{"id":10326,"date":"2011-12-07T16:09:37","date_gmt":"2011-12-07T08:09:37","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=10326"},"modified":"2017-03-31T23:20:35","modified_gmt":"2017-03-31T15:20:35","slug":"%e3%80%90%e5%8c%96%e5%ad%b8%e5%a4%a7%e6%9c%aa%e4%be%86%e3%80%91%e9%a1%9e%e5%9b%ba%e9%86%87%e8%8d%b7%e7%88%be%e8%92%99-%e7%94%9f%e5%91%bd%e7%9a%84%e9%a9%85%e5%8b%95%e7%a8%8b%e5%bc%8f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=10326","title":{"rendered":"\u3010\u5316\u5b78\u5927\u672a\u4f86\u3011\u985e\u56fa\u9187\u8377\u723e\u8499\u2014\u2014\u751f\u547d\u7684\u9a45\u52d5\u7a0b\u5f0f"},"content":{"rendered":"<p><strong><span style=\"color: #333399;\"><strong>\u25a0<\/strong>\u79d1\u5b78\u7684\u57fa\u790e\u662f\u5065\u5eb7\u7684\u8eab\u9ad4\u3002-----\u5c45\u91cc\u592b\u4eba<\/span><\/strong><\/p>\n<figure id=\"attachment_10327\" aria-describedby=\"caption-attachment-10327\" style=\"width: 513px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=10327\" rel=\"attachment wp-att-10327\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-10327\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/12\/128899453.jpg\" alt=\"\" width=\"513\" height=\"334\"><\/a><figcaption id=\"caption-attachment-10327\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1a David W. Hamilton \u2502Getty Images<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587<\/strong> | \u67ef\u662d\u5100<\/p>\n<p>\u9084\u8a18\u5f97\u300c\u683c\u5217\u4f5b\u904a\u8a18\u300d\u7ae5\u8a71\u55ce\uff1f\u66f8\u4e2d\u90a3\u4f4d\u559c\u6b61\u5230\u8655\u65c5\u884c\u7684\u683c\u5217\u4f5b\u91ab\u5e2b\uff0c\u5728\u822a\u9014\u4e2d\u9047\u5230\u72c2\u98a8\u66b4\u96e8\uff0c\u5148\u5f8c\u6f02\u6d41\u5230\u300c\u5c0f\u4eba\u570b\u300d\u548c\u300c\u5de8\u4eba\u570b\u300d\uff0c\u56e0\u800c\u767c\u751f\u4e00\u9023\u4e32\u9a5a\u96aa\u7684\u906d\u9047\uff0c\u5176\u4e2d\u6700\u6559\u8b80\u8005\u4e0d\u53ef\u601d\u8b70\u7684\u7576\u7136\u8981\u7b97\u662f\u4ed6\u8207\u5de8\u4eba\u3001\u77ee\u4eba\u751f\u6d3b\u7684\u7a2e\u7a2e\u8da3\u4e8b\u3002\u5f9e\u73fe\u4ee3\u91ab\u5b78\u7684\u89d2\u5ea6\u4f86\u770b\uff0c\u5de8\u4eba\u75c7\u53ca\u4f8f\u5112\u75c7\u90fd\u662f\u8377\u723e\u8499\u5206\u6ccc\u4e0d\u6b63\u5e38\u6240\u5f15\u8d77\u7684\u75be\u75c5\uff1b\u4eba\u9ad4\u7684\u8166\u4e0b\u5782\u9ad4\u6703\u88fd\u9020\u4e00\u7a2e\u5f71\u97ff\u8eab\u9ad8\u589e\u9577\u7684\u8377\u723e\u8499\u2015\u751f\u9577\u6fc0\u7d20\uff0c\u4e00\u65e6\u751f\u9577\u6fc0\u7d20\u5206\u6ccc\u904e\u91cf\u5c31\u6703\u5c0e\u81f4\u5de8\u4eba\u75c7\uff0c\u7f3a\u4e4f\u5247\u6703\u9020\u6210\u4f8f\u5112\u75c7\uff0c\u4e8b\u5be6\u4e0a\u8377\u723e\u8499\u5c0d\u5065\u5eb7\u7684\u5f71\u97ff\u4e0d\u50c5\u65bc\u6b64\uff0c\u6709\u4e9b\u8377\u723e\u8499\u638c\u63a7\u9752\u6625\u671f\u3001\u66f4\u5e74\u671f\u7684\u751f\u7406\u8b8a\u5316\uff0c\u6709\u7684\u5247\u8207\u9ad4\u91cd\u3001\u4ee3\u8b1d\u3001\u751f\u80b2\u606f\u606f\u76f8\u95dc\uff0c\u4ee4\u4eba\u96e3\u4ee5\u7f6e\u4fe1\u7684\u662f\u5c0d\u67d0\u4e9b\u751f\u7269\u800c\u8a00\uff0c\u8377\u723e\u8499\u65e9\u5728\u80da\u80ce\u6642\u671f\u5c31\u958b\u59cb\u65bd\u5c55\u5b83\u90a3\u7121\u9060\u5f17\u5c46\u7684\u5f71\u97ff\u529b\uff01<\/p>\n<p>\u4e2d\u7814\u9662\u5206\u5b50\u751f\u7269\u6240\u7684