{"id":10555,"date":"2012-01-30T17:05:44","date_gmt":"2012-01-30T09:05:44","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=10555"},"modified":"2017-03-31T23:20:30","modified_gmt":"2017-03-31T15:20:30","slug":"%e3%80%90%e7%94%9f%e7%89%a9%e9%86%ab%e5%ad%b8%e3%80%91%e7%8c%b4%e9%a1%9e%e7%96%ab%e8%8b%97%e8%a3%a1%e9%98%bb%e6%ad%a2%e6%84%9b%e6%bb%8b%e7%97%85%e6%af%92%e7%9a%84%e3%80%8c%e6%a0%aa%e3%80%8d%e7%b5%b2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=10555","title":{"rendered":"\u3010\u751f\u7269\u91ab\u5b78\u3011\u7334\u985e\u75ab\u82d7\u88e1\u963b\u6b62\u611b\u6ecb\u75c5\u6bd2\u7684\u300c\u682a\u300d\u7d72\u99ac\u8de1"},"content":{"rendered":"

\u25a0\u4e00\u9805\u7334\u985e\u75ab\u82d7\u7814\u7a76\u53ef\u4ee5\u5e6b\u52a9\u7814\u7a76\u4eba\u54e1\u958b\u767c\u4eba\u985e\u75ab\u82d7\u3002<\/strong><\/span><\/p>\n

\"\"<\/a>
\u5716\u7247\u4f86\u6e90\uff1aL. BROWN\/LONELY PLANET IMAGES\/GETTY<\/figcaption><\/figure>\n

\u7de8\u8b6f<\/strong>\u2502\u5f35\u5b5d\u8018<\/p>\n

      \u6709\u4e00\u7a2e\u7334\u985e\u75c5\u6bd2\u75ab\u82d7\u53ef\u63d0\u4f9b\u6230\u52dd\u4eba\u985e\u611b\u6ecb\u75c5\u6bd2\u7684\u7dda\u7d22\u3002\u79d1\u5b78\u5bb6\u5df2\u88fd\u9020\u51fa\u4e00\u7a2e\u75ab\u82d7\u53ef\u4ee5\u9632\u6b62\u6046\u6cb3\u7334\u611f\u67d3\u4e00\u7a2e\u9ad8\u6d3b\u6027\u7684\u7334\u985e\u514d\u75ab\u4e0d\u5168\u75c5\u6bd2(simian immunodeficiency virus\uff0c\u4ee5\u4e0b\u7c21\u7a31SIV)\uff0c\u9019\u7a2e\u75c5\u6bd2\u662f\u4eba\u985e\u611b\u6ecb\u75c5\u6bd2(\u4ee5\u4e0b\u7c21\u7a31HIV)\u7684\u9060\u89aa\u3002<\/p>\n

      \u904e\u53bb\u66fe\u6709\u958b\u767c\u6210\u529f\u7684SIV\u75ab\u82d7\uff0c\u4f46\u662f\u5176\u9810\u9632\u6548\u679c\u5df2\u8b49\u660e\u96e3\u4ee5\u8f49\u79fb\u5230HIV\u4e0a\u3002\u79d1\u5b78\u5bb6\u5e0c\u671b\u6700\u8fd1\u7684\u7814\u7a76\u7d50\u679c(\u520a\u767b\u5728\u4e00\u6708\u4efd\u300a\u81ea\u7136\u300b\u7db2\u8def\u671f\u520a\u4e0a1<\/sup><\/a>)\u548c\u4eba\u985e\u75ab\u82d7\u5be6\u9a57\u6709\u9650\u7684\u767c\u73fe2<\/sup><\/a>\uff0c\u80fd\u5920\u6307\u51fa\u767c\u5c55\u6709\u6548\u7684HIV\u75ab\u82d7\u7684\u65b9\u5411\u3002<\/p>\n

      \u5e03\u9b6f\u65af\u2027\u6c83\u514b(Bruce Walker)\u662f\u4f4d\u65bc\u6ce2\u58eb\u9813\u7684\u9ebb\u85a9\u8af8\u585e\u5dde\u7d9c\u5408\u91ab\u9662\u3001\u9ebb\u7701\u7406\u5de5\u5b78\u9662\u548c\u54c8\u4f5b\u5927\u5b78\u7684\u96f7\u6839\u7814\u7a76\u6240(Ragon Institute of MGH, MIT and Harvard)\u7684\u75c5\u6bd2\u5b78\u5bb6\uff0c\u4ed6\u4e26\u6c92\u6709\u53c3\u8207\u8a72\u7814\u7a76\uff0c\u4f46\u4ed6\u8868\u793a\uff0c\u300c\u5728\u6211\u770b\u4f86\uff0c\u5982\u679c\u5c0d\u7334\u5b50\u53ef\u80fd\u7684\u8a71\uff0c\u4e00\u5b9a\u5c0d\u4eba\u985e\u4e5f\u53ef\u80fd\u3002\u300d<\/p>\n

