{"id":12445,"date":"2013-01-03T11:53:00","date_gmt":"2013-01-03T03:53:00","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=12445"},"modified":"2017-08-01T22:06:56","modified_gmt":"2017-08-01T14:06:56","slug":"%e3%80%90%e6%8e%a2%e7%b4%a2%e5%85%ab%e3%80%91%e5%80%8b%e4%ba%ba%e5%8c%96%e9%86%ab%e7%99%82-%e6%89%be%e5%87%ba%e8%b6%a8%e5%90%89%e9%81%bf%e5%87%b6%e7%9a%84%e9%9d%88%e8%97%a5","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=12445","title":{"rendered":"\u3010\u63a2\u7d22\u516b\u3011\u500b\u4eba\u5316\u91ab\u7642  \u627e\u51fa\u8da8\u5409\u907f\u51f6\u7684\u9748\u85e5"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong><span style=\"color: #800000;\">\u7b2c\u4e03\u8b1b\u2027\u7279\u7a3f<\/span><\/strong><\/h2>\n<p><strong><span style=\"color: #333399;\"><strong>\u25a0 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sizes=\"(max-width: 304px) 100vw, 304px\" \/><\/a><figcaption id=\"caption-attachment-12446\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1aJasper White\u2502Getty 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<\/strong><strong>\u8b93\u75be\u75c5\u73fe\u51fa\u539f\u5f62<\/strong><\/p>\n<p>\u57fa\u56e0\u6703\u88fd\u9020\u5177\u6709\u529f\u80fd\u7684\u86cb\u767d\u8cea\uff0c\u85c9\u6b64\u64cd\u63a7\u4eba\u5011\u7684\u8eab\u9ad8\u3001\u8840\u58d3\u3001\u500b\u6027\u53ca\u667a\u529b\u7b49\u907a\u50b3\u8868\u5fb5\uff0c\u4e0d\u904e\u57fa\u56e0\u4e00\u65e6\u640d\u58de\uff0c\u5c07\u6703\u6539\u8b8a\u86cb\u767d\u8cea\u5e8f\u5217\uff0c\u4f7f\u5176\u529f\u80fd\u7522\u751f\u8b8a\u5316\uff0c\u9032\u800c\u5f15\u8d77\u75be\u75c5\u3002\u57fa\u56e0\u8207\u75be\u75c5\u4e4b\u9593\u7684\u95dc\u806f\u5927\u81f4\u53ef\u5206\u70ba\u300c\u55ae\u4e00\u57fa\u56e0\u5931\u8abf\u300d\u8207\u300c\u8907\u5408\u6027\u57fa\u56e0\u75be\u75c5\u300d\u5169\u5927\u985e\uff1b\u524d\u8005\u662f\u6307\u907a\u50b3\u6027\u75be\u75c5\u50c5\u8207\u55ae\u4e00\u57fa\u56e0\u8b8a\u7570\u6709\u95dc\uff1b\u5f8c\u8005\u7684\u75c5\u767c\u539f\u56e0\u5247\u8207\u591a\u91cd\u57fa\u56e0\u53ca\uff08\u6216\uff09\u74b0\u5883\u56e0\u5b50\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\u6709\u95dc\uff0c\u95dc\u4fc2\u8f03\u70ba\u8907\u96dc\u3002<\/p>\n<p>\u70ba\u4e86\u638c\u63e1\u75be\u75c5\u8207\u57fa\u56e0\u4e4b\u9593\u7684\u95dc\u9023\u6027\uff0c\u91ab\u5b78\u9818\u57df\u4e0d\u65b7\u767c\u5c55\u57fa\u56e0\u6aa2\u6e2c\u65b9\u6cd5\uff1b\u5305\u62ec\u5728\u767c\u75c5\u524d\u91dd\u5c0d\u67d0\u4e9b\u5177\u6709\u4ee3\u8868\u6027\u7684\u81f4\u75c5\u57fa\u56e0\u9032\u884c\u7be9\u6aa2\uff0c\u4f86\u9810\u6e2c\u7f79\u60a3\u7279\u5b9a\u75be\u75c5\u7684\u53ef\u80fd\u6027\uff0c\u6216\u662f\u5728\u75c5\u4eba\u767c\u75c5\u5f8c\u7531\u91ab\u5e2b\u9032\u884c\u8a3a\u65b7\u3002\u76ee\u524d\u5e38\u898b\u7684\u57fa\u56e0\u6aa2\u6e2c\u9805\u76ee\u5305\u62ec\u7528\u4f86\u8a55\u4f30\u7f79\u764c\u98a8\u96aa\u7684P53\u57fa\u56e0\u3001\u9810\u6e2c\u963f\u8332\u6d77\u9ed8\u75c7\u7684Apolipoprotein E\uff0c\u4ee5\u53ca\u7f3a\u4e4f\u6703\u5c0e\u81f4\u8836\u8c46\u75c7\u7684G-6-PD\u7b49\u3002<!