{"id":15432,"date":"2013-12-05T10:08:50","date_gmt":"2013-12-05T02:08:50","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=15432"},"modified":"2017-08-01T09:30:47","modified_gmt":"2017-08-01T01:30:47","slug":"%e3%80%90%e6%8e%a2%e7%b4%a210-%e3%80%91%e8%a7%a3%e5%af%86%e5%ad%9f%e5%be%b7%e7%88%be%ef%bc%9a%e6%a9%9f%e7%8e%87%e8%88%87%e5%9f%ba%e5%9b%a0%e5%ae%9a%e4%bd%8d","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=15432","title":{"rendered":"\u3010\u63a2\u7d2210 \u3011\u89e3\u5bc6\u5b5f\u5fb7\u723e\uff1a\u6a5f\u7387\u8207\u57fa\u56e0\u5b9a\u4f4d"},"content":{"rendered":"<h3 style=\"text-align: center;\"><span style=\"color: #800000;\"><strong>\u7b2c\u4e94\u8b1b\u2027\u7279\u7a3f<\/strong><\/span><\/h3>\n<p><span style=\"color: #008080;\"><strong>\u25a0 \u5c0f\u5c0f\u8c4c\u8c46\u958b\u555f\u4e86\u907a\u50b3\u5b78\u7814\u7a76\u5927\u9580\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_16709\" aria-describedby=\"caption-attachment-16709\" style=\"width: 789px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/P26-\u65b0\u914d\u5716.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-16709 \" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/P26-\u65b0\u914d\u5716.jpg\" alt=\"P26 \u65b0\u914d\u5716\" width=\"789\" height=\"526\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/P26-\u65b0\u914d\u5716.jpg 1024w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/P26-\u65b0\u914d\u5716-300x200.jpg 300w\" sizes=\"(max-width: 789px) 100vw, 789px\" \/><\/a><figcaption id=\"caption-attachment-16709\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90|Flickr@ DaveFayram<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587<\/strong><strong>\u2502<\/strong>\u5f35\u601d\u9060<\/p>\n<p><b><br \/>\n\u7a2e\u8c46\u53ea\u5f97\u8c46\uff1f<\/b><\/p>\n<p>\u683d\u7a2e\u690d\u7269\u53ef\u4ee5\u9676\u51b6\u6027\u60c5\uff0c\u53ef\u662f\u6211\u5011\u53c8\u77e5\u4e0d\u77e5\u9053\uff0c\u8c4c\u8c46\u83a2\u9664\u4e86\u7da0\u8272\u4ee5\u5916\u9084\u6709\u9ec3\u8272\uff0c\u6709\u4e9b\u98fd\u6eff\u6709\u4e9b\u76ba\u7e2e\uff0c\u7a2e\u76ae\u6709\u7684\u5713\u6f64\u6709\u7684\u9577\u76ba\u7d0b\uff0c\u690d\u682a\u6709\u4e9b\u9577\u5f97\u6bd4\u8f03\u77ee\uff0c\u9802\u751f\u6216\u8005\u814b\u751f\uff0c\u82b1\u9664\u4e86\u767d\u8272\u9084\u6709\u7d2b\u8272\uff0c\u89c0\u5bdf\u5230\u8c4c\u8c46\u5177\u6709\u9019\u4e03\u7a2e\u907a\u50b3\u6027\u72c0\u7684\uff0c\u5c31\u662f\u907a\u50b3\u5b78\u4e4b\u7236\u5b5f\u5fb7\u723e\uff0c\u4f5c\u70ba\u4e00\u540d\u795e\u8077\u4eba\u54e1\uff0c\u7a7a\u9918\u6642\u9593\u4ee5\u7a2e\u8c4c\u8c46\u505a\u5be6\u9a57\u70ba\u6a02\u3002<\/p>\n<p>\u9ad8\u500b\u5b50\u8c4c\u8c46\u7684\u5b50\u4ee3\u53ef\u80fd\u51fa\u73fe\u77ee\u500b\u5b50\uff0c\u800c\u77ee\u500b\u5b50\u8c4c\u8c46\u7684\u5b50\u4ee3\u4e5f\u6709\u9ad8\u500b\u5b50\uff0c\u5b5f\u5fb7\u723e\u63a8\u65b7\u7576\u4e2d\u61c9\u8a72\u662f\u6709\u67d0\u4e9b\u56e0\u5b50\u5728\u652f\u914d\u8457\u907a\u50b3\u6027\u72c0\u7684\u8868\u73fe\uff0c\u65bc\u662f\u5c55\u958b\u9577\u9054\u516b\u5e74\uff0c\u683d\u7a2e\u8c4c\u8c46\u6578\u76ee\u9054\u5230