{"id":11863,"date":"2012-10-11T09:37:17","date_gmt":"2012-10-11T01:37:17","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=11863"},"modified":"2017-08-07T09:12:47","modified_gmt":"2017-08-07T01:12:47","slug":"%e3%80%902012%e8%ab%be%e8%b2%9d%e7%88%be%e3%80%912012%e5%b9%b4%e8%ab%be%e8%b2%9d%e7%88%be%e7%8d%8e%e7%b0%a1%e4%bb%8b","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=11863","title":{"rendered":"\u30102012\u8afe\u8c9d\u723e\u30112012\u5e74\u8afe\u8c9d\u723e\u734e\u7c21\u4ecb"},"content":{"rendered":"<p style=\"text-align: center;\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=11881\" rel=\"attachment wp-att-11881\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-11881\" title=\"Figure 1_chinese\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/Figure-1_chinese.png\" alt=\"\" width=\"722\" height=\"455\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/Figure-1_chinese.png 1003w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/Figure-1_chinese-300x189.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/Figure-1_chinese-800x504.png 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/Figure-1_chinese-600x378.png 600w\" sizes=\"(max-width: 722px) 100vw, 722px\" \/><\/a><\/p>\n<p style=\"text-align: left;\"><strong>\u7ffb\u8b6f<\/strong> \u2223\u8521\u860a\u660e\u8b6f\ufe5d\u53f0\u5927\u5316\u5b78\u7cfb\u540d\u8b7d\u6559\u6388\ufe5e<\/p>\n<p><strong>\u7d30\u80de\u8207\u611f\u77e5<\/strong><strong>(Cell and Senses)<\/strong><\/p>\n<p><em>\u6211\u5011\u773c<\/em>\u3001<em>\u9f3b\u53ca\u53e3\u4e2d\u7684\u611f\u5b98\u64c1\u6709\u5c0d\u5149<\/em>\u3001<em>\u55c5\u6216\u5473\u7684\u611f\u6e2c\u5668\u3002\u5728\u4eba\u9ad4\u5167\uff0c\u7d30\u80de\u5177\u6709\u985e\u4f3c\u7684\u611f\u6e2c\u5668\u4f86\u63a2\u77e5\u8377\u723e\u8499\u4ee5\u53ca\u5404\u7a2e\u8a0a\u865f\u7269\u8cea\uff0c\u5e38\u77e5\u7684\u6709\u814e\u4e0a\u817a\u7d20<\/em><em>(adrenalin)<\/em>\u3001<em>\u8840\u6e05\u7d20<\/em><em>(serotonin)<\/em>\u3001<em>\u7d44\u7e54\u80fa<\/em><em>(histamine)<\/em><em>\u8207\u591a\u5df4\u80fa(dopamine)<\/em><em>\u3002\u7576\u751f\u547d\u5728\u6f14\u5316\u6642\uff0c\u7d30\u80de\u4e0d\u65b7\u7684\u5229\u7528\u540c\u6a23\u7684\u57fa\u672c\u6a5f\u5236\u4f86\u8b80\u53d6\u5b83\u5011\u7684\u74b0\u5883\uff1a\u4f46\u662f\u8ca0\u8cac\u611f\u6e2c\u7684\u4e3b\u89d2<\/em><em>\u2500G-<\/em><em>\u86cb\u767d\u5076\u806f\u53d7\u9ad4(G-protein coupled receptors)<\/em><em>\u591a\u5e74\u4f86\u537b\u96b1\u85cf\u5728\u7814\u7a76\u8005\u672a\u77e5\u4e4b\u8655\u3002<\/em><\/p>\n<p>\u5982\u679c\u4f60\u5de5\u4f5c\u5230\u5f88\u665a\uff0c\u6708\u4eae\u5df2\u9ad8\u61f8\u591c\u7a7a\uff0c\u4f60\u6b63\u5f9e\u504f\u50fb\u7684\u516c\u8eca\u7ad9\u8d70\u56de\u5bb6\u3002\u4f60\u7a81\u7136\u807d\u898b\u5f8c\u65b9\u50b3\u4f86\u7684\u8173\u6b65\u8072\uff0c\u8072\u97f3\u5feb\u901f\u7684\u8feb\u8fd1\u3002\u300c\u6c92\u4ec0\u9ebc\u597d\u64d4\u5fc3\u7684\u3002\u300d\u4f60\u544a\u8a34\u81ea\u5df1\uff1a\u300c\u4e0d\u904e\u662f\u53e6\u4e00\u500b\u88ab\u64cd\u5230\u592a\u665a\u7684\u54e1\u5de5\u7f77\u4e86\u3002\u300d\u4f46\u662f\uff0c\u4e00\u7a2e\u6bdb\u9aa8\u609a\u7136\u7684\u611f\u89ba\u6cb9\u7136\u800c\u5347\uff0c\u6709\u4eba\u4f3c\u4e4e\u8feb\u8fd1\u5230\u4e86\u4f60\u8eab\u5f8c...<\/p>\n<p>\u4f60\u7acb\u523b\u62d4\u817f\u5411\u5bb6\u9580\u72c2\u5954\uff0c\u6253\u958b\u524d\u9580\u7684\u9396\u6642\uff0c\u4f60\u6574\u500b\u8eab\u9ad4\u90fd\u5728\u986b\u6296\uff0c\u5fc3\u5728\u72c2\u8df3\uff0c\u800c\u4e14\u4e0d\u65b7\u5927\u529b\u7684\u5598\u606f\u3002<!