      \u4e39\u2027\u5df4\u82e5\u8a31(Dan Barouch)\u662f\u6ce2\u58eb\u9813\u8c9d\u65af\u4ee5\u8272\u5217\u5973\u57f7\u4e8b\u91ab\u7642\u4e2d\u5fc3(Beth Israel Deaconess Medical Center)\u7684\u75c5\u6bd2\u5b78\u5bb6\uff0c\u4e5f\u662f\u4e0a\u8ff0\u6700\u65b0\u8ad6\u6587\u7684\u4e3b\u8981\u4f5c\u8005\u3002\u4ed6\u8aaa\uff0c\u7531\u65bcHIV\u4e0d\u6703\u8b93\u7334\u5b50\u81f4\u75c5\uff0c\u6240\u4ee5SIV\u662f\u9032\u884c\u4eba\u9ad4\u5be6\u9a57\u524d\u6700\u597d\u7684\u75ab\u82d7\u8a55\u4f30\u6a21\u578b\u3002\u904e\u53bb\u7684SIV\u75ab\u82d7\u53ea\u80fd\u4fdd\u8b77\u737c\u7334\u4e0d\u6703\u611f\u67d3\u7528\u4f86\u88fd\u4f5c\u8a72\u75ab\u82d7\u7684\u90a3\u7a2e\u75c5\u6bd2\uff0c\u6216\u8005\u662f\u5f88\u5bb9\u6613\u88ab\u6bba\u6b7b\u7684SIV\u75c5\u682a\u3002<\/p>\n

      \u5df4\u82e5\u8a31\u7684\u7814\u7a76\u5718\u968a\u66ff\u6046\u6cb3\u737c\u7334\uff08Macaca mulatta<\/em>\uff09\u6ce8\u5c04\u6578\u7a2e\u4e0d\u540c\u7684\u5169\u968e\u6bb5\u75ab\u82d7\uff0c\u7b2c\u4e00\u5291\u662f\u7d93\u904e\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u5f8c\u5e36\u6709SIV\u57fa\u56e0\u7684\u75c5\u6bd2\uff0c\u4f5c\u70ba\u4e3b\u5291(prime)\uff0c\u534a\u5e74\u5f8c\u518d\u6ce8\u5c04\u542b\u6709\u53e6\u5916\u4e00\u7a2e\u5177\u76f8\u540c\u57fa\u56e0\u8868\u73fe\u7684\u75c5\u6bd2\u4f5c\u70ba\u8ffd\u52a0\u5291(boost)\u3002\u516d\u500b\u6708\u4e4b\u5f8c\uff0c\u5df4\u82e5\u8a31\u7684\u7814\u7a76\u5718\u968a\u8b93\u9019\u4e9b\u7334\u5b50\u611f\u67d3\u53e6\u5916\u4e00\u7a2eSIV\u75c5\u682a\uff0c\u9019\u7a2e\u75c5\u682a\u4e0d\u540c\u65bc\u7528\u4f86\u88fd\u4f5c\u75ab\u82d7\u7684\u75c5\u6bd2\uff0c\u800c\u4e14\u7334\u5b50\u5c0d\u5176\u5f88\u96e3\u7522\u751f\u6709\u6548\u7684\u514d\u75ab\u529b\u3002<\/p>\n

      \u5176\u4e2d\uff0c\u4ee5\u817a\u75c5\u6bd2\u70ba\u9996\u5291(adenovirus prime)\uff0c\u52a0\u4e0a\u57fa\u56e0\u6539\u9020\u904e\u7684\u75d8\u75c5\u6bd2\u70ba\u8ffd\u52a0\u5291(modified-pox-virus boost) \u662f\u963b\u6b62\u611f\u67d3\u6700\u6709\u6548\u7684\u4e00\u652f\u75ab\u82d7\u3002\u6c92\u6709\u63a5\u7a2e\u8a72\u75ab\u82d7\u7684\u7334\u5b50\u5728\u9996\u6b21\u66b4\u9732\u65bcSIV\u5f8c\u6709\u56db\u5206\u4e4b\u4e09\u88ab\u611f\u67d3\uff0c\u800c\u6709\u63a5\u7a2e\u7684\u7334\u5b50\u53ea\u670912% \u88ab\u611f\u67d3\u3002<\/p>\n