\u5169\u842c\u516b\u5343\u682a\u7684\u96dc\u4ea4\u5be6\u9a57\u3002\u5047\u8a2d\u6bcf\u9846\u8c46\u5b50\u9ad4\u5167\u5404\u5e36\u6709\u4e00\u6210\u5c0d\u56e0\u5b50\uff0c\u56e0\u5b50\u6709\u4e00\u5c0dG\u7684\uff0c\u6709\u4e00\u5c0dg\u7684\uff0c\u4e5f\u6709G\u8ddfg\u6df7\u642d\uff0c\u73fe\u5728\u628a\u540c\u70baG\u7684\u9ad8\u500b\u5b50\u8ddf\u540c\u70bag\u7684\u77ee\u500b\u5b50\u9032\u884c\u96dc\u4ea4\uff0c\u5f97\u5230G\u8ddfg\u4e26\u5b58\u7684\u975e\u7d14\u7a2e\uff0c\u5b50\u4ee3\u5168\u70ba\u9ad8\u500b\u5b50\uff0c\u77ee\u500b\u5b50\u66ab\u6642\u9000\u96b1\uff0c\u6240\u4ee5\u9ad8\u500b\u5b50\u662f\u986f\u6027\u6027\u72c0\uff0c\u9019\u5c31\u662f\u986f\u6027\u539f\u5247(Law of dominance)\u3002<\/p>\n<p>\u9019\u4e9b\u975e\u7d14\u7a2e\u7684\u5b50\u4ee3\u518d\u9032\u884c\u96dc\u4ea4\uff0c\u6392\u5217\u7d44\u5408\u61c9\u8a72\u70baGG\u3001Gg\u3001Gg\u8ddfgg\uff0c\u6240\u4ee5\u7b2c\u4e00\u5b50\u4ee3\u4e2d\u92b7\u8072\u533f\u8de1\u7684\u77ee\u500b\u5b50\u5728\u7b2c\u4e8c\u5b50\u4ee3\u91cd\u73fe\uff0c\u6839\u64da\u7d71\u8a08\u7d50\u679c\uff0c\u9ad8\u500b\u5b50\u8ddf\u77ee\u500b\u5b50\u7684\u6578\u91cf\u7d04\u70ba3\uff1a1\uff0c\u5370\u8b49\u4e86\u5b5f\u5fb7\u723e\u7684\u5047\u8aaa\uff0c\u6210\u5c0d\u56e0\u5b50\u5728\u96dc\u4ea4\u904e\u7a0b\u4e2d\u6703\u88ab\u6253\u6563\uff0c\u7136\u5f8c\u518d\u91cd\u65b0\u9032\u884c\u7d44\u5408\uff0c\u9019\u5c31\u662f\u5206\u96e2\u5b9a\u5f8b(Law of segregation)\uff0c\u4e5f\u662f\u5b5f\u5fb7\u723e\u7b2c\u4e00\u5b9a\u5f8b\u3002<\/p>\n<p>\u5982\u679c\u89ba\u5f97\u55ae\u4e00\u6027\u72c0\u592a\u55ae\u8abf\uff0c\u63a5\u4e0b\u4f86\u662f\u9ec3\u8272\u5713\u6f64\u8ddf\u7da0\u8272\u76ba\u647a\u8c4c\u8c46\u7684\u96dc\u4ea4\u5be6\u9a57\uff0c\u7d50\u679c\u767c\u73fe\u9ec3\u8272\u5713\u6f64\u3001\u9ec3\u8272\u76ba\u647a\u3001\u7da0\u8272\u5713\u6f64\u4ee5\u53ca\u7da0\u8272\u76ba\u647a\u7684\u6bd4\u4f8b\u7d04\u70ba9\uff1a3\uff1a3\uff1a1\uff0c\u5149\u770b\u6578\u5b57\u8b93\u4eba\u773c\u82b1\u77ad\u4e82\uff0c\u5982\u679c\u5f9e\u9ec3\u8ddf\u7da0\u3001\u5713\u8ddf\u76ba\u5169\u7d44\u986f\u96b1\u6027\u72c0\u5206\u5225\u89c0\u5bdf\uff0c\u5c31\u6703\u767c\u73fe\u9ec3\u8272\u8ddf\u7da0\u8272\u6bd4\u4f8b\u70ba3\uff1a1\uff0c\u53e6\u5916\u5713\u6f64\u8207\u76ba\u647a\u7684\u6bd4\u4f8b\u9084\u662f3\uff1a1\uff0c\u8aaa\u660e\u6210\u5c0d\u56e0\u5b50\u7684\u81ea\u7531\u7d44\u5408\u5176\u5be6\u662f\u5404\u81ea\u70ba\u653f\u7684\u904e\u7a0b\uff0c\u4e0d\u540c\u907a\u50b3\u6027\u72c0\u4e0d\u5b58\u5728\u4efb\u4f55\u4ea4\u6d41\uff0c\u9019\u5c31\u662f\u81ea\u7531\u7d44\u5408\u5b9a\u5f8b(Law of independent assortment)\uff0c\u4e5f\u662f\u5b5f\u5fb7\u723e\u7b2c\u4e8c\u5b9a\u5f8b\u3002<!