{"id":14318,"date":"2013-10-12T09:03:50","date_gmt":"2013-10-12T01:03:50","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=14318"},"modified":"2017-07-27T11:08:59","modified_gmt":"2017-07-27T03:08:59","slug":"%e3%80%902013%e8%ab%be%e8%b2%9d%e7%88%be%e3%80%91%e7%94%9f%e9%86%ab%e7%8d%8e%e2%94%80%e7%a0%b4%e8%a7%a3%e7%b4%b0%e8%83%9e%e5%82%b3%e8%bc%b8%e7%b3%bb%e7%b5%b1%e4%b9%8b%e8%ac%8e","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=14318","title":{"rendered":"\u30102013\u8afe\u8c9d\u723e\u3011\u751f\u91ab\u734e\u2500\u7834\u89e3\u7d30\u80de\u50b3\u8f38\u7cfb\u7d71\u4e4b\u8b0e"},"content":{"rendered":"<figure id=\"attachment_14319\" aria-describedby=\"caption-attachment-14319\" style=\"width: 590px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=14319\" rel=\"attachment wp-att-14319\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-14319 \" title=\"nobelpristagare_2013_00\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/10\/nobelpristagare_2013_00.jpg\" alt=\"\" width=\"590\" height=\"242\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/10\/nobelpristagare_2013_00.jpg 590w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/10\/nobelpristagare_2013_00-300x123.jpg 300w\" sizes=\"(max-width: 590px) 100vw, 590px\" \/><\/a><figcaption id=\"caption-attachment-14319\" class=\"wp-caption-text\">2013\u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u5f97\u4e3b\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.nobelprizemedicine.org\/\uff09<\/figcaption><\/figure>\n<p><strong>\u7de8\u8b6f<\/strong>\u2502\u9ad8\u82f1\u54f2<\/p>\n<p>2013 \u5e74\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u5f97\u4e3b\u5df2\u65bc\u5341\u6708\u4e03\u65e5\u51fa\u7210\uff0c\u7531\u8a79\u59c6\u58eb\uff0e\u62c9\u65af\u66fc (James E. Rathman) \u3001\u85cd\u8fea\uff0e\u859b\u514b\u66fc (Randy W. Schekman) \u3001\u6e6f\u746a\u58eb\uff0e\u5c45\u5fb7\u970d\u592b (Thomas C. S\u00fcdhof) \u4e09\u4eba\u5171\u540c\u5f97\u734e\u3002\u4ed6\u5011\u89e3\u958b\u4eba\u9ad4\u7d30\u80de\u5982\u4f55\u8abf\u7bc0\u50b3\u8f38\u7cfb\u7d71\u4e4b\u8b0e\uff0c\u56e0\u800c\u7372\u734e\u3002<\/p>\n<p>\u6bcf\u500b\u4eba\u9ad4\u7d30\u80de\u90fd\u662f\u4e00\u5ea7\u5de5\u5ee0\uff0c\u6703\u88fd\u9020\u5206\u5b50\u4e26\u5c07\u5176\u8f38\u51fa\u3002\u8209\u4f8b\u4f86\u8aaa\uff0c\u4eba\u9ad4\u7d30\u80de\u6703\u88fd\u9020\u51fa\u80f0\u5cf6\u7d20\uff0c\u5c07\u5176\u91cb\u653e\u5230\u8840\u6db2\u4e2d\uff0c\u9084\u6703\u5728\u795e\u7d93\u7d30\u80de\u4e2d\u50b3\u9001\u4e00\u7a2e\u7a31\u70ba\u300c\u795e\u7d93\u50b3\u905e\u8cea\u300d (neurotransmitter) \u7684\u8a0a\u865f\u5206\u5b50\u3002\u9019\u4e9b\u5206\u5b50\u6703\u5305\u5728\u4e00\u7a2e\u53eb\u505a\u300c\u56ca\u6ce1\u300d (vesicle) \u7684\u5c0f\u5305\u88e1\uff0c\u5728\u7d30\u80de\u5468\u570d\u9032\u884c\u50b3\u8f38\u3002\u62c9\u65af\u66fc\u7b49\u4e09\u4f4d\u79d1\u5b78\u5bb6\u767c\u73fe\u9019\u7a2e\u7d30\u80de\u9593\u7684\u50b3\u8f38\u65b9\u5f0f\uff0c\u5982\u4f55\u80fd\u5920\u5728\u6b63\u78ba\u6642\u9593\uff0c\u5c07\u5206\u5b50\u9001\u5230\u6b63\u78ba\u5730\u9ede\u7684\u7b87\u4e2d\u539f\u7406\uff1a\u859b\u514b\u66fc\u767c\u73fe\u8207\u56ca\u6ce1\u50b3\u8f38\u6709\u95dc\u7684\u4e00\u7d44\u5fc5\u5099\u57fa\u56e0\uff1b\u62c9\u65af\u66fc\u63ed\u958b\u4f7f\u56ca\u6ce1\u8207\u76ee\u6a19\u7d30\u80de\u878d\u5408\uff0c\u4ee5\u5b8c\u6210\u50b3\u8f38\u4efb\u52d9\u7684\u86cb\u767d\u8cea\u904b\u4f5c\u6a5f\u5236\uff1b\u5c45\u5fb7\u970d\u592b\u5247\u662f\u63ed\u9732\u8a0a\u865f\u5206\u5b50\u5982\u4f55\u4f7f\u56ca\u6ce1\u7cbe\u78ba\u91cb\u653e\u5167\u5bb9\u7269\u7684\u5967\u7955\u3002\u4ed6\u5011\u4e09\u4eba\u5171\u540c\u63ed\u9732\u4e86\u4eba\u9ad4\u7d30\u80de\u5982\u4f55\u900f\u904e\u512a\u7f8e\u7684\u7cbe\u78ba\u63a7\u5236\u6a5f\u5236\uff0c\u9054\u5230\u50b3\u8f38\u6548\u679c\u7684\u904e\u7a0b\uff1b\u9019\u5957\u7cfb\u7d71\u82e5\u662f\u53d7\u5230\u5e72\u64fe\uff0c\u5c31\u6703\u9020\u6210\u6709\u5bb3\u4eba\u9ad4\u7684\u5f71\u97ff\uff0c\u5c0e\u81f4\u795e\u7d93\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u4ee5\u53ca\u514d\u75ab\u7cfb\u7d71\u75be\u75c5\u7b49\u7b49\u75c5\u75c7\u3002<!--more--><\/p>\n<p><strong>\u7d30\u80de\u5982\u4f55\u50b3\u8f38\u5206\u5b50\uff1f<\/strong><\/p>\n<p>\u5fd9\u788c\u7684\u5927\u578b\u6e2f\u53e3\u9700\u8981\u5efa\u7acb\u4e00\u5957\u7cfb\u7d71\uff0c\u4ee5\u78ba\u4fdd\u8ca8\u7269\u80fd\u5920\u5728\u6b63\u78ba\u7684\u6642\u9593\u904b\u9001\u5230\u6b63\u78ba\u7684\u76ee\u7684\u5730\u3002\u4eba\u9ad4\u7d30\u80de\u4e5f\u6709\u985e\u4f3c\u7684\u554f\u984c\uff1a\u7d30\u80de\u5404\u6709\u4e0d\u540c\u7684\u80de\u5668 (organelles) \uff0c\u88fd\u9020\u51fa\u8377\u723e\u8499\u3001\u795e\u7d93\u50b3\u905e\u8cea\u3001\u7d30\u80de\u4ecb\u7d20\u8207\u9175\u7d20\u7b49\u7b49\u5404\u5f0f\u5404\u6a23\u7684\u5206\u5b50\uff1b\u9019\u4e9b\u5206\u5b50\u90fd\u5fc5\u9808\u5728\u5b8c\u5168\u6b63\u78ba\u7684\u6642\u9593\u9ede\uff0c\u904b\u9001\u5230\u7d30\u80de\u4e2d\u7684\u5176\u4ed6\u5340\u57df\uff0c\u6216\u662f\u9001\u5230\u7d30\u80de\u5916\u7684\u5176\u4ed6\u5730\u65b9\u3002\u638c\u63e1\u6642\u5730\u662f\u95dc\u