{"id":12403,"date":"2012-12-18T12:10:31","date_gmt":"2012-12-18T04:10:31","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=12403"},"modified":"2017-08-07T08:59:32","modified_gmt":"2017-08-07T00:59:32","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e5%a4%a9%e7%94%9f%e6%84%9b%e7%9d%a1%e8%a6%ba%e7%9a%84%e6%95%91%e6%98%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=12403","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u5929\u751f\u611b\u7761\u89ba\u7684\u6551\u661f"},"content":{"rendered":"<p><strong><span style=\"color: #333399;\">\u25a0\u00a0\u60f3\u8fa6\u6cd5\u6291\u5236 GABA \u4fc3\u9032\u7761\u610f\u7684\u6548\u61c9\uff0c\u53ef\u80fd\u662f\u6bd4\u8f03\u6709\u7528\u7684\u7b56\u7565\u2014\u2014\u8207\u5176\u8e29\u52a0\u901f\u5668\uff0c\u4e0d\u5982\u653e\u6389\u624b\u715e\u8eca\u3002<\/span><\/strong><\/p>\n<figure id=\"attachment_12404\" aria-describedby=\"caption-attachment-12404\" style=\"width: 398px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=12404\" rel=\"attachment wp-att-12404\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-12404 \" title=\"sleep\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/sleep.jpg\" alt=\"\" width=\"398\" height=\"378\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/sleep.jpg 627w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/sleep-300x285.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/sleep-600x570.jpg 600w\" sizes=\"(max-width: 398px) 100vw, 398px\" \/><\/a><figcaption id=\"caption-attachment-12404\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1aDigital Vision\/Thinkstock<\/figcaption><\/figure>\n<p><strong>\u7de8\u8b6f<\/strong>\u2502\u9ad8\u82f1\u54f2<\/p>\n<p>\u5728\u7e41\u5fd9\u7684\u5de5\u4f5c\u65e5\u6253\u778c\u7761\u662f\u7a00\u9b06\u5e73\u5e38\u7684\u4e8b\uff0c\u4f86\u9ede\u5496\u5561\u56e0\u63d0\u63d0\u795e\uff0c\u901a\u5e38\u5c31\u80fd\u8b93\u6211\u5011\u53c8\u662f\u4e00\u5c3e\u6d3b\u9f8d\u3002\u7136\u800c\u60a3\u6709\u67d0\u4e9b\u7761\u7720\u5931\u8abf\u75c7\u72c0\u7684\u4eba\u5011\uff0c\u5373\u4f7f\u665a\u4e0a\u7761\u4e86\u5341\u500b\u5c0f\u6642\u4ee5\u4e0a\uff0c\u5927\u767d\u5929\u9084\u662f\u5f97\u8981\u8ddf\u774f\u9813\u6b32\u7720\u596e\u6230\u3002\u5c0d\u4ed6\u5011\u4f86\u8aaa\uff0c\u5496\u5561\u56e0\u5b8c\u5168\u4e0d\u7ba1\u7528\uff0c\u66f4\u5f37\u529b\u7684\u8655\u65b9\u8208\u596e\u5291\u4e5f\u597d\u4e0d\u5230\u54ea\u88e1\u53bb\u3002\u5982\u4eca\u6709\u4e00\u9805\u91dd\u5c0d\u4e00\u5c0f\u7fa4\u75c5\u60a3\u6240\u505a\u7684\u7814\u7a76\u6307\u51fa\uff0c\u4ed6\u5011\u9019\u7a2e\u7cbe\u795e\u4e0d\u6fdf\u7684\u72c0\u6cc1\uff0c\u5176\u6210\u56e0\u9817\u4ee4\u4eba\u9a5a\u8a1d\uff1a\u4ed6\u5011\u8166\u4e2d\u6709\u4e00\u7a2e\u81ea\u7136\u5f62\u6210\u7684\u5316\u5408\u7269\uff0c\u4f5c\u7528\u8ddf\u300c\u7169\u5be7\u300d (Valium) \u8207\u300c\u8d0a\u5b89\u8afe\u300d (Xanax) \u9019\u985e\u93ae\u975c\u5291\u85e5\u4e38\u7684\u95dc\u9375\u6210\u5206\u76f8\u7576\u985e\u4f3c\u3002<\/p>\n<p>\u9019\u7a2e\u75c5\u75c7\u53eb\u505a\u300c\u539f\u767c\u6027\u55dc\u7761\u75c7\u300d (primary hypersomnia) \uff0c\u9019\u8ddf\u6bd4\u8f03\u6709\u540d\u7684\u731d\u7761\u75c7 (narcolepsy) \u4e0d\u540c\u4e4b\u8655\uff0c\u5728\u65bc\u75c5\u60a3\u6574\u500b\u767d\u5929\u90fd\u6703\u660f\u6c88\u6b32\u7761\uff0c\u800c\u4e0d\u662f\u7a81\u7136\u9593\u300c\u7761\u795e\u4f86\u8972\u300d\u3002\u7f8e\u570b\u4e9e\u7279\u862d\u5927\u827e\u9ed8\u7406\u5927\u5b78\u795e\u7d93\u5b78\u5bb6\u5927\u885b\uff0e\u91cc\u8036 (David Rye) \uff0c\u5c0d\u65bc\u539f\u767c\u6027\u55dc\u7761\u75c7\u6210\u56e0\u4e0d\u660e\u53c8\u7f3a\u4e4f\u7642\u6cd5\u7684\u73fe\u6cc1\uff0c\u611f\u5230\u7169\u60f1\u4e0d\u5df2\u3002\u300c\u6211\u5011\u6709\u4e09\u5206\u4e4b\u4e00\u7684\u75c5\u60a3\u7121\u529b\u81ea\u7406\u751f\u6d3b\uff0c\u300d\u4ed6\u8aaa\uff0c\u300c\u800c\u4e14\u4ed6\u5011\u90fd\u662f\u5e74\u65b9\u4e8c\u4e09\u5341\u6b72\u7684\u5e74\u8f15\u4eba\u3002\u300d<\/p>\n<p>\u91cc\u8036\u7b49\u4eba\u9760\u8457\u4e00\u80a1\u76f4\u89ba\uff0c\u958b\u59cb\u8457\u624b\u9032\u884c\u9019\u9805\u65b0\u7814\u7a76\u3002\u6709\u4e9b\u7528\u4f86\u6cbb\u7642\u5931\u7720\u7684\u85e5\u7269\uff0c\u91dd\u5c0d\u4f7f\u795e\u7d93\u6d3b\u52d5\u8da8\u7de9\u7684\u795e\u7d93\u50b3\u905e\u8cea GABA \u53d7\u5668\u4e0b\u624b\uff0c\u85c9\u6b64\u4fc3\u9032\u7761\u7720\u3002\u91cc\u8036\u5047\u8a2d\u4ed6\u7684\u55dc\u7761\u75c7\u75c5\u60a3\u5927\u8166\u4e2d\uff0c\u53ef\u80fd\u6709\u67d0\u7a2e\u4f5c\u7528\u985e\u4f3c\u7684\u672a\u77e5\u5316\u5408\u7269\uff0c\u6703\u589e\u5f37\u53eb\u505a GABAA \u7684\u53d7\u5668\u6d3b\u52d5\u3002\u70ba\u4e86\u627e\u51fa\u9019\u7a2e\u795e\u79d8\u5316\u5408\u7269\uff0c\u91cc\u8036\u7b49\u4eba\u5c0d\u4e09\u5341\u4e8c\u540d\u55dc\u7761\u75c7\u75c5\u60a3\u9032\u884c\u810a\u690e\u7a7f\u523a\uff0c\u6536\u96c6\u6d78\u6ce1\u5927\u8166\u8207\u810a\u690e\uff0c\u4f7f\u5b83\u5011\u8207\u5916\u754c\u9694\u7d55\u7684\u8166\u810a\u6db2 (CSF) \uff0c\u7136\u5f8c\u628a\u75c5\u60a3\u7684\u8166\u810a\u6db2\u52a0\u9032\u7d93\u904e\u57fa\u56e0\u6539\u9020\u7684\u7d30\u80de\u4e2d\uff0c\u88fd\u9020\u51fa GABAA \u53d7\u5668\uff0c\u7136\u5f8c\u770b\u770b\u662f\u5426\u6709\u53ef\u986f\u793a\u51fa\u53d7\u5668\u6d3b\u5316\u7684\u7d30\u5fae\u96fb\u6d41\u3002<!