{"id":13908,"date":"2013-09-03T17:05:45","date_gmt":"2013-09-03T09:05:45","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=13908"},"modified":"2017-08-01T21:14:00","modified_gmt":"2017-08-01T13:14:00","slug":"%e3%80%90%e7%94%9f%e7%90%86%e5%ad%b8%e3%80%91%e6%80%8e%e9%ba%bc%e5%a5%b6%e6%b2%b9%e8%9b%8b%e7%b3%95%e4%b8%80%e5%90%83%e5%b0%b1%e5%81%9c%e4%b8%8d%e4%b8%8b%e6%89%8b%e5%91%a2%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=13908","title":{"rendered":"\u3010\u751f\u7406\u5b78\u3011\u600e\u9ebc\u5976\u6cb9\u86cb\u7cd5\u4e00\u5403\u5c31\u505c\u4e0d\u4e0b\u624b\u5462\uff1f"},"content":{"rendered":"<p><strong><strong><span style=\"color: #800000;\">\u25a0 \u6301\u7e8c\u5730\u5403\u9ad8\u71b1\u91cf\u98df\u7269\u6703\u64fe\u4e82\u8178\u9053\u8ddf\u5927\u8166\u7684\u6e9d\u901a\uff0c\u7e7c\u800c\u5f62\u6210\u4e00\u7a2e\u4e0d\u826f\u7684\u98f2\u98df\u7fd2\u6163\u3002<\/span><\/strong><\/strong><\/p>\n<p><strong><strong><span style=\"color: #800000;\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=13909\" rel=\"attachment wp-att-13909\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-13909 alignleft\" title=\"cake\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/09\/cake.jpg\" alt=\"\" width=\"309\" height=\"172\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/09\/cake.jpg 309w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/09\/cake-300x166.jpg 300w\" sizes=\"(max-width: 309px) 100vw, 309px\" \/><\/a><\/span><\/strong><\/strong><\/p>\n<p><strong>\u7de8\u8b6f<\/strong>\u2502\u9ec3\u4f73\u6b23<\/p>\n<p>\u9577\u671f\u7684\u9ad8\u8102\u98f2\u98df\u5df2\u7d93\u88ab\u8a8d\u70ba\u6703\u6e1b\u4f4e\u5927\u8166\u5c0d\u65bc\u5403\u5b8c\u4e00\u9910\u4e4b\u5f8c\u7684\u98fd\u8db3\u611f\uff0c\u4fc3\u4f7f\u4eba\u5011\u8981\u7e7c\u7e8c\u5403\u9032\u66f4\u591a\u98df\u7269\u624d\u80fd\u7372\u5f97\u76f8\u540c\u7a0b\u5ea6\u7684\u98fd\u8db3\u611f\u3002\u7136\u800c\uff0c\u767c\u8868\u65bc\u300a\u79d1\u5b78\u300b\u7684\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0c\u98fd\u8db3\u611f\u6e1b\u4f4e\u5be6\u969b\u4e0a\u662f\u5f9e\u8178\u9053\u672c\u8eab\u958b\u59cb\uff0c\u8178\u9053\u4e0a\u76ae\u7d30\u80de\u6703\u5206\u6ccc\u4e00\u7a2e\u6eff\u8db3\u56e0\u5b50\u4f86\u544a\u8a34\u5927\u8166\u505c\u6b62\u9032\u98df\uff0c\u800c\u6301\u7e8c\u5730\u651d\u53d6\u9ad8\u8102\u98df\u7269\u6703\u4f7f\u5f97\u8178\u9053\u7d30\u80de\u6e1b\u5c11\u5206\u6ccc\u6eff\u8db3\u56e0\u5b50\u3002<\/p>\n<p>\u4f4d\u65bc\u4f5b\u7f85\u91cc\u9054\u5dde\u90b1\u6bd4\u7279\u93ae\uff0c\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u7684\u5206\u5b50\u6cbb\u7642\u5b78\u6559\u6388\u4fdd\u7f85\u2027\u80af\u5c3c(Paul