{"id":12224,"date":"2012-12-05T11:22:00","date_gmt":"2012-12-05T03:22:00","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=12224"},"modified":"2017-08-07T09:02:30","modified_gmt":"2017-08-07T01:02:30","slug":"%e3%80%90%e6%8e%a2%e7%b4%a2%e5%85%ab%e3%80%91%e4%bb%a5%e8%9f%b2%e7%82%ba%e5%b8%ab","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=12224","title":{"rendered":"\u3010\u63a2\u7d22\u516b\u3011\u4ee5\u87f2\u70ba\u5e2b"},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong><span style=\"color: #800000;\">\u7b2c\u56db\u8b1b\u2027\u7279\u7a3f<\/span><\/strong><\/h2>\n<p><span style=\"color: #333399;\"><strong>\u25a0 \u300c\u7dda\u87f2\u662f\u5927\u81ea\u7136\u9001\u7d66\u79d1\u5b78\u754c\u7684\u79ae\u7269\u3002\u300d\u2500\u2500Sydney Brenner<\/strong><\/span><a href=\"file:\/\/\/D:\/%E6%88%91%E7%9A%84%E6%96%87%E4%BB%B6\/Downloads\/%E4%BB%A5%E8%9F%B2%E7%82%BA%E5%B8%AB%20%E7%89%B9%E7%A8%BF.doc#_ftn1\">[1]<\/a><\/p>\n<figure id=\"attachment_12225\" aria-describedby=\"caption-attachment-12225\" style=\"width: 321px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=12225\" rel=\"attachment wp-att-12225\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-12225 \" title=\"97404219\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/97404219.jpg\" alt=\"\" width=\"321\" height=\"342\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/97404219.jpg 401w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/97404219-281x300.jpg 281w\" sizes=\"(max-width: 321px) 100vw, 321px\" \/><\/a><figcaption id=\"caption-attachment-12225\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90: Matthew Hertel \u2502Getty Images<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587<\/strong>\u2502\u90ed\u51a0\u5ef7<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u6a21\u5f0f\u751f\u7269<\/strong><\/p>\n<p>\u300c\u91cd\u5927\u767c\u73fe\u6240\u53d6\u7528\u7684\u6750\u6599\u5176\u5be6\u90fd\u975e\u5e38\u7c21\u55ae\uff0c\u7c21\u55ae\u5230\u5e73\u5e38\u6211\u5011\u90fd\u4e0d\u4ee5\u70ba\u7136\u7684\u751f\u7269\u3002\u300d\u57281952\u5e74\u7684Hershey-Chase\u5be6\u9a57\uff0c\u4ee5\u566c\u83cc\u9ad4\u70ba\u6750\u6599\uff0c\u5229\u7528\u86cb\u767d\u8cea\u548cDNA\u5316\u5b78\u6210\u5206\u7d44\u6210\u7684\u5dee\u7570\uff0c\u767c\u73feDNA\u624d\u662f\u7528\u4f86\u5132\u5b58\u300c\u907a\u50b3\u8a0a\u606f\u300d\u7684\u7269\u8cea\uff0c\u4f7f\u5f8c\u4ee3\u5f97\u4ee5\u7372\u5f97\u89aa\u4ee3\u7279\u5fb5\u7684\u300c\u907a\u50b3\u7269\u8cea\u300d\u3002\u6642\u81f3\u4eca\u65e5\uff0c\u79d1\u5b78\u5bb6\u4e0d\u65b7\u5c0b\u627e\u65b0\u7684\u7814\u7a76\u5c0d\u8c61\uff0c\u5229\u7528\u300c\u6a21\u5f0f\u751f\u7269\uff08Model Organisms\uff09\u300d\u4f86\u9032\u884c\u7814\u7a76\uff0c\u4ee5\u7c21\u99ad\u7e41\uff0c\u537b\u53c8\u4e0d\u81f3\u65bc\u904e\u300c\u7c21\u300d\uff0c\u4f86\u5e6b\u52a9\u6211\u5011\u77ad\u89e3\u66f4\u8907\u96dc\u7684\u751f\u7269\u3002\u5e38\u898b\u7684\u6709\u810a\u690e\u52d5\u7269\u7684\u5c0f\u9f20\uff08<em>Mus musculus<\/em>\uff09\u3001\u6591\u99ac\u9b5a\uff08<em>Danio rerio<\/em>\uff09\uff1b\u7121\u810a\u690e\u52d5\u7269\u7684\u679c\u8805\uff08<em>Drosophila melanogaster<\/em>\uff09\u3001\u7dda\u87f2\uff08<em>Caenorhabditis elegans<\/em>\uff09\uff1b\u690d\u7269\u754c\u7684\u963f\u62c9\u4f2f\u82a5\uff08<em>Arabidopsis