--more--><\/p>\n<p>P53\u57fa\u56e0\u4f4d\u65bc\u4eba\u9ad4\u7b2c17\u5c0d\u67d3\u8272\u9ad4\u77ed\u81c2\u4e0a\uff0c\u662f\u4e00\u7a2e\u816b\u7624\u6291\u5236\u57fa\u56e0\uff0c\u6b63\u5e38\u60c5\u5f62\u4e0bP53\u57fa\u56e0\u53ef\u6291\u5236\u7a81\u8b8a\u7d30\u80de\u7e7c\u7e8c\u5206\u88c2\u3002\u4f46\u662f\u4e00\u65e6\u767c\u751f\u7a81\u8b8a\u6642\uff0c\u7d30\u80de\u5167\u7684\u8abf\u63a7\u5c31\u6703\u5931\u8abf\uff0c\u9020\u6210\u7d30\u80de\u7684\u4e0d\u7576\u589e\u751f\u3002\u7531\u65bcP53\u57fa\u56e0\u7a81\u8b8a\u51fa\u73fe\u65bc\u764c\u75c7\u7684\u767c\u751f\u8207\u64f4\u5f35\u6642\u671f\uff0c\u6240\u4ee5\u81e8\u5e8a\u4e0a\uff0c\u5e38\u7528\u5b83\u4f86\u8a55\u4f30\u4e73\u764c\u7b49\u764c\u75c7\u7684\u5fa9\u767c\u6a5f\u6703\u3002<\/p>\n<p>Apolipoprotein E\uff08\u7c21\u7a31Apo E\uff09\u4f4d\u65bc\u4eba\u9ad4\u7b2c19\u67d3\u8272\u9ad4\u4e0a\u8102\u86cb\u767d(apolipoprotein)\u4e0a\uff0c\u5b83\u7684\u529f\u80fd\u662f\u751f\u7522\u651c\u5e36\u81bd\u56fa\u9187\u7684\u53bb\u8102\u86cb\u767d\uff0c\u85c9\u4ee5\u63a7\u5236\u8840\u6db2\u4e2d\u8102\u80aa\u542b\u91cfApolipoprotein E\u8207\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u7684\u767c\u751f\u6709\u5bc6\u5207\u7684\u95dc\u4fc2\u3002<\/p>\n<p>\u8461\u8404\u7cd6-6-\u78f7\u9178\u9e7d\u812b\u6c2b\u9175\u7d20\uff08G-6-PD\uff09\u7f3a\u4e4f\u8005\uff0c\u5176\u7d05\u8840\u7403\u5f88\u5bb9\u6613\u88ab\u7834\u58de\uff0c\u8a72\u75c5\u75c7\u4fd7\u7a31\u8836\u8c46\u75c7\uff0c\u7531\u65bc\u8a72\u75c5\u75c7\u662f\u4e2d\u570b\u4eba\u5e38\u898b\u7684\u5148\u5929\u6027\u4ee3\u8b1d\u75be\u75c5\uff0c\u6240\u4ee5\u88ab\u885b\u751f\u7f72\u5217\u70ba\u65b0\u751f\u5152\u512a\u751f\u4fdd\u5065\u7be9\u6aa2\u7684\u9805\u76ee\u3002<\/p>\n<p>\u57fa\u56e0\u7be9\u6aa2\u80fd\u5e6b\u52a9\u4eba\u5011\u53ca\u65e9\u767c\u73fe\u75be\u75c5\uff0c\u4e26\u4e14\u900f\u904e\u53ca\u65e9\u5c31\u91ab\u4f86\u638c\u63e1\u6cbb\u7642\u7684\u6700\u4f73\u6642\u6a5f\uff0c\u6216\u662f\u6539\u8b8a\u751f\u6d3b\u7fd2\u6163\u4f86\u964d\u4f4e\u75be\u75c5\u7684\u767c\u751f\u6a5f\u7387\u3002\u4e0d\u904e\uff0c\u9673\u91ab\u5e2b\u63d0\u9192\u5927\u5bb6\uff0c\u7531\u65bc\u57fa\u56e0\u7be9\u6aa2\u7684\u8cbb\u7528\u4e26\u4e0d\u4f4e\uff0c\u5982\u679c\u5bb6\u65cf\u4e2d\u4e26\u6c92\u6709\u4eba\u7f79\u60a3\u67d0\u4e00\u985e\u75be\u75c5\u6642\uff0c\u4e26\u4e0d\u9700\u8981\u7279\u610f\u5c31\u6b64\u75be\u75c5\u9032\u884c\u6aa2\u6e2c\uff0c\u6b64\u5916\uff0c\u6709\u4e9b\u57fa\u56e0\u75be\u75c