--more--><\/p>\n<p>\u5b5f\u5fb7\u723e\u5960\u5b9a\u4e86\u907a\u50b3\u5b78\u7684\u7406\u8ad6\u57fa\u790e\u5916\uff0c\u540c\u6642\u4e5f\u7387\u5148\u628a\u6578\u5b78\u5de5\u5177\u5f15\u9032\u5230\u7814\u7a76\u7576\u4e2d\uff0c\u539f\u4f86\u907a\u50b3\u5b78\u554f\u984c\u53ef\u4ee5\u901a\u904e\u6578\u7406\u7d71\u8a08\u5f97\u5230\u89e3\u7b54\uff0c\u6b64\u5f8c\u76f8\u95dc\u7684\u7814\u7a76\u6709\u5982\u96e8\u5f8c\u6625\u7b4d\u822c\u840c\u767c\uff0c\u6db5\u84cb\u5230\u8c4c\u8c46\u4ee5\u5916\u5176\u4ed6\u751f\u7269\uff0c\u5305\u62ec\u4eba\u985e\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><b>\u9023\u9396\u5206\u6790\u8207\u76f8\u95dc\u6027\u7814\u7a76<\/b><\/p>\n<p>\u4eba\u9ad4\u670923\u5c0d\u67d3\u8272\u9ad4(Chromosome)\uff0c\u5f62\u614b\u4e0a\u9177\u4f3c\u4e0d\u898f\u5247\u7248\u7684\u82f1\u6587\u5b57\u6bcdX\uff0c\u7531\u4e2d\u7bc0(Ceretromere)\u5206\u6210\u5169\u6bb5\uff0c\u8f03\u77ed\u7684\u4e00\u6bb5\u7a31\u70bap\u81c2(p arm)\uff0c\u8f03\u9577\u7684\u4e00\u6bb5\u5247\u7a31\u70baq\u81c2(q arm)\uff0c\u6210\u5206\u7531ATCG\u5373\u817a\u560c\u5464(Adenine)\u3001\u80f8\u817a\u5627\u5576(Thymine)\u3001\u80de\u5627\u5576(Cytosine)\u53ca\u9ce5\u560c\u5464(Guanine)\u6240\u69cb\u6210\u3002<\/p>\n<p>\u907a\u50b3\u75be\u75c5\u6839\u64da\u4e0d\u540c\u81f4\u75c5\u6210\u56e0\u53ef\u4ee5\u5206\u70ba\u55ae\u4e00\u57fa\u56e0\u7a81\u8b8a\u3001\u67d3\u8272\u9ad4\u8b8a\u7570\u4ee5\u53ca\u591a\u57fa\u56e0\u5171\u540c\u5f71\u97ff\uff0c\u7576\u4e2d\u7531\u65bc\u55ae\u57fa\u56e0\u7a81\u8b8a\u6240\u5f15\u767c\u7684\u907a\u50b3\u75be\u75c5\u53c8\u7a31\u70ba\u5b5f\u5fb7\u723e\u578b\u75c5\u75c7\u3002<\/p>\n<p>\u4e0d\u7ba1\u8abf\u67e5\u4f55\u7a2e\u985e\u578b\u7684\u72af\u7f6a\uff0c\u78ba\u5b9a\u5acc\u72af\u90fd\u6703\u662f\u524d\u63d0\u689d\u4ef6\uff0c\u540c\u6a23\u5730\uff0c\u8981\u5c0d\u75c7\u4e0b\u85e5\uff0c\u9996\u5148\u8981\u627e\u51fa\u907a\u50b3\u75be\u75c5\u7684\u81f4\u75c5\u57fa\u56e0\u3002\u4e16\u754c\u4e4b\u5927\uff0c\u5305\u7f85\u842c\u8c61\uff0c\u6211\u5011\u9700\u8981\u5730\u5716\uff0c\u9700\u8981\u5c0e\u822a\u5b9a\u4f4d\uff0c\u5f9e\u524d\u7528\u6307\u5357\u91dd\uff0c\u5f8c\u4f86\u66f4\u6709\u4e86\u5168\u7403\u885b\u661f\u5b9a\u4f4d\u7cfb\u7d71\uff0c\u624d\u4e0d\u81f4\u65bc\u8ff7\u5931\u65b9\u5411\uff0c\u67d3\u8272\u9ad4\u4e0a\u7684\u57fa\u56e0\u4f4d\u9ede(Locus)\u591a\u5982\u725b\u6bdb\uff0c\u6240\u4ee5\u8981\u627e\u5230\u81f4\u75c5\u57fa\u56e0\u7684\u4f4d\u7f6e\u540c\u6a23\u9700\u8981\u5730\u5716\uff0c\u9700\u8981\u5b9a\u4f4d\u3002\u5b9a\u4f4d\u81f4\u75c5\u57fa\u56e0\u7684\u7d71\u8a08\u65b9\u6cd5\uff0c\u5206\u5225\u6709\u9023\u9396\u5206\u6790(Linkage analysis)\u548c\u76f8\u95dc\u6027\u7814\u7a76(Association study)\u5169\u7a2e\u3002<\/p>\n<p>\u57fa\u56e0\u6a19\u8a18(Genetic marker)\u7528\u4f5c\u5b9a\u4f4d\u81f4\u75c5\u57fa\u56e0\uff0c\u7576\u4e2d\u7279\u5225\u662f\u55ae\u4e00\u6838\u82f7\u9178\u591a\u578b\u6027(Single Nucleotide Polymorphism, SNP)\uff0c\u6839\u64da\u7f8e\u570b\u570b\u7acb\u751f\u7269\u6280\u8853\u8a0a\u606f\u4e2d\u5fc3\u7684\u6578\u64da\uff0c\u4eba\u985e\u67091\u5104\u591a\u500bSNP\uff0c\u51fa\u73fe\u983b\u7387\u7d04\u70ba0.1%\uff0c\u5728\u4eba\u9ad4\u5167\u5206\u4f48\u5ee3\u6cdb\uff0c\u662f\u512a\u826f\u7684\u5730\u6a19\u6027\u53c3\u8003\u7269\u3002\u6709\u6c92\u6709\u60f3\u904e\u91ab\u7642\u4e5f\u53ef\u4ee5\u5ba2\u88fd\u5316\uff1fSNP\u662f\u9020\u6210\u500b\u9ad4\u9593\u9ad4\u8cea\u5dee\u7570\u7684\u4e3b\u56e0\uff0c\u6240\u4ee5\u628aSNP\u5f15\u5165\u5230\u57fa\u56e0\u8a3a\u65b7\uff0c\u80fd\u5920\u505a\u5230\u8a3a\u65b7\u91ab\u7642\u7684\u91cf\u8eab\u8a02\u505a\uff0c\u6e1b\u5c11\u75c5\u4eba\u5c0d\u85e5\u7269\u7522\u751f\u4e0d\u826f\u53cd\u61c9\u7684\u6a5f\u6703\u3002\u53e6\u5916\uff0c\u79d1\u5b78\u5bb6\u5c0dSNP\u7684\u5e8f\u5217\u5df2\u7d93\u6709\u76f8\u7576\u4e86\u89e3\uff0c\u5229\u7528\u57fa\u56e0\u6676\u7247(Gene