{"id":15343,"date":"2013-11-25T11:02:13","date_gmt":"2013-11-25T03:02:13","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=15343"},"modified":"2017-09-18T13:22:03","modified_gmt":"2017-09-18T05:22:03","slug":"%e3%80%90%e7%94%9f%e7%90%86%e7%a7%91%e5%ad%b8%e3%80%91%e7%94%9f%e7%90%86%e6%99%82%e9%90%98%e6%b2%92%e8%aa%bf%e5%a5%bd%ef%bc%8c%e7%99%bc%e7%82%8e%e7%99%bc%e5%88%b0%e8%80%81","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=15343","title":{"rendered":"\u751f\u7406\u6642\u9418\u6c92\u8abf\u597d\uff0c\u767c\u708e\u767c\u5230\u8001"},"content":{"rendered":"<p><strong>\u7de8\u8b6f<\/strong>\uff5c\u9ad8\u82f1\u54f2<\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/11\/800px-Spring-cover_pocket_clock3_open_clockface2.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignright wp-image-15345\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/11\/800px-Spring-cover_pocket_clock3_open_clockface2.jpg\" alt=\"800px-Spring-cover_pocket_clock3_open_clockface2\" width=\"512\" height=\"384\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/11\/800px-Spring-cover_pocket_clock3_open_clockface2.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/11\/800px-Spring-cover_pocket_clock3_open_clockface2-300x225.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/11\/800px-Spring-cover_pocket_clock3_open_clockface2-600x450.jpg 600w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/a><\/p>\n<p>\u6839\u64da\u4e00\u7bc7\u767c\u8868\u65bc\u300a\u79d1\u5b78\u300b\u671f\u520a\u7684\u7814\u7a76\u6307\u51fa\uff0c\u9020\u6210\u767c\u708e\u4f5c\u7528\u7684 T<sub>H<\/sub>17 \u514d\u75ab\u7d30\u80de\uff08\u53c8\u7a31\u8f14\u52a9\u578b\uff34\u7d30\u80de\uff09\uff0c\u5728\u767d\u5929\u589e\u751f\u7684\u901f\u5ea6\u6bd4\u665a\u4e0a\u66f4\u5feb\uff1b\u4f46\u662f\u7d66\u8001\u9f20\u88fd\u9020\u4e00\u500b\u5be6\u9a57\u6027\u7684\u6642\u5dee\uff0c\u537b\u6703\u5c0e\u81f4\u9019\u7a2e\u7d30\u80de\u589e\u751f\u904e\u591a\uff0c\u4f7f\u5176\u5167\u81df\u767c\u708e\u3002<\/p>\n<p>\u300c\u9019\u9805\u7814\u7a76\u5f88\u6709\u610f\u601d\uff0c\u5f88\u6709\u7368\u5275\u6027\uff0c\u4ed6\u5011\u767c\u73fe\u4e86\u4e00\u7a2e\u63a7\u5236\u514d\u75ab\u7cfb\u7d71\u7684\u65b0\u5947\u65b9\u5f0f\u3002\u300d\u4e26\u672a\u53c3\u8207\u9019\u9805\u7814\u7a76\u7684\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78\u5fae\u751f\u7269\u5b78\u66a8\u514d\u75ab\u5b78\u6559\u6388\u4f0a\u74e6\u6d1b\uff0e\u4f0a\u74e6\u8afe\u592b (Ivylo Ivanov) \u8aaa\u3002\u540c\u6a23\u4e26\u672a\u53c3\u8207\u9019\u9805\u7814\u7a76\u7684\u7d10\u7d04\u5927\u5b78\u5206\u5b50\u514d\u75ab\u5b78\u6559\u6388\u4e39\uff0e\u5229\u7279\u66fc (Dan