9375\u6240\u5728\u3002\u570d\u7e5e\u5728\u7d30\u80de\u819c\u5468\u570d\u7684\u8ff7\u4f60\u56ca\u6ce1\uff0c\u6703\u5728\u5404\u80de\u5668\u4e4b\u9593\u8f38\u9001\u5206\u5b50\uff0c\u6216\u662f\u8ddf\u5916\u7d30\u80de\u819c\u878d\u5408\uff0c\u628a\u5206\u5b50\u91cb\u653e\u5230\u7d30\u80de\u5916\u3002\u9019\u500b\u529f\u80fd\u76f8\u7576\u91cd\u8981\uff0c\u50b3\u8f38\u795e\u7d93\u50b3\u905e\u8cea\u6642\u6703\u89f8\u767c\u795e\u7d93\u6d3b\u5316\uff0c\u50b3\u8f38\u8377\u723e\u8499\u6642\u5247\u6703\u89f8\u767c\u65b0\u9673\u4ee3\u8b1d\u3002\u7136\u800c\u9019\u4e9b\u56ca\u6ce1\u5982\u4f55\u77e5\u9053\u8a72\u5728\u4ec0\u9ebc\u6642\u5019\uff0c\u628a\u6771\u897f\u9001\u5230\u54ea\u88e1\uff1f<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5f9e\u585e\u8eca\u770b\u51fa\u63a7\u5236\u57fa\u56e0<\/strong><\/p>\n<p>\u859b\u514b\u66fc\u5c0d\u4eba\u9ad4\u7d30\u80de\u7ba1\u7406\u50b3\u8f38\u7cfb\u7d71\u5f88\u611f\u8208\u8da3\uff0c\u5728 1970 \u5e74\u4ee3\u6c7a\u5b9a\u947d\u7814\u5176\u907a\u50b3\u539f\u7406\u3002\u4ed6\u7528\u9175\u6bcd\u83cc\u6a21\u64ec\u50b3\u8f38\u7cfb\u7d71\uff0c\u627e\u51fa\u50b3\u8f38\u6a5f\u5236\u6709\u7f3a\u9677\uff0c\u6703\u9020\u6210\u985e\u4f3c\u5927\u773e\u904b\u8f38\u7cfb\u7d71\u8a2d\u8a08\u4e0d\u826f\uff0c\u5f15\u8d77\u6df7\u4e82\u5c40\u9762\u7684\u9175\u6bcd\u83cc\u7d30\u80de\uff0c\u56ca\u6ce1\u6703\u5728\u9019\u7a2e\u7d30\u80de\u7684\u67d0\u4e9b\u90e8\u4f4d\u64e0\u6210\u4e00\u5718\u3002\u859b\u514b\u66fc\u767c\u73fe\u9020\u6210\u9019\u7a2e\u963b\u585e\u73fe\u8c61\u662f\u907a\u50b3\u9020\u6210\u7684\uff0c\u5c31\u7e7c\u7e8c\u5c0b\u627e\u7a81\u8b8a\u57fa\u56e0\uff0c\u627e\u51fa\u63a7\u5236\u7d30\u80de\u50b3\u8f38\u7cfb\u7d71\u4e0d\u540c\u60c5\u6cc1\u7684\u4e09\u7a2e\u57fa\u56e0\uff0c\u70ba\u5bc6\u5207\u8abf\u7bc0\u7d30\u80de\u56ca\u6ce1\u50b3\u8f38\u7684\u6a5f\u5236\uff0c\u63d0\u4f9b\u4e86\u65b0\u7684\u898b\u89e3\u3002<\/p>\n<p><strong>\u7cbe\u78ba\u63a5\u5408<\/strong><\/p>\n<p>\u62c9\u65af\u66fc\u5c0d\u7d30\u80de\u50b3\u8f38\u7cfb\u7d71\u7684\u672c\u8cea\u4e5f\u5f88\u611f\u8208\u8da3\u3002\u4ed6\u5728 1980 \u8ddf 1990 \u5e74\u4ee3\uff0c\u5229\u7528\u54fa\u4e73\u985e\u7d30\u80de\u7814\u7a76\u56ca\u6ce1\u50b3\u8f38\uff0c\u767c\u73fe\u6709\u4e00\u7a2e\u86cb\u767d\u8cea\u5408\u6210\u7269\uff0c\u53ef\u4f7f\u56ca\u6ce1\u8207\u76ee\u6a19\u7d30\u80de\u819c\u63a5\u5408\u878d\u5408\uff1b\u56ca\u6ce1\u8ddf\u76ee\u6a19\u7d30\u80de\u819c\u7684\u86cb\u767d\u8cea\u5728\u878d\u5408\u904e\u7a0b\u4e2d\uff0c\u6703\u50cf\u62c9\u934a\u5169\u5074\u4e00\u6a23\u5f7c\u6b64\u7d50