{"id":11046,"date":"2012-05-01T10:52:23","date_gmt":"2012-05-01T02:52:23","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=11046"},"modified":"2017-03-31T23:20:26","modified_gmt":"2017-03-31T15:20:26","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e7%82%ba%e5%ad%a9%e5%ad%90%e5%80%91%e9%96%8b%e7%99%bc%e5%87%ba%e6%9b%b4%e5%a5%bd%e7%9a%84%e8%97%a5%e7%89%a9","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=11046","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u70ba\u5b69\u5b50\u5011\u958b\u767c\u51fa\u66f4\u597d\u7684\u85e5\u7269"},"content":{"rendered":"<figure id=\"attachment_11047\" aria-describedby=\"caption-attachment-11047\" style=\"width: 329px\" class=\"wp-caption alignleft\"><a rel=\"attachment wp-att-11047\" href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=11047\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-11047\" title=\"03_12_baby-hand\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/05\/03_12_baby-hand.jpg\" alt=\"\" width=\"329\" height=\"432\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/05\/03_12_baby-hand.jpg 380w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/05\/03_12_baby-hand-228x300.jpg 228w\" sizes=\"(max-width: 329px) 100vw, 329px\" \/><\/a><figcaption id=\"caption-attachment-11047\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/the-scientist.com\/2012\/03\/01\/what-it-takes-to-develop-better-drugs-for-kids\/<\/figcaption><\/figure>\n<p><span style=\"color: #800000;\"><strong>\u25a0\u7814\u7a76\u767c\u73fe\u907a\u50b3\u8207\u74b0\u5883\u56e0\u5b50\u90fd\u6703\u9020\u6210\u5b69\u7ae5\u53ca\u6210\u4eba\u85e5\u7269\u52d5\u529b\u5b78\uff08pharmacokinetics\uff09\u7684\u6539\u8b8a\u3002\u56e0\u6b64\uff0c\u5728\u767c\u5c55\u9069\u5408\u5152\u7ae5\u7684\u85e5\u7269\u6642\uff0c\u6700\u5927\u7684\u6311\u6230\u5728\u65bc\u5fc5\u9808\u5c07\u907a\u50b3\u8b8a\u7570\u3001\u74b0\u5883\u56e0\u5b50\u4ee5\u53ca\u5404\u500b\u767c\u80b2\u968e\u6bb5\u9032\u884c\u85e5\u7269\u4ee3\u8b1d\u4e4b\u5668\u5b98\u7684\u6539\u8b8a\u90fd\u5217\u5165\u8003\u91cf\u3002<\/strong><\/span><\/p>\n<p><strong>\u7de8\u8b6f<\/strong>\u2502\u9ec3\u4f73\u6b23<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u5728\u904e\u53bb\u7684\u5341\u4e94\u5e74\uff0c\u7f8e\u570b\u8207\u6b50\u76df\u5df2\u7d93\u5236\u5b9a\u591a\u9805\u65b0\u7684\u6cd5\u5f8b\u8207\u6cd5\u898f\uff0c\u64f4\u589e\u85e5\u7269\u81e8\u5e8a\u8a66\u9a57\u7684\u5c0d\u8c61\u5fc5\u9808\u5305\u62ec\u00ad\u5152\u7ae5\u5728\u5167\u3002\u5728\u9019\u4e9b\u6cd5\u5f8b\u9812\u5e03\u4e4b\u524d\uff0c\