{"id":13172,"date":"2013-05-01T09:55:15","date_gmt":"2013-05-01T01:55:15","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=13172"},"modified":"2017-08-01T21:47:34","modified_gmt":"2017-08-01T13:47:34","slug":"%e3%80%90%e7%94%9f%e7%89%a9%e9%86%ab%e5%ad%b8%e3%80%91%e6%a8%99%e9%9d%b6%e5%9e%8b%e6%8a%97%e7%99%8c%e8%97%a5%e7%89%a9%e7%9e%84%e5%90%91eg5","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=13172","title":{"rendered":"\u3010\u751f\u7269\u91ab\u5b78\u3011\u6a19\u9776\u578b\u6297\u764c\u85e5\u7269\u7784\u5411Eg5"},"content":{"rendered":"<p><strong><span style=\"color: #800000;\">\u25a0 \u79d1\u5b78\u5bb6\u627e\u5230\u6a19\u9776\u4e0d\u540c\u65bc\u7d2b\u6749\u9187\u7684\u6709\u7d72\u5206\u88c2\u6291\u5236\u5291\u3002<\/span><\/strong><\/p>\n<figure id=\"attachment_13173\" aria-describedby=\"caption-attachment-13173\" style=\"width: 246px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=13173\" rel=\"attachment wp-att-13173\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-13173\" title=\"1\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/05\/1.jpg\" alt=\"\" width=\"246\" height=\"468\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/05\/1.jpg 246w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/05\/1-157x300.jpg 157w\" sizes=\"(max-width: 246px) 100vw, 246px\" \/><\/a><figcaption id=\"caption-attachment-13173\" class=\"wp-caption-text\">\u5c0d\u7167\u7d44\u7684\u6709\u7d72\u5206\u88c2\u7d30\u80de\uff08\u4e0a\u5716\uff09\uff0c\u6b63\u5e38\u7684\u96d9\u6975\u7d21\u9318\u9ad4\uff0c\u5176\u67d3\u8272\u9ad4\uff08\u7d93\u514d\u75ab\u87a2\u5149\u67d3\u8272\u5f8c\u5448\u85cd\u8272\uff09\u5728\u4e2d\u9593\u6392\u6210\u4e00\u5217\u3002\u63a5\u53d7monastrol\u6cbb\u7642\u7684\u6709\u7d72\u5206\u88c2\u7d30\u80de\uff08\u4e0b\u5716\uff09\uff0c\u7d21\u9318\u9ad4\u8b8a\u6210\u74b0\u72c0\u6216\u300c\u55ae\u4e00\u661f\u9ad4\u300d\uff0c\u7d30\u80de\u5206\u88c2\u88ab\u963b\u65b7\u3002<\/figcaption><\/figure>\n<p><span style=\"color: #000000;\"><strong>\u7de8\u8b6f<\/strong>\u2502\u5f35\u5b5d\u8018<\/span><\/p>\n<p>\u54c8\u4f5b\u7814\u7a76\u4eba\u54e1\u5c07\u4e00\u6279\u5c0f\u5206\u5b50\u52a0\u4ee5\u5de7\u5999\u7684\u7be9\u9078\u5f8c\uff0c\u767c\u73fe\u4e86\u4e00\u7a2e\u5f88\u6709\u6f5b\u529b\u7684\u6297\u764c\u5291\uff0c\u7a31\u4e4b\u70ba monastrol\u3002Monastrol\u85c9\u4ee5\u6291\u5236\u7d30\u80de\u5206\u88c2\uff08mitosis\uff0c\u6709\u7d72\u5206\u88c2 \uff09 \u7684\u6a19\u9776\u662f\u4e00\u7a2e\u53eb\u505aEg5\u7684\u99ac\u9054\u86cb\u767d \uff08motor