Littman) \uff0c\u4e5f\u8a8d\u70ba\u5148\u524d\u4eba\u5011\u5927\u591a\u6c92\u60f3\u5230\u751f\u7406\u6642\u9418\u6703\u5c0d\u514d\u75ab\u53cd\u61c9\u6709\u6240\u5f71\u97ff\u3002\u751a\u81f3\u5c31\u9023\u9818\u982d\u9032\u884c\u9019\u9805\u7814\u7a76\u7684\u5fb7\u5dde\u5927\u5b78\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3\u514d\u75ab\u5b78\u6559\u6388\u863f\u62c9\uff0e\u7425\u73c0 (Lora Hooper) \uff0c\u539f\u672c\u4e5f\u4e0d\u662f\u8981\u7814\u7a76\u751f\u7406\u6642\u9418\u5c0d\u65bc\u514d\u75ab\u529f\u80fd\u6709\u4ec0\u9ebc\u5f71\u97ff\u3002\u5979\u8aaa\uff1a\u300c\u8d77\u521d\u6211\u5011\u5c0d\u65bc\u751f\u7406\u6642\u9418\u6216 T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u6839\u672c\u4e00\u7121\u6240\u77e5\uff0c\u6211\u5011\u5728\u627e\u7684\u662f\u5225\u7684\u6771\u897f\u3002\u9019\u7a2e\u79d1\u5b78\u767c\u73fe\u53ef\u9047\u800c\u4e0d\u53ef\u6c42\u3002\u300d<\/p>\n<p>\u7425\u73c0\u7684\u5be6\u9a57\u5ba4\u5718\u968a\u5728\u7814\u7a76\u5167\u81df\u514d\u75ab\u529f\u80fd\u7684\u5404\u7a2e\u5c64\u9762\uff0c\u5979\u5728\u7814\u7a76\u767c\u708e\u6027\u8178\u9053\u75be\u75c5 (IBD) \u6642\uff0c\u610f\u5916\u767c\u73fe\u9019\u9ede\u3002\u4eba\u985e\u7684\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\uff0c\u8ddf\u4e00\u7a2e\u53eb\u505a NFIL3 \uff0c\u8ca0\u8cac\u8abf\u7bc0\u5404\u7a2e\u514d\u75ab\u529f\u80fd\u7684\u86cb\u767d\u8cea\u591a\u5f62\u6027\u6709\u95dc\u3002\u7425\u73c0\u5728\u7814\u7a76\u6b20\u7f3a NFIL3 \u86cb\u767d\u8cea\u7684\u8001\u9f20\u514d\u75ab\u529f\u80fd\u6642\uff0c\u6ce8\u610f\u5230\u9019\u7a2e\u8001\u9f20\u8178\u9053\u88e1\u7684 &nbsp;T<sub>H<\/sub>17&nbsp;\u7d30\u80de\uff0c\u6bd4\u91ce\u751f\u8001\u9f20\u4f86\u5f97\u591a\uff0c\u7136\u800c\u5176\u4ed6\u985e\u578b\u7684\uff34\u7d30\u80de\u537b\u4f3c\u4e4e\u5dee\u4e0d\u4e86\u591a\u5c11\u3002\u300c T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u662f\u5c0d\u6297\u7d30\u83cc\u8207\u9ef4\u83cc\u611f\u67d3\u7684\u95dc\u9375\uff34\u7d30\u80de\uff0c\u4f46\u662f\u6578\u91cf\u82e5\u662f\u904e\u591a\u4e86\uff0c\u4e5f\u6703\u9020\u6210\u50b7\u5bb3\u3002\u300d\u4f0a\u74e6\u8afe\u592b\u8868\u793a\uff0c T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u82e5\u662f\u904e\u591a\uff0c\u78ba\u5be6\u6703\u9020\u6210\u514b\u9686\u6c0f\u75c7 (Crohn's disease) \u3001\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u3001\u591a\u91cd\u786c\u5316\u75c7\u3001\u4ee5\u53ca\u725b\u76ae\u766c\u7b49\u7b49\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002<!--more--><\/p>\n<p>\u4eba\u5011\u5df2\u77e5 NFIL3 \u86cb\u767d\u8cea\u53ef\u85c9\u7531\u751f\u7406\u6642\u9418\u9032\u884c\u8abf\u7bc0\uff0c\u56e0\u6b64\u7425\u73c0\u7b49\u4eba\u5c31\u958b\u59cb\u8457\u624b\u89e3\u958b\u8b0e\u5718\u3002\u9996\u5148\u4ed6\u5011\u5148\u78ba\u5b9a\u91ce\u751f\u8001\u9f20\u7684 NFIL3 \u86cb\u767d\u8cea\uff0c\u767d\u5929\u6642\u6578\u91cf\u8f03\u5c11\uff0c\u5230\u4e86\u665a\u4e0a\u6703\u6bd4\u8f03\u591a\uff1b\u4ed6\u5011\u4e5f\u767c\u73fe