{"id":16054,"date":"2014-01-21T10:21:57","date_gmt":"2014-01-21T02:21:57","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=16054"},"modified":"2017-07-27T10:40:13","modified_gmt":"2017-07-27T02:40:13","slug":"%e3%80%90%e5%9f%ba%e5%9b%a0%e7%a7%91%e5%ad%b8%e3%80%91coffee-or-beer%ef%bc%9f%e4%b8%8d%e5%90%8c%e9%81%b8%e6%93%87%e5%8f%af%e8%83%bd%e5%bd%b1%e9%9f%bf%e5%9f%ba%e5%9b%a0%e7%b5%84","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=16054","title":{"rendered":"\u3010\u57fa\u56e0\u79d1\u5b78\u3011Coffee or Beer\uff1f\u4e0d\u540c\u9078\u64c7\u53ef\u80fd\u5f71\u97ff\u57fa\u56e0\u7d44"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u25a0 \u5496\u5561\u80fd\u63d0\u795e\u9192\u8166\uff0c\u5564\u9152\u5247\u4f7f\u4eba\u660f\u660f\u6b32\u7761\uff1b\u4ee5\u8272\u5217\u7814\u7a76\u5718\u968a\u767c\u73fe\u9019\u5169\u6a23\u98f2\u6599\u5c0d\u57fa\u56e0\u7d44\u7684\u5f71\u97ff\u7adf\u4e5f\u5927\u4e0d\u76f8\u540c\uff01<\/strong><\/span><\/p>\n<p><strong>\u7de8\u8b6f\uff5c<\/strong>\u9673\u51a0\u541f<\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/01\/131205142127-large.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-16056 alignright\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/01\/131205142127-large.jpg\" alt=\"131205142127-large\" width=\"560\" height=\"420\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/01\/131205142127-large.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/01\/131205142127-large-300x225.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/01\/131205142127-large-600x450.jpg 600w\" sizes=\"(max-width: 560px) 100vw, 560px\" \/><\/a><\/p>\n<p>\u65e9\u671f\u7814\u7a76\u5df2\u6307\u51fa\u4eba\u985e\u67d3\u8272\u9ad4\u672b\u7aef\u7684\u7aef\u7c92(telomeres)\u8207\u8870\u8001\u3001\u764c\u75c7\u6709\u95dc\uff0c\u4ee5\u8272\u5217\u81fa\u62c9\u7dad\u592b\u5927\u5b78\u99ac\u4e01\u2027\u5361\u76ae\u514b\u6559\u6388(Martin Kupiec)\u7814\u7a76\u5718\u968a\u5247\u9032\u4e00\u6b65\u767c\u73fe\uff0c\u5496\u5561\u548c\u5564\u9152\u5c0d\u57fa\u56e0\u7d44\u7684\u5f71\u97ff\u66f4\u53ef\u8aaa\u662f\u5357\u8f45\u5317\u8f4d\u3002\u7814\u7a76\u4eba\u54e1\u4ee5\u91cd\u8981\u57fa\u56e0\u8207\u4eba\u985e\u76f8\u8fd1\u7684\u9175\u6bcd\u83cc(\uff08Saccharomyces ceravisiae\uff09)\u505a\u70ba\u5be6\u9a57\u6750\u6599\uff0c\u767c\u73fe\u5496\u5561\u56e0\u6703\u4f7f\u7aef\u7c92\u7e2e\u77ed\uff0c\u5564\u9152\u537b\u80fd\u4f7f\u7aef\u7c92\u8b8a\u9577\uff01\u99ac\u4e01\u2027\u5361\u76ae\u514b\u6559\u6388\u8aaa\uff1a\u300c\u9019\u662f\u6211\u5011\u7b2c\u4e00\u6b21\u627e\u51fa\u6539\u8b8a\u7aef\u7c92\u9577\u5ea6\u7684\u74b0\u5883\u56e0\u7d20\uff0c\u800c\u4e14\u4e5f\u8b49\u660e\u4e86\u9019\u4e9b\u7269\u8cea\u5982\u4f55\u6539\u8b8a\u7aef\u7c92\u9577\u5ea6\u3002\u7814\u7a76\u7d50\u679c\u5728\u672a\u4f86\u6216\u8a31\u80fd\u7528\u65bc\u4eba\u985e\u75be\u75c5\u7684\u9810\u9632\u548c\u6cbb\u7642\u3002\u300d\u8a72\u7814\u7a76\u6210\u679c\u5df2\u65bc2012\u5e74\u767c\u8868\u65bcPLoS Genetics\u671f\u520a\u3002<\/p>\n<p>\u67d3\u8272\u9ad4\u662f\u7531\u53bb\u6c27\u6838\u7cd6\u6838\u9178(Deoxyribonucleic