chip)\u53ef\u4ee5\u5feb\u901f\u7cbe\u78ba\u6aa2\u5b9a\u57fa\u56e0\u591a\u578b\u6027\uff0c\u5df2\u7d93\u9032\u5165\u5546\u696d\u5316\u91cf\u7522\uff0c\u6210\u672c\u4f4e\u5ec9\u3002<\/p>\n<p>\u57fa\u56e0\u4f4d\u9ede\u4e4b\u9593\u8ddd\u96e2\u6709\u9577\u6709\u77ed\uff0c\u8d8a\u8fd1\u7684\u7f88\u7d46\u6df1\u539a\uff0c\u9023\u9396\u5b58\u5728\uff0c\u8d8a\u9060\u7684\u5bb9\u6613\u898b\u7570\u601d\u9077\uff0c\u9023\u9396\u4e0d\u5b58\u5728\uff0c\u91cd\u7d44\u7387\u4e5f\u8d8a\u9ad8\uff0c\u900f\u904e\u89c0\u5bdf\u57fa\u56e0\u6a19\u8a18\u7684\u57fa\u56e0\u578b\u7531\u89aa\u4ee3\u907a\u50b3\u5230\u5b50\u4ee3\u7684\u6a21\u5f0f\uff0c\u7528\u7d71\u8a08\u65b9\u6cd5\u8a08\u7b97\u81f4\u75c5\u57fa\u56e0\u8207\u6bcf\u500b\u57fa\u56e0\u6a19\u8a18\u7684\u91cd\u7d44\u7387(Recombination fraction)\uff0c\u91cd\u7d44\u7387\u8d8a\u9ad8\u8868\u793a\u81f4\u75c5\u57fa\u56e0\u8207\u57fa\u56e0\u6a19\u8a18\u8ddd\u96e2\u8d8a\u9060\uff0c\u53cd\u4e4b\u4ea6\u7136\uff0c\u5927\u81f4\u5b9a\u51fa\u81f4\u75c5\u57fa\u56e0\u7684\u76f8\u5c0d\u4f4d\u7f6e\u3002<\/p>\n<p>\u73fe\u5728\u5047\u8a2d\u670911\u500b\u5c0f\u5b69\uff0c\u57fa\u56e0\u6a19\u8a18A\u3001B\u548cC\uff0c\u5176\u4e2d\u67091\u500b\u5c0f\u5b69AB\u767c\u751f\u91cd\u7d44\uff0c\u5247AB\u7684\u91cd\u7d44\u7387\u70ba1\/11\uff0c3\u500b\u5c0f\u5b69\u7684AC\u767c\u751f\u91cd\u7d44\uff0cAC\u7684\u91cd\u7d44\u7387\u662f3\/11\uff0c\u5b5f\u5fb7\u723e\u7b2c\u4e8c\u5b9a\u5f8b\u6240\u4f9d\u64da\u7684\u4e8b\u5be6\u662f\u57fa\u56e0\u4e0d\u9023\u9396\uff0c\u4e5f\u5c31\u662f\u57fa\u56e0\u53ef\u4ee5\u5b8c\u5168\u6253\u6563\u5f8c\u518d\u91cd\u7d44\uff0c\u5169\u500b\u57fa\u56e0\u6a19\u8a18\u4e0d\u9023\u9396\uff0c\u524711\u500b\u5c0f\u5b69\u90fd\u767c\u751f\u91cd\u7d44\u7684\u6a5f\u7387\u70ba \uff0c\u5982\u679c11\u500b\u5c0f\u5b69\u4e2d\u67091\u500b\u6a19\u8a8c\u57fa\u56e0AB\u9023\u9396\uff0c\u4e5f\u5c31\u662f\u9055\u53cd\u5b5f\u5fb7\u723e\u7b2c\u4e8c\u5b9a\u5f8b\uff0c\u524710\u500b\u6c92\u6709\u767c\u751f\u91cd\u7d44\u7684\u6a5f\u7387\u70ba<a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/011.png\"><img decoding=\"async\" class=\"alignnone wp-image-16717\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/011.png\" alt=\"01\" width=\"78\" height=\"22\" \/><\/a> \uff0c\u67093\u500b\u57fa\u56e0\u91cd\u7d44\uff0c\u90a3\u9ebc8\u500b\u6c92\u6709\u91cd\u7d44\u7684\u6a5f\u7387\u70ba <a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/02.png\"><img decoding=\"async\" class=\"alignnone wp-image-16716\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/02.png\" alt=\"02\" width=\"78\" height=\"22\" \/><\/a>\u3002<\/p>\n<p>\u767c\u751f\u91cd\u7d44\u6a5f\u7387\u8207\u6c92\u6709\u767c\u751f\u91cd\u7d44\u6a5f\u7387\u7684\u6bd4\u503c\u5c31\u662f\u52dd\u7b97\u6bd4(Odds)\uff0c\u53d6\u5c0d\u6578\u5f8c\u5f97\u5230LOD