      \u5df4\u82e5\u8a31\u7684\u7814\u7a76\u5718\u968a\u6301\u7e8c\u8b93\u7334\u5b50\u6bcf\u9694\u4e00\u9031\u66b4\u9732\u5728SIV\u4e4b\u4e0b\uff0c\u6700\u5f8c\u5927\u591a\u6578\u63a5\u7a2e\u75ab\u82d7\u7684\u7334\u5b50\u90fd\u9084\u662f\u611f\u67d3\u4e86\u75c5\u6bd2\uff0c\u4f46\u662f\u7814\u7a76\u4eba\u54e1\u8a08\u7b97\u51fa\u9019\u652f\u6700\u6709\u6548\u7684\u75ab\u82d7\uff0c\u8b93\u52d5\u7269\u55ae\u6b21\u66b4\u9732\u65bcSIV\u5f8c\u611f\u67d3\u7684\u6a5f\u6703\u964d\u4f4e\u4e8680% \u4ee5\u4e0a\u3002<\/p>\n

\u555f\u52d5\u6297\u9ad4 <\/strong><\/p>\n

      \u70ba\u4e86\u627e\u51fa\u75ab\u82d7\u767c\u751f\u4f5c\u7528\u7684\u539f\u56e0\uff0c\u7814\u7a76\u4eba\u54e1\u5206\u6790\u4e86\u5e7e\u5341\u7a2e\u7334\u5b50\u514d\u75ab\u53cd\u61c9\u7684\u7279\u5fb5\u3002\u4ed6\u5011\u767c\u73fe\u6700\u4e0d\u5bb9\u6613\u88ab\u611f\u67d3\u7684\u662f\u90a3\u4e9b\u9ad4\u5167\u88fd\u9020\u51fa\u6700\u591a\u6703\u5438\u9644\u5728\u75c5\u6bd2\u5957\u819c\u86cb\u767d('envelope' protein)\u4e0a\u7684\u6297\u9ad4\u7684\u7334\u5b50\u3002\u800c\u4e00\u4e9b\u88ab\u611f\u67d3\u4f46\u75c5\u6bd2\u6fc3\u5ea6\u5f88\u4f4e\u7684\u7334\u5b50\u9ad4\u5167\uff0c\u5247\u767c\u73fe\u5c0d\u5957\u819c\u86cb\u767d\u4ee5\u53ca\u53e6\u5916\u4e00\u7a2e\u7a31\u70baGag\u7684SIV\u75c5\u6bd2\u86cb\u767d\u6709\u4e0d\u540c\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n

      \u5176\u4ed6\u5e0c\u671b\u80fd\u88fd\u9020\u51faHIV\u75ab\u82d7\u7684\u7814\u7a76\u5718\u9ad4\u975e\u5e38\u95dc\u5fc3\u9019\u9805\u7814\u7a76\u7684\u7d50\u679c\u3002\u5df4\u82e5\u8a31\u8aaa\uff1a\u300c\u4ed6\u5011\u63d0\u4f9b\u4e86\u4eca\u5f8c\u8a72\u5982\u4f55\u505a\u75ab\u82d7\u6e2c\u8a66\uff0c\u4ee5\u53ca\u6211\u5011\u5e0c\u671b\u75ab\u82d7\u80fd\u5f15\u767c\u4f55\u7a2e\u53cd\u61c9\u7684\u4e00\u500b\u85cd\u5716\u3002\u300d<\/p>\n

      \u5df4\u82e5\u8a31\u8868\u793a\uff0c\u7334\u5b50\u75ab\u82d7\u5be6\u9a57\u4e2d\u7684\u67d0\u4e9b\u514d\u75ab\u53cd\u61c9\uff0c\u4e5f\u5728\u76ee\u524d\u552f\u4e00\u80fd\u9810\u9632\u611b\u6ecb\u75c5\u7684\u4eba\u9ad4HIV\u75ab\u82d7\u5be6\u9a57\u4e2d\u770b\u5230\u3002RV144\u5be6\u9a57(\u4e5f\u7a31\u70ba\u300c\u6cf0\u570b\u5be6\u9a57\u300d\uff0cThai trial)\u8a08\u756b\u7684\u4e3b\u6301\u4eba\u65bc2009\u5e74\u5831\u544a\u6307\u51fa\uff0c2<\/sup><\/a>\u4ed6\u5011\u7684\u6df7\u5408\u75ab\u82d7\u628a\u611f\u67d3HIV\u7684\u6a5f\u6703\u964d\u4f4e\u4e8630%\u3002\u6c92\u6709\u611f\u67d3HIV\u7684\u53d7\u8a66\u8005\u4e5f\u901a\u5e38\u6703\u88fd\u9020\u51fa\u9ad8\u6fc3\u5ea6\u7684\u5c0d\u6297HIV\u5957\u819c\u86cb\u767d\u7684\u6297\u9ad4\u3002(\u8acb\u898b\u3008\u611b\u6ecb\u75ab\u82d7\u5be6\u9a57\u6210\u529f\u9996\u4f8b\u7684\u53ef\u80fd\u539f\u56e0<\/a>\u3009)<\/p>\n