thaliana<\/em>\uff09\u7b49\u3002<\/p>\n<p>\u6a21\u5f0f\u751f\u7269\u6709\u5e7e\u500b\u4e3b\u8981\u7684\u7279\u9ede\uff1a\u751f\u547d\u9031\u671f\u77ed\u3001\u500b\u9ad4\u4e0d\u80fd\u592a\u5927\u3001\u57fa\u56e0\u7d44\u5c0f\u3001\u53ef\u9032\u884c\u907a\u50b3\u5206\u6790\u3002\u53d7\u9650\u65bc\u4eba\u985e\u7684\u58fd\u547d\uff0c\u6211\u5011\u5e0c\u671b\u7814\u7a76\u5728\u77ed\u6642\u9593\u5167\u80fd\u5927\u91cf\u7e41\u884d\u3001\u4e16\u4ee3\u4ea4\u66ff\u8fc5\u901f\u7684\u5c0d\u8c61\u3002\u300c\u6c92\u4eba\u6703\u60f3\u7528\u5927\u8c61\u5427\uff01\u300d\u666e\u904d\u5be6\u9a57\u5ba4\u7684\u5927\u5c0f\u6709\u9650\uff0c\u7814\u7a76\u5c0d\u8c61\u4e0d\u5b9c\u904e\u5927\u3002\u540c\u6642\uff0c\u907a\u50b3\u6703\u727d\u6d89\u5230\u6578\u5b78\uff0c\u300c\u5f88\u591a\u6642\u5019\u6211\u5011\u6703\u8981\u770b\u6027\u72c0\u5728\u7fa4\u9ad4\u7576\u4e2d\u5448\u73fe\u7684\u6bd4\u4f8b\u3002\u300d\u500b\u9ad4\u5c0f\u3001\u6578\u91cf\u591a\uff0c\u6709\u4fbf\u65bc\u6211\u5011\u5c0d\u6027\u72c0\u7684\u89c0\u5bdf\u3002\u4e5f\u56e0\u70ba\u500b\u9ad4\u5c0f\uff0c\u7d30\u80de\u4e0d\u6703\u592a\u591a\uff0c\u6240\u4ee5\u6211\u5011\u6bcf\u500b\u7d30\u80de\u90fd\u6709\u8fa6\u6cd5\u53bb\u638c\u63e1\u3002\u6b64\u5916\uff0c\u6211\u5011\u6700\u597d\u5c0d\u5b83\u7684\u6240\u6709\u7d30\u80de\u4e5f\u90fd\u80fd\u6709\u57fa\u672c\u77ad\u89e3\uff0c\u4f7f\u6211\u5011\u5f97\u4ee5\u5c0d\u5176\u9032\u884c\u907a\u50b3\u5206\u6790\u3002\u4f8b\u5982\uff0c\u767c\u80b2\u751f\u7269\u5b78\uff0c\u70ba\u4e86\u7814\u7a76\u53d7\u7cbe\u5375\u4e00\u8def\u5206\u88c2\u5206\u5316\uff0c\u6211\u5011\u5c31\u6703\u89c0\u5bdf\u53ea\u6709\u5343\u500b\u7d30\u80de\u7684\u7dda\u87f2\uff0c\u5c0d\u6bcf\u500b\u7d30\u80de\u505a\u9010\u4e00\u7684\u8ffd\u8e64\u3002<!--more--><\/p>\n<p>\u300c\u4e00\u500b\u9818\u57df\u7684\u8208\u8d77\u767c\u5c55\uff0c\u9760\u7684\u662f\u4e00\u7fa4\u4eba\uff0c\u800c\u4e0d\u662f\u55ae\u4e00\u500b\u9ad4\u3002\u300d\u57281952\u5e74\u7531Alfred Hershey\uff0844\u6b72\uff09\u548cMartha Chase\uff0825\u6b72\uff09\u7684\u5be6\u9a57\uff0c\u5f97\u77e5DNA\u662f\u566c\u83cc\u9ad4\u4e2d\u907a\u50b3\u7269\u8cea\uff1b1953\u5e74James Watson\uff0825\u6b72\uff09\u548cFrancis Crick\uff0837\u6b72\uff09\u63d0\u51faDNA\u96d9\u80a1\u87ba\u65cb\u7d50\u69cb\u5716\u3002\u6b64\u4e8c\u8005\u80cc\u666f\u4e0b\uff0c\u6211\u5011\u9032\u4e00\u6b65\u60f3\u8981\u77ad\u89e3\uff0cDNA\u548c\u86cb\u767d\u8cea\u662f\u5982\u4f55\u5f62\u6210\u7684\uff1f\u9019\u4e9b\u7269\u8cea\u53ef\u4ee5\u63d0\u4f9b\u4ec0\u9ebc\u6a23\u7684\u529f\u80fd\uff1f\u4e26\u4e14\uff0c\u9032\u4e00\u6b65\u63a2\u8a0e\uff0c\u7d30\u80de\u4e4b\u6240\u4ee5\u4e0d\u540c\uff0c\u662f\u4f86\u81ea\u57fa\u56e0\u6216\u86cb\u767d\u8cea\u600e\u9ebc\u6a23\u7684\u5de5\u4f5c\uff1f\u4e09\u5341\u9918\u6b72\u7684Sydney Brenner\u300c\u60f3\u77ad\u89e3\u500b\u9ad4\u7684\u884c\u70ba\u5982\u4f55\u53d7\u5230\u57fa\u56e0\u7684\u63a7\u5236\u300d\uff0c\u65bc\u662f\u5728\u7d93\u904e\u5341\u5e74\u7684\u7814\u7a76\u5f8c\u30021974\u5e74\uff0847\u6b72\uff09\u767c\u8868\u3008The genetics of <em>Caenorhabditis elegans<\/em>\u3009\u5efa\u7acb\u8a98\u767c\u7dda\u87f2\u7a81\u8b8a\uff0c\u4ee5\u89c0\u5bdf\u500b\u9ad4\u884c\u70ba\u8868\u73fe\u8b8a\u7570\u7684\u65b9\u6cd5\u3002\u800c\u9019\u4e5f\u662f\u9996\u7bc7\u4ee5\u7dda\u87f2\u70ba\u6a21\u5f0f\u751f\u7269\u7814\u7a76\u7684\u6587\u7ae0\u3002<\/p>\n<figure id=\"attachment_12227\" aria-describedby=\"caption-attachment-12227\" style=\"width: 270px\" class=\"wp-caption alignright\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=12227\" rel=\"attachment wp-att-12227\"><img decoding=\"async\" class=\"size-medium wp-image-12227 \" title=\"DIC\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/DIC-300x300.jpg\" alt=\"\" width=\"270\" height=\"270\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/DIC-300x300.