scores\uff0c\u4e0a\u4f8b\u4e2d\u767c\u751fAB\u91cd\u7d44\u7684\u53ef\u80fd\u60271\/11\uff0c\u4ee3\u5165\u8a08\u7b97LOD scores\u70ba1.85\uff0c\u767c\u751fAC\u91cd\u7d44\u7684\u53ef\u80fd\u6027\u70ba3\/11\uff0c\u4ee3\u5165\u8a08\u7b97LOD scores\u5f97\u52300.51\uff0cLOD scores\u8f03\u5927\u4ee3\u8868\u8ddd\u96e2\u6bd4\u8f03\u8fd1\uff0c\u53cd\u4e4b\u4ea6\u7136\uff0c\u7531\u6b64\u53ef\u77e5\u6a19\u8a8c\u57fa\u56e0A\u96e2B\u8f03\u8fd1\uff0c\u96e2C\u8f03\u9060\u3002<\/p>\n<p>\u96fb\u5f71\u300a\u90a3\u4e9b\u5e74\uff0c\u6211\u5011\u4e00\u8d77\u8ffd\u7684\u5973\u5b69\u300b\u7684\u7537\u4e3b\u89d2\u67ef\u666f\u9a30\u66fe\u7d93\u8aaa\u904e\uff1a\u300c\u6211\u6562\u8ddf\u59b3\u8ced\uff0c\u5341\u5e74\u5f8c\uff0c\u6211\u9023log\u662f\u4ec0\u9ebc\u90fd\u4e0d\u77e5\u9053\uff0c\u7167\u6a23\u6d3b\u5f97\u5f88\u597d\u3002\u300d\u5f88\u907a\u61be\u7684\u662f\uff0c\u4e0d\u7528\u7b49\u5341\u5e74\uff0c\u4e0d\u61c2\u5f97log\uff0c\u73fe\u5728\u5c31\u6c92\u8fa6\u6cd5\u9032\u884c\u57fa\u56e0\u5b9a\u4f4d\u3002\u9023\u9396\u5206\u6790\u4e4b\u6240\u4ee5\u9078\u64c7log\u4f5c\u70ba\u8a08\u7b97\u5de5\u5177\uff0c\u662f\u57fa\u65bclog\u80fd\u5920\u76f8\u52a0\u7684\u6027\u8cea\uff0c\u525b\u624d11\u500b\u5c0f\u5b69\u7684\u5bb6\u5ead\u4e2d\u67091\u500b\u767c\u751f\u57fa\u56e0\u91cd\u7d44\u7684LOD scores\u70ba1.85\uff0c\u5047\u8a2d\u53e6\u5916\u6709\u76f8\u540c\u72c0\u6cc1\u7684\u5bb6\u5ead\uff0c\u5247LOD scores\u5c07\u6703\u662f1.85\u52a0\u4e0a1.85\u4e5f\u5c31\u662f3.70\uff0cLOD scores\u80fd\u5920\u4e0d\u65b7\u7d2f\u52a0\uff0c\u5728\u6a19\u8a8c\u57fa\u56e0\u5b9a\u4f4d\u81f4\u75c5\u57fa\u56e0\u7684\u60c5\u5f62\uff0cLOD scores\u5fc5\u9808\u5927\u65bc3\u624d\u5177\u6709\u7d71\u8a08\u4e0a\u986f\u8457\u6027\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u5229\u7528\u57fa\u56e0\u7684\u76f8\u5c0d\u4f4d\u7f6e\u63cf\u7e6a\u51fa\u57fa\u56e0\u5716\u8b5c(Genetic map)\uff0c\u627e\u5230\u907a\u50b3\u75be\u75c5\u7684\u81f4\u75c5\u57fa\u56e0\u7684\u5927\u6982\u4f4d\u7f6e\u3002\u5bb6\u65cf\u652f\u7cfb\u5f80\u5f80\u932f\u7d9c\u8907\u96dc\uff0c\u4ea8\u4e01\u9813\u821e\u8e48\u75c7(Huntington\u2019s disease)\u662f\u55ae\u4e00\u57fa\u56e0\u7a81\u8b8a\u7684\u986f\u6027\u907a\u50b3\u75be\u75c5\uff0c\u60a3\u8005\u8166\u7d30\u80de\u795e\u7d93\u539f\u6301\u7e8c\u9000\u5316\uff0c\u5c0e\u81f4\u6d3b\u52d5\u5931\u63a7\uff0c\u667a\u80fd\u6e1b\u9000\uff0c\u5982\u679c\u8981\u4f30\u8a08\u4e00\u500bm\u4eba\u5bb6\u65cf\u8b5c\u7cfb\u5e36\u6709\u9019\u7a2e\u57fa\u56e0\u578b\u7684\u6a5f\u7387\uff0c\u53ef\u4ee5\u900f\u904e\u500b\u4eba\u6240\u5e36\u57fa\u56e0\u7684\u5916\u986f\u7387\u4e58\u4e0a\u500b\u4eba\u6240\u5e36\u57fa\u56e0\u7684\u57fa\u56e0\u578b\u7576\u4e2d\u4f86\u81ea\u7236\u6bcd\u57fa\u56e0\u578b\u7684\u6a5f\u7387\u6216\u662f\u4f86\u81ea\u65cf\u7fa4\u7684\u983b\u7387\uff0c\u6240\u6709\u5bb6\u65cf\u6210\u54e1\u90fd\u5982\u662f\u64cd\u4f5c\uff0c\u6700\u5f8c\u628a\u5404\u4eba\u7684\u6a5f\u7387\u52a0\u7e3d\u800c\u6c42\u5f97\uff0c\u904e\u7a0b\u7e41\u96dc\u8b93\u4eba\u60f3\u7761\u89ba\uff0c\u80fd\u5920\u6709\u4eca\u5929\u7684\u7814\u7a76\u898f\u6a21\uff0c\u8a08