5\u7684\u6cbb\u7642\u65b9\u6cd5\u5c1a\u672a\u554f\u4e16\uff0c\u4e8b\u524d\u77e5\u9053\u4e0d\u4f46\u65bc\u4e8b\u7121\u88dc\uff0c\u751a\u81f3\u53ef\u80fd\u5f71\u97ff\u53d7\u8a66\u8005\u7684\u5fc3\u7406\u5065\u5eb7\u3002\u96d6\u7136\u57fa\u65bc\u5c0a\u91cd\u75c5\u4eba\u77e5\u7684\u6b0a\u5229\uff0c\u57fa\u56e0\u6aa2\u6e2c\u6709\u5176\u5fc5\u8981\u6027\uff0c\u4e0d\u904e\uff0c\u91ab\u7642\u4eba\u54e1\u61c9\u8a72\u4e8b\u5148\u63d0\u4f9b\u8a73\u7d30\u7684\u89e3\u91cb\u8207\u8aee\u8a62\uff0c\u8b93\u53d7\u6e2c\u8005\u4e86\u89e3\u6aa2\u9a57\u7684\u539f\u56e0\u53ca\u76ee\u7684\u5f8c\uff0c\u518d\u81ea\u884c\u6c7a\u5b9a\u662f\u5426\u9858\u610f\u63a5\u53d7\u57fa\u56e0\u6aa2\u9a57\u3002<\/p>\n<p><strong>\u85e5\u7269\u57fa\u56e0\u9ad4\u5b78\u00a0\u00a0 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\u6642\uff0c\u60a3\u8005\u6703\u6709\u9ad8\u7684\u8840\u6e05\u4e2dC\u809d\u75c5\u6bd2\u6e05\u9664\u901f\u7387\uff0c\u4e5f\u56e0\u6b64\u5728\u63a5\u53d7\u5e72\u64fe\u7d20\u76f8\u95dc\u6cbb\u7642\u5f8c\u6709\u8f03\u9ad8\u7684\u6210\u529f\u6a5f\u6703\u3002<\/p>\n<p>\u9673\u91ab\u5e2b\u53e6\u5916\u4ee5\u8840\u6813\u7684\u6cbb\u7642\u4f86\u8aaa\u660e\u500b\u4eba\u5316\u91ab\u85e5\u7684\u61c9\u7528\u3002\u7531\u65bc\u4e00\u65e6\u7522\u751f\u8840\u6813\uff0c\u4e0d\u4f46\u6703\u5835\u585e\u8840\u7ba1\uff0c\u751a\u81f3\u53ef\u80fd\u4f7f\u4eba\u9ad4\u7f3a\u4e4f\u6c27\u6c23\u53ca\u990a\u5206\uff0c\u56e0\u6b64\uff0c\u7528\u4f86\u9810\u9632\u53ca\u6cbb\u7642\u8840\u6813\u7684\u6297\u51dd\u8840\u5291\uff08Warfarin\uff09\u986f\u5f97\u76f8\u7576\u91cd\u8981\uff0c\u5b83\u7684\u4e3b\u8981\u529f\u7528\u662f\u5e72\u64fe\u7dad\u4ed6\u547dK\uff0c\u4f7f\u5f97\u51dd\u8840\u56e0\u5b50\u7684\u51dd\u8840\u6548\u7387\u5927\u5e45\u4e0b\u964d\uff0c\u56e0\u800c\u9054\u5230\u6297\u51dd\u8840\u7684\u6548\u679c\u3002\u81e8\u5e8a\u4e0a\u767c\u73fe\u5728\u4e0d\u540c\u4eba\u7a2e\u7684\u60a3\u8005\uff0c\u6240\u9700\u8981Warfarin\u7684\u5291\u91cf\u6709\u6975\u5927\u5dee\u7570\uff0c\u50cf\u662f\u83ef\u4eba\u6240\u9700\u7684\u5291\u91cf\u5927\u6982\u70ba\u9ad8\u52a0\u7d22\u4eba\u7684\u4e00\u534a\uff0c\u56e0\u6b64\u4f7f\u7528Warfarin\u524d\uff0c\u5fc5\u9808\u5148\u9451\u5b9a\u60a3\u8005\u7684\u57fa\u56e0\u578b\uff0c\u7136\u5f8c\u9078\u64c7\u6700\u9069\u7576\u7684\u5291\u91cf\uff0c\u4ee5\u907f\u514d\u56b4\u91cd\u51fa\u8840\u4e4b\u4f75\u767c\u75c7\uff0c\u540c\u6642\u9054\u5230\u6700\u4f73\u7684\u6cbb\u7642\u6548\u679c\uff0c\u7576\u7136\uff0c\u5982\u679c\u518d\u52a0\u4e0a\u8eab\u9ad8\u3001\u9ad4\u91cd\u3001\u5e74\u9f61\u7b49\u5f71\u97ffWarfarin\u4f7f\u7528\u5291\u91cf\u7684\u81e8\u5e8a\u56e0\u5b50\uff0c\u5c31\u80fd\u66f4\u6e96\u78ba\u5730\u8a55\u4f30\u6240\u9700\u5291\u91cf\u3002<\/p>\n<p>\u500b\u4eba\u5316\u91ab\u7642\u4e0d