acid, DNA)\u548c\u86cb\u767d\u8cea\u6240\u7e8f\u7e5e\u7d44\u6210\u7684\u58d3\u7e2e\u7d50\u69cb\u3002\u800c\u7aef\u7c92\u4f4d\u65bc\u67d3\u8272\u9ad4\u672b\u7aef\uff0c\u7576\u7d30\u80de\u5206\u88c2\u6642\uff0c\u7aef\u7c92\u5305\u542b\u6709\u7368\u7279\u7684DNA\u5e8f\u5217\u80fd\u4fdd\u8b77\u67d3\u8272\u9ad4\u514d\u65bc\u964d\u89e3\u3002\u7136\u800c\uff0c\u7d30\u80de\u5728\u6bcf\u4e00\u6b21\u5206\u88c2\u7684\u904e\u7a0b\u4e2d\uff0c\u7aef\u7c92\u7d50\u69cb\u90fd\u6703\u88ab\u6d88\u8017\u6389\u4e00\u4e9b\uff0c\u6240\u4ee5\u96a8\u8457\u7d30\u80de\u5206\u88c2\u7684\u6b21\u6578\u589e\u52a0\uff0c\u7aef\u7c92\u5b50\u7684\u7d50\u69cb\u5c31\u8d8a\u4f86\u8d8a\u5c0f\uff0c\u5230\u6700\u5f8c\u7576\u7aef\u7c92\u7684\u7d50\u69cb\u4e0d\u8db3\u4ee5\u4fdd\u8b77\u67d3\u8272\u9ad4\u7684\u7aef\u9ede\u6642\uff0c\u67d3\u8272\u9ad4\u6240\u651c\u5e36\u7684\u907a\u50b3\u8cc7\u8a0a\u5c31\u6703\u5728\u5206\u88c2\u904e\u7a0b\u4e2d\u53d7\u5230\u50b7\u5bb3\u3002\u7d30\u80de\u5c31\u6703\u5931\u53bb\u5206\u88c2\u7684\u80fd\u529b\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u8b8a\u8001\uff0c\u7d42\u81f3\u65bc\u6b7b\u4ea1\u3002\u53ef\u662f\u5728\u751f\u6b96\u7d30\u80de\u6216\u764c\u7d30\u80de\u88e1\uff0c\u56e0\u70ba\u7aef\u7c92\u9176\u7684\u6d3b\u6027\u5f88\u9ad8\uff0c\u4f7f\u5f97\u7aef\u7c92\u4fdd\u6301\u6046\u5b9a\uff0c\u6240\u4ee5\u751f\u6b96\u7d30\u80de\u548c\u764c\u7d30\u80de\u80fd\u5448\u73fe\u51fa\u7121\u9650\u8907\u88fd\u589e\u6b96\u7684\u80fd\u529b\u3002<!--more--><\/p>\n<p>\u9019\u9805\u7814\u7a76\u662f\u5960\u57fa\u65bc2009\u751f\u91ab\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u4f0a\u8389\u838e\u767d\u2027\u5e03\u96f7\u514b\u672c(Elizabeth H. Blackburn) 2004\u5e74\u7684\u7814\u7a76\u3002\u8a72\u7814\u7a76\u6307\u51fa\uff0c\u60c5\u7dd2\u58d3\u529b\u6240\u5c0e\u81f4\u7522\u751f\u7684\u81ea\u7531\u57fa\u5c07\u5c0e\u81f4\u7aef\u7c92\u7e2e\u77ed\u3002\u5728\u9019\u6b21\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u5728\u6703\u7522\u751f\u81ea\u7531\u57fa\u7684\u74b0\u5883\u4e2d\u7e41\u6b96\u9175\u6bcd\u83cc\u7d30\u80de\uff0c\u4ee5\u6e2c\u8a66\u7aef\u7c92\u7684\u9577\u5ea6\u662f\u5426\u56e0\u6b64\u6539\u8b8a\uff0c\u4f46\u8b93\u4eba\u610f\u5916\u7684\u662f\uff0c\u672b\u7aef\u9577\u5ea6\u4e26\u672a\u6539\u8b8a\u3002\u7814\u7a76\u4eba\u54e1\u9032\u800c\u8b93\u9175\u6bcd\u83cc\u7d30\u80de\u66b4\u9732\u65bc\u5176\u4ed612\u7a2e\u74b0\u5883\u61c9\u529b\u4e0b\uff0c\u5927\u591a\u6578\u7684\u74b0\u5883\u8b8a\u56e0\u5982\u6eab\u5ea6\u3001\u9178\u9e7c\u503c\u3001\u4e0d\u540c\u5316\u5b78\u7269\u8cea\u7b49\uff0c\u90fd\u7121\u6cd5\u5c0d\u7aef\u7c92\u9577\u5ea6\u9020\u6210\u5f71\u97ff\uff1b\u4f46\u53ea\u8981\u4e00\u9ede\u5496\u5561\u56e0 (\u7d04\u662f\u4e00\u676f\u7fa9\u5f0f\u6fc3\u7e2e\u5496\u5561\u6240\u542b\u7684\u91cf)\u5c31\u6703\u4f7f\u7aef\u7c92\u7e2e\u77ed\uff0c 5~7%\u7684\u4e59\u9187\u6eb6\u6db2\u5247\u4f7f\u9175\u6bcd\u83cc\u7d30\u80de\u7684\u7aef\u7c92\u8b8a\u9577\u3002<\/p>\n<p>\u70ba\u4e86\u89e3\u9019\u4e9b\u6539\u8b8a\uff0c\u7814\u7a76\u5718\u968a\u57286,000\u682a\u9175\u6bcd\u83cc\u5167\u5206\u5225\u8b93\u4e0d\u540c\u57fa\u56e0\u53bb\u6d3b\u5316(gene