\u7b97\u6a5f\u53ef\u8b02\u529f\u4e0d\u53ef\u6c92\u3002<\/p>\n<p>\u7136\u800c\uff0c\u8cc7\u6599\u8490\u96c6\u4e26\u4e0d\u5168\u7136\u90fd\u8981\u5927\u5bb6\u65cf\uff0c\u6709\u75c5\u540c\u80de\u624b\u8db3(SIB)\u8cc7\u6599\u5206\u6790\u6cd5\u5c31\u904b\u7528\u5b5f\u5fb7\u723e\u7b2c\u4e8c\u5b9a\u5f8b\uff0c\u6bd4\u8f03\u5e36\u75c5\u7684\u5144\u5f1f\u59d0\u59b9\u4e4b\u9593\uff0c\u5c0d\u5076\u57fa\u56e0\u7684\u76f8\u540c\u7a76\u662f\u6e90\u81ea\u7236\u6bcd(IBS)\uff0c\u9084\u662f\u7d14\u7cb9\u5de7\u5408(IBD)\uff0c\u5982\u679c\u5e36\u6709\u7684\u57fa\u56e0\u53ea\u6709\u7236\u6216\u6bcd\u4e00\u4eba\u6240\u6709\uff0c\u53ef\u4ee5\u8a8d\u70ba\u4f86\u81ea\u7236\u6bcd\uff0c\u4f46\u7236\u6bcd\u96d9\u65b9\u90fd\u6709\u7684\u8a71\uff0c\u53ef\u80fd\u53ea\u662f\u5de7\u5408\uff0c\u5982\u679c\u6c92\u6709\u7236\u6bcd\u7684\u8cc7\u6599\uff0c\u4f46\u8a72\u57fa\u56e0\u5728\u65cf\u7fa4\u88e1\u76f8\u7576\u7f55\u898b\uff0c\u5c31\u6bd4\u8f03\u6709\u53ef\u80fd\u51fa\u81ea\u7236\u6bcd\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002\u4f46\u73fe\u5be6\u8207\u7406\u60f3\u4e0d\u514d\u5b58\u5728\u843d\u5dee\uff0c\u4ee5\u4e0a\u662f\u9810\u8a2d\u53d7\u8a66\u8005\u70ba\u89aa\u751f\u624b\u8db3\u540c\u80de\uff0c\u4f46\u70ba\u4e86\u7372\u5f97\u5be6\u9a57\u5831\u916c\u800c\u5192\u5145\u7684\u6bd4\u6bd4\u7686\u662f\uff0c\u91d1\u9322\u4e0d\u8981\u7dca\uff0c\u5f71\u97ff\u5be6\u9a57\u7d50\u679c\u4e8b\u95dc\u91cd\u5927\uff0c\u9084\u597d\u5f8c\u4f86\u767c\u73fe\u53ea\u8981\u638c\u63e1\u523050\u500b\u57fa\u56e0\u6a19\u8a18\u5c31\u80fd\u5920\u78ba\u5b9a\u89aa\u5c6c\u95dc\u4fc2\uff0c\u57fa\u56e0\u539f\u4f86\u4e5f\u6703\u8aaa\u8a71\u7684\u3002<\/p>\n<p>\u9023\u9396\u5206\u6790\u7528\u65bc\u5b9a\u4f4d\u55ae\u4e00\u57fa\u56e0\u907a\u50b3\u75be\u75c5\u7684\u81f4\u75c5\u57fa\u56e0\u6210\u6548\u986f\u8457\uff0c\u4f46\u591a\u57fa\u56e0\u907a\u50b3\u75be\u75c5\u662f\u591a\u500b\u81f4\u75c5\u57fa\u56e0\u5206\u5de5\u5408\u4f5c\u7684\u7d50\u679c\uff0c\u81f4\u75c5\u57fa\u56e0\u4e4b\u9593\u767c\u75c5\u7a0b\u5ea6\u9ad8\u4f4e\u6709\u5225\uff0c\u6709\u4e9b\u751a\u81f3\u4e0d\u767c\u75c5\uff0c\u9084\u6709\u74b0\u5883\u56e0\u7d20\u647b\u96dc\u5176\u4e2d\uff0c\u8b8a\u6578\u592a\u591a\uff0c\u7528\u9023\u9396\u5206\u6790\u53ea\u80fd\u6293\u5230\u500b\u5225\u5c0f\u6df7\u6df7\uff0c\u610f\u7fa9\u4e0d\u5927\uff0c\u8981\u628a\u6574\u500b\u72af\u7f6a\u96c6\u5718\u4e00\u7db2\u6253\u76e1\uff0c\u9700\u8981\u76f8\u95dc\u6027\u7814\u7a76\u3002<\/p>\n<p>\u7b49\u4f4d\u57fa\u56e0(Allele)\u4f5c\u7528\u4e0a\u985e\u4f3c\u65bc\u8c4c\u8c46\u5c0d\u5076\u6027\u72c0\u7684\u907a\u50b3\u56e0\u5b50\uff0c\u67d3\u8272\u9ad4\u5c31\u50cf\u628a\u5b57\u6bcdX\u4e2d\u5206\u90a3\u6a23\u7684\u5169\u689d\u6210\u5c0d\u5b58\u5728\uff0c\u4f4d\u65bc\u540c\u6e90\u67d3\u8272\u9ad4\u5169\u908a\u76f8\u540c\u4f4d\u7f6e\u4e0a\u8ca0\u8cac\u63a7\u5236\u67d0\u4e00\u907a\u50b3\u6027\u72c0\u7684\u4e0d\u540c\u8868\u73fe\u5f62\u614b\uff0c\u4f8b\u5982\u9ed1\u9aee\u6216\u8005\u91d1\u9aee\u7684\u8868\u73fe\uff0c\u7b49\u4f4d\u57fa\u56e0\u983b\u7387(Allele