\u50c5\u70ba\u6d88\u8cbb\u8005\u63d0\u4f9b\u66f4\u8cbc\u8fd1\u7684\u91ab\u7642\u670d\u52d9\uff0c\u4e5f\u70ba\u91ab\u7642\u7522\u696d\u5e36\u4f86\u65b0\u5546\u6a5f\uff0c\u50cf\u662f\u900f\u904e\u85e5\u7269\u57fa\u56e0\u9ad4\u5b78\u7684\u7814\u7a76\uff0c\u4e0d\u4f46\u80fd\u70ba\u85e5\u5ee0\u964d\u4f4e\u65b0\u85e5\u7684\u958b\u767c\u6210\u672c\uff0c\u9084\u80fd\u85c9\u7531\u85e5\u6548\u8207\u5b89\u5168\u6027\u7684\u63d0\u5347\uff0c\u4f7f\u5f97\u85e5\u7269\u66f4\u53d7\u5e02\u5834\u6b61\u8fce\uff0c\u82e5\u80fd\u91dd\u5c0d\u500b\u9ad4\u5dee\u7570\u6027\u4f86\u958b\u767c\u65b0\u85e5\uff0c\u66f4\u53ef\u70ba\u696d\u8005\u62d3\u5c55\u5e02\u5834\u7248\u5716\uff0c\u6b64\u5916\uff0c\u66f4\u6709\u5229\u65bc\u76f8\u95dc\u751f\u7269\u6a19\u8a18\u7684\u5206\u5b50\u8a3a\u65b7\u7522\u696d\u4e4b\u767c\u5c55\uff0c\u76f8\u4fe1\u5728\u85e5\u7269\u57fa\u56e0\u5b78\u65b9\u8208\u672a\u827e\u4e4b\u969b\uff0c\u500b\u4eba\u5316\u91ab\u5b78\u7684\u6642\u4ee3\u6307\u65e5\u53ef\u5f85\u3002<br \/>\n--<\/p>\n<pre><span style=\"color: #333333;\">\u672c\u6587\u6574\u7406\u81ea\uff1a101\/12\/08\u4e0b\u5348\u7531\u9673\u6c9b\u9686\u91ab\u5e2b\u5728\u81fa\u5927\u61c9\u529b\u6240\u570b\u969b\u6f14\u8b1b\u5ef3\u6240\u4e3b\u8b1b\u4e4b\u300c\u57fa\u56e0\u8207\u500b\u4eba\u5316\u91ab\u7642\u300d\u7684\u6f14\u8b1b\u5167\u5bb9<\/span><\/pre>\n<pre><span style=\"color: #333333;\">\u5ef6\u4f38\u95b1\u8b80\uff1a\u53f0\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3\u63a2\u7d22\u57fa\u790e\u79d1\u5b78\u8b1b\u5ea72012\u5e7412\u670808\u65e5\u7b2c\u4e03\u8b1b\u3008\u57fa\u56e0\u8207\u500b\u4eba\u5316\u91ab\u7642\u3009<\/span><a href=\"https:\/\/case.ntu.edu.tw\/CASTUDIO\/course.php?speech_ID=3173#video_top\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #333333;\">\u5168\u7a0b\u5f71\u97f3<\/span><\/a><\/pre>\n<p><span style=\"color: #333399;\"><strong><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita Hsu<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7b2c\u4e03\u8b1b\u2027\u7279\u7a3f \u25a0 \u62dc\u57fa\u56e0\u79d1\u6280\u4e4b\u8cdc\uff0c\u91ab\u7642\u6280<\/p>\n","protected":false},"author":20,"featured_media":12446,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,872],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2013\/01\/107070121.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12445"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12445"}],"version-history":[{"count":12,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12445\/revisions"}],"predecessor-version":[{"id":29200,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12445\/revisions\/29200"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/12446"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}