      RV144\u5be6\u9a57\u7684\u5f8c\u7e8c\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u800c\u6c83\u514b\u7684\u5718\u968a\u6b63\u5728\u70ba\u4e00\u500b\u5357\u975eHIV\u75ab\u82d7\u5be6\u9a57\u7c4c\u8cc7\u3002\u6c83\u514b\u4f7f\u7528\u7684HIV\u75ab\u82d7\u548c\u5df4\u82e5\u8a31\u7684SIV\u75ab\u82d7\u57fa\u672c\u4e0a\u76f8\u540c\uff0c\u4ed6\u8aaa\uff1a\u300c\u6211\u60f3\u672a\u4f86\u5e7e\u5e74\u6211\u5011\u9700\u8981\u4e0d\u65b7\u591a\u6b21\u7684\u5617\u8a66\u624d\u80fd\u6210\u529f\u9054\u9663\u3002\u300d<\/p>\n

      \u502b\u6566\u5927\u5b78\u5b78\u9662(University College London)\u7684\u75c5\u6bd2\u5b78\u5bb6\u7f85\u8cd3\u2027\u9b4f\u65af(Robin Weiss)\uff0c\u7a31\u9019\u500b\u7814\u7a76\u662f\u500b\u300c\u6709\u8da3\u7684\u767c\u5c55\u300d\uff0c\u4f46\u662f\u4ed6\u5e0c\u671b\u8a72\u7814\u7a76\u80fd\u8b49\u660e\u5176SIV\u75ab\u82d7\u53ef\u4ee5\u62b5\u6297\u4e0d\u53ea\u4e00\u7a2eSIV\u75c5\u682a\u3002<\/p>\n

      \u4f4d\u65bc\u99ac\u91cc\u862d\u5dde\u8c9d\u585e\u65af\u9054\u7684\u7f8e\u570b\u570b\u5bb6\u904e\u654f\u548c\u50b3\u67d3\u75c5\u7814\u7a76\u6240(US National Institute of Allergy and Infectious Diseases in Bethesda, Maryland)\u6240\u9577\u5b89\u6771\u5c3c\u2027\u5085\u897f(Anthony Fauci)\u8868\u793a\uff0c\u6211\u5011\u5c0d\u65bc\u9019\u500bSIV\u75c5\u6bd2\u7814\u7a76\u7684\u7d50\u679c\uff0c\u61c9\u8a72\u8981\u6709\u6240\u4fdd\u7559\uff0c\u56e0\u70ba\u8a72\u7814\u7a76\u662f\u4ee5\u52d5\u7269\u70ba\u5c0d\u8c61\uff0c\u800c\u4e0d\u662f\u4eba\u985e\u3002\u4f46\u662f\u8a72\u7814\u7a76\u7d50\u679c\u548cRV144\u5be6\u9a57\u6216\u5176\u4ed6\u7814\u7a76\u767c\u73fe\u7d50\u5408\u4ee5\u5f8c\uff0c\u4f3c\u4e4e\u6307\u51fa\u6709\u4e9b\u4eba\u53ef\u4ee5\u5c0dHIV\u7522\u751f\u5f37\u5927\u7684\u514d\u75ab\u53cd\u61c9\uff0c3<\/sup><\/a>, <\/sup>4<\/sup><\/a>\u5728\u9019\u4e00\u9ede\u4e0a\u7d66\u4e86\u6211\u5011\u6a02\u89c0\u7684\u7406\u7531\u3002\u5085\u897f\u8aaa\uff1a\u300c\u5927\u5bb6\u666e\u904d\u89ba\u5f97\u6211\u5011\u76ee\u524d\u7684\u65b9\u5411\u662f\u5c0d\u7684\u3002\u300d
\n--<\/p>\n

 \u7814\u7a76\u51fa\u8655\uff1aMonkey vaccine hints at how to stop HIV<\/a><\/strong><\/span><\/pre>\n
 \u5ef6\u4f38\u95b1\u8b80\uff1a\u3010\u91ab\u5b78\u65b0\u77e5\u3011\u8c93\u611b\u6ecb\u7684\u57fa\u56e0\u9ad4\u7642\u6cd5<\/a><\/strong><\/span><\/pre>\n
\u8cac\u4efb\u7de8\u8f2f\uff1aNita  Hsu<\/strong><\/strong><\/span><\/p>\n
\"\"<\/a>
\n<\/strong><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"
\u25a0\u4e00\u9805\u7334\u985e\u75ab\u82d7\u7814\u7a76\u53ef\u4ee5\u5e6b\u52a9\u7814\u7a76\u4eba\u54e1\u958b\u767c\u4eba<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,26,1025],"tags":[254,751,27],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10555"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10555"}],"version-history":[{"count":13,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10555\/revisions"}],"predecessor-version":[{"id":10571,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10555\/revisions\/10571"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}