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/DIC-150x150.jpg 150w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/DIC-600x599.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/DIC-800x798.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/DIC.jpg 1004w\" sizes=\"(max-width: 270px) 100vw, 270px\" \/><\/a><figcaption id=\"caption-attachment-12227\" class=\"wp-caption-text\">\u7dda\u87f2\u5168\u8eab\u900f\u660e\uff0c\u53ef\u4ee5\u5728\u986f\u5fae\u93e1\u4e0b\u76f4\u63a5\u89c0\u5bdf\u3002\u3000\u3000\u651d\u5f71\u2502\u8523\u6c86\u7965<\/figcaption><\/figure>\n<p><strong>\u7d30\u80de\u6df5\u6e90\u5716<\/strong><\/p>\n<p>John Sulston\u57281963\u5e74\uff0821\u6b72\uff09\u81ea\u528d\u6a4b\u5927\u5b78\u7562\u696d\uff0c\u516d\u5e74\u5f8c\u52a0\u5165Brenner\u7684\u7814\u7a76\u5718\u968a\uff0c\u4e4b\u5f8c\u8017\u8cbb\u5341\u9918\u5e74\u7684\u5149\u666f\uff0c\u65bc1983\u5e74\uff0841\u6b72\uff09\u5efa\u7acb\u7dda\u87f2\u5f9e\u80da\u80ce\u7d93\u5e7c\u87f2\uff0c\u5230\u64c1\u6709959\u500b\u9ad4\u7d30\u80de\u6210\u87f2\u7684\u300c\u7d30\u80de\u6df5\u6e90\u5716\uff08cell lineage\uff09\u300d\u3002\u4ed6\u5229\u7528\u7dda\u87f2\u5168\u8eab\u900f\u660e\u7684\u7279\u9ede\uff0c\u5728\u986f\u5fae\u93e1\u4e0b\u8010\u5fc3\u89c0\u5bdf\u80da\u80ce\u767c\u80b2\uff0c\u6bcf\u6b21\u5206\u88c2\u70ba\u4e00\u6a6b\u6392\uff0c\u96a8\u6642\u9593\u7e31\u5411\u7e6a\u88fd\uff0c\u8a18\u9304\u6bcf\u4e00\u500b\u7d30\u80de\u7684\u5206\u88c2\u72c0\u6cc1\u3002<\/p>\n<p><strong>\u8a08\u756b\u6027\u7d30\u80de\u6b7b\u4ea1<\/strong><\/p>\n<p>\u800c\u4ee4\u4eba\u9a5a\u8a1d\u7684\u662f\uff0c\u5728\u8ffd\u8e64\u767c\u80b2\u7684\u904e\u7a0b\u7576\u4e2d\uff0c\u537b\u4e5f\u767c\u73fe\u5728\u986f\u5fae\u93e1\u4e0b\uff0c\u6709\u4e9b\u7d30\u80de\u5206\u88c2\u5230\u6700\u5f8c\u5c31\u300c\u51f8\u300d\u8d77\u4f86\uff0c\u6210\u70ba\u9215\u6263\u72c0\u7684\u7d30\u80de\u5c4d\u9ad4\u3002\u4e26\u4e14\u5728\u4e8b\u60c5\u767c\u751f\u5f8c42\u5206\u9418\uff0c\u5c31\u6703\u6d88\u5931\u5f97\u7121\u5f71\u7121\u8e64\u3002\u4ed6\u8d95\u7dca\u53c8\u770b\u770b\u5176\u4ed6\u7dda\u87f2\uff0c\u767c\u73fe\u6240\u6709\u7dda\u87f2\uff0c\u5728\u767c\u80b2\u7684\u904e\u7a0b\u4e2d\uff0c\u90fd\u6703\u767c\u751f\u9019\u500b\u73fe\u8c61\uff0c\u597d\u50cf\u4e00\u5207\u90fd\u65e9\u5df2\u8a08\u756b\u597d\u3002\u9019\u5c31\u53eb\u505a\u300c\u8a08\u756b\u6027\u7d30\u80de\u6b7b\u4ea1\uff08\u53c8\u7a31\uff1a\u7d30\u80de\u51cb\u4ea1\uff0cProgrammed Cell Death or apoptosis\uff09\u300d\u3002<\/p>\n<p>1968\u5e74Robert Horvitz\u81ea\u9ebb\u7701\u7406\u5de5\u5b78\u9662\u6578\u5b78\u548c\u7d93\u6fdf\u5b78\u7cfb\u7562\u696d\uff0c\u800c\u5f8c1974\u5e74\u53d6\u5f97\u54c8\u4f5b\u5927\u5b78\u535a\u58eb\u5b78\u4f4d\u30021986\u5e74\uff0839\u6b72\uff09\u5728\u77e5\u540d\u671f\u520a\u300aCell\u300b\u767c\u8868\u3008Genetic control of programmed cell death in the nematode <em>C. elegans.