protein\uff09\uff0c\u9019\u500b\u65b0\u6a19\u9776\u7684\u767c\u73fe\u4e0d\u50c5\u5c07\u80fd\u5f15\u5c0e\u51fa\u4e00\u7cfb\u5217\u65b0\u578b\u7684\u6297\u764c\u85e5\u7269\uff0c\u540c\u6642\u4e5f\u6703\u5c0d\u6709\u7d72\u5206\u88c2\u7684\u6a5f\u5236\u5e36\u4f86\u66f4\u6839\u672c\u7684\u4e86\u89e3\u3002<\/p>\n<p>\u627e\u5230\u9019\u500b\u5316\u5408\u7269\u7684\u662f\u54c8\u4f5b\u5927\u5b78\u5316\u5b78\u7cfb\u6559\u6388\u53f2\u90fd\u83ef\u2027 \u859b\u67cf\uff08Stuart L. Schreiber\uff09\u53ca\u54c8\u4f5b\u91ab\u5b78\u9662\u7d30\u80de\u751f\u7269\u5b78\u6559\u6388\u63d0\u6469\u897f\u2027\u7c73\u5947\u68ee \uff08Timothy J. Mitchison\uff09\u7684\u7814\u7a76\u5718\u968a\uff0c\u6210\u54e1\u5305\u62ec\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u6e6f\u99ac\u58eb\u2027\u6885\u723e\uff08Thomas U. Mayer \uff09\u548c\u5854\u502b\u2027\u5361\u666e\u723e\uff08 Tarun M. Kapoor\uff09\uff0c\u7814\u7a76\u751f\u53f2\u8482\u82ac\u2027\u6d77\u683c\u63d0\uff08Stephen J. Haggarty\uff09\uff0c\u4ee5\u53ca\u7d30\u80de\u751f\u7269\u5b78\u7cfb\u85cd\u9053\u723e\u2027\u91d1\uff08Randall W. King\uff09[\u79d1\u5b78\u671f\u520a<em>\uff08Science, <\/em>286, 971 \uff081999\uff09] \u3002<\/p>\n<p>\u4ee5\u5f80\u6291\u5236\u6709\u7d72\u5206\u88c2\u7684\u5c0f\u5206\u5b50\u6297\u764c\u85e5\u7269\u5168\u90fd\u4f5c\u7528\u5728\u5fae\u7ba1\u86cb\u767d\uff08 tubulin\uff09\u4e0a\uff0c\u4f8b\u5982\u79cb\u6c34\u4ed9\u7d20\uff08colchicines\uff09\u3001\u7d2b\u6749\u9187\uff08Taxol\uff09\u3001doxorubicin<a href=\"file:\/\/\/D:\/%E6%88%91%E7%9A%84%E6%96%87%E4%BB%B6\/Downloads\/%E6%A8%99%E9%9D%B6%E5%9E%8B%E6%8A%97%E7%99%8C%E8%97%A5%E7%89%A9%E7%9E%84%E5%90%91Eg5(%E5%BC%B5%E5%AD%9D%E8%80%98).doc#_msocom_1\">[W1]<\/a> \u3001etoposide \u3001\u9577\u6625\u9e7c \uff08vinblastine\uff09\u3001\u53ca\u9577\u6625\u65b0\u9e7c\uff08vincristine\uff09\u00a0 \u7b49\u7b49\u85e5\u7269\u90fd\u662f\u4ee5\u5176\u70ba\u6a19\u9776 \u3002\u5fae\u7ba1\u86cb\u767d\u662f\u69cb\u6210\u5fae\u7ba1 \uff08microtubule\uff09\u7684\u4e3b\u8981\u7d50\u69cb\uff0c\u800c\u5fae\u7ba1\u8ca0\u8cac\u5728\u6709\u7d72\u5206\u88c2\u9032\u884c\u6642\u5c07\u5206\u88c2\u4e2d\u7684\u67d3\u8272\u9ad4\u5206\u958b\uff0c\u6240\u4ee5\u9019\u4e9b\u85e5\u7684\u300c\u7d30\u80de\u6bd2\u6027\uff08cytotoxic\uff09\u53ef\u80fd\u90fd\u5f88\u5f37\uff0c\u56e0\u70ba\u5fae\u7ba1\u662f\u7d30\u80de\u904b\u8f38\u7684\u8ecc\u9053\uff0c\u300d\u5361\u666e\u723e\u8aaa\uff0c\u300c\u5982\u679c\u4f60\u64fe\u4e82\u90a3\u4e9b\u7d50\u69cb\uff0c\u5c31\u6703\u5f71\u97ff\u5230\u8a31\u591a\u5176\u4ed6\u7684\u7d30\u80de\u904b\u4f5c\u904e\u7a0b\uff0c\u4e5f\u8a31\u56e0\u6b64\u69cb\u6210\u4e86\u9019\u985e\u85e5\u7269\u90e8\u5206\u7684\u7d30\u80de\u6bd2\u6027\uff08 