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5141\u8a31\u985e\u4f3c\u75be\u75c5\u8207\u85e5\u7269\u6210\u6548\u80fd\u5920\u5f9e\u6210\u4eba\u7684\u7814\u7a76\u61c9\u7528\u65bc\u5152\u7ae5\u8eab\u4e0a\u3002\u7136\u800c\uff0c\u5152\u7ae5\u7684\u7528\u85e5\u5b89\u5168\u662f\u5426\u80fd\u5920\u5f9e\u6210\u4eba\u7684\u7814\u7a76\u76f4\u63a5\u505a\u5ef6\u4f38\u4f7f\u7528\u7684\u9019\u9805\u7591\u616e\uff0c\u5728\u4ee5\u524d\u4e26\u672a\u7372\u5f97\u5145\u8db3\u7684\u8003\u91cf<sup>1<\/sup>\u3002\u85e5\u7269\u52d5\u529b\u5b78\uff08pharmacokinetics\uff09\u63a2\u8a0e\u85e5\u7269\u5728\u9ad4\u5167\u7684\u52d5\u5411\uff0c\u986f\u793a\u5728\u5b69\u7ae5\u8eab\u4e0a\u8207\u6210\u4eba\u4e4b\u9593\u6709\u660e\u986f\u7684\u5dee\u7570\uff0c\u7279\u5225\u662f\u5728\u4e0d\u540c\u767c\u80b2\u6642\u671f\u7684\u5b69\u7ae5\u4e5f\u5177\u6709\u8b8a\u7570<sup>2<\/sup>\u3002\u8fd1\u4f86\u7684\u7814\u7a76\u767c\u73fe\u907a\u50b3\u8207\u74b0\u5883\u56e0\u5b50\u90fd\u6703\u9020\u6210\u5b69\u7ae5\u53ca\u6210\u4eba\u85e5\u7269\u52d5\u529b\u5b78\u7684\u6539\u8b8a\u3002\u56e0\u6b64\uff0c\u5728\u767c\u5c55\u9069\u5408\u5152\u7ae5\u7684\u85e5\u7269\u6642\uff0c\u6700\u5927\u7684\u6311\u6230\u5728\u65bc\u5fc5\u9808\u5c07\u907a\u50b3\u8b8a\u7570\u3001\u74b0\u5883\u56e0\u5b50\u4ee5\u53ca\u5404\u500b\u767c\u80b2\u968e\u6bb5\u9032\u884c\u85e5\u7269\u4ee3\u8b1d\u4e4b\u5668\u5b98\u7684\u6539\u8b8a\u90fd\u5217\u5165\u8003\u91cf<sup>3<\/sup>\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u9069\u9f61\u5291\u91cf\u6307\u5f15\uff08age-appropriate dosing guidelines\uff09\u5fc5\u9808\u6839\u64da\u5291\u91cf\u5982\u4f55\u8207\u4f9d\u751f\u9577\u767c\u80b2\u6240\u63a5\u53d7\u66b4\u9732\u5291\u91cf\u6539\u8b8a\u7684\u4e92\u52d5\u95dc\u4fc2\u4f86\u505a\u8a55\u4f30\u3002\u4f8b\u5982\u7d30\u80de\u8272\u7d20P450 (cytochrome P450, CYP\uff09\u5bb6\u65cf\u7684\u57fa\u56e0\u7fa4\uff0c\u70ba\u809d\u81df\u4ee3\u8b1d\u85e5\u7269\u7684\u4e3b\u8981\u9175\u7d20\uff0c\u6709\u4e9b\u4e26\u4e0d\u6703\u5728\u80ce\u5152\u7684\u809d\u81df\u8868\u73fe\uff0c\u9700\u8981\u7b49\u5230\u61f7\u5b55\u5f8c\u671f\u6216\u51fa\u751f\u5f8c\u6578\u500b\u5c0f\u6642\u5230\u6578\u5929\u7684\u6642\u9593\u624d\u6703\u767c\u5c55\u800c\u5177\u6709\u529f\u80fd\uff08\u5305\u62ecCYP2C9, CYP2C19, CYP2D6, CYP2E1, \u53caCYP3A4\uff09\uff1b\u7136\u800c\u5176\u4ed6\u57fa\u56e0\u751a\u81f3\u8981\u5230\u767c\u80b2\u7684\u66f4\u665a\u671f\u624d\u6703\u767c\u63ee\u5176\u5b8c\u6574\u7684\u529f\u80fd\uff08\u4f8b\u5982CYP1A2, flavin monooxygenase 3\uff09<sup>4<\/sup>\u3002<!