\u5408\u3002\u9019\u7a2e\u86cb\u767d\u8cea\u6709\u5f88\u591a\u7a2e\uff0c\u53ea\u6703\u4ee5\u7279\u5b9a\u7684\u65b9\u5f0f\u7d44\u5408\u8d77\u4f86\uff0c\u5982\u6b64\u4fbf\u53ef\u78ba\u4fdd\u5206\u5b50\u53ef\u4ee5\u9001\u5230\u7cbe\u78ba\u7684\u4f4d\u7f6e\u3002\u56ca\u6ce1\u8ddf\u5916\u7d30\u80de\u819c\u7d50\u5408\uff0c\u91cb\u653e\u5176\u5167\u5bb9\u7269\u7684\u539f\u7406\uff0c\u8ddf\u5728\u7d30\u80de\u5167\u904b\u4f5c\u7684\u60c5\u6cc1\u662f\u4e00\u6a23\u7684\u3002<\/p>\n<p>\u7d50\u679c\u859b\u514b\u66fc\u5728\u9175\u6bcd\u83cc\u88e1\u767c\u73fe\u7684\u67d0\u4e9b\u86cb\u767d\u8cea\u7de8\u78bc\u57fa\u56e0\uff0c\u8ddf\u62c9\u65af\u66fc\u5728\u54fa\u4e73\u985e\u8eab\u4e0a\u767c\u73fe\u7684\u57fa\u56e0\u529f\u6548\u76f8\u7576\uff0c\u9019\u986f\u793a\u7d30\u80de\u50b3\u8f38\u7cfb\u7d71\u5728\u6f14\u5316\u4e0a\u5176\u4f86\u6709\u81ea\uff0c\u6df5\u9060\u6d41\u9577\u3002\u9019\u4e9b\u57fa\u56e0\u5408\u8d77\u4f86\uff0c\u5c0d\u61c9\u5230\u7d30\u80de\u50b3\u8f38\u6a5f\u5236\u7684\u95dc\u9375\u529f\u80fd\u3002<\/p>\n<p><strong>\u6642\u6a5f\u5c31\u662f\u95dc\u9375<\/strong><\/p>\n<p>\u5c45\u5fb7\u970d\u592b\u5247\u662f\u5c0d\u65bc\u5927\u8166\u795e\u7d93\u7d30\u80de\u5f7c\u6b64\u5982\u4f55\u6e9d\u901a\u5f88\u611f\u8208\u8da3\u3002\u8207\u795e\u7d93\u7d30\u80de\u5916\u7d30\u80de\u819c\u878d\u5408\u7684\u56ca\u6ce1\uff0c\u900f\u904e\u62c9\u65af\u66fc\u8ddf\u859b\u514b\u66fc\u767c\u73fe\u7684\u6a5f\u5236\uff0c\u5c07\u8ca0\u8cac\u50b3\u905e\u8a0a\u606f\u7684\u795e\u7d93\u50b3\u905e\u8cea\u5206\u5b50\u91cb\u653e\u51fa\u4f86\uff0c\u7136\u800c\u9019\u4e9b\u56ca\u6ce1\u53ea\u6709\u5728\u795e\u7d93\u7d30\u80de\u50b3\u9001\u8a0a\u606f\u7d66\u9130\u8fd1\u7684\u795e\u7d93\u7d30\u80de\u6642\uff0c\u624d\u80fd\u5920\u628a\u5167\u5bb9\u7269\u91cb\u653e\u51fa\u4f86\u3002\u91cb\u653e\u52d5\u4f5c\u662f\u600e\u9ebc\u4ee5\u5982\u6b64\u7cbe\u78ba\u7684\u65b9\u5f0f\u63a7\u5236\u9032\u884c\u7684\u5462\uff1f\u6211\u5011\u5df2\u77e5\u91cb\u653e\u904e\u7a0b\u8ddf\u9223\u96e2\u5b50\u6709\u95dc\uff0c\u5c45\u5fb7\u970d\u592b\u5728 1990 \u5e74\u4ee3\uff0c\u65bc\u795e\u7d93\u7d30\u80de\u5167\u5c0b\u627e\u5c0d\u9223\u975e\u5e38\u654f\u611f\u7684\u86cb\u767d\u8cea\uff0c\u767c\u73fe\u6703\u5c0d\u9223\u96e2\u5b50\u6d41\u5165\u7522\u751f\u53cd\u61c9\u7684\u5206\u5b50\u6a5f\u5236\uff1b\u9019\u6a5f\u5236\u6703\u8fc5\u901f\u5f15\u5c0e\u9130\u8fd1\u7684\u86cb\u767d\u8cea\uff0c\u4f7f\u56ca\u6ce1\u8207\u795e\u7d93\u7d30\u80de\u5916\u7d30\u80de\u819c\u7d50\u5408\uff0c\u62c9\u934a\u4e00\u62c9\u958b\uff0c\u5c31\u6703\u91cb\u653