--more--><\/p>\n<p>\u7576\u4f60\u7684\u773c\u775b\u77a5\u5230\u8feb\u8fd1\u7684\u9ed1\u5f71\u6642\uff0c\u6574\u500b\u8eab\u9ad4\u5df2\u7d93\u8f49\u63db\u5230\u9003\u8dd1\u7684\u6a21\u5f0f(\u57161)\u3002\u8166\u90e8\u50b3\u4f86\u7684\u795e\u7d93\u8a0a\u865f\u50b3\u7d66\u4e86\u8eab\u9ad4\u4e00\u500b\u521d\u6b65\u7684\u8b66\u8a0a\u3002\u8166\u4e0b\u817a\u5c07\u6fc0\u7d20(\u6216\u7a31\u8377\u723e\u8499)\u91cb\u653e\u5230\u8840\u6d41\u4e2d\uff0c\u88ab\u559a\u9192\u7684\u814e\u4e0a\u817a\u958b\u59cb\u6e67\u51fa\u76ae\u8cea\u9187(cortisol\uff0c\u6216\u7a31\u53ef\u9ad4\u677e)\u3001\u814e\u4e0a\u817a\u7d20\u4ee5\u53ca\u53bb\u7532\u57fa\u814e\u4e0a\u817a\u7d20(noradrenalin\uff0c\u53c8\u7a31\u6b63\u814e\u4e0a\u817a\u7d20)\u3002\u9019\u4e9b\u7269\u8cea\u767c\u5e03\u4e86\u7b2c\u4e8c\u6b21\u7684\u8b66\u544a\uff1a\u61c9\u8a72\u662f\u62d4\u8173\u800c\u9003\u7684\u6642\u6a5f\u4e86\uff01\u8102\u80aa\u7d30\u80de\u3001\u808c\u8089\u7d30\u80de\u3001\u809d\u3001\u5fc3\u81df\u3001\u80ba\u4ee5\u53ca\u8840\u7ba1\u5168\u90e8\u7acb\u5373\u53cd\u61c9\uff0c\u8840\u7ba1\u5167\u6e67\u5165\u4e86\u7cd6\u8207\u8102\u80aa\uff0c\u6c23\u7ba1\u64f4\u5f35\uff0c\u5fc3\u8df3\u52a0\u5feb \u2014 \u9019\u4e9b\u90fd\u53ef\u8b93\u4f60\u7684\u808c\u8089\u7372\u5f97\u80fd\u91cf\u8207\u6c27\u6c23\uff0c\u76ee\u6a19\u5728\u4f7f\u4f60\u8dd1\u5f97\u6108\u5feb\u6108\u597d\uff0c\u4ee5\u4fbf\u6551\u547d\u3002<\/p>\n<p>\u4e00\u500b\u4eba\u7684\u9ad4\u5167\uff0c\u6709\u6578\u5341\u5104\u8a08\u7684\u7d30\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u5b83\u5011\u5927\u90e8\u5206\u5404\u81ea\u767c\u5c55\u51fa\u4e86\u4e0d\u540c\u7684\u89d2\u8272\u3002\u6709\u4e9b\u5132\u5b58\u8102\u80aa\uff0c\u6709\u4e9b\u7522\u751f\u8996\u89ba\uff0c\u53c8\u6709\u7684\u7522\u751f\u6fc0\u7d20\u6216\u88fd\u9020\u808c\u8089\u7d44\u7e54\u2026\u3002\u70ba\u4e86\u80fd\u8b93\u8eab\u9ad4\u9069\u7576\u904b\u4f5c\uff0c\u975e\u5e38\u91cd\u8981\u7684\u662f\u7d30\u80de\u5fc5\u9808\u548c\u5354\u904b\u4f5c\u3002\u8981\u80fd\u611f\u77e5\u74b0\u5883\uff0c\u800c\u4e14\u8a8d\u77e5\u9053\u5468\u906d\u767c\u751f\u7684\u4e8b\u60c5\uff0c\u8eab\u9ad4\u5c31\u9700\u8981\u611f\u77e5\u5668\u3002<\/p>\n<p>\u4f4d\u65bc\u7d30\u80de\u8868\u9762\u7684\u611f\u77e5\u5668\u7a31\u70ba\u53d7\u9ad4 (receptors)\uff0c\u7f8e\u570b\u675c\u514b\u5927\u5b78(Duke University)\u7684\u7f85\u4f2f\u96f7\u67ef\u7dad\u8332(Robert J. Lefkowitz)\u8207\u53f2\u4e39\u798f\u5927\u5b78\u7684\u5e03\u840a\u6069\u67ef\u6bd4\u5361Brian K. Kobilka \u4e8c\u4eba\u56e0\u70ba\u91d0\u6e05\u4e86\u4e00\u985e\u88ab\u7a31\u70baG-\u86cb\u767d\u5076\u806f\u53d7\u9ad4\u5bb6\u65cf(\u7c21\u7a31GPCRs)\u7684\u7269\u8cea\u53ca\u5176\u5728\u9ad4\u5167\u7684\u904b\u4f5c\uff0c\u5171\u4eab\u4eca\u5e74(2012)\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u7684\u6842\u51a0\u3002\u5728\u9019\u500b\u9f90\u5927\u7684\u751f\u5316\u7269\u8cea\u5bb6\u65cf\u4e2d\uff0c\u5305\u62ec\u4e86\u814e\u4e0a\u817a\u7d20\u3001\u591a\u5df4\u80fa\u3001\u8840\u6e05\u7d20\u3001\u5149\u7dda\u3001\u53e3\u5473\u8207\u55c5\u89ba\u7b49\u2026\u7684\u53d7\u9ad4\u7269\u8cea\u3002\u8a31\u591a\u7684\u751f\u7406\u4f5c\u7528\u5927\u90fd\u8207GPCRs\u6709\u95dc\uff0c\u5927\u7d04\u6709\u4e00\u534a\u7684\u85e5\u7269\u4f8b\u5982b-\u963b\u65b7\u5291\u3001\u6297\u7d44\u7e54\u80fa\u4ee5\u53ca\u5404\u7a2e\u7cbe\u795e\u85e5\u7269\u7b49\uff0c\u662f\u900f\u904eGPCRs\u53d7\u9ad4\u7269\u8cea\u767c\u63ee\u4f5c\u7528\u3002<\/p>\n<p>\u4e86\u89e3GPCRs\u751f\u5316\u904b\u4f5c\u7684\u77e5\u8b58\u6703\u5927\u5927\u7684\u9020\u798f\u4eba\u985e\uff0c\u4e0d\u904e\u9019\u4e9b\u53d7\u9ad4\u537b\u5728\u79d1\u5b78\u5bb6\u7684\u773c\u4e0b\u85cf\u533f\u4e86\u5f88\u4e45\u3002<\/p>\n<p><strong>\u90a3\u500b\u53d7\u9ad4 \u2014 \u4e00\u500b\u96b1\u85cf\u7684\u8b0e\u5718<\/strong><\/p>\n<p>\u5341\u4e5d\u4e16\u7d00\u672b\u671f\uff0c\u79d1\u5b78\u5bb6\u5011\u958b\u59cb\u5be6\u9a57\u814e\u4e0a\u817a\u7d20\u5c0d\u4eba\u9ad4\u7684\u5f71\u97ff\u6642\uff0c\u5c31\u767c\u73fe\u5b83\u6703\u4f7f\u5fc3\u8df3\u52a0\u901f\u3001\u8840\u58d3\u5347\u9ad8\u3001\u4ee5\u53ca\u77b3\u5b54\u8212\u5f35\u3002\u7531\u65bc\u4ed6\u5011\u61f7\u7591\u814e\u4e0a\u817a\u7d20\u662f\u900f\u904e\u9ad4\u5167\u7684\u795e\u7d93\u4f86\u904b\u4f5c\uff0c\u5c31\u7671\u7613\u52d5\u7269\u4f86\u5be6\u9a57\u3002\u7136\u800c\uff0c\u814e\u4e0a\u817a\u7d20\u7684\u4f5c\u7528\u4ecd\u7136\u53ef\u4ee5\u8868\u73fe\u3002\u4ed6\u5011\u7576\u6642\u7684\u7d50\u8ad6\u662f\uff1a\u7d30\u80de\u4e00\u5b9a\u5177\u6709\u67d0\u7a2e\u53d7\u9ad4\uff0c\u80fd\u5728\u5176\u74b0\u5883\u4e2d\u611f\u77e5\u4e00\u4e9b\u5316\u5b78\u7269\u8cea\u2014\u53ef\u80fd\u662f\u6fc0\u7d20\u3001\u6bd2\u7269\u6216\u85e5\u7269\u3002<\/p>\n<p>\u4f46\u662f\u7576\u7814\u7a76\u4eba\u54e1\u4f01\u5716\u627e\u5c0b\u90a3\u4e9b\u53d7\u9ad4\u6642\uff0c\u4ed6\u5011\u537b\u649e\u4e86\u58c1\u3002\u79d1\u5b78\u5bb6\u5e0c\u671b\u77ad\u89e3\u53d7\u9ad4\u7684\u9577\u50cf\u4ee5\u53ca\u5b83\u5011\u5982\u4f55\u8f38\u9001\u8a0a\u865f\u7d66\u7d30\u80de\u3002\u7576\u814e\u4e0a\u817a\u7d20\u65bd\u52a0\u65bc\u7d30\u80de\u7684\u5916\u5074\u6642\uff0c\u6703\u5c0e\u81f4\u7d30\u80de\u5167\u90e8\u7684\u4ee3\u8b1d\u767c\u751f\u8b8a\u5316\u3002\u6bcf\u4e00\u500b\u7d30\u80de\u90fd\u6709\u4e00\u9762\u5916\u819c\u58c1\uff1a\u5c31\u662f\u4e00\u5c64\u8102\u80aa\u5206\u5b50\u819c\u5c07\u7d30\u80de\u7269\u8cea\u8207\u74b0\u5883\u5340\u9694\u3002<em>\u5230\u5e95\u8a0a\u865f\u662f\u5982\u4f55\u7a7f\u900f\u9019\u9762\u819c\u58c1\u7684\uff1f\u7d30\u80de\u7684\u5167\u90e8\u5982\u4f55\u77e5\u9053\u5916\u9762\u767c\u751f\u4e86\u4ec0\u9ebc\u4e8b\uff1f<\/em><\/p>\n<p>\u6709\u6578\u5341\u5e74\uff0c\u4e00\u76f4\u7121\u6cd5\u627e\u5230\u9019\u4e9b\u53d7\u9ad4\u3002\u5373\u4fbf\u5982\u6b64\uff0c\u79d1\u5b78\u5bb6\u5011\u4ecd\u767c\u5c55\u51fa\u4e86\u4e00\u4e9b\u85e5\u7269\u80fd\u5c08\u4e00\u7684\u91dd\u5c0d\u9019\u4e00\u985e\u53d7\u9ad4\u4e2d\u7684\u7279\u5b9a\u985e\u578b\u767c\u63ee\u6548\u679c\u3002\u57281940\u5e74\u4ee3\uff0c\u7f8e\u570b\u79d1\u5b78\u5bb6\u96f7\u8499\u963f\u723e\u594e\u65af\u7279(Raymond Ahlquist)\u6aa2\u9a57\u4e0d\u540c\u7684\u7d44\u7e54\u5c0d\u5404\u7a2e\u814e\u4e0a\u817a\u7d20\u985e\u4f3c\u7684\u7269\u8cea\u5982\u4f55\u53cd\u61c9\uff0c\u5f97\u5230\u4e00\u500b\u7d50\u8ad6\uff1a\u4e00\u5b9a\u6709\u5169\u7a2e\u4e0d\u540c\u7684\u814e\u4e0a\u817a\u7d20\u53d7\u9ad4\u5b58\u5728\u3002\u4e00\u7a2e\u4e3b\u8981\u8b93\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u6536\u7e2e\uff0c\u800c\u53e6\u4e00\u7a2e\u4e3b\u8981\u523a\u6fc0\u5fc3\u81df\u3002\u4ed6\u7a31\u9019\u5169\u7a2e\u53d7\u9ad4\u70ba a \u548c b\u3002\u5f88\u5feb\u7684\uff0c\u79d1\u5b78\u5bb6\u5011\u767c\u5c55\u51fa\u4e86\u7b2c\u4e00\u500b 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of the National Academy of