--more-->\u5118\u7ba1\u4e0d\u540c\u767c\u80b2\u6642\u671f\u57fa\u56e0\u8868\u73fe\u7684\u8b8a\u5316\u5728\u5206\u5b50\u6a5f\u5236\u4e0a\u9084\u6c92\u6709\u88ab\u7814\u7a76\u900f\u5fb9\uff0c\u4f46\u662f\u5229\u7528\u52d5\u7269\u7814\u7a76\u6a21\u5f0f\u8207\u5152\u7ae5\u85e5\u7269\u4ee3\u8b1d\u7684\u9ad4\u5916\u7814\u7a76\uff0c\u9084\u662f\u80fd\u5920\u63d0\u4f9b\u597d\u7684\u89c0\u5ff5\u7d66\u6211\u5011\u53c3\u8003\u3002\u8b6c\u5982\u80ce\u5152\u809d\u81df\u7684\u767c\u80b2\u9054\u5230\u6210\u719f\u53ef\u4ee5\u5f9e\u85e5\u7269\u4ee3\u8b1d\u9175\u7d20CYP3A\u57fa\u56e0\u7684\u8868\u73fe\u8f49\u8b8a\u70baCYP3A4\u57fa\u56e0\u4f86\u505a\u78ba\u8a8d\uff1b\u5176\u4e2dCYP3A\u57fa\u56e0\u4e3b\u8981\u662f\u7522\u751f\u96cc\u4e09\u9187\uff08estriol\uff09\uff0c\u9019\u88ab\u8a8d\u70ba\u5728\u61f7\u5b55\u6642\u671f\u8ddf\u80ce\u5152\u5065\u5eb7\u76f8\u95dc\u7684\u5176\u4e2d\u4e00\u7a2e\u96cc\u6fc0\u7d20\uff0c\u800cCYP3A4\u5247\u662f\u5728\u51fa\u751f\u5f8c\u7684\u809d\u81df\u4e2d\u6700\u5927\u91cf\u8868\u73fe\u7684\u7d30\u80de\u8272\u7d20\u57fa\u56e0\u3002\u5728\u5c0f\u767d\u9f20\u7684\u5916\u907a\u50b3\u7814\u7a76\u4e2d\uff0c\u4e5f\u986f\u793a\u5176\u809d\u81df\u6703\u6709\u7d44\u86cb\u767d\u7532\u57fa\u5316\uff08histone methylation\uff09\u72c0\u614b\u7684\u8f49\u63db\uff0c\u5f9e\u65b0\u751f\u80ce\u5152\u7684Cyp3a16\u57fa\u56e0\u6539\u8b8a\u5230\u6210\u9f20\u7684Cyp3a11\u57fa\u56e0\u4e0a<sup>5<\/sup>\u3002\u800c\u7121\u83cc\u74b0\u5883\u4e0b\u751f\u9577\u7684\u8001\u9f20\uff0cCyp3a11\u7684\u6d3b\u6027\u6703\u53d7\u5230\u8178\u9053\u7d30\u83cc\u83cc\u843d\u7684\u8a98\u767c\u3002\u5728\u4eba\u9ad4\u8eab\u4e0a\uff0c\u8178\u9053\u83cc\u76f8\u6703\u5728\u51fa\u751f\u5f8c\u7684\u7b2c\u4e00\u5468\u958b\u59cb\u767c\u5c55\uff0c\u7d93\u904e\u4e00\u5e74\u5f8c\u6703\u8f49\u63db\u8da8\u8fd1\u65bc\u6210\u4eba\u7684\u83cc\u76f8\u7d44\u6210\u3002\u56e0\u6b64\uff0c\u4e0d\u96e3\u60f3\u50cf\u5177\u6709\u4fdd\u8b77\u4f5c\u7528\u7684\u8178\u9053\u5171\u751f\u83cc\u5c07\u6709\u52a9\u65bc\u85e5\u7269\u4ee3\u8b1d\u7684\u76f8\u95dc\u9175\u7d20\u767c\u5c55<sup>6, 7<\/sup>\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u7531\u65bc\u6211\u5011\u7fd2\u6163\u6027\u8a8d\u70ba\u5c0f\u5b69\u7f79\u60a3\u7684\u75c5\u75c7\u8ddf\u6210\u4eba\u985e\u4f3c\u6642\uff0c\u5c31\u63d0\u4f9b\u7d66\u5152\u7ae5\u8ddf\u6210\u4eba\u76f8\u540c\u7684\u7528\u85e5\uff0c\u5982\u6b64\u4e00\u4f86\u5145\u5176\u91cf\u662f\u6c92\u6709\u767c\u63ee\u529f\u6548\uff0c\u66f4\u56b4\u91cd\u7684\u5f8c\u679c\u662f\u5c0d\u5c0f\u5b69\u9020\u6210\u5371\u5bb3\u751a\u81f3\u6b7b\u4ea1\u3002\u8209\u4f8b\u4f86\u8aaa\uff0c\u5e7c\u7ae5\u80c3\u8178\u9053\u57fa\u8cea\u816b\u7624\uff08gastrointestinal