<\/em>\u3009\u627e\u5230\u7d30\u80de\u7684\u300c\u6bba\u624b\u57fa\u56e0\uff08cell-death genes\uff09\u300d<em>ced-3<\/em>\u53ca<em>ced-4<\/em>\u3002\u4e5f\u767c\u73fe\u300c\u4fdd\u9463\u57fa\u56e0\u300d<em>ced-9<\/em>\u7528\u4f86\u907f\u514d\u7d30\u80de\u6b7b\u4ea1\u3002\u4ed6\u5148\u5047\u5b9a\u4fdd\u9463\u57fa\u56e0\u767c\u751f\u7a81\u8b8a\u6703\u9020\u6210\u904e\u591a\u7684\u7d30\u80de\u5c4d\u9ad4\uff1b\u5229\u7528\u7a81\u8b8a\u5291\uff0c\u5728\u67d0\u4e9b\u57fa\u56e0\u4e0a\u9762\u52d5\u624b\u8173\uff0c\u5047\u82e5\u9019\u4e9b\u57fa\u56e0\u662f\u4fdd\u9463\u57fa\u56e0\uff0c\u90a3\u5c31\u6c92\u8fa6\u6cd5\u4fdd\u8b77\u7d30\u80de\u514d\u65bc\u4e00\u6b7b\uff0c\u5c07\u6703\u9020\u6210\u904e\u591a\u7684\u7d30\u80de\u5c4d\u9ad4\u3002\u5982\u6b64\u53cd\u8986\u5617\u8a66\u4e0b\uff0c\u4ed6\u8a66\u9a57\u51fa\u5018\u82e5\u67d0\u57fa\u56e0\u7a81\u8b8a\u5c07\u6703\u7522\u751f\u5927\u91cf\u7684\u7d30\u80de\u5c4d\u9ad4\uff0c\u5b9b\u82e5\u4fdd\u9463\u4e00\u822c\uff0c\u800c\u9019\u5c31\u662f<em>ced-9<\/em>\u3002\u540c\u6a23\u5730\uff0c\u7576\u6bba\u624b\u57fa\u56e0\u7684\u767c\u751f\u7a81\u8b8a\u6642\uff0c\u7dda\u87f2\u8eab\u4e0a\u7684130\u500b\u7d30\u80de\u5c31\u5b58\u6d3b\u4e86\u4e0b\u4f86\u3002\u6240\u4ee5\u4ed6\u7684\u7814\u7a76\u5c31\u767c\u73fe\uff0c\u5018\u82e5\u8981\u7d30\u80de\u6d3b\u4e0b\u4f86\uff0c\u4e0d\u80fd\u6c92\u6709\u4fdd\u9463\u57fa\u56e0\uff1b\u5982\u679c\u8981\u7d30\u80de\u6b7b\u6389\uff0c\u6bba\u624b\u57fa\u56e0\u7684\u6d3b\u6027\u5c31\u8981\u88ab\u958b\u555f\u3002<\/p>\n<p>\u6bba\u624b\u57fa\u56e0\u548c\u4fdd\u9463\u57fa\u56e0\u6297\u8861\uff0c\u6c7a\u5b9a\u7d30\u80de\u7684\u751f\u6b7b\u3002\u56e0\u6b64\uff0c\u9019\u76f8\u4e92\u9593\u7684\u8abf\u63a7\u6a5f\u5236\u5c31\u986f\u5f97\u683c\u5916\u91cd\u8981\u3002\u4e26\u767c\u73fe\u300c\u7c92\u7dda\u9ad4\u300d\u5728\u8a08\u5283\u6027\u7d30\u80de\u6b7b\u4ea1\u4e2d\u5c31\u626e\u6f14\u76f8\u7576\u91cd\u8981\u7684\u89d2\u8272\u3002\u7c92\u7dda\u9ad4\u53c8\u7a31\u70ba\u300c\u80fd\u91cf\u5de5\u5ee0\u300d\uff0c\u5b83\u662f\u500b\u96d9\u5c64\u80de\u5668\uff0c\u5728\u6211\u5011\u7d30\u80de\u4e2d\u80fd\u5920\u7522\u751fATP(Adenosine Triphosphate)\uff1b\u800c\u5b83\u7684\u5167\u819c\u8207\u5916\u819c\u7576\u4e2d\uff0c\u5b58\u653e\u6709\u5f88\u591a\u7684\u86cb\u767d\u8cea\uff0c\u300c\u7d30\u80de\u8272\u7d20C\uff08cytochrome C\uff09\u300d\u5e73\u5e38\u5c31\u88ab\u5b58\u653e\u5728\u9019\u88e1\u3002\u7576\u7d30\u80de\u8981\u6b7b\u4ea1\u7684\u6642\u5019\uff0c\u5c31\u6703\u6263\u677f\u6a5f\uff0c\u7d30\u80de\u8272\u7d20C\u5c31\u6703\u5f9e\u7d30\u80de\u4e2d\u7684\u7c92\u7dda\u9ad4\u4e2d\u7684\u5167\u5916\u819c\u7576\u4e2d\u91cb\u653e\u51fa\u4f86\uff0c\u800c\u4e00\u4f46\u5b83\u88ab\u91cb\u653e\u51fa\u4f86\uff0c\u5c31\u6703\u5f15\u7206\u7d30\u80de\u5167\u7684\u300c\u51cb\u4ea1\u86cb\u767d\u9176\uff08caspase\uff09\u300d\uff0c\u7136\u5f8c\uff0c\u7d30\u80de\u6b7b\u4ea1\uff0c\u5c31\u6703\u88ab\u9694\u58c1\u8ca0\u8cac\u6536\u5c4d\u7684\u300c\u541e\u566c\u7d30\u80de\uff08phagocyte\uff09\u300d\u6240\u541e\u566c\u3002<\/p>\n<p>\u66f4\u4ee4\u4eba\u9a5a\u5947\u7684\u767c\u73fe\u662f\uff0c\u9019\u4e9b\u57fa\u56e0\u662f\u4eba\u985e\u57fa\u56e0\u9ad4\u4e2d\u7684\u540c\u6e90\u57fa\u56e0\u3002\u800c\u8a08\u756b\u6027\u7d30\u80de\u6b7b\u4ea1\uff0c\u5728\u4eba\u9ad4\u4e2d\u4e5f\u5b58\u5728\u8457\u3002\u4eba\u9ad4\u7576\u4e2d\uff0c\u6bcf\u5929\u4e5f\u6709\u4e0a\u5343\u842c\u7684\u7d30\u80de\u5728\u9032\u884c\u7d30\u80de\u51cb\u4ea1\u3002\u4f8b\u5982\uff1a\u5c0f\u8178\u9053\u7684\u7d68\u6bdb\u7d30\u80de\uff0c\u53ea\u6709\u4e00\u5c64\u539a\u5ea6\u7684\u8868\u76ae\u7d30\u80de\uff0c\u6211\u5011\u53ef\u4ee5\u60f3\u50cf\u5728\u5c0f\u8178\u7684\u74b0\u5883\u7576\u4e2d\uff0c\u6709\u5f88\u591a\u7684\u7d30\u83cc\u5728\u88e1\u9762\uff0c\u56e0\u6b64\u5c0f\u8178\u7d30\u80de\u8981\u4e0d\u65b7\u5730\u66f4\u65b0\uff0c\u624d\u4e0d\u6703\u5c0d\u6211\u5011\u9020\u6210\u50b7\u5bb3\uff1b