Sciences<\/em><em>\uff0cPNAS)<\/em>\u8207\u79d1\u5b78(<em>Science<\/em>)\u767c\u8868\u4e86\u5e7e\u7bc7\u91cd\u8981\u8ad6\u6587\uff0c\u4ed6\u63cf\u8ff0\u767c\u73fe\u4e86\u4e00\u500b\u6709\u6548\u53d7\u9ad4\u3002\u9019\u9805\u6210\u5c31\u8b93\u4ed6\u611f\u53d7\u5230\u505a\u7814\u7a76\u7684\u8208\u596e\uff0c\u6700\u5f8c\u4ed6\u88ab\u5ef6\u652c\u81f3\u5317\u5361\u7f85\u4f86\u7d0d\u5dde\u7684\u675c\u514b\u5927\u5b78\u3002\u4ed6\u4e26\u975e\u7279\u5225\u60f3\u53bb\u675c\u5927\uff0c\u53ea\u662f\u5c0d\u65b9\u7d66\u7684\u689d\u4ef6\u5be6\u5728\u597d\u5f97\u8b93\u4ed6\u7121\u6cd5\u62d2\u7d55\u3002<\/p>\n<p>\u5728\u5d84\u65b0\u7684\u5be6\u9a57\u5ba4\u88e1\uff0c\u96f7\u67ef\u7dad\u8332\u7d44\u6210\u81ea\u5df1\u7684\u7814\u7a76\u5c0f\u7d44\u3002\u96d6\u7136\u770b\u8d77\u4f86\u4ed6\u53ef\u80fd\u6c38\u9060\u7121\u6cd5\u6210\u70ba\u4e00\u4f4d\u5fc3\u81df\u75c5\u79d1\u91ab\u5e2b\u4e86\uff0c\u4f46\u4ed6\u4ecd\u7136\u60f3\u8981\u7814\u7a76\u5fc3\u81df\u7684\u75be\u75c5\u3002\u56e0\u6b64\uff0c\u4ed6\u958b\u59cb\u628a\u7126\u9ede\u653e\u5728\u814e\u4e0a\u817a\u7d20\u8207\u53bb\u7532\u57fa\u814e\u4e0a\u817a\u7d20\u7684\u53d7\u9ad4\uff0c\u5b83\u5011\u88ab\u7a31\u70ba\u814e\u4e0a\u817a\u7d20\u6fc0\u5c0e\u6027\u53d7\u9ad4(adrenergic receptors)\u3002\u5229\u7528\u8f3b\u5c04\u6027\u6a19\u8a18\u7684\u7269\u8cea\uff0c\u5305\u62ec\u4e86 b-\u963b\u65b7\u5291\u3002\u4ed6\u7684\u7814\u7a76\u5c0f\u7d44\u6aa2\u9a57\u4e86\u9019\u4e9b\u53d7\u9ad4\u5982\u4f55\u904b\u4f5c\uff0c\u5728\u7cbe\u7d30\u7684\u8abf\u6574\u6240\u4f7f\u7528\u7684\u5de5\u5177\u5f8c\uff0c\u4ed6\u5011\u7d42\u65bc\u638c\u63e1\u4e86\u9ad8\u8d85\u7684\u6280\u5de7\u4f86\u53d6\u5f97\u4e00\u7cfb\u5217\u5f9e\u751f\u7269\u7d44\u7e54\u4e2d\u8403\u53d6\u5f97\u5230\u7684\u53d7\u9ad4\u3002<\/p>\n<p>\u540c\u6642\uff0c\u6709\u95dc\u7d30\u80de\u5167\u90e8\u4f5c\u7528\u7684\u77e5\u8b58\u4e0d\u65b7\u7d2f\u7a4d\uff0c\u7814\u7a76\u8005\u767c\u73fe\u4e86\u4ed6\u5011\u7a31\u4e4b\u70ba G-\u86cb\u767d (1994\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e) \u7684\u7269\u8cea\u3002\u5b83\u6703\u63a5\u5230\u53d7\u9ad4\u50b3\u4f86\u7684\u8a0a\u865f\u800c\u6d3b\u5316\uff0c\u63a5\u8457G-\u86cb\u767d\u958b\u555f\u4e00\u7cfb\u5217\u7684\u53cd\u61c9\uff0c\u5c0e\u81f4\u7d30\u80de\u4ee3\u8b1d\u7684\u6539\u8b8a\u3002\u57281980\u5e74\u4ee3\u521d\u671f\uff0c\u79d1\u5b78\u5bb6\u5011\u958b\u59cb\u77ad\u89e3\u8a0a\u865f\u5f9e\u7d30\u80de\u5916\u9762\u50b3\u905e\u5230\u88e1\u9762\u7684\u904e\u7a0b (\u57162)\u3002<\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=11865\" rel=\"attachment wp-att-11865\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-11865\" title=\"nobel100_clip_image004\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image004.gif\" alt=\"\" width=\"661\" height=\"442\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image004.gif 661w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image004-300x200.gif 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image004-600x401.gif 600w\" sizes=\"(max-width: 661px) 100vw, 661px\" \/><\/a><\/p>\n<p><strong>\u57fa\u56e0 \u2014 \u65b0\u770b\u6cd5\u7684\u4e00\u500b\u95dc\u9375<\/strong><\/p>\n<p>\u57281980\u5e74\u4ee3\uff0c\u96f7\u67ef\u7dad\u8332\u6c7a\u5b9a\u4ed6\u7684\u7814\u7a76\u5c0f\u7d44\u61c9\u8a72\u53bb\u5c0b\u627e b-\u963b\u65b7\u5291\u53d7\u9ad4\u7684\u57fa\u56e0\u5bc6\u78bc\uff0c\u9019\u9805\u6c7a\u5b9a\u61c9\u53ef\u78ba\u5b9a\u662f\u4eca\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u7372\u734e\u7684\u95dc\u9375\u3002\u4e00\u500b\u57fa\u56e0\u5c31\u597d\u50cf\u662f\u500b\u85cd\u5716\uff0c\u5b83\u5305\u542b\u4e86\u4e00\u500b\u5bc6\u78bc\uff0c\u80fd\u88ab\u7d30\u80de\u8b80\u53d6\uff0c\u4f9d\u7167\u6307\u793a\u5c07\u8a31\u591a\u80fa\u57fa\u9178\u7d44\u5408\u88fd\u6210\u86cb\u767d\u8cea\uff0c\u8b6c\u5982\u88fd\u9020\u4e00\u500b\u86cb\u767d\u8cea\u53d7\u9ad4\u3002\u4ed6\u7684\u60f3\u6cd5\u662f\uff0c\u5982\u679c\u7814\u7a76\u5c0f\u7d44\u80fd\u5206\u96e2\u51fa\u8ca0\u8cac\u7684\u57fa\u56e0\uff0c\u4e26\u8b80\u53d6 