NFIL3 \u86cb\u767d\u8cea\u662f\u76f4\u63a5\u63a5\u5728 <em>Ror<\/em>\u03b3<em>t<\/em>&nbsp;\u57fa\u56e0\u7684\u555f\u52d5\u5340\u4e0a\uff08\u9019\u662f T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u7522\u751f\u5206\u5316\u7684\u95dc\u9375\u5340\u57df\uff09\uff0c\u58d3\u6291\u4e86\u9019\u500b\u57fa\u56e0\u8868\u5fb5\u3002\u56e0\u6b64 <em>Ror<\/em>\u03b3<em>t&nbsp;<\/em>\u767d\u5929\u6642\u6bd4\u8f03\u6703\u8868\u73fe\u51fa\u4f86\uff0c\u5230\u4e86\u665a\u4e0a\u5c31\u8b8a\u5f97\u4f4e\u8abf\u3002\u4ed6\u5011\u540c\u6642\u53c8\u767c\u73fe\u5728\u767d\u5929\u5f9e\u8001\u9f20\u8eab\u4e0a\u5206\u96e2\u51fa\u4f86\uff0c\u5c1a\u672a\u6210\u719f\u7684\uff34\u7d30\u80de\uff0c\u6bd4\u8d77\u5728\u665a\u4e0a\u5206\u96e2\u51fa\u4f86\u7684\uff34\u7d30\u80de\uff0c\u66f4\u80fd\u5920\u5206\u5316\u6210 T<sub>H<\/sub>17&nbsp;&nbsp;\u7d30\u80de\uff1b\u7136\u800c\uff34\u7d30\u80de\u82e5\u662f\u5f9e\u6b20\u7f3a NFIL3 \u86cb\u767d\u8cea\u7684\u8001\u9f20\u8eab\u4e0a\u5206\u96e2\u51fa\u4f86\uff0c\u5c31\u6c92\u6709\u9019\u7a2e\u65e5\u591c\u5dee\u5225\u3002<\/p>\n<p>\u96d6\u7136 T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u7684\u5206\u5316\u80fd\u529b\uff0c\u6703\u96a8\u8457\u4e00\u5929\u6642\u9593\u8b8a\u5316\u6709\u6240\u4e0d\u540c\uff0c\u4e0d\u904e\u5b83\u5011\u4e00\u822c\u4f86\u8aaa\uff0c\u90fd\u9700\u8981\u4e00\u500b\u661f\u671f\u5de6\u53f3\u624d\u80fd\u5206\u5316\u5b8c\u6210\uff1b\u56e0\u6b64\u4ee5 24 \u5c0f\u6642\u70ba\u671f\uff0c T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u7e3d\u6578\u4e26\u4e0d\u6703\u6709\u4ec0\u9ebc\u8b8a\u52d5\u3002\u300c\u4ee4\u4eba\u9a5a\u8a1d\u7684\u662f\uff0c\u96d6\u7136\u751f\u7406\u6642\u9418\u6703\u63a7\u5236\u5176\u5206\u5316\u901f\u5ea6\uff0c\u4f46\u5018\u82e5\u4f60\u53ea\u770b\u6700\u7d42\u6210\u679c\uff0c\u751f\u7406\u6642\u9418\u4f3c\u4e4e\u5c31\u6c92\u6709\u4ec0\u9ebc\u5f71\u97ff\u3002\u300d\u4e26\u672a\u53c3\u8207\u9019\u9805\u7814\u7a76\uff0c\u5728\u5fb7\u570b\u6155\u5c3c\u9ed1\u5927\u5b78\u7814\u7a76\u751f\u7406\u6642\u9418\u8207\u514d\u75ab\u53cd\u61c9\u95dc\u4fc2\u7684\u514b\u91cc\u65af\u591a\u592b\uff0e\u859b\u723e\u66fc (Christoph Scheiermann) \u8aaa\u3002<\/p>\n<p>\u7136\u800c\u7425\u73c0\u64fe\u4e82\u8001\u9f20\u6b63\u5e38\u65e5\u591c\u5faa\u74b0\u5169\u500b\u661f\u671f\uff08\u57fa\u672c\u4e0a\u662f\u5728\u6a21\u64ec\u6642\u5dee\uff09\u4e4b\u5f8c\uff0c\u537b\u6703\u9020\u6210 T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u751f\u6210\u983b\u7387\u7522\u751f\u8b8a\u5316\u3002\u300c\u6211\u5011\u7d66\u8001\u9f20\u88fd\u9020\u5be6\u9a57\u6027\u8cea\u7684\u6642\u5dee\u5f8c\uff0c\u5e7e\u4e4e\u4ec0\u9ebc\u4e8b\u60c5\u90fd\u6709\u9ede\u4e82\u4e86\u5957\u3002 