--more--><\/p>\n<p>\u7b2c\u4e00\u6b21\u8a66\u505a\u4ec0\u9ebc\u4e8b\u90fd\u6c92\u767c\u751f\u3002\u4e0d\u904e\u7576\u7814\u7a76\u8005\u628a\u8166\u810a\u6db2\u8ddf\u4e00\u9ede GABA \u52a0\u5230\u7d30\u80de\u5167\u4e4b\u5f8c\uff0c\u5c31\u767c\u73fe\u6709\u96fb\u5b50\u53cd\u61c9\u7522\u751f\uff0c\u800c\u4e14\u5f37\u5ea6\u5e7e\u4e4e\u662f\u53ea\u6709\u52a0\u5165 GABA \u6642\u7684\u5169\u500d\u3002\u7814\u7a76\u8005\u5728\u300a\u79d1\u5b78\u8f49\u8b6f\u91ab\u5b78\u300b\u671f\u520a\u4e0a\u5831\u544a\u8aaa\uff0c\u9019\u986f\u793a\u75c5\u60a3\u7684\u8166\u810a\u6db2\u4e26\u4e0d\u6703\u76f4\u63a5\u6d3b\u5316 GABAA \u53d7\u5668\uff0c\u4f46\u78ba\u5be6\u6703\u5c07 GABAA \u53d7\u5668\u7684\u654f\u611f\u5ea6\u63d0\u9ad8\u5230\u5e7e\u4e4e\u662f GABA \u7684\u5169\u500d\u3002\u9019\u7a2e\u6548\u679c\u8ddf\u300c\u7169\u5be7\u300d\u4e4b\u985e\u7684\u6297\u7126\u616e\u85e5\u7269\uff0c\u88e1\u982d\u7684\u6d3b\u5316\u6210\u5206\u82ef\u4e8c\u6c2e\u5e73\u985e (benzodiazepines) \u7684\u6548\u7528\u76f8\u4f3c\u3002\u7814\u7a76\u8005\u53e6\u5916\u7528\u7761\u7720\u6b63\u5e38\u7684\u4eba\u5011\u8166\u810a\u6db2\u8655\u7406\u7d30\u80de\uff0c\u5c31\u6c92\u6709\u767c\u751f\u9019\u6a23\u7684\u72c0\u6cc1\u3002<\/p>\n<p>\u5f8c\u7e8c\u5be6\u9a57\u986f\u793a\uff0c\u75c5\u60a3\u8166\u810a\u6db2\u88e1\u4ee4\u4eba\u60f3\u7761\u7684\u5316\u5408\u7269\u662f\u4e00\u7a2e\u80bd\u6216\u662f\u5c0f\u578b\u86cb\u767d\u8cea\uff0c\u6709\u53ef\u80fd\u662f\u5927\u8166\u88fd\u9020\u51fa\u4f86\u7684\uff0c\u9664\u6b64\u4e4b\u5916\u4e00\u5207\u90fd\u9084\u662f\u500b\u8b0e\u3002<\/p>\n<p>\u54c8\u4f5b\u91ab\u5b78\u9662\u795e\u7d93\u79d1\u5b78\u5bb6\u514b\u5229\u4f5b\uff0e\u85a9\u6ce2 (Clifford Saper) \u8868\u793a\uff0c\u5167\u751f\u6027\u7684\u82ef\u4e8c\u6c2e\u5e73\u985e\u5316\u5408\u7269\u9020\u6210\u55dc\u7761\u75c7\u7684\u60f3\u6cd5\uff0c\u662f\u5728\u4e00\u4e5d\u4e5d\u3007\u5e74\u4ee3\u521d\u671f\u7531\u7761\u7720\u75c5\u75c7\u9818\u57df\u5148\u9a45\uff0c\u7fa9\u5927\u5229\u7761\u7720\u81e8\u5e8a\u91ab\u5e2b\u827e\u5229\u6b50\uff0e\u9b6f\u52a0\u745e\u897f (Elio