stromal tumors, GISTs\uff09\u4e26\u4e0d\u662f\u56e0\u70baKIT\u6216PDGFRA\u7372\u5f97\u529f\u80fd\u7684\u7a81\u8b8a\uff08gain-of-function mutations\uff09\u800c\u8868\u73fe\u52a0\u5f37\u6240\u5c0e\u81f4\uff0c\u5118\u7ba1\u5728\u6210\u4eba\u7684\u816b\u7624\u4e2d\u666e\u904d\u767c\u73fe\u662f\u6e90\u81ea\u9019\u5169\u500b\u57fa\u56e0\u767c\u751f\u7a81\u8b8a\u3002\u9019\u7a2e\u4e0d\u5c0d\u7b49\u7684\u73fe\u8c61\u986f\u793a\u8a72\u764c\u75c7\u767c\u5c55\u53ef\u80fd\u662f\u7531\u4e0d\u540c\u7684\u5206\u5b50\u6a5f\u5236\u6240\u9020\u6210\uff0c\u4e5f\u610f\u5473\u8457\u5152\u7ae5\u5c07\u6e1b\u5c11\u6216\u7f3a\u4e4f\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u88fd\u5291\uff08tyrosine kinase inhibitors\uff09\u7684\u53cd\u61c9\uff0c\u800c\u9019\u662f\u7d93\u5e38\u88ab\u7528\u4f86\u6cbb\u7642\u9019\u985e\u764c\u75c7\u7684\u85e5\u7269\uff0c\u5305\u62ecimatinib\u8207sunitinib<sup>8<\/sup>\u3002\u986f\u7136\u5730\uff0c\u91dd\u5c0d\u5152\u7ae5\u7684\u7814\u7a76\u662f\u8feb\u5207\u9700\u8981\u7684\u3002\u70ba\u6b64\uff0c\u5e0c\u671b\u5f9e\u7814\u7a76\u5e7c\u5152\u75be\u75c5\u6a5f\u5236\u7684\u5206\u5b50\u4e9e\u578b\uff08molecular subtypes\uff09\u4ee5\u53d6\u5f97\u66f4\u512a\u8cea\u7684\u85e5\u7269\u6cbb\u7642\u8cc7\u8a0a\u4e5f\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u6700\u5f8c\u8981\u63d0\u5230\u7684\u662f\u76ee\u524d\u7121\u6cd5\u78ba\u8a8d\u5982\u679c\u6539\u8b8a\u85e5\u7269\u539f\u672c\u7684\u5291\u578b\u8207\u5473\u9053\u4f86\u7528\u5728\u5152\u7ae5\u8eab\u4e0a\u662f\u5426\u4ecd\u5177\u6709\u7642\u6548<sup>9<\/sup>\u3002\u6240\u5e78\u6709\u65b0\u7684\u79d1\u5b78\u6280\u8853\u7814\u767c\u51fa\u4e0d\u540c\u53e3\u611f\u8207\u5473\u9053\u7528\u65bc\u85e5\u7269\u958b\u767c\u7684\u5291\u578b\u4e0a\uff0c\u80fd\u5920\u8b93\u5152\u7ae5\u63d0\u9ad8\u5c0d\u85e5\u5291\u7684\u63a5\u53d7\u7a0b\u5ea6\uff0c\u5c24\u5176\u7576\u4ed6\u5011\u9084\u6c92\u5b78\u6703\u5982\u4f55\u541e\u4e0b\u81a0\u56ca\u6642\u3002\u5176\u4e2d\u4e00\u7a2e\u7b56\u7565\u662f\u6539\u8b8a\u5316\u5b78\u85e5\u7269\u672c\u8eab\u7684\u7279\u6027\uff0c\u900f\u904e\u82e6\u5473\u62ee\u6297\u5291\u4f86\u7d50\u5408\u82e6\u5473\u53d7\u5668\u6216\u662f\u5e72\u64fe\u82e6\u5473\u7684\u611f\u53d7\u5ea6\uff0c\u8a66\u5716\u6291\u5236\u6216\u662f\u906e\u84cb\u85e5\u5291\u9020\u6210\u7684\u82e6\u611f\u5473\u89ba\u3002\u7279\u5225\u503c\u5f97\u4e00\u63d0\u7684\u662f\u6709\u4e9b\u7814\u7a76\u6307\u51fa\u5152\u7ae5\u5c0d\u65bc\u82e6\u5473\u7684\u5473\u89ba\u611f\u53d7\u662f\u6975\u5ea6\u654f\u611f\u7684<sup>10, 