Kenny) \u8aaa\uff1a\u300c\u9019\u662f\u76f8\u7576\u68d2\u7684\u7814\u7a76\uff01\u53ef\u4ee5\u8aaa\u662f\u586b\u88dc\u4e86\u8178\u9053\u548c\u5927\u8166\u6e9d\u901a\u4e4b\u9593\u7f3a\u5c11\u7684\u74b0\u7bc0\uff0c\u800c\u4e14\u4e00\u76f4\u4ee5\u4f86\u90fd\u662f\u4e00\u500b\u8b0e\u3002\u300d\u80af\u5c3c\u535a\u58eb\u672c\u8eab\u672a\u53c3\u8207\u9019\u9805\u7814\u7a76\u3002<!--more--><\/p>\n<p>\u6839\u64da\u80af\u5c3c\u535a\u58eb\u6240\u8aaa\uff0c\u4e94\u82b1\u8089\uff0c\u51b0\u6dc7\u6dcb\u548c\u5176\u4ed6\u9ad8\u8102\u98df\u54c1\u8ddf\u5473\u857e\u63a5\u89f8\u5f8c\u6703\u4fc3\u4f7f\u5927\u8166\u7522\u751f\u8166\u5167\u5561\uff0c\u800c\u8178\u9053\u7d30\u80de\u4e5f\u540c\u6a23\u6703\u76f4\u63a5\u767c\u9001\u4fe1\u865f\u5230\u5927\u8166\uff0c\u63a7\u5236\u6211\u5011\u651d\u53d6\u98df\u7269\u7684\u884c\u70ba\u3002\u4e8b\u5be6\u4e0a\uff0c\u4f7f\u7528\u9f3b\u80c3\u7ba1\u9935\u990a\u7684\u8001\u9f20\uff0c\u4e5f\u5c31\u662f\u4e0d\u7d93\u904e\u53e3\u8154\uff0c\u7260\u5011\u7684\u5927\u8166\u4ecd\u7136\u6703\u7522\u751f\u5927\u91cf\u7684\u591a\u5df4\u80fa (dopamine)\uff0c\u5982\u540c\u90a3\u4e9b\u6b63\u5e38\u5403\u6771\u897f\u7684\u8001\u9f20\u6703\u6709\u7684\u53cd\u61c9\u3002\u591a\u5df4\u80fa\u662f\u4e00\u7a2e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u8ca0\u8cac\u52a0\u5f37\u5927\u8166\u5167\u7684\u734e\u8cde\u56de\u994b\u7cfb\u7d71\u3002<\/p>\n<p>\u8001\u9f20\u8ddf\u4eba\u5728\u98fd\u9910\u4e00\u9813\u4e4b\u5f8c\uff0c\u5927\u8166\u90fd\u6703\u5206\u6ccc\u5927\u91cf\u7684\u591a\u5df4\u80fa\u3002\u4f46\u662f\u6709\u8b49\u64da\u986f\u793a\uff0c\u80a5\u80d6\u7684\u4eba\u5927\u8166\u5167\u6709\u591a\u5df4\u80fa\u5206\u6ccc\u5931\u8abf\u7684\u73fe\u8c61\u3002\u4f86\u81ea\u8036\u9b6f\u5927\u5b78\u91ab\u5b78\u9662\u7684\u7cbe\u795e\u75c5\u5b78\u6559\u6388\u4f0a\u51e1\u2027\u5fb7\u2027\u963f\u52de\u970d(Ivan de