Lugaresi) \u6240\u63d0\u51fa\u3002\u4e0d\u904e\u5f8c\u4f86\u767c\u73fe\u9b6f\u52a0\u745e\u897f\u7684\u75c5\u60a3\u4e2d\u6709\u4eba\u670d\u7528\u82ef\u4e8c\u6c2e\u5e73\u985e\u85e5\u7269\uff0c\u9019\u4f7f\u5f97\u4ed6\u7684\u8ad6\u9ede\u7ad9\u4e0d\u4f4f\u8173\uff0c\u9019\u5957\u8aaa\u6cd5\u5c31\u6b64\u5931\u5bf5\u3002\u85a9\u6ce2\u8aaa\u9019\u9805\u65b0\u7684\u7814\u7a76\u6210\u679c\u300c\u76f8\u7576\u7ad9\u5f97\u4f4f\u8173\u300d\u3002<\/p>\n<p>\u91cc\u8036\u7b49\u4eba\u6839\u64da\u9019\u4e9b\u7814\u7a76\u7d50\u679c\uff0c\u8a2d\u8a08\u4e86\u4e00\u5957\u8a66\u9a57\u6027\u7814\u7a76\uff0c\u8b93\u5e7e\u540d\u75c5\u60a3\u670d\u7528\u4e00\u7a2e\u53eb\u505a\u300c\u5b89\u6613\u9192\u300d (flumazenil) \u7684\u85e5\u7269\u3002\u9019\u7a2e\u85e5\u53ef\u4ee5\u62b5\u6d88\u82ef\u4e8c\u6c2e\u5e73\u985e\u7684\u6548\u679c\uff0c\u7d93\u5e38\u7528\u4f86\u6cbb\u7642\u670d\u7528\u90a3\u4e9b\u85e5\u7269\u904e\u91cf\u7684\u75c5\u4eba\u3002\u7814\u7a76\u8005\u5831\u544a\u8aaa\uff0c\u75c5\u60a3\u5728\u6ce8\u5c04\u300c\u5b89\u6613\u9192\u300d\u4e4b\u5f8c\uff0c\u5728\u6a5f\u9748\u6027\u8207\u8b66\u89ba\u6027\u7684\u5e7e\u9805\u6e2c\u8a66\u4e2d\u90fd\u6709\u6240\u6539\u5584\uff0c\u8868\u73fe\u5e7e\u4e4e\u6709\u6b63\u5e38\u4eba\u7684\u6c34\u6e96\u3002\u91cc\u8036\u8aaa\u9019\u4e9b\u85e5\u6548\u53ef\u4ee5\u6301\u7e8c\u9054\u5169\u500b\u5c0f\u6642\u5de6\u53f3\u3002<\/p>\n<p>\u70ba\u4e86\u8981\u5ef6\u9577\u85e5\u6548\uff0c\u7814\u7a76\u8005\u8aaa\u670d\u88fd\u9020\u9019\u7a2e\u85e5\u7269\u7684\u7f85\u6c0f\u85e5\u5ee0 (Hoffmann-La Roche) \uff0c\u8d0a\u52a9\u4ed6\u5011\u4e00\u7a2e\u53ef\u4ee5\u505a\u6210\u820c\u4e0b\u6eb6\u89e3\u9320\u7684\u7c89\u72c0\u85e5\u7269\uff0c\u4ee5\u53ca\u53ef\u4ee5\u64e6\u5728\u76ae\u819a\u4e0a\u7684\u4e73\u971c\u85e5\u7269\u3002\u7814\u7a76\u8005\u5728\u8ad6\u6587\u4e2d\u63d0\u5230\uff0c\u4e00\u540d\u4e09\u5341\u591a\u6b72\u7684\u75c5\u60a3\u670d\u7528\u9019\u4e9b\u85e5\u7269\u9577\u9054\u56db\u5e74\u5f8c\uff0c\u55dc\u7761\u75c7\u72c0\u6709\u76f8\u7576\u5927\u7684\u6539\u5584\u3002\u9019\u540d\u75c5\u60a3\u539f\u672c\u662f\u540d\u5f8b\u5e2b\uff0c\u55dc\u7761\u75c7\u8feb\u4f7f\u5979\u4e0d\u5f97\u4e0d\u6b47\u696d\u4f11\u5047\uff0c\u4f46\u73fe\u5728\u5979\u53c8\u56de\u5230\u5de5\u4f5c\u5d17\u4f4d\u4e86\u3002<\/p>\n<p>\u85a9\u6ce2\u8aaa\u9019\u4e9b\u7814\u7a76\u767c\u73fe\u300c\u78ba\u5be6\u76f8\u7576\u4ee4\u4eba\u52d5\u5fc3\u300d\uff0c\u4e0d\u904e\u9084\u662f\u5f97\u8981\u4ee5\u66f4\u5927\u898f\u6a21\u7684\u96d9\u76f2\u8a66\u9a57\u52a0\u4ee5\u91cd\u73fe\uff0c\u624d\u80fd\u5920\u771f\u6b63\u5177\u6709\u8aaa\u670d\u529b\u3002<\/p>\n<p>\u897f\u5317\u5927\u5b78\u795e\u7d93\u5b78\u5bb6\u83f2\u8389\u7d72\uff0e\u9f4a (Phyllis Zee) \u8aaa\uff0c\u5373\u4fbf\u5982\u6b64\uff0c\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u9084\u662f\u7d66\u4ed6\u5011\u4e00\u500b\u601d\u8003\u539f\u767c\u6027\u55dc\u7761\u75c7\u7642\u6cd5\u7684\u65b0\u65b9\u5411\u3002\u9019\u4e9b\u75c5\u60a3\u5c0d\u8208\u596e\u5291\u53cd\u61c9\u4e0d\u5f70\uff0c\u6240\u4ee5\u60f3\u8fa6\u6cd5\u6291\u5236 GABA \u4fc3\u9032\u7761\u610f\u7684\u6548\u61c9\uff0c\u53ef\u80fd\u662f\u6bd4\u8f03\u6709\u7528\u7684\u7b56\u7565\u2014\u2014\u5c31\u5982\u540c\u91cc\u8036\u7684\u6bd4\u55bb\u4e00\u6a23\uff0c\u8207\u5176\u8e29\u52a0\u901f\u5668\uff0c\u4e0d\u5982\u653e\u6389\u624b\u715e\u8eca\u3002<\/p>\n<p>\u91cc\u8036\u8aaa\u63a5\u4e0b\u4f86\u7684\u5de5\u4f5c\u5f88\u660e\u78ba\uff1a\u78ba\u5b9a\u9019\u7a2e\u795e\u7955\u5316\u5408\u7269\u662f\u4ec0\u9ebc\uff0c\u627e\u51fa\u80fd\u5920\u66f4\u5feb\u5075\u6e2c\u5230\u9019\u7a2e\u5316\u5408\u7269\u7684\u65b9\u6cd5\uff0c\u7136\u5f8c\u9032\u884c\u66f4\u5927\u578b\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u6e2c\u8a66\u300c\u5b89\u6613\u9192\u300d\u7684\u529f\u6548\u3002\u4e0d\u904e\u7814\u7a76\u8005\u9996\u5148\u5f97\u8981\u5148\u627e\u4eba\u8cc7\u52a9\u9019\u6a23\u7684\u7814\u7a76\u5de5\u4f5c\u3002\u91cc\u8036\u8aaa\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u8cb4\u4eba\u9084\u6c92\u51fa\u73fe\u3002<\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\"> \u5831\u5c0e\u51fa\u8655\uff1a<strong><a href=\"http:\/\/news.sciencemag.org\/sciencenow\/2012\/11\/putting-themselves-to-sleep.html?ref=hp\">Putting Themselves to Sleep<\/a><\/strong><\/span><\/pre>\n<p><span style=\"color: #333399;\"><strong><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita Hsu<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u00a0\u60f3\u8fa6\u6cd5\u6291\u5236 GABA \u4fc3\u9032\u7761\u610f\u7684\u6548\u61c9<\/p>\n","protected":false},"author":20,"featured_media":12404,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/sleep.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12403"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12403"}],"version-history":[{"count":17,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12403\/revisions"}],"predecessor-version":[{"id":19193,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12403\/revisions\/19193"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/12404"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}