11<\/sup>\u3002\u4f46\u662f\uff0c\u5c0d\u65bc\u82e6\u5473\u611f\u53d7\u6027\u96a8\u6210\u9577\u800c\u6709\u6539\u8b8a\u662f\u53d7\u5230\u57fa\u56e0\u578b\u6c7a\u5b9a\uff0c\u56e0\u6b64\u4e0d\u662f\u6bcf\u4f4d\u5c0f\u5b69\u90fd\u6709\u76f8\u540c\u7a0b\u5ea6\u7684\u82e6\u611f\u5473\u89ba\u3002\u5728\u904e\u53bb\u768410\u523015\u5e74\u9593\uff0c\u5df2\u7d93\u9010\u6f38\u5730\u91cd\u8996\u5230\u5c0f\u5b69\u5c0d\u65bc\u85e5\u7269\u7684\u4ee3\u8b1d\u8207\u53cd\u61c9\u8ddf\u6210\u4eba\u6709\u5f88\u5927\u7684\u4e0d\u540c\u4e4b\u8655\u3002\u6700\u8fd1\u9084\u6709\u8a31\u591a\u5be6\u9a57\u8b49\u5be6\u5152\u7ae5\u8207\u6210\u4eba\u76f8\u4f3c\u75be\u75c5\u53ef\u80fd\u5728\u5206\u5b50\u5c64\u6b21\u4e0a\u5b58\u5728\u4e86\u6839\u672c\u4e0a\u7684\u5dee\u7570\u3002\u96d6\u7136\u7576\u524d\u85e5\u7269\u7684\u767c\u5c55\u6a21\u5f0f\uff0c\u7279\u5225\u91dd\u5c0d\u5152\u7ae5\u7684\u85e5\u7269\u8a66\u9a57\u5728\u7d93\u6fdf\u9762\u4e0a\u7121\u6cd5\u5be6\u969b\u9032\u884c\uff0c\u4f46\u662f\u5c0d\u5152\u7ae5\u75c5\u7a0b\u7684\u7d30\u80de\u8a0a\u606f\u50b3\u5c0e\u8207\u751f\u7269\u7db2\u7d61\u57fa\u790e\u9032\u884c\u6df1\u5165\u7814\u7a76\u7684\u52aa\u529b\u4e4b\u4e0b\uff0c\u6216\u8a31\u80fd\u5920\u5f9e\u958b\u767c\u7d66\u6210\u4eba\u7684\u65b0\u85e5\u7269\u4e2d\u627e\u5230\u76f8\u8fd1\u7684\u4f5c\u7528\u6a19\u9776\u6a5f\u5236\uff0c\u4ee5\u61c9\u7528\u5728\u5152\u7ae5\u75be\u75c5\u4e0a\u3002<br \/>\n--<br \/>\n\u53c3\u8003\u6587\u737b<br \/>\n1.\tR. Steinbrook, \u201cTesting medications in children,\u201d New Engl J Med, 347:1462-70, 2002.<br \/>\n2.\tR. Johann-Liang et al.,\u201dPediatric drug surveillance and the food and drug administration\u2019s adverse event reporting system: an overview of reports, 2003-2007,\u201d Pharmacoepidemiol. Drug Safety, 18: 24-27, 2009.<br \/>\n3.\tG.L. Kearns et al., \u201cDevelopmental Pharmacology \u2014 Drug Disposition, Action, and Therapy in Infants and Children,\u201d New Engl J Med, 349:1157-67, 2003.<br \/>\n4.\tR.N. Hines, \u201cThe ontogeny of drug metabolism enzymes and implications for adverse drug events,\u201d Pharmacol Ther, 118:250-67, 2008.<br \/>\n5.\tY. Li et al., \u201cDynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation,\u201d Mol Pharmacol, 75:1171-79, 2009.<br \/>\n6.\tS.P. Claus et al., \u201cColonization-induced host-gut microbial metabolic interaction,\u201d mBio, 2: e00271-00210, 2011.<br \/>\n7.\tC. Palmer et al., \u201cDevelopment of the Human Infant Intestinal Microbiota,\u201d PLoS Biol, 5: e177,2007.