cytotoxicity\uff09\u3002\u300d<\/p>\n<p>\u70ba\u4e86\u627e\u51fa\u975e\u4ee5\u5fae\u7ba1\u86cb\u767d\u70ba\u6a19\u9776\u7684\u6709\u7d72\u5206\u88c2\u6291\u5236\u5291\uff0c\u6885\u723e\u548c\u540c\u4e8b\u5c07\u4e00\u500b\u6709\u6a5f\u5c0f\u5206\u5b50\u5eab\u4e2d16,320\u500b\u5206\u5b50\u505a\u4e86\u4e00\u9023\u4e32\u7684\u7be9\u9078\u3002\u7b2c\u4e00\u9053\u7be9\u9078\u662f\u8981\u6311\u51fa\u6240\u6709\u6703\u904f\u6b62\u6709\u7d72\u5206\u88c2\u7684\u5316\u5408\u7269\uff0c\u6d77\u683c\u63d0\u627e\u5230\u4e86139\u500b\uff0c\u7136\u5f8c\u5728\u7b2c\u4e8c\u9053\u7be9\u9078\u6642\u53bb\u6389\u90a3\u4e9b\u4ee5\u5fae\u7ba1\u86cb\u767d\u70ba\u6a19\u9776\u7684\u6297\u6709\u7d72\u5206\u88c2\u5316\u5408\u7269\uff08\u670953\u500b\uff09\uff0c\u6700\u5f8c\u7b2c\u4e09\u9053\u7be9\u9078\u662f\u5f9e\u5269\u4e0b\u768486\u500b\u5206\u5b50\u4e2d\u627e\u51fa\u53ea\u6703\u6291\u5236\u6b63\u5728\u5206\u88c2\u4e2d\u7684\u7d30\u80de\u4f46\u4e0d\u6703\u59a8\u5bb3\u5176\u4ed6\u672a\u5206\u88c2\u7d30\u80de\u7684\u5316\u5408\u7269\u3002<\/p>\n<p>\u5171\u6709\u4e94\u500b\u5316\u5408\u7269\u901a\u904e\u4e86\u4e09\u6b21\u7684\u7be9\u9078\uff0c\u5176\u4e2d\u6709\u4e00\u500b\u6703\u8b93\u6709\u7d72\u5206\u88c2\u6642\u7684\u7d21\u9318\u9ad4\uff08spindle\uff0c\u67d3\u8272\u9ad4\u5206\u88c2\u6642\u7684\u7d50\u69cb\uff09\u5f62\u6210\u300c\u55ae\u661f\u9ad4\u300d \uff08monasters\uff09\uff0c\u9019\u7a2e\u74b0\u72c0\u7684\u7d21\u9318\u9ad4\u770b\u8d77\u4f86\u548c\u5e73\u5e38\u62c9\u958b\u5c0d\u9f4a\u7684\u5169\u6975\u7d21\u9318\u9ad4 \uff08bipolar spindles\uff09\u5927\u4e0d\u76f8\u540c\u3002\u300c\u6211\u5011\u628a\u9019\u500b\u5316\u5408\u7269\u53eb\u505a monastrol\uff0c\u300d\u5361\u666e\u723e\u89e3\u91cb\uff0c\u300c\u56e0\u70ba\u5b83\u5c0e\u81f4\u55ae\u661f\u9ad4\u7684\u5f62\u6210\uff0c\u4e26\u5177\u6709\u7fa5\u57fa\uff08 hydroxyl\uff09\u529f\u80fd\u3002\u300d<!--more--><\/p>\n<p>\u6885\u723e\u548c\u540c\u4e8b\u5011\u63a8\u6e2c\u55ae\u661f\u9ad4\u5f62\u6210\u7684\u539f\u56e0\u4e5f\u8a31\u662f\u7531\u65bcmonastrol\u5728\u6709\u7d72\u5206\u88c2\u6642\u963b\u64fe\u4e86\u8b93\u4e2d\u5fc3\u9ad4 \uff08centrosomes\uff0c\u7d21\u9318\u9ad4\u76f8\u9023\u8655\uff09\u5206\u88c2\u7684\u6a5f\u5236\uff0c\u800c\u4e4b\u5f8c\u4ed6\u5011\u4e5f\u8b49\u660e\u4e86monastrol\u78ba\u5be6\u6703\u6291\u5236\u9a45\u52d5\u86cb\u767d\uff08kinesin\uff09 