e\u8a0a\u865f\u7269\u8cea\u3002\u5c45\u5fb7\u970d\u592b\u7684\u767c\u73fe\u89e3\u91cb\u4e86\u70ba\u4f55\u50b3\u8f38\u6a5f\u5236\u5728\u6642\u9593\u4e0a\u80fd\u5920\u505a\u5230\u5982\u6b64\u7cbe\u78ba\uff0c\u56ca\u6ce1\u7684\u5167\u5bb9\u7269\u5982\u4f55\u4e00\u6536\u5230\u6307\u4ee4\u5c31\u91cb\u653e\u51fa\u4f86\u3002<\/p>\n<p><strong>\u56ca\u6ce1\u50b3\u8f38\u7684\u6cbb\u75c5\u5553\u767c<\/strong><\/p>\n<p>\u9019\u4e09\u4f4d\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u767c\u73fe\u4e86\u7d30\u80de\u751f\u7406\u5b78\u7684\u4e00\u5927\u57fa\u672c\u6a5f\u5236\uff0c\u5927\u5927\u589e\u9032\u6211\u5011\u5c0d\u65bc\u7d30\u80de\u5167\u5916\u5982\u4f55\u7cbe\u78ba\u53ca\u6642\u5730\u905e\u9001\u7269\u8cea\u7684\u4e86\u89e3\u3002\u9175\u6bcd\u83cc\u8ddf\u4eba\u985e\u7684\u56ca\u6ce1\u50b3\u8f38\u8207\u878d\u5408\u6a5f\u5236\uff0c\u96d6\u7136\u6709\u4e9b\u5171\u901a\u4e4b\u8655\uff0c\u7136\u800c\u4ecd\u7136\u4e0d\u662f\u540c\u4e00\u56de\u4e8b\u3002\u9019\u5957\u7cfb\u7d71\u5c0d\u65bc\u5404\u7a2e\u751f\u7406\u6a5f\u5236\u76f8\u7576\u91cd\u8981\uff0c\u8209\u51e1\u5927\u8166\u795e\u7d93\u7d30\u80de\u767c\u9001\u8a0a\u865f\uff0c\u4ee5\u53ca\u4eba\u9ad4\u91cb\u653e\u8377\u723e\u8499\u4ee5\u53ca\u514d\u75ab\u7d30\u80de\u4ecb\u7d20\u7b49\u7b49\u56ca\u6ce1\u878d\u5408\u904e\u7a0b\uff0c\u90fd\u5fc5\u9808\u53d7\u5230\u9019\u5957\u7cfb\u7d71\u7684\u63a7\u5236\u3002\u56ca\u6ce1\u50b3\u8f38\u82e5\u662f\u51fa\u4e86\u554f\u984c\uff0c\u5c31\u53ef\u80fd\u6703\u9020\u6210\u597d\u5e7e\u7a2e\u795e\u7d93\u8207\u514d\u75ab\u75c5\u8b8a\uff0c\u4ee5\u53ca\u7cd6\u5c3f\u75c5\u7b49\u7b49\u75be\u75c5\u3002\u8981\u662f\u6c92\u6709\u9019\u5957\u7cbe\u78ba\u5f97\u4e0d\u5f97\u4e86\u7684\u63a7\u5236\u6a5f\u5236\uff0c\u7d30\u80de\u53ef\u662f\u6703\u4e82\u6210\u4e00\u934b\u7ca5\u7684\u5537\uff01<\/p>\n<p><strong>\u4e09\u4f4d\u5f97\u4e3b\u7c21\u4ecb\uff1a<\/strong><\/p>\n<p>\u62c9\u65af\u66fc\u65bc 1950 \u5e74\u751f\u65bc\u7f8e\u570b\u9ebb\u5dde\u54c8\u4f5b\u5e0c\u723e\u5e02\uff0c\u65bc 1976 \u5e74\u62ff\u5230\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u535a\u58eb\uff0c\u5728\u9ebb\u7701\u7406\u5de5\u5b78\u9662\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u7136\u5f8c\u5728 1978 \u5e74\u524d\u5f80\u53f2\u4e39\u4f5b\u5927\u5b78\uff0c\u958b\u59cb\u7814\u7a76\u7d30\u80de\u56ca\u6ce1\u3002\u62c9\u65af\u66fc\u4e5f\u5728\u666e\u6797\u65af\u9813\u5927\u5b78\u3001\u53f2\u9686\u51f1\u7279\u6797\u764c\u75c7\u7d00\u5ff5\u7814\u7a76\u4e2d\u5fc3\u3001\u4ee5\u53ca\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78\u670d\u52d9\u3002\u4ed6\u5728 