Araujo)\u6240\u767c\u8868\u7684\u6700\u65b0\u7814\u7a76\uff0c\u767c\u73fe\u9577\u671f\u5403\u9ad8\u8102\u98df\u7269\u7684\u80a5\u80d6\u8001\u9f20\uff0c\u6539\u7528\u9f3b\u80c3\u7ba1\u76f4\u63a5\u9935\u98df\u9ad8\u8102\u98df\u7269\u5f8c\uff0c\u5c45\u7136\u4e5f\u51fa\u73fe\u591a\u5df4\u80fa\u5206\u6ccc\u7f3a\u4e4f\u7684\u73fe\u8c61\u3002<\/p>\n<p>\u70ba\u4e86\u78ba\u8a8d\u8178\u9053\u662f\u7522\u751f\u8abf\u63a7\u591a\u5df4\u80fa\u7684\u8a0a\u865f\u4f86\u6e90\uff0c\u963f\u52de\u970d\u535a\u58eb\u548c\u4ed6\u7684\u5718\u968a\u8a2d\u8457\u627e\u51fa\u53ef\u80fd\u7684\u5019\u9078\u56e0\u5b50\u3002\u963f\u52de\u970d\u535a\u58eb\u8aaa\uff1a\u300c\u7576\u4f60\u89c0\u5bdf\u9019\u4e9b\u9577\u671f\u5403\u9ad8\u8102\u98df\u7269\u7684\u52d5\u7269\uff0c\u4f60\u6703\u770b\u5230\u5e7e\u4e4e\u6240\u6709\u5728\u8840\u6db2\u5faa\u74b0\u4e2d\u76f8\u95dc\u7684\u56e0\u5b50\u5305\u62ec\u7626\u7d20\u3001\u80f0\u5cf6\u7d20\u3001\u4e09\u9178\u7518\u6cb9\u916f\u3001\u8461\u8404\u7cd6\u7b49\u7b49\u90fd\u7dad\u6301\u5728\u4e00\u500b\u5f88\u9ad8\u7684\u6c34\u5e73\u3002\u4f46\u662f\uff0c\u6709\u4e00\u985e\u7684\u8a0a\u606f\u5206\u5b50\u53cd\u800c\u662f\u88ab\u6291\u5236\u3002\u300d\u963f\u52de\u970d\u535a\u58eb\u5f9e\u4e2d\u6311\u9078\u51fa\u4e00\u500b\u5019\u9078\u56e0\u5b50\u2500\u6cb9\u9178\u4e59\u9187\u80fa(oleoylethanolamide, OEA)\u3002\u4ed6\u8aaa\uff1a\u300c\u9019\u500b\u5206\u5b50\u4e0d\u50c5\u662f\u7531\u8178\u9053\u7d30\u80de\u5728\u63a5\u89f8\u5230\u98df\u7269\u6642\u6240\u88fd\u9020\uff0c\u800c\u4e14\u5728\u9577\u671f\u7684\u9ad8\u8102\u98f2\u98df\u74b0\u5883\uff0c\u9019\u500b\u5206\u5b50\u88ab\u6291\u5236\u7684\u72c0\u6cc1\u770b\u8d77\u4f86\u4f3c\u4e4e\u8ddf\u964d\u4f4e\u591a\u5df4\u80fa\u91cb\u653e\uff0c\u6709\u8457\u67d0\u7a2e\u7a0b\u5ea6\u4e0a\u7684\u5951\u5408\u3002\u300d<\/p>\n<p>\u963f\u52de\u970d\u535a\u58eb\u5229\u7528\u4eba\u5de5\u5c0e\u7ba1\u628aOEA\u5c0e\u5165\u5230\u8178\u9053\u5468\u908a\u7684\u7d44\u7e54\u4e2d\u4ee5\u8b49\u5be6\u9019\u500b\u5206\u5b50\u5728\u8001\u9f20\u8eab\u4e0a\u5177\u6709\u8abf\u7bc0\u591a\u5df4\u80fa\u5206\u6ccc\u7684\u80fd\u529b\u3002\u4ed6\u8aaa\uff1a\u300c\u6211\u5011\u767c\u73fe\u85c9\u7531\u4eba\u5de5\u65b9\u5f0f\u4f7f\u8178\u9053\u88e1\u7684OEA\u6fc3\u5ea6\u56de\u5fa9\u5230\u4e00\u822c\u7684\u57fa\u6e96\u503c\uff0c\u2026\u90a3\u4e9b\u9935\u98df\u9ad8\u8102\u98df\u7269\u7684\u80d6\u8001\u9f20\u4fbf\u958b\u59cb\u6709\u6b63\u5e38\u7684\u591a\u5df4\u80fa\u91cb\u653e\uff0c\u5176\u5206\u6ccc\u7684\u91cf\u8ddf\u5c0d\u7167\u7d44\u7684\u7626\u8001\u9f20