b-\u963b\u65b7\u5291\u53d7\u9ad4\u7684\u85cd\u5716\uff0c\u4ed6\u5011\u5c31\u53ef\u4ee5\u5f97\u5230\u8a72\u53d7\u9ad4\u5982\u4f55\u904b\u4f5c\u7684\u7dda\u7d22\u3002<\/p>\n<p>\u5dee\u4e0d\u591a\u5728\u540c\u6642\uff0c\u96f7\u67ef\u7dad\u8332\u9304\u7528\u4e86\u4e00\u4f4d\u5e74\u8f15\u7684\u91ab\u5e2b\uff0c\u5e03\u840a\u6069\u67ef\u6bd4\u5361\u3002\u67ef\u6bd4\u5361\u5c0d\u814e\u4e0a\u817a\u7d20\u6fc0\u5c0e\u6027\u53d7\u9ad4\u4e4b\u8457\u8ff7\uff0c\u4f86\u81ea\u65bc\u91ab\u9662\u52a0\u8b77\u75c5\u623f\u7684\u7d93\u9a57\uff0c\u4e00\u91dd\u814e\u4e0a\u817a\u7d20\u53ef\u4ee5\u6c7a\u5b9a\u75c5\u4eba\u7684\u751f\u8207\u6b7b\u3002\u9019\u500b\u6fc0\u7d20\u53ef\u4ee5\u6253\u958b\u4e00\u500b\u816b\u8139\u7684\u547c\u5438\u7cfb\u7d71\uff0c\u4e26\u52a0\u901f\u5fc3\u8df3\u3002\u67ef\u6bd4\u5361\u60f3\u8981\u5f9e\u814e\u4e0a\u817a\u7d20\u7684\u57fa\u790e\u7d50\u69cb\u7d30\u7bc0\u4f86\u7814\u7a76\u5b83\u7684\u529b\u91cf\u4f86\u6e90\uff0c\u4e5f\u56e0\u6b64\u52a0\u5165\u96f7\u67ef\u7dad\u8332\u7684\u5718\u968a\u3002<\/p>\n<p>\u67ef\u6bd4\u5361\u4f5c\u4e86\u57fa\u56e0\u641c\u5c0b\u3002\u7136\u800c\uff0c\u57281980\u5e74\u4ee3\u60f3\u8981\u5728\u4eba\u9ad4\u9f90\u5927\u7684\u57fa\u56e0\u9ad4\u5167\u5c0b\u627e\u4e00\u500b\u7279\u5b9a\u57fa\u56e0\uff0c\u5c31\u597d\u50cf\u5728\u5927\u6d77\u88e1\u6488\u91dd\u4e00\u6a23\u56f0\u96e3\u3002\u9019\u500b\u5728\u6280\u8853\u4e0a\u9ad8\u5ea6\u6311\u6230\u7684\u8a08\u756b\u56e0\u6b64\u9032\u5c55\u5f97\u5341\u5206\u7de9\u6162\u3002\u4e0d\u904e\u67ef\u6bd4\u5361\u5229\u7528\u4e86\u4e00\u500b\u5f88\u5de7\u5999\u7684\u60f3\u6cd5\uff0c\u4f7f\u5f97\u9019\u500b\u57fa\u56e0\u7d42\u65bc\u88ab\u5206\u96e2\u51fa\u4f86\u3002\u5e36\u8457\u9ad8\u5ea6\u7684\u671f\u5f85\uff0c\u9019\u4e9b\u7814\u7a76\u8005\u958b\u59cb\u5206\u6790\u57fa\u56e0\u5bc6\u78bc\u3002\u7814\u7a76\u986f\u793a\u53d7\u9ad4\u5177\u6709\u4e03\u689d\u9577\u800c\u4e14\u5177\u6cb9\u6027(\u758f\u6c34\u6027)\u7684\u87ba\u65cb\u5f62\u5e36\u5b50\u2500\u7a31\u70ba\u87ba\u65cb\u9ad4 (\u57163)\uff0c\u9019\u6697\u793a\u4e86\u79d1\u5b78\u5bb6\u5011\uff0c\u9019\u500b\u53d7\u9ad4\u53ef\u80fd\u7e5e\u9032\u548c\u7e5e\u51fa\u7d30\u80de\u819c\u4e03\u6b21\u3002<\/p>\n<p>\u4e03\u6b21\uff01\u9019\u8207\u5728\u4eba\u9ad4\u5167\u5176\u5b83\u5730\u65b9\u5df2\u7d93\u627e\u5230\u7684\u53e6\u4e00\u500b\u53d7\u9ad4\uff0c\u5177\u6709\u76f8\u540c\u6578\u76ee\u7684\u5e36\u5b50\u4ee5\u53ca\u540c\u6a23\u7684\u87ba\u65cb\u5f62\u72c0\u3002\u90a3\u5c31\u662f\u773c\u775b\u8996\u7db2\u819c\u4e0a\u7684\u8996\u7d2b\u8cea(rhodopsin)\u5149\u53d7\u9ad4\u3002\u9019\u5de7\u5408\u5b55\u80b2\u51fa\u4e00\u500b\u65b0\u7684\u60f3\u6cd5\uff1a<em>\u9019\u5169\u7a2e\u53d7\u9ad4\u6709\u7121\u53ef\u80fd\u662f\u76f8\u95dc\u7684\uff0c\u96d6\u7136\u5169\u8005\u7684\u529f\u80fd\u4e0d\u540c\uff1f<\/em><\/p>\n<p>\u96f7\u67ef\u7dad\u8332\u5f8c\u4f86\u63cf\u8ff0\u90a3\u624d\u662f\u300e\u771f\u6b63\u7684\u767c\u73fe\u6642\u523b\u300f(real eureka moment)\u3002\u4ed6\u77e5\u9053\u9019\u5169\u7a2e\u53d7\u9ad4\u90fd\u6703\u5728\u7d30\u80de\u5167\u5074\u8207G-\u86cb\u767d\u4f5c\u7528\uff0c\u4ed6\u4e5f\u77e5\u9053\u7d04\u670930\u500b\u5176\u5b83\u7684\u53d7\u9ad4\u662f\u900f\u904eG-\u86cb\u767d\u904b\u4f5c\u3002\u7d50\u8ad6\u662f\uff1a<em>\u4e00\u5b9a\u6709\u4e00\u500b\u5b8c\u6574\u7684\u53d7\u9ad4\u5bb6\u65cf\uff0c\u9577\u76f8\u985e\u4f3c\u800c\u4e14\u904b\u4f5c\u7684\u65b9\u5f0f\u76f8\u540c\uff01<\/em><\/p>\n<p>\u56e0\u70ba\u9019\u500b\u7a81\u7834\u6027\u7684\u767c\u73fe\uff0c\u8b0e\u5e95\u4e00\u6b65\u6b65\u7684\u88ab\u7d44\u5408\u6d6e\u73fe\u51fa\u4f86\u3002\u73fe\u5728\u79d1\u5b78\u5bb6\u5011\u5c0d\u65bcGPCRs\u5df2\u7d93\u5177\u6709\u8a73\u76e1\u7684\u77e5\u8b58\u2500\u5b83\u5011\u5982\u4f55\u904b\u4f5c\uff0c\u4ee5\u53ca\u5982\u4f55\u5728\u5206\u5b50\u7684\u5c64\u6b21\u88ab\u8abf\u63a7\u3002\u96f7\u67ef\u7dad\u8332\u8207\u67ef\u6bd4\u5361\u4e00\u76f4\u7ad9\u5728\u9019\u6574\u500b\u79d1\u5b78\u63a2\u7d22\u5de5\u4f5c\u7684\u6700\u524d\u7dda\u3002\u53bb\u5e74\uff0c2011\u5e74\uff0c\u67ef\u6bd4\u5361\u8207\u5176\u7814\u7a76\u5718\u968a\u5831\u5c0e\u4e86\u4e00\u9805\u65b0\u767c\u73fe\uff0c\u4ed6\u5011\u7684\u5de5\u4f5c\u7d42\u65bc\u8b93\u4ed6\u5011\u6234\u4e0a\u4e86\u6842\u51a0\u3002<\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=11866\" rel=\"attachment wp-att-11866\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-11866\" title=\"nobel100_clip_image006\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image006.gif\" alt=\"\" width=\"672\" height=\"355\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image006.gif 672w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image006-300x158.gif 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image006-600x317.gif 600w\" sizes=\"(max-width: 672px) 100vw, 672px\" \/><\/a><\/p>\n<p><strong>\u814e\u4e0a\u817a\u904b\u4f5c\u7684\u986f\u50cf<\/strong><\/p>\n<p>\u6210\u529f\u7684\u5206\u96e2\u51fa\u57fa\u56e0\u5f8c\uff0c\u67ef\u6bd4\u5361\u642c\u5230\u4e86\u52a0\u5dde\u53f2\u4e39\u798f\u5927\u5b78\u7684\u85e5\u5b78\u9662\uff0c\u4ed6\u5728\u90a3\u88e1\u958b\u59cb\u7814\u7a76\u5982\u4f55\u53d6\u5f97\u4e00\u500b\u53d7\u9ad4\u7684\u5f71\u50cf\uff1a\u5927\u90e8\u5206\u79d1\u5b78\u754c\u7684\u4eba\u8a8d\u70ba\u662f\u4e0d\u53ef\u80fd\u7684\u4efb\u52d9 \u2500 \u800c\u5c0d\u67ef\u6bd4\u5361\u4f86\u8aaa\uff0c\u90a3\u6210\u70ba\u4e86\u4e00\u689d\u6f2b\u9577\u7684\u65c5\u9014\u3002<\/p>\n<p>\u8981\u5c07\u4e00\u500b\u86cb\u767d\u8cea\u986f\u50cf\uff0c\u727d\u6d89\u5230\u8a31\u591a\u8907\u96dc\u7684\u6b65\u9a5f\uff0c\u86cb\u767d\u8cea\u5c0f\u5230\u7121\u6cd5\u7528\u666e\u901a\u7684\u96fb\u5b50\u986f\u5fae\u93e1\u4f86\u89c0\u5bdf\uff0c\u56e0\u6b64\u79d1\u5b78\u5bb6\u5011\u4f7f\u7528\u4e00\u7a2e\u7a31\u70baX-\u5c04\u7dda\u7d50\u6676\u5b78(X-ray crystallography)\u7684\u65b9\u6cd5\uff0c\u4ed6\u5011\u5148\u57f9\u990a\u51fa\u4e00\u9846\u86cb\u767d\u8cea\u7684\u6676\u9ad4\uff0c\u5176\u4e2d\u86cb\u767d\u8cea\u5206\u5b50\u4ee5\u6574\u9f4a\u4e14\u5177\u5c0d\u7a31\u6027\u7684\u6a21\u5f0f\u6574\u9f4a\u6392\u5217\uff0c\u5c31\u597d\u50cf\u6c34\u5206\u5b50\u5728\u51b0\u6676\u4e2d\uff0c\u6216\u662f\u78b3\u539f\u5b50\u5728\u947d\u77f3\u4e2d\u7684\u6392\u5217\u4e00\u822c\u3002\u7814\u7a76\u8005\u7528X-\u5c04\u7dda\u7167\u5c04\u9019\u500b\u86cb\u767d\u8cea\u6676\u9ad4\uff0c\u7576\u5c04\u7dda\u6253\u5230\u86cb\u767d\u8cea\u6642\u767c\u751f\u7e5e\u5c04(diffraction)\uff0c\u79d1\u5b78\u5bb6\u5011\u53ef\u5f9e\u7e5e\u5c04\u7684\u5716\u8b5c\u63a8\u5c0e\u51fa\u86cb\u767d\u8cea\u5728\u5206\u5b50\u5c64\u6b21\u7684\u69cb\u9020\u8207\u6392\u5217\u3002<\/p>\n<p>\u6b77\u53f2\u4e0a\u7b2c\u4e00\u500b\u86cb\u767d\u8cea\u6676\u9ad4\u7684\u7d50\u69cb\u5716\u50cf\u662f\u57281950\u5e74\u4ee3\u7522\u751f\u3002\u5f9e\u90a3\u6642\u958b\u59cb\uff0c\u79d1\u5b78\u5bb6\u5011\u5df2\u7d93\u5229\u7528X-\u5c04\u7dda\u5c07\u4e0a\u5343\u7684\u86cb\u767d\u8cea\u986f\u50cf\u3002\u4e0d\u904e\u5b83\u5011\u5927\u90fd\u662f\u6c34\u6eb6\u6027\u7684\uff0c\u4f7f\u5f97\u990a\u6676\u8f03\u70ba\u5bb9\u6613\u3002\u5c11\u6709\u7814\u7a76\u8005\u80fd\u5c07\u4f4d\u65bc\u6cb9\u6027\u7d30\u80de\u819c\u4e0a\u7684\u86cb\u767d\u8cea\u55ae\u96e2\u986f\u50cf\u3002\u5728\u6c34\u88e1\uff0c\u9019\u985e\u86cb\u767d\u8cea\u5c31\u50cf\u6cb9\u96e3\u6eb6\u65bc\u6c34\uff0c\u800c\u4e14\u975e\u5e38\u5bb9\u6613\u5f62\u6210\u975e\u6676\u6027\u7684\u6cb9\u5718\u3002\u6b64\u5916\uff0cGPCRs \u5929\u751f\u6e38\u52d5\u6027\u8f03\u9ad8\u3002(\u8a18\u5f97\u5b83\u5011\u662f\u85c9\u8457\u79fb\u52d5\u4f86\u50b3\u905e\u8a0a\u865f!)