<br \/>\n8.\tL. Rink, A.K. Godwin, \u201cClinical and molecular characteristics of gastrointestinal stromal tumor in the pediatric and young adult population,\u201d Curr Oncol Rep, 11:314-21, 2009.<br \/>\n9.\tJ.A. Mennella, G.K. Beauchamp, \u201cOptimizing oral medications for children,\u201d Clin Ther, 30:2120-32, 2008.<br \/>\n10.\tJ.A. Mennella et al., \u201cGenetic and environmental determinants of bitter perception and sweet preferences,\u201d Pediatrics, e216-e222, 2005.<br \/>\n11.\tJ.A. Mennella et al.,\u201dAge modifies the genotype-phenotype relationship for the bitter taste receptor TAS2R38,\u201d BMC Genetics, 11:60, 2010.<br \/>\n--<\/p>\n<pre><span style=\"color: #333333;\"> \u7814\u7a76\u51fa\u8655\uff1a<strong><a href=\"What it Takes to Develop Better Drugs for Kids \">What it Takes to Develop Better Drugs for Kids<\/a><\/strong><\/span><\/pre>\n<pre><span style=\"color: #333333;\"> \u63a8\u85a6\u95b1\u8b80\uff1a<strong><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=9444\">\u3010\u91ab\u85e5\u5316\u5b78\u3011\u5929\u7136\u311f\u5c1a\u597d \u99ac\u8e44\u82b1\u6b62\u75db\u5291\u5408\u6210\u6210\u529f<\/a><\/strong><\/span><\/pre>\n<p><span style=\"color: #333399;\"><strong><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita  Hsu<\/strong><\/strong><\/span><\/p>\n<p><span style=\"color: #333399;\"><strong><strong><a rel=\"attachment wp-att-11057\" href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=11057\"><img decoding=\"async\" class=\"alignleft size-full wp-image-11057\" title=\"kid\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/05\/kid.png\" alt=\"\" width=\"140\" height=\"140\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/05\/kid.png 234w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2012\/05\/kid-150x150.png 150w\" sizes=\"(max-width: 140px) 100vw, 140px\" \/><\/a><br \/>\n<\/strong><\/strong><\/span><\/p>\n<p><span style=\"color: #333399;\"><strong><strong><br \/>\n<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u7814\u7a76\u767c\u73fe\u907a\u50b3\u8207\u74b0\u5883\u56e0\u5b50\u90fd\u6703\u9020\u6210\u5b69\u7ae5\u53ca\u6210<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/11046"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11046"}],"version-history":[{"count":15,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/11046\/revisions"}],"predecessor-version":[{"id":11050,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/11046\/revisions\/11050"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}