u9913\u611f\u662f\u5ef6\u7e8c\u751f\u547d\u7684\u5fc5\u8981\u56e0\u5b50\uff0c\u4f46\u8981\u662f\u592a\u904e\u65fa\u76db\uff0c\u4e5f\u6703\u5c0e\u81f4\u80a5\u80d6\u6216\u98f2\u98df\u75be\u60a3\u3002\u4e8b\u5be6\u4e0a\uff0c\u9019\u985e\u554f\u984c\u65e9\u5df2\u5e2d\u6372\u5168\u7403\u4e86\u3002<\/p>\n<p>\u4e8c\u5341\u5e74\u4f86\uff0c\u4efb\u8077\u65bc\u8c9d\u65af\u4ee5\u8272\u5217\u72c4\u80af\u5c3c\u65af\u91ab\u7642\u4e2d\u5fc3(Beth Israel Deaconess Medical Center)\u7684\u795e\u7d93\u5167\u5206\u6ccc\u5b78\u5bb6\u5e03\u840a\u4f5b\u5fb7\uff0e\u6d1b\u5a01\u723e(Bradford Lowell)\u8a66\u5716\u89e3\u958b\u98e2\u9913\u611f\u5982\u4f55\u53d7\u8166\u4e2d\u7684\u795e\u7d93\u5143\u63a7\u5236\uff0c\u4e26\u52fe\u52d2\u51fa\u5176\u5f71\u97ff\u8def\u5f91\u3002\u900f\u904e\u8001\u9f20\u5be6\u9a57\uff0c\u4ed6\u767c\u73fe\u4f4d\u65bc\u4e0b\u8996\u4e18\u4e2d\u7684\u523a\u9f20\u80bd(Agouti peptide, AgRP)\u795e\u7d93\u5143\uff0c\u6703\u56e0\u70ba\u8eab\u9ad4\u7f3a\u4e4f\u71b1\u91cf\u800c\u6d3b\u8e8d\u8d77\u4f86\u3002\u9019\u4e9b\u795e\u7d93\u5143\u7121\u8ad6\u662f\u7d93\u904e\u81ea\u7136\u523a\u6fc0\u6216\u4eba\u70ba\u523a\u6fc0\uff0c\u90fd\u6703\u8b93\u8001\u9f20\u62fc\u547d\u8993\u98df\uff0c\u63a5\u8457\u5403\u500b\u4e0d\u505c\u3002<\/p>\n<p>\u66f4\u7cbe\u78ba\u7684\u8aaa\uff0c\u523a\u9f20\u80bd\u795e\u7d93\u5143\u662f\u4f4d\u65bc\u5ba4\u65c1\u6838(paraventricular nucleus)\u4e2d\u3002\u4ee5\u524d\u8a8d\u70ba\uff0c\u5ba4\u65c1\u6838\u7684\u529f\u80fd\u662f\u5e36\u4f86\u6eff\u8db3\u611f\uff0c\u4f46\u73fe\u5728\u537b\u767c\u73fe\uff0c\u5176\u4e2d\u7684\u795e\u7d93\u5143\u53cd\u800c\u6703\u5e36\u4f86\u98df\u617e\uff0c\u8b93\u6211\u5011\u7522\u751f\u8993\u98df\u7684\u5ff5\u982d\u3002\u9019\u9805\u9a5a\u4eba\u7684\u767c\u73fe\uff0c\u8fd1\u65e5\u5df2\u7d93\u520a\u5728\u300aNature\u300b\u4e0a\u4e86\u3002<!--more--><\/p>\n<p>\u6d1b\u5a01\u723e\u8868\u793a\uff0c\u7814\u7a76\u4eba\u54e1\u60f3\u77e5\u9053\u5927\u8166\u6703\u600e\u9ebc\u63a7\u5236\u98e2\u9913\u611f\uff1a\u300c\u8981\u662f\u98e2\u9913\u611f\u7570\u5e38\u65fa\u76db\uff0c\u53ef\u80fd\u6703\u5c0e\u81f4\u80a5\u80d6\u75c7\u8207\u98f2\u98df\u75be\u60a3\u3002\u89e3\u6c7a\u554f\u984c\u7684\u7b2c\u4e00\u6b65\uff0c\u5c31\u662f\u4e86\u89e3\u76f8\u95dc\u751f\u7406\u5982\u4f55\u904b\u4f5c\uff0c\u5426\u5247\u4fbf\u7121\u6cd5\u5c0d\u75c7\u4e0b\u85e5\u3002\u300d\u98e2\u9913\u611f\u7684\u6210\u56e0\u78ba\u5be6\u8907\u96dc\uff0c\u5b78\u754c\u5411\u4f86\u62b1\u6301\u8af8\u591a\u7591\u554f\uff0c\u50cf\u662f\u70ba\u4f55\u5403\u98fd\u5f8c\u6216\u7bc0\u98df\u5f8c\uff0c\u98e2\u9913\u611f\u6703\u589e\u52a0\u9084\u662f\u6e1b\