frequency)\u662f\u6307\u4e00\u500b\u7fa4\u9ad4\u5728\u7279\u5b9a\u7684\u57fa\u56e0\u4f4d\u9ede\u4e0a\u67d0\u7a2e\u7b49\u4f4d\u57fa\u56e0\u51fa\u73fe\u6b21\u6578\u5360\u6574\u9ad4\u7684\u6bd4\u4f8b\uff0c\u76f8\u95dc\u6027\u7814\u7a76\u5728\u6c92\u6709\u89aa\u5c6c\u95dc\u4fc2\u7684\u65cf\u7fa4\u88e1\uff0c\u900f\u904e\u6bd4\u8f03\u75c5\u60a3\u8207\u5c0d\u7167\u7d44\uff0c\u89c0\u5bdf\u53ef\u80fd\u7684\u81f4\u75c5\u57fa\u56e0\u51fa\u73fe\u6b21\u6578\uff0c\u8207\u671f\u671b\u51fa\u73fe\u6b21\u6578\u4e4b\u9593\u4f5c\u6bd4\u8f03\uff0c\u7528\u5361\u65b9\u6aa2\u5b9a\u7d71\u8a08\u8a72\u57fa\u56e0\u8207\u767c\u75c5\u662f\u5426\u986f\u8457\u76f8\u95dc\uff0c\u6211\u5011\u53ea\u95dc\u5fc3\u75c5\u60a3\u7d44\u7b49\u4f4d\u57fa\u56e0\u983b\u7387\u8207\u5c0d\u7167\u7d44\u7684\u5dee\u7570\uff0c\u500b\u9ad4\u57fa\u56e0\u578b\u5728\u6240\u4e0d\u554f\u3002<\/p>\n<p>\u5bb6\u5ead\u5371\u96aa\u56e0\u5b50\u6bd4\u7387(L)\u662f\u5bb6\u4eba\u5f97\u75c5\u6a5f\u7387\u8207\u4e00\u822c\u4eba\u5f97\u75c5\u6a5f\u7387\u7684\u6bd4\u503c\uff0cL\u5927\u65bc2\u5c31\u4ee3\u8868\u6709\u907a\u50b3\u56e0\u7d20\u5b58\u5728\uff0c\u4ee5\u963f\u8332\u6d77\u9ed8\u75c7(Alzheimer\u2019s disease)\u70ba\u4f8b\uff0c\u75c5\u4eba\u5144\u5f1f\u59d0\u59b9\u5f97\u75c5\u6a5f\u7387\u70ba30%\uff0c\u800c\u4e00\u822c\u4eba\u5f97\u75c5\u6a5f\u7387\u70ba10%\uff0c\u5247L\u7b49\u65bc3\uff0c\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\u7684L\u7b49\u65bc5000\uff0c\u5177\u6709\u9ad8\u5ea6\u907a\u50b3\u6027\uff0c\u5bb6\u4eba\u6bd4\u4e00\u822c\u4eba\u5f97\u75c5\u6a5f\u7387\u9ad8\u51fa5000\u500d\uff0c\u5e7e\u4e4e\u7121\u6cd5\u8ff4\u907f\uff0c\u4e0d\u904e\u4e0a\u5f97\u5c71\u591a\u7d42\u9047\u864e\uff0c\u907a\u50b3\u6027\u8d8a\u9ad8\u5c31\u4ee3\u8868\u66dd\u5149\u7387\u8d8a\u9ad8\uff0c\u81f4\u75c5\u57fa\u56e0\u5bb9\u6613\u88ab\u5b9a\u4f4d\uff0c\u5c0d\u75be\u75c5\u6cbb\u7642\u5177\u6709\u83ab\u5927\u52a9\u76ca\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><b>\u672a\u4f86\u5b9a\u4f4d\u81f4\u75c5\u57fa\u56e0\u7814\u7a76\u7684\u6311\u6230<\/b><\/p>\n<p>\u8907\u96dc\u6027\u75be\u75c5(Complex disease)\u4e5f\u5c31\u662f\u591a\u57fa\u56e0\u907a\u50b3\u75be\u75c5\uff0c\u5c31\u50cf\u6c92\u6709\u982d\u76ee\u7684\u72af\u7f6a\u96c6\u5718\uff0c\u9700\u8981\u91d0\u6e05\u9019\u4e9b\u81f4\u75c5\u57fa\u56e0\u9593\u7684\u95dc\u4fc2\uff0c\u4ee5\u671f\u5728\u75be\u75c5\u6cbb\u7642\u8a3a\u65b7\u4e0a\u4f5c\u9032\u4e00\u6b65\u7a81\u7834\uff0c\u53e6\u5916\uff0c\u907a\u50b3\u75be\u75c5\u4e26\u4e0d\u5168\u7136\u7531\u57fa\u56e0\u6240\u4e3b\u5bb0\uff0c\u74b0\u5883\u4e5f\u662f\u4e0d\u53ef\u5ffd\u7565\u7684\u56e0\u7d20\uff0c\u50cf\u5148\u5929\u6027\u80a5\u80d6\uff0c\u66b4\u98f2\u66b4\u98df\u52a0\u4e0a\u7f3a\u4e4f\u904b\u52d5\u6703\u4f7f\u75c7\u72c0\u52a0\u5287\uff0c\u7576\u4e2d\u57fa\u56e0\u8207\u74b0\u5883\u7684\u89d2\u8272\u8f15\u91cd\u8a72\u5982\u4f55\u5b9a\u4f4d\u5c07\u6703\u662f\u4e00\u5927\u6311\u6230\u3002\u53d7\u60e0\u65bc\u79d1\u6280\u9032\u6b65\uff0c\u6210\u672c\u4e0d\u65b7\u964d\u4f4e\uff0c\u4f46\u4e00\u822c\u5be6\u9a57\u5ba4\u4ecd\u7136\u96e3\u4ee5\u8ca0\u64d4\uff0c\u540c\u6642\u4f34\u96a8\u8cc7\u6599\u91cf\u65e5\u76ca\u589e\u52a0\uff0