\u5e7e\u4e4e\u6c92\u6709\u5dee\u7570\u3002\u300d<\/p>\n<p>\u8a72\u5718\u968a\u9084\u767c\u73feOEA\u5f71\u97ff\u591a\u5df4\u80fa\u7684\u91cb\u653e\u662f\u900f\u904e\u9023\u63a5\u5927\u8166\u8ddf\u8179\u90e8\u4e4b\u9593\u7684\u8ff7\u8d70\u795e\u7d93\uff0c\u800c\u4f5c\u7528\u6a5f\u5236\u662f\u8ddf\u4e00\u7a2e\u7a31\u4f5cPPAR-\u03b1\u7684\u8f49\u9304\u56e0\u5b50\u7d50\u5408\u3002<\/p>\n<p>\u53d7\u5230\u7981\u98df\u7684\u52d5\u7269\uff0c\u5176\u8178\u9053\u88e1\u9762OEA\u6fc3\u5ea6\u4e5f\u662f\u5448\u73fe\u8f03\u4f4e\u7684\u6c34\u5e73\uff0c\u7576\u5403\u6771\u897f\u4e4b\u5f8c\u4fbf\u6703\u958b\u59cb\u4e0a\u5347\u76f4\u5230\u809a\u5b50\u5df2\u7d93\u98fd\u4e86\uff0c\u5c31\u6703\u544a\u8a34\u5927\u8166\u8981\u505c\u6b62\u9032\u98df\u3002\u4e8b\u5be6\u4e0a\uff0cOEA\u5df2\u7d93\u88ab\u8b49\u5be6\u662f\u52d5\u7269\u9ad4\u5167\u7684\u300c\u98fd\u8db3\u611f\u300d\u56e0\u5b50\u3002\u56e0\u6b64\uff0c\u7576\u9577\u671f\u651d\u53d6\u9ad8\u8102\u80aa\u98df\u7269\u800c\u6e1b\u4f4e\u5b83\u7684\u88fd\u9020\uff0c\u5c31\u6c92\u6709\u8fa6\u6cd5\u6709\u300c\u5403\u98fd\u300d\u7684\u611f\u89ba\uff1b\u5927\u8166\u57fa\u672c\u4e0a\u5c31\u7121\u8996\u65bc\u5361\u8def\u91cc\u5728\u8178\u9053\u88e1\u9762\u7684\u5b58\u5728\uff0c\u56e0\u6b64\u9700\u8981\u5403\u9032\u66f4\u591a\u7684\u98df\u7269\u3002<\/p>\n<p>\u52a0\u5dde\u5927\u5b78\u723e\u7063\u5206\u6821\u7684\u6559\u6388\u4e39\u5c3c\u723e\u2027\u7562\u6b50\u6885\u91cc(Daniele Piomelli)\u8aaa\uff1a\u300c\u76ee\u524d\u9084\u4e0d\u6e05\u695a\u70ba\u4ec0\u9ebc\u9577\u671f\u7684\u9ad8\u8102\u98f2\u98df\u6703\u6291\u5236OEA\u7684\u751f\u6210\u3002\u4f46\u662f\uff0c\u60e1\u6027\u5faa\u74b0\u4e00\u65e6\u958b\u59cb\u4e4b\u5f8c\uff0c\u56e0\u70ba\u5927\u8166\u6703\u4e0b\u610f\u8b58\u5730\u63a5\u6536\u4fe1\u606f\uff0c\u4fbf\u5f88\u96e3\u6539\u6389\u9019\u7a2e\u4e0d\u826f\u7fd2\u6163\u3002\u300d<\/p>\n<p>\u7562\u6b50\u6885\u91cc\u63d0\u5230\uff1a\u300c\u6211\u5011\u6703\u5403\u90a3\u4e9b\u6211\u5011\u559c\u6b61\u7684\u98df\u7269\uff0c\u800c\u4e14\u90fd\u8a8d\u70ba\u6211\u5011\u662f\u77e5\u9053\u6211\u5011\u559c\u6b61\u4ec0\u9ebc\uff0c\u4f46\u6211\u89ba\u5f97\u9019\u7bc7\u7814\u7a76\u5831\u544a\u8ddf\u5176\u4ed6\u4eba\u90fd\u9ede\u51fa\u8eab\u9ad4\u9084\u6709\u6f5b\u5728\u7684\u53e6\u5916\u4e00\u9762\uff0c\u53cd\u800c\u662f\u6211\u5011\u7121\u6cd5\u53bb\u610f\u8b58\u5230\u7684\u3