u5c11\uff1f\u5927\u8166\u7684\u916c\u8cde\u6a5f\u5236\u548c\u98e2\u9913\u611f\u7684\u95dc\u806f\u7a76\u7adf\u70ba\u4f55\uff1f\u5403\u5b8c\u6b63\u9910\u5f8c\uff0c\u70ba\u4f55\u53ea\u60f3\u5403\u51b0\u6dc7\u6dcb\uff0c\u800c\u4e0d\u60f3\u5403\u751f\u83dc\u6c99\u62c9\uff1f<\/p>\n<p>\u6d1b\u5a01\u723e\u6307\u51fa\uff0c\u5fc3\u7406\u5b78\u5bb6\u6703\u4ee5\u74b0\u5883\u56e0\u5b50\u53ca\u9ad4\u5167\u56e0\u5b50\u7684\u4e92\u52d5\u4f86\u89e3\u91cb\uff0c\u4e5f\u5c31\u662f\u5c07\u98df\u7269\u8207\u98df\u7269\u76f8\u95dc\u523a\u6fc0\u56e0\u5b50(\u8b6c\u5982\u9ea5\u7576\u52de\u7684\u62db\u724c)\u662f\u6709\u95dc\u7684\uff0c\u5f8c\u8005\u6703\u900f\u904e\u916c\u8cde\u6a5f\u5236\u523a\u6fc0\u5927\u8166\uff0c\u8b93\u4eba\u7522\u751f\u98e2\u9913\u611f\u3002\u5c31\u6b64\u770b\u4f86\uff0c\u7bc0\u98df\u5f8c\u6703\u975e\u5e38\u60f3\u627e\u98df\u7269\u5403\uff0c\u4f46\u98fd\u98df\u5f8c\u5247\u98df\u617e\u5927\u6e1b\u3002\u4f46\u6d1b\u5a01\u723e\u4e5f\u8aaa\uff0c\u9019\u7a2e\u8aaa\u6cd5\u53ea\u80fd\u89e3\u91cb\u8868\u8c61\uff0c\u7121\u6cd5\u6e05\u6670\u63cf\u7e6a\u8166\u5167\u7684\u98e2\u9913\u611f\u795e\u7d93\u751f\u7406\u6a5f\u5236\u3002<\/p>\n<p>\u70ba\u4e86\u89e3\u958b\u8b0e\u984c\uff0c\u7814\u7a76\u5718\u968a\u6c7a\u5b9a\u4f7f\u7528\u5148\u9032\u79d1\u6280\uff0c\u8a66\u5716\u4e00\u6b65\u4e00\u6b65\u91d0\u6e05\u8eab\u9ad4\u5728\u7bc0\u98df\u53ca\u98fd\u98df\u5f8c\u7684\u795e\u7d93\u53cd\u61c9\u3002\u4ed6\u5011\u4f7f\u7528\u7684\u79d1\u6280\u5305\u62ec\u4e86\u72c2\u72ac\u75c5\u8ff4\u8def\u5206\u6790(rabies circuit mapping) \u53ca\u5149\u654f\u611f\u901a\u9053\u86cb\u767d\u8ff4\u8def\u5206\u6790(channelrhodopsin-assisted circuit mapping)\uff0c\u9019\u5169\u9805\u6280\u8853\u80fd\u9010\u4e00\u6aa2\u8996\u5404\u500b\u795e\u7d93\u5143\uff0c\u6709\u52a9\u65bc\u5f97\u51fa\u7cbe\u6e96\u5206\u6790\u3002\u6d1b\u5a01\u723e\u8868\u793a\uff1a\u300c\u6709\u4e86\u9019\u4e9b\u79d1\u6280\uff0c\u6211\u5011\u5c31\u80fd\u8ffd\u8e64\u5404\u500b\u7a81\u89f8\u53ca\u8ef8\u7a81\u7684\u53cd\u61c9\u3002\u9019\u500b\u6982\u5ff5\u770b\u4f3c\u7c21\u55ae\uff0c\u537b\u662f\u76f8\u7576\u4e0d\u5bb9\u6613\u8de8\u51fa\u7684\u4e00\u6b65\u3002\u300d<\/p>\n<p>\u6839\u64da\u9019\u4efd\u525b\u51fa\u7210\u7684\u7814\u7a76\u5831\u544a\uff0c\u7814\u7a76\u5718\u968a\u9996\u5148\u4f7f\u7528\u4e86\u72c2\u72ac\u75c5\u8ff4\u8def\u5206\u6790\uff0c\u4e5f\u5c31\u662f\u5c07\u6539\u9020\u904e\u7684\u72c2\u72ac\u75c5\u75c5\u6bd2\uff0c\u6ce8\u5c04\u9032\u55ae\u4e00\u4e00\u7a2e\u795e\u7d93\u5143\uff0c\u4f7f\u5176\u53d7\u5230\u611f\u67d3\uff0c\u800c\u7b2c\u4e00\u500b\u63a5\u53d7\u6e2c\u8a66\u7684\u7a2e\u985e\uff0c\u5373\u70ba\u523a\u9f20\u80bd\u795e\u7d93\u5143\u3002\u6ce8\u5165\u5f8c\uff0c\u75c5\u6bd2\u6703\u7a7f\u904e\u7a81\u89f8\uff0c\u4e26\u9032\u4e00\u6b65\u6a19\u8a18\u51fa\u6240\u6709\u7d66\u4e88\u8a72\u795e\u7d93\u5143\u523a\u6fc0\u7684\u5468\u908a\u795e\u7d93\u5143\u3002\u63a5\u8457\uff0c\u900f\u904e\u53e6\u4e00\u6279\u9ad4\u5167\u5bcc\u542bcre\u91cd\u7d44\u9176(cre