\u800c\u6211\u5011\u8eab\u9ad4\u5167\u7684\u7d05\u8840\u7403\u4e5f\u662f\uff0c\u7d04\u6bcf\u4e09\u500b\u6708\u6703\u5168\u90e8\u66f4\u65b0\u4e00\u6b21\u3002<\/p>\n<p>\u4e0a\u5929\u65e2\u8b93\u67d0\u7d30\u80de\u964d\u751f\uff0c\u70ba\u4f55\u53c8\u8981\u8017\u8cbb\u5fc3\u6a5f\u7684\u8cdc\u6b7b\u5b83\u5462\uff1f\u8a08\u756b\u6027\u7d30\u80de\u6b7b\u4ea1\u7684\u91cd\u8981\u6027\u5927\u81f4\u6709\u4e09\uff1a\u5176\u4e00\uff0c\u7d30\u80de\u51cb\u4ea1\u5728\u751f\u7269\u767c\u80b2\u7684\u904e\u7a0b\u4e2d\uff0c\u4e5f\u626e\u6f14\u8457\u96d5\u523b\u5bb6\u7684\u89d2\u8272\u3002\u874c\u86aa\u3001\u9752\u86d9\u6d88\u5931\u7684\u5c3e\u5df4\uff0c\u4eba\u985e\u80da\u80ce\u767c\u80b2\u904e\u7a0b\u7576\u4e2d\u7684\u624b\u6307\u3001\u8173\u8dbe\u9593\u7684\u300c\u8e7c\u300d\uff0c\u4ee5\u53ca\u4eba\u9ad4\u8178\u9053\u7684\u4e2d\u7a7a\u7ba1\u9053\uff0c\u90fd\u548c\u8a08\u756b\u6027\u7d30\u80de\u6b7b\u4ea1\u6709\u8457\u5bc6\u5207\u7684\u95dc\u4fc2\u3002\u5176\u4e8c\uff0c\u5728\u514d\u75ab\u7cfb\u7d71\u5f62\u6210\u7684\u904e\u7a0b\u7576\u4e2d\uff0c\u5f97\u4ee5\u9664\u53bb\u6709\u5bb3\u7684\u7d30\u80de\uff0c\u53ea\u7559\u4e0b\u80fd\u5c0d\u6297\u5916\u4f86\u6297\u539f\uff08antigen\uff09\u7684\u7d30\u80de\uff0c\u6703\u50b7\u5bb3\u81ea\u8eab\u7684\u7d30\u80de\uff0c\u5247\u9032\u884c\u7d30\u80de\u6b7b\u4ea1\u3002\u5176\u4e09\uff0c\u7dad\u6301\u500b\u9ad4\u7d30\u80de\u6578\u7684\u6046\u5b9a\uff0c\u7d30\u80de\u904e\u5c11\u56fa\u7136\u662f\u58de\u4e8b\uff0c\u5982\u7d30\u80de\u51cb\u4ea1\u904e\u65bc\u56b4\u91cd\uff0c\u5c31\u662f\u300c\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheimer's disease\uff09\u300d\uff1b\u4f46\u662f\u7d30\u80de\u7e41\u6b96\u904e\u591a\uff0c\u5c31\u662f\u300c\u764c\u75c7\u300d\uff0c\u6bd4\u5982\u5c0f\u7403\u6dcb\u5df4\u764c\uff08small lymphocytic lymphoma\uff09\u4e2d\u5c31\u662f\u6709\u4e9b\u4fdd\u9463\u57fa\u56e0\u904e\u5ea6\u6d3b\u5316\uff0c\u9020\u6210\u67d0\u4e9b\u61c9\u8a72\u8981\u6b7b\u53bb\u7684\u7d30\u80de\u5b58\u6d3b\u4e0b\u4f86\u3002<\/p>\n<p>\u7d30\u80de\u51cb\u4ea1\u4e4b\u5f8c\u7684\u6b7b\u7d30\u80de\uff0c\u600e\u9ebc\u88ab\u6e05\u9664\u7684\u5462\uff1f\u6b7b\u7d30\u80de\u5fc5\u9808\u8981\u548c\u6d3b\u7d30\u80de\u9577\u5f97\u4e0d\u4e00\u6a23\uff0c\u6bd4\u5982\u8aaa\u6709\u7279\u5225\u5206\u5b50\u5b58\u5728\u7d30\u80de\u8868\u9762\uff0c\u544a\u8a34\u541e\u566c\u7d30\u80de\u8aaa\uff1a\u6211\u662f\u5783\u573e\u7d30\u80de\uff01\u4f46\u662f\u70ba\u4ec0\u9ebc\u9019\u91cd\u8981\u5462\uff1f\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u5982\u679c\u6c92\u6709\u628a\u6b7b\u7d30\u80de\u53ca\u6642\u6e05\u9664\uff0c\u5728\u7d30\u80de\u5167\u907a\u50b3\u7269\u8cea\u88ab\u5b8c\u5168\u788e\u5c4d\u4e4b\u524d\uff0c\u7d30\u80de\u6709\u53ef\u80fd\u6703\u8d77\u6b7b\u56de\u751f\u3002\u4f8b\u5982\uff0c\u82e5\u6211\u5011\u628a\u541e\u566c\u7d30\u80de\u7684\u6d3b\u6027\u964d\u4f4e\uff0c\u9020\u6210\u8a31\u591a\u61c9\u8a72\u9818\u6b7b\u7684\u7d30\u80de\u672a\u80fd\u5982\u9858\uff0c\u8eab\u9ad4\u4e2d\u5b58\u6709\u8868\u9762\u4e0a\u6709\u6240\u5dee\u7570\u7684\u6b7b\u7d30\u80de\uff0c\u6b64\u6642\uff0c\u5982\u679c\u78b0\u5230\u80fd\u5920\u8fa8\u8b58\u9019\u4e9b\u4e0d\u6b63\u5e38\u6b7b\u7d30\u80de\u7684\u5206\u5b50\uff0c\u6050\u6015\u6703\u5f15\u767c\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u3002<\/p>\n<p><strong>\u87a2\u5149\u86cb\u767d<\/strong><\/p>\n<p>\u90a3\u5982\u679c\u6211\u5011\u60f3\u8981\u89c0\u5bdf\u7dda\u87f2\u7d30\u80de\u7684\u6210\u9577\u6216\u79fb\u52d5\u8def\u7dda\u5462\uff1f\u9019\u5c31\u548c2008\u5e74\u8afe\u8c9d\u723e\u734e\u300c\u767c\u73fe\u548c\u6539\u9020\u4e86\u7da0\u8272\u87a2\u5149\u86cb\u767d\uff08GFP\uff09\u300d\u6709\u95dc\u4fc2\u4e86\u3002\u300d1960\u5e74Osamu