c\u9020\u6210\u5132\u5b58\u8207\u5206\u6790\u4e0a\u7684\u56f0\u96e3\uff0c\u672a\u4f86\u51fa\u8def\u57fa\u672c\u4e0a\u662f\u5f80\u5546\u696d\u5316\u63a8\u5ee3\u6295\u7522\u3002<\/p>\n<p>\u63a2\u7d22\u79d1\u5b78\u4e0d\u662f\u7279\u5b9a\u4eba\u7684\u5c08\u5229\uff0c\u4e5f\u4e0d\u9700\u8981\u4eae\u9e97\u6d6e\u8a87\u7684\u62db\u5f0f\uff0c\u5c0d\u5f8c\u4e16\u5f71\u97ff\u6df1\u9060\u7684\u907a\u50b3\u5b78\u7814\u7a76\u662f\u7531\u4e00\u500b\u696d\u9918\u7684\u79d1\u5b78\u611b\u597d\u8005\u6240\u958b\u5275\uff0c\u6240\u9700\u8981\u7684\uff0c\u53ea\u662f\u55ae\u7d14\u5c0d\u4e8b\u7269\u7684\u89c0\u5bdf\u5165\u5fae\u4ee5\u53ca\u5c0d\u79d1\u5b78\u7684\u4e0d\u6368\u8ffd\u6c42\uff0c\u9019\u4e9b\u7279\u8cea\u90fd\u662f\u6211\u5011\u8207\u751f\u4ff1\u4f86\u7684\uff0c\u4e0d\u8981\u81ea\u6211\u8a2d\u9650\uff0c\u79d1\u5b78\u7684\u63a2\u7d22\u672c\u4f86\u5c31\u662f\u6c38\u4e0d\u6b62\u606f\uff0c\u96d6\u7136\u4e0d\u77e5\u9053\u524d\u65b9\u6703\u9047\u5230\u4e9b\u751a\u9ebc\uff0c\u4f46\u4ecd\u7136\u52c7\u5f80\u76f4\u524d\uff0c\u9019\u5c31\u662f\u79d1\u5b78\u7cbe\u795e\uff0c\u611b\u56e0\u65af\u5766\u66fe\u7d93\u8aaa\u904e\uff1a\u300c\u6211\u559c\u6b61\u65c5\u884c\uff0c\u4f46\u4e0d\u559c\u6b61\u5230\u9054\u76ee\u7684\u5730\u3002\u300d<\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\"> \u672c\u6587\u6574\u7406\u81ea\uff1a102\/11\/16\u4e0b\u5348\u7531\u8303\u76db\u5a1f\u7814\u7a76\u54e1\u5728\u81fa\u5927\u61c9\u529b\u6240\u570b\u969b\u6f14\u8b1b\u5ef3\u6240\u4e3b\u8b1b\u4e4b\u300c\u89e3\u5bc6\u5b5f\u5fb7\u723e\uff1a\u6a5f\u7387\u8207\u57fa\u56e0\u5b9a\u4f4d\u300d\u7684\u6f14\u8b1b\u5167\u5bb9<\/span><\/pre>\n<pre><span style=\"color: #333333;\"> \u5ef6\u4f38\u95b1\u8b80\uff1a\u81fa\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3\u63a2\u7d22\u57fa\u790e\u79d1\u5b78\u8b1b\u5ea72013\u5e7411\u670816\u65e5\u7b2c\u4e94\u8b1b\u3008\u89e3\u5bc6\u5b5f\u5fb7\u723e\uff1a\u6a5f\u7387\u8207\u57fa\u56e0\u5b9a\u4f4d\u3009<\/span><a href=\"https:\/\/case.ntu.edu.tw\/CASTUDIO\/course.php?speech_ID=3383#video_top\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #333333;\">\u5168\u7a0b\u5f71\u97f3<\/span><\/a><\/pre>\n<p><strong><span style=\"color: #333399;\">\u8cac\u4efb\u7de8\u8f2f\uff1aVita Chen<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7b2c\u4e94\u8b1b\u2027\u7279\u7a3f \u25a0 \u5c0f\u5c0f\u8c4c\u8c46\u958b\u555f\u4e86\u907a\u50b3\u5b78\u7814<\/p>\n","protected":false},"author":20,"featured_media":29098,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,892],"tags":[944,946,947,945],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/12\/P26-\u65b0\u914d\u5716-1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15432"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15432"}],"version-history":[{"count":18,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15432\/revisions"}],"predecessor-version":[{"id":29099,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15432\/revisions\/29099"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/29098"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}