2008 \u5e74\u52a0\u5165\u8036\u9b6f\u5927\u5b78\uff0c\u73fe\u4efb\u7d30\u80de\u751f\u7269\u5b78\u7cfb\u6559\u6388\u66a8\u7cfb\u4e3b\u4efb\u3002<\/p>\n<p>\u859b\u514b\u66fc\u65bc 1948 \u5e74\u751f\u65bc\u7f8e\u570b\u660e\u5c3c\u8607\u9054\u5dde\u8056\u4fdd\u7f85\u5e02\uff0c\u5728\u52a0\u5dde\u5927\u5b78\u6d1b\u6749\u78ef\u5206\u6821\u8207\u53f2\u4e39\u4f5b\u5927\u5b78\u6c42\u5b78\uff0c\u5538\u7684\u662f\u62c9\u65af\u66fc\u5e7e\u5e74\u5f8c\u52a0\u5165\u7684\u540c\u4e00\u500b\u7cfb\u6240\u3002\u5728 1959 \u5e74\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u4e9e\u745f\uff0e\u5b54\u6069\u4f2f\u683c (Arthur Kornberg) \u6307\u5c0e\u4e0b\uff0c\u859b\u514b\u66fc\u65bc 1974 \u5e74\u7372\u5f97\u535a\u58eb\u5b78\u4f4d\uff0c\u4e26\u65bc 1976 \u5e74\u52a0\u5165\u52a0\u5dde\u5927\u5b78\u67cf\u514b\u840a\u5206\u6821\uff0c\u73fe\u4efb\u5206\u5b50\u7d30\u80de\u751f\u7269\u5b78\u7cfb\u6559\u6388\u3002\u859b\u514b\u66fc\u4ea6\u65bc\u970d\u83ef\u4f11\u65af\u91ab\u5b78\u7814\u7a76\u6240\u64d4\u4efb\u7814\u7a76\u54e1\u3002<\/p>\n<p>\u5c45\u5fb7\u970d\u592b\u65bc 1955 \u5e74\u751f\u65bc\u5fb7\u570b\u54e5\u5ef7\u6839\u5e02\uff0c\u5728\u7576\u5730\u55ac\u6cbb\u5967\u53e4\u65af\u90fd\u5927\u5b78\u6c42\u5b78\uff0c\u65bc 1982 \u5e74\u7372\u5f97\u91ab\u5b78\u535a\u58eb\u5b78\u4f4d\uff0c\u540c\u6642\u62ff\u5230\u795e\u7d93\u5316\u5b78\u535a\u58eb\u5b78\u4f4d\u3002\u5c45\u5fb7\u970d\u592b\u65bc 1983 \u5e74\u524d\u5f80\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3\uff0c\u8ddf 1985 \u5e74\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u5f97\u4e3b\u9ea5\u53ef\uff0e\u5e03\u6717 (Michael Brown) \u8207\u7d04\u745f\u592b\uff0e\u6208\u5fb7\u65af\u5766 (Joseph Goldstein) \uff0c\u4e00\u8d77\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u3002\u5c45\u5fb7\u970d\u592b\u5728 1991 \u5e74\u6210\u70ba\u970d\u83ef\u4f11\u65af\u91ab\u5b78\u4e2d\u5fc3\u7684\u7814\u7a76\u54e1\uff0c\u4e26\u65bc 2008 \u5e74\u64d4\u4efb\u53f2\u4e39\u4f5b\u5927\u5b78\u5206\u5b50\u66a8\u7d30\u80de\u751f\u7406\u5b78\u6559\u6388\u3002<\/p>\n<p>\u53c3\u8003\u8cc7\u6599\uff1a<\/p>\n<p><a href=\"http:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/2013\/press.html\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/2013\/press.html<\/a><\/p>\n<p><strong><span style=\"color: #000080;\">\u8cac\u4efb\u7de8\u8f2f Vita Chen<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7de8\u8b6f\u2502\u9ad8\u82f1\u54f2 2013 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