Shimomura\uff0832\u6b72\uff09\u958b\u59cb\u7814\u7a76\u6c34\u6bcd\uff0c\u60f3\u8981\u77ad\u89e3\u70ba\u4ec0\u9ebc\u6c34\u6bcd\u6703\u6563\u767c\u6f02\u4eae\u7684\u5149\u8292\uff0c\u800c\u5f8c\u4ed6\u6210\u529f\u5206\u96e2\u51fa\u8b93\u6c34\u6bcd\u7522\u751f\u7da0\u8272\u87a2\u5149\u7269\u8cea\u7684GFP\uff08green fluorescent protein\uff09\u30021988\u5e74\uff0847\u6b72\uff09\u7684Martin Chalfie\u5f97\u77e5\u4e86\u9019\u500b\u7814\u7a76\u6210\u679c\uff0c\u5c31\u628a\u5f97\u4ee5\u7522\u751fGFP\u7684\u57fa\u56e0\u9023\u63a5\u5728\u4ed6\u60f3\u8981\u7814\u7a76\u7684\u57fa\u56e0\u5f8c\u9762\uff0c\u6ce8\u5165\u5230\u7dda\u87f2\u9ad4\u5167\uff0c\u4f86\u6307\u5f15\u4ed6\u60f3\u8981\u7814\u7a76\u7684\u86cb\u767d\u8cea\u7522\u751f\u7684\u6642\u9593\u8ddf\u4f4d\u7f6e\u3002\u800c\u5f8cRoger Y. Tsien\u66f4\u9032\u4e00\u6b65\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u7684\u6280\u8853\uff0c\u6539\u9020\u51fa\u80fd\u7522\u751f\u87a2\u5149\u6548\u679c\u66f4\u5f37\u66f4\u7a69\u5b9a\u7684EGFP\uff08enhanced GFP\uff09\u548c\u4e0d\u540c\u984f\u8272\u8b8a\u7a2eGFP\u7684\u57fa\u56e0\uff0c\u8b93\u6211\u5011\u5f97\u4ee5\u7814\u7a76\u5169\u7a2e\u4ee5\u4e0a\u86cb\u767d\u8cea\u5728\u751f\u7269\u9ad4\u4e2d\u7684\u8b8a\u5316\u8207\u5f7c\u6b64\u4e4b\u9593\u7684\u4ea4\u4e92\u95dc\u4fc2\u3002<\/p>\n<figure id=\"attachment_12252\" aria-describedby=\"caption-attachment-12252\" style=\"width: 300px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=12252\" rel=\"attachment wp-att-12252\"><img decoding=\"async\" class=\"size-medium wp-image-12252 \" title=\"GFP\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/GFP1-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/GFP1-300x300.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/GFP1-150x150.jpg 150w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/GFP1-600x599.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/GFP1-800x798.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/GFP1.jpg 1004w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-12252\" class=\"wp-caption-text\">\u7dda\u87f2\u5728GFP\u4e0b\u7684\u795e\u7d93\u8868\u73fe\u3002\u651d\u5f71\u2502\u8523\u6c86\u7965<\/figcaption><\/figure>\n<figure id=\"attachment_12254\" aria-describedby=\"caption-attachment-12254\" style=\"width: 300px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=12254\" rel=\"attachment wp-att-12254\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-12254 \" title=\"Merge\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/Merge2-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/Merge2-300x300.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/Merge2-150x150.jpg 150w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/Merge2-800x798.