recombinase)\u7684\u8001\u9f20\uff0c\u7814\u7a76\u4eba\u54e1\u5f97\u4ee5\u63cf\u7e6a\u51fa\u76f8\u95dc\u795e\u7d93\u7db2\u7d61\uff0c\u4ee5\u4fbf\u9032\u4e00\u6b65\u63a7\u5236\u98e2\u9913\u611f\u795e\u7d93\u5143\uff0c\u7531\u5916\u90e8\u4e88\u5176\u523a\u6fc0\u6216\u6291\u5236\u3002<\/p>\n<p>\u6d1b\u5a01\u723e\u8aaa\uff0c\u8001\u9f20\u8166\u5167\u6709\u6210\u5343\u4e0a\u842c\u500b\u795e\u7d93\u5143\uff0c\u7814\u7a76\u5718\u968a\u7684\u76ee\u6a19\uff0c\u4fbf\u662f\u627e\u5230\u54ea\u500b\u6703\u63d0\u4f9b\u523a\u9f20\u80bd\u795e\u7d93\u5143\u523a\u6fc0\u3002\u7814\u7a76\u7d50\u679c\u9817\u4ee4\u4eba\u610f\u5916\uff1a\u539f\u4f86\uff0c\u53ea\u6709\u4e0b\u8996\u4e18\u80cc\u5167\u5074\u6838(dorsal medial hypothalamus)\u53ca\u5ba4\u65c1\u6838\u6703\u53c3\u8207\u523a\u6fc0\u53cd\u61c9\uff0c\u5176\u4e2d\uff0c\u5ba4\u65c1\u6838\u63d0\u4f9b\u7684\u523a\u6fc0\u6700\u5f37\u3002<\/p>\n<p>\u7576\u7814\u7a76\u7d50\u679c\u51fa\u7210\uff0c\u65b0\u7684\u52d5\u7269\u6a21\u578b\u4fbf\u61c9\u904b\u800c\u751f\u4e86\u3002\u6d1b\u5a01\u723e\u8868\u793a\uff0c\u5718\u968a\u731c\u6e2c\u5ba4\u65c1\u6838\u88e1\u982d\u7684\u795e\u7d93\u5143\u6703\u8207\u523a\u9f20\u80bd\u795e\u7d93\u5143\u806f\u7d61\uff0c\u4e26\u6fc0\u767c\u4e4b\uff1a\u300c\u6211\u5011\u990a\u51fa\u8166\u5167\u5bcc\u542bcre\u7d44\u5408\u9176\u7684\u8001\u9f20\uff0c\u63a5\u8457\u9010\u4e00\u5206\u6790\u5ba4\u65c1\u6838\u5167\u7684\u5404\u500b\u795e\u7d93\u5143\uff0c\u4e86\u89e3\u5404\u81ea\u7684\u806f\u7d61\u5c0d\u8c61\u3002\u300d\u7d50\u679c\u986f\u793a\uff0c\u6703\u91cb\u653e\u7532\u72c0\u817a\u523a\u6fc0\u7d20 (thyrotropin-releasing hormone, TRH) \u53ca\u8166\u5782\u9ad4\u817a\u82f7\u9178\u74b0\u5316\u9176\u6fc0\u6d3b\u80bd(pituitary adenylate cylcase-activating polypeptide, PACAP)\u6703\u5f62\u6210\u6e9d\u901a\u7db2\u7d61\u3002<\/p>\n<p>\u6700\u5f8c\uff0c\u7814\u7a76\u5718\u968a\u518d\u900f\u904e\u540d\u70baDREADD(Designer Receptors Exclusively Activated by Designer