\u53ef\u662f\u5728\u6676\u9ad4\u4e2d\uff0cGPCRs\u7684\u5206\u5b50\u53c8\u5e7e\u4e4e\u5b8c\u5168\u975c\u6b62\uff0c\u8981\u8b93\u5b83\u5011\u55ae\u96e2\u7d50\u6676\u51fa\u4f86\u9042\u6210\u70ba\u6975\u5927\u7684\u6311\u6230\u3002<\/p>\n<p>\u67ef\u6bd4\u5361\u82b1\u4e86\u8d85\u904e\u4e8c\u5341\u5e74\u7684\u6642\u9593\u53bb\u627e\u5230\u9019\u6240\u6709\u554f\u984c\u7684\u89e3\u7b54\uff0c\u8981\u611f\u8b1d\u7814\u7a76\u8005\u7684\u6c7a\u5fc3\u3001\u5275\u610f\u548c\u5206\u5b50\u751f\u7269\u5be6\u9a57\u7684\u5de7\u624b\uff0c\u67ef\u6bd4\u5361\u8207\u5176\u7814\u7a76\u5718\u968a\u7d42\u65bc\u57282011\u5e74\u5b8c\u6210\u4e86\u6700\u7d42\u76ee\u6a19\uff1a\u4ed6\u5011\u5f97\u5230\u4e86\u4e00\u5f35\u5716\u50cf\uff0c\u986f\u793a\u53d7\u9ad4\u6b63\u5728\u5c07\u4f86\u81ea\u65bc\u7d30\u80de\u5916\u6fc0\u7d20\u7684\u8a0a\u865f\uff0c\u50b3\u5230\u7d30\u80de\u5167\u7684G-\u86cb\u767d (\u57163)\u3002<\/p>\n<p>\u9019\u500b\u5716\u50cf\u767c\u8868\u5728\u300c\u81ea\u7136\u300d\u671f\u520a\u4e0a\uff0c\u8ad6\u6587\u986f\u793a\u4e86GPCRs\u65b0\u7684\u7d30\u7bc0\u3002\u4f8b\u5982\uff0c\u7576\u88ab\u6d3b\u5316\u7684\u53d7\u9ad4\u6253\u958b\u4e00\u500b\u5b54\u6d1e\uff0c\u6e96\u5099\u8207G-\u86cb\u767d\u5728\u8a72\u8655\u7d50\u5408\u6642\u7684\u9577\u50cf\u70ba\u4f55(\u57164)\uff0c\u9019\u7a2e\u8cc7\u8a0a\u5c0d\u672a\u4f86\u767c\u5c55\u65b0\u7684\u85e5\u7269\u6975\u70ba\u6709\u7528\u3002<\/p>\n<p><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=11867\" rel=\"attachment wp-att-11867\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-11867\" title=\"nobel100_clip_image008\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image008.gif\" alt=\"\" width=\"665\" height=\"476\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image008.gif 665w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/nobel100_clip_image008-300x214.gif 300w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/a><\/p>\n<p>\u4eba\u985e\u57fa\u56e0\u9ad4\u7684\u6309\u5716\u7d22\u9a65\uff0c\u66b4\u9732\u4e86\u7d04\u6709\u4e00\u5343\u500b\u57fa\u56e0\u662fGPCRs \u7684\u5bc6\u78bc\u3002\u5927\u7d04\u4e00\u534a\u7684GPCRs\u53d7\u9ad4\u63a5\u53d7\u6c23\u5473\uff0c\u4e26\u4e14\u662f\u55c5\u89ba\u7cfb\u7d71\u7684\u4e00\u90e8\u5206\u3002\u7d04\u4e09\u5206\u4e4b\u4e00\u662f\u6fc0\u7d20\u8207\u8a0a\u865f\u7269\u8cea\u7684\u53d7\u9ad4\uff0c\u50cf\u662f\u591a\u5df4\u80fa\u3001\u8840\u6e05\u7d20\uff0c\u524d\u5217\u817a\u7d20\u3001\u5347\u7cd6\u7d20(glucagon)\u6216\u7d44\u7e54\u80fa\u3002\u6709\u4e00\u4e9b\u53d7\u9ad4\u53ef\u6355\u6349\u9032\u5165\u773c\u775b\u7684\u5149\u7dda\uff0c\u9084\u6709\u4e00\u4e9b\u4f4d\u65bc\u820c\u982d\uff0c\u7d66\u6211\u5011\u5473\u89ba\u3002\u8d85\u904e\u767e\u7a2e\u7684\u53d7\u9ad4\u4ecd\u7136\u662f\u79d1\u5b78\u5bb6\u7684\u6311\u6230\uff0c\u5b83\u5011\u7684\u529f\u80fd\u4ecd\u7136\u6709\u5f85\u78ba\u8a8d\u3002<\/p>\n<p>\u9664\u4e86\u767c\u73fe\u9019\u4e9b\u53d7\u9ad4\u7684\u5404\u7a2e\u8b8a\u9ad4\uff0c\u8ddf\u5728\u96f7\u67ef\u7dad\u8332\u8207\u67ef\u6bd4\u5361\u8173\u6b65\u4e4b\u5f8c\u7684\u7814\u7a76\u8005\u767c\u73fe\u5b83\u5011\u5177\u6709\u591a\u91cd\u529f\u80fd\u3002\u4e00\u500b\u55ae\u4e00\u7684\u53d7\u9ad4\u4e5f\u8a31\u53ef\u4ee5\u8fa8\u8b58\u597d\u5e7e\u7a2e\u7d30\u80de\