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/Merge2-600x599.jpg 600w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/Merge2.jpg 1004w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-12254\" class=\"wp-caption-text\">\u7dda\u87f2\u5728GFP\u4e0b\u7684\u795e\u7d93\u8868\u73fe\u3002\u651d\u5f71\u2502\u8523\u6c86\u7965<\/figcaption><\/figure>\n<p><strong>\u9752\u6625\u4e4b\u6cc9<\/strong><\/p>\n<p>\u300c\u7529\u958b\u5370\u8c61\uff0c\u775c\u958b\u96d9\u773c\u3002\u4e00\u63a2\u8996\u91ce\u5e95\u4e0b\u7dda\u87f2\u7684\u6a23\u8c8c\u3002\u5b83\u662f\u975e\u5e38\u5fae\u4e0d\u8db3\u9053\u7684\u751f\u7269\u3002\u53ef\u662f\u5b83\u53ef\u4ee5\u63d0\u4f9b\u6211\u5011\u751f\u7269\u91ab\u5b78\u4e0a\u7684\u7814\u7a76\u3002\u300d\u57281992\u5e74\uff0cCynthia Kenyon\uff0837\u6b72\uff09\u767c\u73fe\uff0c\u5728\u6b63\u5e38\u60c5\u6cc1\u4e0b\uff0c\u7dda\u87f2\u7d04\u53ef\u5b58\u6d3b14\u5929\uff0c\u53ef\u662f\u7f3a\u4e4f\u300c\u985e\u80f0\u5cf6\u7d20\u53d7\u5668\u9ad4\u57fa\u56e0\uff08<em>daf-2<\/em>\uff09\u300d\u7684\u7dda\u87f2\u53ef\u4ee5\u6d3b30\u5929\u3002\u4e5f\u5c31\u662f\uff0c\u7576\u6211\u5011\u53bb\u9664\u67d0\u96bb\u7dda\u87f2\u7684\u300c\u985e\u80f0\u5cf6\u7d20\u53d7\u9ad4\u57fa\u56e0\u300d\u4e4b\u5f8c\uff0c\u9019\u96bb\u7dda\u87f2\u5c31\u6703\u6d3b\u5f97\u6bd4\u8f03\u4e45\u3002\u4e5f\u8a31\uff0c\u751f\u7269\u8001\u5316\u7684\u6642\u9418\uff0c\u5c31\u88dd\u5728\u81ea\u8eab\u7684\u57fa\u56e0\u5e8f\u5217\u88e1\u9762\u3002<\/p>\n<p>\u4e5f\u8a31<em>daf-2<\/em>\u57fa\u56e0\u5c31\u50cf\u751f\u547d\u5217\u8eca\u7684\u300c\u715e\u8eca\u300d\u3002\u6709\u5b83\u7684\u5b58\u5728\uff0c\u58fd\u547d\u5c31\u6703\u53d7\u5230\u4fb7\u9650\u3002\u795e\u5947\u7684\u662f\uff0c\u6211\u5011\u4e5f\u767c\u73fe\u53e6\u4e00\u500b\u57fa\u56e0<em>daf-16<\/em>\uff0c\u5b83\u5c31\u50cf\u300c\u6cb9\u9580\u300d\u4e00\u822c\uff0c\u7576\u4e00\u96bb\u7dda\u87f2\u88ab\u540c\u6642\u62ff\u6389<em>daf-2<\/em>\uff08\u715e\u8eca\uff09\u548c<em>daf-16<\/em>\uff08\u6cb9\u9580\uff09\u4e4b\u5f8c\uff0c\u7dda\u87f2\u7684\u58fd\u547d\u5c31\u5f9e30\u5929\u53c8\u56de\u5fa9\u523014\u5929\u3002\u6211\u5011\u9032\u4e00\u6b65\u53bb\u63a2\u8a0e\uff0c\u70ba\u4ec0\u9ebc\u9664\u53bb<em>daf-2<\/em>\u6703\u5ef6\u9577\u58fd\u547d\uff0c\u800c\u6d3b\u5316<em>daf-16<\/em>\u5247\u53ef\u80fd\u6703\u5ef6\u9577\u58fd\u547d\u3002<\/p>\n<p>\u5982\u679c\u7dda\u87f2\u7684\u8eab\u9ad4\u5c31\u50cf\u4e00\u68df\u516c\u5bd3\uff0c<em>daf-16<\/em>\u4e5f\u53ef\u4ee5\u5f62\u5bb9\u662f\u300c\u5927\u5ec8\u7684\u7ba1\u7406\u54e1\u300d\u3002\u9019\u7ba1\u7406\u54e1\u5728\u6b63\u5e38\u7684\u7dda\u87f2\u7576\u4e2d\uff0c\u975e\u5e38\u7684\u61f6\u6563\uff0c\u6bcf\u5929\u904e\u8457\u6df7\u6c34\u6478\u9b5a\u7684\u65e5\u5b50\u3002\u800c\u6d3b\u5316<em>daf-16<\/em>\u5c31\u76f8\u7576\u65bc\u544a\u8a34\u9019\u4f4d\u7ba1\u7406\u54e1\uff1a\u300c\u98b1\u98a8\u8981\u4f86\u4e86\uff01\u300d\u7ba1\u7406\u54e1\u56db\u8655\u5954\u8d70\uff0c\u4e00\u4e0b\u5b50\u4fee\u88dc\u7a97\u6236\uff0c\u4e00\u4e0b\u53c8\u6e05\u6383\u6a13\u68af\u9593\u96dc\u7269\uff0c\u4e26\u4e14\u53ee\u5680\u4f4f\u6236\u8981\u5099\u59a5\u4e7e\u7ce7\uff0c\u9084\u53bb\u4e3b\u52d5\u66ff\u63db\u6389\u904e\u671f\u7684\u6ec5\u706b\u5668\uff0c\u4e26\u767b\u9ad8\u68af\u4fee\u88dc\u5373\u5c07\u812b\u843d\u7684\u78da\u7246\u3002\u9019\u4e9b\u4e8b\u60c5\u52a0\u5728\u4e00\u8d77\uff0c\u623f\u5b50\u81ea\u7136\u5c31\u6703\u8b8a\u5f97\u8212\u9069\u5b9c\u4eba\u3002\u7dda\u87f2\u662f\u5927\u81ea\u7136\u7d66\u79d1\u5b78\u754c\u7684\u79ae\u7269\u3002\u7dda\u87f2\u5e36\u7d66\u6211\u5011\u975e\u5e38\u591a\u7684\u9a5a\u5947\u3002\u4e5f\u8a31\u4e0d\u4e45\u7684\u5c07\u4f86\uff0c\u6211\u5011\u6703\u9a5a\u8a1d\uff0c\u773c\u524d\u4e00\u5c0d\u8c8c\u4f3c\u5927\u5b78\u525b\u7562\u696d\u7684\u4fca\u7f8e\u7537\u5973\uff0c\u5be6\u969b\u4e0a\u537b\u5df2\u5c46\u8004\u800b\u4e4b\u5e74\u3002<\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\"> \u672c\u6587\u6574\u7406\u81ea\uff1a101\/11\/10\u4e0b\u5348\u7531\u5433\u76ca\u7fa4\u6559\u6388\u5728\u81fa\u5927\u61c9\u529b\u6240\u570b\u969b\u6f14\u8b1b\u5ef3\u6240\u4e3b\u8b1b\u4e4b\u300c\u4ee5\u87f2\u70ba\u5e2b\u300d\u7684\u6f14\u8b1b\u5167\u5bb9<\/span><\/pre>\n<pre><span