002\u56e0\u70ba\u9019\u662f\u4e00\u7a2e\u8207\u751f\u4ff1\u4f86\u7684\u9a45\u529b\uff0c\u4f60\u6839\u672c\u7121\u6cd5\u63a7\u5236\u5b83\u3002\u300d\u63db\u53e5\u8a71\u8aaa\uff0c\u5373\u4f7f\u4f60\u53ef\u4ee5\u6b3a\u9a19\u4f60\u7684\u5473\u857e\u4eab\u53d7\u4f4e\u8102\u512a\u683c\uff0c\u800c\u4f60\u4e0d\u53ef\u80fd\u6b3a\u9a19\u4f60\u7684\u8178\u5b50\u3002<\/p>\n<p>\u4e0d\u904e\u9084\u6709\u4e00\u500b\u597d\u6d88\u606f\uff0c\u963f\u52de\u970d\u535a\u58eb\u8aaa\uff1a\u300c\u9019\u7a2e\u591a\u5df4\u80fa\u5206\u6ccc\u7f3a\u5931\u5728\u52d5\u7269\u8eab\u4e0a\u4e26\u4e0d\u662f\u6c38\u4e45\u6027\u7684\u3002\u300d\u5982\u679c\u53ef\u4ee5\u91dd\u5c0d\u8abf\u63a7\u8178\u9053\u4e2dOEA\u5230PPAR-\u03b1\u8a0a\u606f\u50b3\u5c0e\u9014\u5f91\u4e4b\u9593\u53bb\u8a2d\u8a08\u51fa\u85e5\u7269\uff0c\u90a3\u5c07\u6703\u5e36\u4f86\u5f88\u5927\u5e6b\u52a9\uff0c\u4f86\u4f7f\u4eba\u5011\u80fd\u5920\u6709\u63a7\u5236\u81ea\u5df1\u98df\u617e\u7684\u80fd\u529b\u3002<\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\"> \u5831\u5c0e\u51fa\u8655\uff1a<strong><a href=\"http:\/\/www.the-scientist.com\/?articles.view\/articleNo\/37068\/title\/Why-One-Cream-Cake-Leads-to-Another\/\">Why One Cream Cake Leads to Another<\/a><\/strong><\/span><\/pre>\n<p>\u539f\u59cb\u8ad6\u6587\uff1aTellez, L.A., et al. 2013. A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency. Science (341) 6147: 800-802. DOI: 10.1126\/science.1239275<\/p>\n<p><span style=\"color: #333399;\"><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita Hsu<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 \u6301\u7e8c\u5730\u5403\u9ad8\u71b1\u91cf\u98df\u7269\u6703\u64fe\u4e82\u8178\u9053\u8ddf\u5927\u8166\u7684<\/p>\n","protected":false},"author":20,"featured_media":13909,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257,3293,1025],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/09\/cake.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/13908"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13908"}],"version-history":[{"count":7,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/13908\/revisions"}],"predecessor-version":[{"id":29132,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/13908\/revisions\/29132"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/13909"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}