Eg5\u3002Eg5\u662f\u4e00\u7a2e\u6703\u50ac\u5316\u4e2d\u661f\u9ad4\u5206\u88c2\u7684ATP\u9176\uff08ATPase\uff09\uff0c\u4f46\u5b83\u6703\u4e0d\u6703\u5f71\u97ff\u5176\u4ed6\u7684\u86cb\u767d\u8cea\uff0c\u5247\u5c1a\u672a\u53ef\u77e5\u3002<\/p>\n<p>\u7c73\u5947\u68ee\u7684\u7814\u7a76\u5c0f\u7d44\u4ee5\u524d\u5c31\u5df2\u767c\u73feEg5\u5728\u5fae\u7ba1\u8f49\u8b8a\u7d44\u6210\u7d21\u9318\u9ad4\u7684\u904e\u7a0b\u4e2d\u4f54\u6709\u5f88\u91cd\u8981\u7684\u89d2\u8272\uff0c\u4f46\u76ee\u524d\u9084\u4e0d\u4e86\u89e3\u5176\u6a5f\u5236\u3002\u300c\u73fe\u5728\u6211\u5011\u627e\u5230\u9019\u500b\u86cb\u767d\u8cea\u7684\u6291\u5236\u5291\u4e86\uff0c\u300d\u6885\u723e\u8aaa\uff0c\u300c\u800c\u6709\u4e86\u9019\u500b\u5316\u5408\u7269\u5f8c\uff0c\u6211\u5011\u73fe\u5728\u53ef\u4ee5\u53cd\u904e\u4f86\u7814\u7a76Eg5\u5728\u6709\u7d72\u5206\u88c2\u4e2d\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u6211\u5011\u4e5f\u60f3\u7528\u9019\u500b\u65b9\u6cd5\u4f86\u627e\u51fa\u53c3\u8207\u6709\u7d72\u5206\u88c2\u7684\u5176\u4ed6\u5c1a\u672a\u767c\u73fe\u7684\u86cb\u767d\u8cea\u3002\u300d<\/p>\n<p>\u820a\u91d1\u5c71\u52a0\u5dde\u5927\u5b78\u7d30\u80de\u8207\u5206\u5b50\u85e5\u7406\u5b78\u52a9\u7406\u6559\u6388\u53ef\u6587\u2027\u4fee\u51f1\uff08Kevan M. Shokat<a href=\"file:\/\/\/D:\/%E6%88%91%E7%9A%84%E6%96%87%E4%BB%B6\/Downloads\/%E6%A8%99%E9%9D%B6%E5%9E%8B%E6%8A%97%E7%99%8C%E8%97%A5%E7%89%A9%E7%9E%84%E5%90%91Eg5(%E5%BC%B5%E5%AD%9D%E8%80%98).doc#_msocom_2\">[W2]<\/a> \uff09\u8868\u793a\uff0c\u54c8\u4f5b\u7814\u7a76\u5718\u968a\u300c\u80fd\u5920\u4ee5\u7d21\u9318\u9ad4\u65e9\u671f\u7684\u55ae\u4e00\u661f\u72c0\u8868\u578b\uff08phenotype\uff09\u63a8\u8ad6\u51faEg5\u53ef\u505a\u70ba monastrol \u9019\u500b\u5c0f\u5206\u5b50\u7684\u6a19\u9776\uff0c\u4e26\u9032\u800c\u8b49\u660e\u4e86\u9019\u500b\u5047\u8a2d\uff0c\u51f8\u986f\u51fa\u751f\u7269\u5b78\u5bb6\u548c\u5316\u5b78\u5bb6\u7684\u5408\u4f5c\uff0c\u5728\u4ee5\u65b0\u5f0f\u5316\u5b78\u5de5\u5177\u4f86\u5206\u6790\u751f\u7269\u7cfb\u7d71\u7684\u767c\u5c55\u4e0a\u64c1\u6709\u6975\u5927\u7684\u512a\u52e2\u3002\u300d<\/p>\n<p>\u5361\u666e\u723e\u8aaa\uff0c\u300c\u9019\u662f\u6211\u5011\u7b2c\u4e00\u6b21\u627e\u5230\u80fd\u6ef2\u900f\u7d30\u80de\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff0c\u800c\u4e14\u662f\u4f5c\u7528\u5728\u8ca0\u8cac\u7d30\u80de\u5206\u88c2\u7684\u9a45\u52d5\u86cb\u767d\u4e0a\uff0c\u9019\u8868\u793a\u9a45\u52d5\u86cb\u767d\u53ef\u4ee5\u505a\u70ba\u764c\u75c7\u6cbb\u7642\u7684\u6a19\u9776\u3002\u300d\u800c\u4e14monastrol\u53ea\u4f5c\u7528\u5728\u7d21\u9318\u9ad4\u7684\u904b\u8f38\u529f\u80fd\u4e0a\uff0c\u5b83\u4e0d\u6703\u5e72\u64fe\u975e\u5206\u88c2\u4e2d\u7d30\u80de\u7684\u6b63\u5e38\u904b\u8f38\u904e\u7a0b\uff0c\u751a\u81f3\u4e5f\u4e0d\u6703\u5f71\u97ff\u4ee5\u5176\u4ed6\u9a45\u52d5\u86cb\u767d\u70ba\u50b3\u8cea\u5a92\u4ecb\u7684\u7d30\u80de\uff0c\u9019\u610f\u5473\u8457\u6839\u64damonastrol\u6240\u505a\u51fa\u4f86\u7684\u85e5\u7269\u526f\u4f5c\u7528\u6bd4\u8f03\u5c0f\u3002<\/p>\n<p>\u5728\u5316\u5b78\u4e0a\uff0cmonastrol\u5177\u6709\u5f88\u591a\u5b98\u80fd\u57fa\uff0c\u4f46\u4e0d\u96e3\u5408\u6210\u53ca\u4fee\u6539\u3002\u5b83\u662f\u4e00\u7a2e\u5fae\u83ab\u8033\uff08micromolar\uff09\u6fc3\u5ea6\u7d1a\u7684Eg5 \u6291\u5236\u5291\uff0c\u6240\u4ee5\u6297\u6709\u7d72\u5206\u88c2\u7684\u6d3b\u6027\u4e0d\u662f\u5f88\u9ad8\uff0c\u4f46\u4e5f\u8a31\u5176\u884d\u751f\u7269\u80fd\u6709\u8f03\u5f37\u7684\u6d3b\u6027\u3002\u5361\u666e\u723e\u8aaa\uff0c\u300c\u6211\u5011\u6b63\u5728\u505amonastrol\u7684\u7d50\u69cb\u985e\u4f3c\u7269\uff0c\u4e8b\u5be6\u4e0a\uff0c\u6211\u5011\u624b\u908a\u5df2\u7d93\u6709\u4e00\u500b\u5c0f\u5c0f\u7684\u5206\u5b50\u5eab\uff0c\u5f88\u5feb\u5c31\u53ef\u4ee5\u958b\u59cb\u6e2c\u8a66\u4e86\u3002\u300d<\/p>\n<hr size=\"1\" \/>\n<p><a href=\"file:\/\/\/D:\/%E6%88%91%E7%9A%84%E6%96%87%E4%BB%B6\/Downloads\/%E6%A8%99%E9%9D%B6%E5%9E%8B%E6%8A%97%E7%99%8C%E8%97%A5%E7%89%A9%E7%9E%84%E5%90%91Eg5(%E5%BC%B5%E5%AD%9D%E8%80%98).doc#_msoanchor_1\">[W1]<\/a>\u4fd7\u7a31\u5c0f\u7d05\u8393\uff1b\u8f1d\u745e\u7684\u53eb\u300c\u827e\u9ef4\u7d20\u300d<\/p>\n<p><a href=\"file:\/\/\/D:\/%E6%88%91%E7%9A%84%E6%96%87%E4%BB%B6\/Downloads\/%E6%A8%99%E9%9D%B6%E5%9E%8B%E6%8A%97%E7%99%8C%E8%97%A5%E7%89%A9%E7%9E%84%E5%90%91Eg5(%E5%BC%B5%E5%AD%9D%E8%80%98).doc#_msoanchor_2\">[W2]<\/a>\u4ed6\u73fe\u5728\u5df2\u662fprofessor &amp; chair \u00a0<a href=\"http:\/\/cancer.ucsf.edu\/people\/profiles\/shokat_kevan.3666\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/cancer.ucsf.edu\/people\/profiles\/shokat_kevan.3666<\/a><br \/>\n--<\/p>\n<pre><span style=\"color: #333333;\"> \u5831\u5c0e\u51fa\u8655\uff1a<strong><a href=\"http:\/\/cen.watchglass.org\/search\/Anticancer+\">Anticancer Research Pans Out<\/a><\/strong><\/span><\/pre>\n<p><span style=\"color: #333399;\"><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita \u00a0Hsu<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0 \u79d1\u5b78\u5bb6\u627e\u5230\u6a19\u9776\u4e0d\u540c\u65bc\u7d2b\u6749\u9187\u7684\u6709\u7d72\u5206\u88c2<\/p>\n","protected":false},"author":20,"featured_media":13173,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/05\/1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/13172"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13172"}],"version-history":[{"count":15,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/13172\/revisions"}],"predecessor-version":[{"id":29171,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/13172\/revisions\/29171"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/13173"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}