Drugs)\u7684\u6280\u8853\uff0c\u5c07\u5316\u5b78\u8a66\u5291\u6ce8\u5165\u53c3\u8207\u6e9d\u901a\u7684\u795e\u7d93\u5143\uff0c\u4ee5\u6fc0\u767c\u6216\u6291\u5236\u795e\u7d93\u5143\u7684\u6d3b\u52d5\u3002\u5718\u968a\u767c\u73fe\uff0c\u5df2\u7d93\u98fd\u98df\u7684\u8001\u9f20\uff0c\u7d93\u904eDREADD\u523a\u6fc0\u5f8c\uff0c\u4fbf\u6703\u7e7c\u7e8c\u8993\u98df\uff0c\u4e26\u4e14\u5927\u5403\u5927\u559d\u3002\u76f8\u53cd\u7684\uff0c\u9913\u4e86\u4e00\u6bb5\u6642\u9593\u7684\u8001\u9f20\uff0c\u5728\u795e\u7d93\u5143\u88ab\u6291\u5236\u4e4b\u5f8c\uff0c\u9032\u98df\u91cf\u5247\u975e\u5e38\u5c0f\u3002\u6d1b\u5a01\u723e\u8aaa\uff0c\u9019\u7a2e\u523a\u6fc0\u523a\u9f20\u80bd\u795e\u7d93\u5143\uff0c\u4ee5\u5f15\u767c\u98e2\u9913\u611f\u7684\u65b9\u5f0f\uff0c\u662f\u7a7a\u524d\u7684\u7814\u7a76\u9032\u5c55\uff1a\u300c\u4ee5\u5f80\u7e3d\u8a8d\u70ba\u5ba4\u65c1\u6838\u7684\u529f\u80fd\u662f\u5e36\u4f86\u6eff\u8db3\u611f\uff0c\u4f46\u5be6\u9a57\u8b49\u660e\uff0c\u523a\u6fc0\u88e1\u982d\u7684\u795e\u7d93\u5143\u53cd\u800c\u6703\u589e\u52a0\u98e2\u9913\u611f\u3002\u300d\u4ed6\u9084\u6307\u51fa\uff0c\u9019\u9805\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5206\u6790\u795e\u7d93\u5143\u6e9d\u901a\u7db2\u7d61\u662f\u76f8\u7576\u95dc\u9375\u7684\u6280\u8853\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5728\u6df1\u5165\u77ad\u89e3\u98e2\u9913\u611f\u76f8\u95dc\u6a5f\u5236\u5f8c\uff0c\u66f4\u6709\u52a9\u65bc\u4eba\u5011\u6cbb\u7642\u98f2\u98df\u75be\u60a3\u8207\u80a5\u80d6\u75c7\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\">\u7814\u7a76\u51fa\u8655\uff1a<strong><a href=\"http:\/\/www.sciencedaily.com\/releases\/2014\/02\/140207132911.htm\" target=\"_blank\" rel=\"noopener noreferrer\">Surprising new clue to the roots of hunger, neurons that drive appetite<\/a><\/strong><\/span><\/pre>\n<p><span style=\"color: #333399;\"><strong><strong>\u8b6f\u8005\uff1a\u67ef\u5b97\u4f51 \u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u7de8\u8b6f\u3002<\/strong><\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u79d1\u5b78\u5bb6\u8fd1\u65e5\u767c\u73fe\uff0c\u8166\u4e2d\u6709\u63a7\u5236\u98df\u617e\u7684\u795e\u7d93\u5143<\/p>\n","protected":false},"author":20,"featured_media":17007,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257,3293],"tags":[1174,1172,593,1171,1173],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/03\/140207132911-large.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/17006"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17006"}],"version-history":[{"count":8,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/17006\/revisions"}],"predecessor-version":[{"id":28855,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/17006\/revisions\/28855"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/17007"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}