deactivated)\uff0c\u518d\u6311\u9078\u6700\u9577\u8207\u6700\u77ed\u7aef\u7c92\u7684\u9175\u6bcd\u83cc\u505a\u9019\u9805\u5be6\u9a57\u3002\u7814\u7a76\u767c\u73fe\uff0c<i>Rap1<\/i>\u548c<i>Rif1<\/i>\u662f\u8abf\u7bc0\u74b0\u5883\u58d3\u529b\u8207\u7aef\u7c92\u9577\u5ea6\u7684\u91cd\u8981\u57fa\u56e0\u3002\u4f46\u7814\u7a76\u4eba\u54e1\u4ea6\u5f37\u8abf\uff0c\u7aef\u7c92\u9577\u77ed\u7684\u7d50\u679c\u5be6\u70ba\u7d04400\u500b\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\u800c\u6210\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u54e1\u8868\u793a\uff1a\u9019\u4e9b\u9175\u6bcd\u83cc\u7684\u57fa\u56e0\u96d6\u4ea6\u5b58\u5728\u65bc\u4eba\u985e\u57fa\u56e0\u7d44\uff0c\u4f46\u4ecd\u9700\u5f85\u66f4\u591a\u5be6\u9a57\u624d\u80fd\u8b49\u660e\u7aef\u7c92\u9577\u5ea6\u8207\u8001\u5316\u6216\u764c\u75c7\u7684\u95dc\u806f\u6027\u662f\u5426\u70ba\u56e0\u679c\u76f8\u95dc\uff0c\u5c46\u6642\u624d\u80fd\u9032\u4e00\u6b65\u9a57\u8b49\u4eba\u985e\u7aef\u7c92\u662f\u5426\u8ddf\u9175\u6bcd\u83cc\u7aef\u7c92\u6709\u985e\u4f3c\u53cd\u61c9\uff0c\u9032\u800c\u904b\u7528\u65bc\u91ab\u5b78\u6cbb\u7642\u53ca\u98f2\u98df\u5efa\u8b70\u4e0a\u3002<\/p>\n<p>\u6700\u5f8c\uff0c\u5361\u76ae\u514b\u6559\u6388\u4e5f\u4e0d\u5fd8\u5e7d\u9ed8\u8aaa\u9053\uff1a\u300c\u653e\u8f15\u9b06\uff0c\u5496\u5561\u548c\u5564\u9152\u5c31\u90fd\u4f86\u4e00\u9ede\u5427\uff01\u300d<\/p>\n<p><strong>--<\/strong><br \/>\n<strong> \u5ef6\u4f38\u95b1\u8b80<\/strong><br \/>\n<strong> <a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=289\" target=\"_blank\" rel=\"noopener noreferrer\">\u30102009 Nobel\u7cfb\u5217\u5831\u5c0e\u4e00\u3011\u7d30\u80de\u8001\u5316\u7814\u7a76 \u6458\u4e0b\u8afe\u8c9d\u723e\u91ab\u5b78\u734e<\/a>\u3000<a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=289\"><br \/>\n<\/a><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=321\" target=\"_blank\" rel=\"noopener noreferrer\">\u30102009 Nobel\u7cfb\u5217\u5831\u5c0e\u4e09\u3011\u7d30\u80de\u4e4b\u8b0e\uff1a\u8001\u5316\u5982\u4f55\u767c\u751f\uff1f<\/a><\/strong><\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\"> \u7814\u7a76\u51fa\u8655\uff1a<strong><a href=\"http:\/\/www.sciencedaily.com\/releases\/2013\/12\/131205142127.htm\" target=\"_blank\" rel=\"noopener noreferrer\">Coffee or Beer? The Choice Could Affect Your Genome<\/a><\/strong><\/span><\/pre>\n<p><span style=\"color: #333399;\"><strong><strong>\u8b6f\u8005\uff1a\u9673\u51a0\u541f \u79d1\u6559\u4e2d\u5fc3\u7279\u7d04\u5beb\u624b\uff0c\u5f9e\u4e8b\u79d1\u666e\u6587\u7ae0\u7de8\u8b6f\u3002<\/strong><\/strong><\/span><br \/>\n<span style=\"color: #333399;\"><strong><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aKerina Huang<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 \u5496\u5561\u80fd\u63d0\u795e\u9192\u8166\uff0c\u5564\u9152\u5247\u4f7f\u4eba\u660f\u660f\u6b32\u7761\uff1b<\/p>\n","protected":false},"author":20,"featured_media":16056,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1015,29,28,30,1024,31],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2014\/01\/131205142127-large.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/16054"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16054"}],"version-history":[{"count":8,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/16054\/revisions"}],"predecessor-version":[{"id":28889,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/16054\/revisions\/28889"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/16056"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}