u5916\u7684\u6fc0\u7d20\u3002\u6b64\u5916\uff0c\u5b83\u5011\u5728\u7d30\u80de\u5167\u5074\u4e0d\u50c5\u50c5\u8207G-\u86cb\u767d\u4f5c\u7528\uff0c\u5b83\u5011\u4e5f\u53ef\u8207\u88ab\u7a31\u70ba\u652b\u6355\u9176(arrestins)\u7684\u86cb\u767d\u8cea\u4f5c\u7528\u3002\u79d1\u5b78\u5bb6\u958b\u59cb\u8a8d\u8b58\u5230\u9019\u985e\u53d7\u9ad4\u4e0d\u898b\u5f97\u4e00\u5b9a\u8207G-\u86cb\u767d\u5076\u5408\uff0c\u5c0e\u81f4\u79d1\u5b78\u5bb6\u5011\u958b\u59cb\u7a31\u547c\u5b83\u5011\u70ba\u4e03\u8de8\u819c\u86cb\u767d\u8cea(7TM)\uff0c\u56e0\u70ba\u5b83\u5011\u5177\u6709\u4e03\u500b\u87ba\u65cb\u5f62\u7684\u5e36\u5b50\u7e5e\u9032\u7e5e\u51fa\u7d30\u80de\u819c\u3002<\/p>\n<p>\u9019\u4e9b\u53d7\u9ad4\u7684\u6578\u76ee\u548c\u9748\u6d3b\u6027\uff0c\u8ce6\u4e88\u7d30\u80de\u70ba\u4e86\u751f\u547d\u6240\u9700\uff0c\u7d93\u904e\u7cbe\u7d30\u8abf\u63a7\u7a0b\u5e8f\u800c\u5177\u5099\u7684\u8abf\u7bc0\u80fd\u529b\u3002\u6211\u5011\u518d\u56de\u5230\u4e00\u958b\u59cb\u5728\u516c\u8eca\u7ad9\u9003\u8dd1\u7684\u5834\u666f\uff0c\u7576\u8840\u6db2\u6e67\u5165\u4e86\u814e\u4e0a\u817a\u7d20\uff0c\u4e0d\u540c\u7684\u7d44\u7e54\u6703\u6709\u4e0d\u540c\u7684\u53cd\u61c9\u3002\u6d41\u5230\u6d88\u5316\u5668\u5b98\u7684\u8840\u6db2\u6e1b\u5c11\uff1b\u540c\u6642\uff0c\u6d41\u5230\u808c\u8089\u7684\u8840\u6db2\u589e\u52a0\u3002\u814e\u4e0a\u817a\u7d20\u7684\u4e0d\u540c\u6548\u61c9\uff0c\u6709\u8cf4\u65bc\u9ad4\u5167\u81f3\u5c11\u6709\u4e5d\u7a2e\u4e0d\u540c\u7684\u53d7\u9ad4\u5c0d\u6b64\u4e00\u6fc0\u7d20\u767c\u751f\u53cd\u61c9\u3002\u67d0\u4e9b\u53d7\u9ad4\u555f\u52d5\u7d30\u80de\u7684\u6d3b\u52d5\uff0c\u800c\u53e6\u4e00\u4e9b\u5247\u5177\u6709\u93ae\u5b9a\u7684\u4f5c\u7528\u3002<\/p>\n<p>\u6240\u4ee5\u4e0b\u4e00\u6b21\u4f60\u611f\u5230\u5bb3\u6015\u6642\uff0c\u56de\u5473\u4e00\u4e0b\u7f8e\u597d\u98df\u7269\u7684\u5473\u9053\uff0c\u6216\u662f\u55ae\u7d14\u7684\u671b\u5411\u5929\u969b\u7684\u661f\u661f\uff0c\u60f3\u4e00\u4e0b\u4f60\u90a3\u8207G-\u86cb\u767d\u5076\u5408\u7684\u53d7\u9ad4\u3002\u6c92\u6709\u5b83\u5011\uff0c\u4f60\u7684\u7d30\u80de\u5c07\u6703\u76f8\u4e92\u885d\u7a81\uff0c\u6df7\u4e82\u5c07\u63a7\u5236\u4f60\u7684\u8eab\u9ad4\u3002<\/p>\n<p>--<\/p>\n<pre><span style=\"color: #333333;\"> \u5168\u6587\u8f49\u9304\u81ea\uff1a<strong><a href=\"http:\/\/www.ch.ntu.edu.tw\/nobel\/nobel101.htm\">2012\u5e74\u8afe\u8c9d\u723e\u734e\u7c21\u4ecb<\/a><\/strong><\/span><\/pre>\n<pre><span style=\"color: #333333;\"> \u672c\u6587\u8b6f\u81ea\uff1a<strong><a href=\"http:\/\/www.nobelprize.org\/nobel_prizes\/chemistry\/laureates\/2012\/popular.html\">\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u59d4\u54e1\u6703\u516c\u4f48\u7d66\u5927\u773e\u7684\u65b0\u805e\u7a3f<\/a><\/strong><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"<p>\u7ffb\u8b6f \u2223\u8521\u860a\u660e\u8b6f\ufe5d\u53f0\u5927\u5316\u5b78\u7cfb\u540d\u8b7d\u6559\u6388\ufe5e <\/p>\n","protected":false},"author":1,"featured_media":11881,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1027,3293],"tags":[874,177],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/10\/Figure-1_chinese.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/11863"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11863"}],"version-history":[{"count":12,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/11863\/revisions"}],"predecessor-version":[{"id":29247,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/11863\/revisions\/29247"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/11881"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}