T<sub>H<\/sub>17&nbsp;\u7d30\u80de\u751f\u6210\u7684\u6578\u76ee\u6c92\u6709\u53d7\u5230\u59a5\u7576\u63a7\u5236\uff0c\u6574\u500b\u7206\u91cf\u51fa\u4f86\u3002\u300d\u5979\u88dc\u5145\u8aaa\u9019\u5c0d\u8001\u9f20\u6703\u9020\u6210\u554f\u984c\uff0c\u9019\u9ebc\u4e00\u4f86\u7260\u5011\u5c31\u6bd4\u8f03\u5bb9\u6613\u7522\u751f\u767c\u708e\u75c7\u72c0\u3002\u9019\u4e9b\u6709\u6642\u5dee\u7684\u8001\u9f20\u78ba\u5be6\u6bd4\u8f03\u6703\u5f97\u7d50\u8178\u708e\u3002<\/p>\n<p>\u7425\u73c0\u8aaa\uff0c\u6642\u5dee\u6216\u8f2a\u73ed\u5de5\u4f5c\u7b49\u7b49\u6703\u64fe\u4e82\u6b63\u5e38\u65e5\u591c\u5faa\u74b0\u7684\u56e0\u7d20\uff0c\u6703\u5c0e\u81f4\u8eab\u9ad4\u7522\u751f\u4e00\u9023\u4e32\u7684\u8b8a\u5316\uff0c\u9020\u6210\u8377\u723e\u8499\u8ddf\u65b0\u9673\u4ee3\u8b1d\u5931\u8abf\u7684\u554f\u984c\u3002\u5979\u8aaa\u9664\u4e86 T<sub>H<\/sub>17&nbsp;\u6578\u76ee\u6709\u8b8a\u5316\u4ee5\u5916\uff0c\u9084\u6709\u5f88\u591a\u5176\u4ed6\u4e8b\u60c5\u4e5f\u51fa\u4e86\u72c0\u6cc1\u3002\u9019\u9805\u7814\u7a76\u7d50\u679c\u4f3c\u4e4e\u591a\u591a\u5c11\u5c11\u53ef\u4ee5\u89e3\u91cb\uff0c\u70ba\u4ec0\u9ebc\u503c\u591c\u73ed\u6216\u7d93\u5e38\u98db\u4f86\u98db\u53bb\u7684\u4eba\u5011\uff0c\u6bd4\u8f03\u5bb9\u6613\u7f79\u60a3\u5404\u7a2e\u767c\u708e\u6027\u75be\u75c5\u3002<\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\"> \u7814\u7a76\u51fa\u8655\uff1a<strong><a href=\"http:\/\/www.the-scientist.com\/?articles.view\/articleNo\/38207\/title\/Time-for-T-cells\/\">Time for T cells<\/a><\/strong><\/span><\/pre>\n<p><span style=\"color: #333399;\"><strong><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aVita Chen<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6839\u64da\u4e00\u7bc7\u767c\u8868\u65bc\u300a\u79d1\u5b78\u300b\u671f\u520a\u7684\u7814\u7a76\u6307\u51fa\uff0c\u9020\u6210\u767c\u708e\u4f5c\u7528\u7684 TH17 \u514d\u75ab\u7d30\u80de\uff08\u53c8\u7a31\u8f14\u52a9\u578b\uff34\u7d30\u80de\uff09\uff0c\u5728\u767d\u5929\u589e\u751f\u7684\u901f\u5ea6\u6bd4\u665a\u4e0a\u66f4\u5feb\uff1b\u4f46\u662f\u7d66\u8001\u9f20\u88fd\u9020\u4e00\u500b\u5be6\u9a57\u6027\u7684\u6642\u5dee\uff0c\u537b\u6703\u5c0e\u81f4\u9019\u7a2e\u7d30\u80de\u589e\u751f\u904e\u591a\uff0c\u4f7f\u5176\u5167\u81df\u767c\u708e\u3002<\/p>\n","protected":false},"author":20,"featured_media":15345,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[938],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/11\/800px-Spring-cover_pocket_clock3_open_clockface2.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15343"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15343"}],"version-history":[{"count":12,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15343\/revisions"}],"predecessor-version":[{"id":29591,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/15343\/revisions\/29591"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/15345"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}