style=\"color: #333333;\"> \u5ef6\u4f38\u95b1\u8b80\uff1a\u53f0\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3\u63a2\u7d22\u57fa\u790e\u79d1\u5b78\u8b1b\u5ea72012\u5e7411\u670810\u65e5\u7b2c\u56db\u8b1b\u3008\u4ee5\u87f2\u70ba\u5e2b\u3009<\/span><a href=\"https:\/\/case.ntu.edu.tw\/CASTUDIO\/course.php?speech_ID=3138#video_top\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #333333;\">\u5168\u7a0b\u5f71\u97f3<\/span><\/a><\/pre>\n<p><strong>\u63a8\u85a6\u95b1\u8b80\uff1a<\/strong><br \/>\n(1) \u9ec3\u624d\u82b3\u3001\u5433\u76ca\u7fa4\uff1a\u30082002\u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u7279\u5225\u5831\u5c0e\u2500\u2500\u7ffb\u958b\u95bb\u7f85\u738b\u7684\u751f\u6b7b\u7c3f\u3009\uff0c\u300a\u79d1\u5b78\u6708\u520a\u300b\uff0c396\u671f\uff0c\u98011042\uff0d1047\u3002<br \/>\n(2) \u9ec3\u624d\u82b3\u3001\u5433\u76ca\u7fa4\uff1a\u30082006\u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u7279\u5225\u5831\u5c0e\u2500\u2500\u751f\u7269\u9ad4\u5167\u7684\u8a0a\u606f\u6b04\u622a\u7ad9\u3009\uff0c\u300a\u79d1\u5b78\u6708\u520a\u300b\uff0c444\u671f\uff0c\u9801916\uff0d921\u3002<br \/>\n(3) \u8523\u6c86\u7965\u3001\u5433\u76ca\u7fa4\uff1a\u30082008\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u7279\u5225\u5831\u5c0e\u2500\u2500\u7e7d\u7d1b\u596a\u76ee\u7684\u87a2\u5149\u86cb\u767d\u3009\uff0c\u300a\u79d1\u5b78\u6708\u520a\u300b\uff0c468 \u671f\uff0c\u9801918\uff0d923\u3002<br \/>\n(4) \u5433\u745e\u83c1\u3001\u5433\u76ca\u7fa4\uff1a\u3008\u7d30\u6578\u7dda\u87f2\u3009\uff0c\u300a\u79d1\u5b78\u4eba\u300b\uff0c127\u671f\uff0c\u980184\uff0d89\u3002<\/p>\n<p>\ufe5d\u672c\u6587\u4f5c\u8005\u64da\u50b3\u66fe\u662f\u4e0d\u52d9\u6b63\u696d\u7684\u7b46\u8015\u8fb2\u592b\uff0c\u73fe\u5c31\u8b80\u81fa\u7063\u5927\u5b78\u517c\u8077\u6587\u5b78\u5beb\u4f5c\ufe5e<\/p>\n<p><span style=\"color: #333399;\"><strong><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita Hsu<\/strong><\/strong><\/span><\/p>\n<hr size=\"1\" \/>\n<p><a href=\"file:\/\/\/D:\/%E6%88%91%E7%9A%84%E6%96%87%E4%BB%B6\/Downloads\/%E4%BB%A5%E8%9F%B2%E7%82%BA%E5%B8%AB%20%E7%89%B9%E7%A8%BF.doc#_ftnref1\">[1]<\/a> \u3008NATURE\u2019S GIFT TO SCIENCE\u3009Nobel Lecture, December 8, 2002 by Sydney Brenner<\/p>\n<p>http:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/2002\/brenner-lecture.pdf<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7b2c\u56db\u8b1b\u2027\u7279\u7a3f \u25a0 \u300c\u7dda\u87f2\u662f\u5927\u81ea\u7136\u9001\u7d66\u79d1\u5b78<\/p>\n","protected":false},"author":20,"featured_media":12225,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,872],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/12\/97404219.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12224"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12224"}],"version-history":[{"count":59,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12224\/revisions"}],"predecessor-version":[{"id":29232,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/12224\/revisions\/29232"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/12225"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12224"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12224"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}