\u937e\u90a6\u67f1\u535a\u58eb\u7814\u7a76\u985e\u56fa\u9187\u8377\u723e\u8499\u8207\u767c\u80b2\u4e4b\u9593\u7684\u95dc\u4fc2\u5df2\u6709\u4e8c\u5341\u5e74\uff0c\u5979\u8207\u5be6\u9a57\u5718\u968a\u5de7\u5999\u69cb\u601d\u4e0d\u540c\u52d5\u7269\u6a21\u5f0f\u7684\u5be6\u9a57\uff0c\u7814\u7a76\u985e\u56fa\u9187\u8377\u723e\u8499\u5728\u80da\u80ce\u3001\u767c\u80b2\u3001\u751f\u7406\u53ca\u7b49\u4e0d\u540c\u751f\u547d\u968e\u6bb5\u6240\u626e\u6f14\u7684\u89d2\u8272\u8207\u8abf\u63a7\u6a5f\u5236\uff0c\u6975\u4f73\u7684\u7814\u7a76\u6210\u679c\u4e5f\u88ab\u8457\u540d\u7684\u201c\u81ea\u7136\u201d\u671f\u520a\u6240\u520a\u767b\uff0c\u5c0d\u65bc\u53f0\u7063\u5b78\u8853\u7814\u7a76\u5728\u570b\u969b\u80fd\u898b\u5ea6\u7684\u63d0\u5347\u8ca2\u737b\u5353\u8d8a\u3002\u5728\u570b\u969b\u5316\u5b78\u5e74\u5373\u5c07\u843d\u5e55\u524d\uff0c\u937e\u535a\u58eb\u70ba\u300c\u5316\u5b78\u5927\u672a\u4f86\u300d\u5e36\u4f86\u5979\u5728\u985e\u56fa\u9187\u8377\u723e\u8499\u7814\u7a76\u9818\u57df\u7684\u8c50\u78a9\u6210\u679c\uff0c\u5f9e\u73fe\u5834\u89c0\u773e\u71b1\u7d61\u7684\u63d0\u554f\u4e0d\u96e3\u770b\u51fa\u4e00\u822c\u5927\u773e\u5c0d\u65bc\u985e\u56fa\u9187\u65e2\u671f\u5f85\u53c8\u6015\u53d7\u50b7\u5bb3\u7684\u77db\u76fe\u5fc3\u60c5\uff0c\u937e\u6559\u6388\u9664\u4e86\u5256\u6790\u985e\u56fa\u9187\u8377\u723e\u8499\u8207\u5065\u5eb7\u7684\u77e5\u8b58\u5916\uff0c\u5979\u4e5f\u544a\u8a34\u5927\u5bb6\u5316\u5b78\u662f\u81ea\u7136\u79d1\u5b78\u7684\u57fa\u790e\u79d1\u5b78\uff0c\u5316\u5b78\u4eba\u5c0d\u65bc\u589e\u9032\u4eba\u985e\u798f\u7949\u8981\u6709\u8cac\u7121\u65c1\u8cb8\u7684\u4f7f\u547d\u611f\u3002<!--more--><\/p>\n<p><strong>\u985e\u56fa\u9187\u8377\u723e\u8499\u7684\u4e00\u4e8c\u4e8b<\/strong><\/p>\n<p>\u985e\u56fa\u9187\u8377\u723e\u8499\u662f\u4eba\u9ad4\u751f\u7406\u6240\u9700\u7684\u5fae\u91cf\u7269\u8cea\uff0c\u4eba\u9ad4\u539f\u672c\u5c31\u6703\u81ea\u884c\u5206\u6ccc\uff0c\u5178\u578b\u7684\u751f\u6210\u5668\u5b98\u70ba\u814e\u4e0a\u817a\u53ca\u6027\u817a\uff08\u5375\u5de2\u3001\u80ce\u76e4\u53ca\u776a\u4e38\uff09\uff0c\u5206\u6ccc\u91cf\u7684\u591a\u5be1\u7531\u8166\u90e8\u7684\u4e0b\u8996\u4e18\u3001\u8166\u4e0b\u5782\u9ad4\u53ca\u814e\u4e0a\u817a\u76ae\u8cea\u5171\u540c\u63a7\u5236\u3002\u985e\u56fa\u9187\u8377\u723e\u8499\u7d93\u7531\u8840\u6db2\u50b3\u9001\u5168\u8eab\uff0c\u662f\u751f\u7269\u9ad4\u8abf\u7bc0\u91a3\u985e\u3001\u86cb\u767d\u8cea\u3001\u8102\u80aa\u3001\u6c34\u4efd\u3001\u96fb\u89e3\u8cea\u4e0d\u53ef\u6216\u7f3a\u7684\u91cd\u8981\u5143\u7d20\uff0c\u7576\u6211\u5011\u9047\u5371\u6025\u6216\u627f\u53d7\u58d3\u529b\u6642\uff0c\u814e\u4e0a\u817a\u7d20\u4e5f\u6703\u8fc5\u901f\u5206\u6ccc\u5927\u91cf\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u85c9\u6b64\u4f7f\u5fc3\u8df3\u52a0\u5feb\u3001\u6ce8\u610f\u529b\u589e\u5f37\uff0c\u4f86\u61c9\u4ed8\u5916\u5728\u74b0\u5883\u7684\u8b8a\u5316\u8207\u6311\u6230\u3002<\/p>\n<p>\u985e\u56fa\u9187\u8377\u723e\u8499\u7684\u5316\u5b78\u7d50\u69cb\u8207\u81bd\u56fa\u9187\u76f8\u4f3c\uff1b\u5305\u62ec\u4e00\u500b\u4ee5\u4e09\u500b\uf9d1\u78b3\u74b0\u53ca\u4e00\u500b\u4e94\u78b3\u74b0\u7d44\u6210\u7684\u56db\u74b0\u6838\u5fc3\u7d50\u69cb\u4e4b\u884d\u751f\u7269\u3002\u9ad4\u5167\u5408\u6210\u591a\u4ee5\u81bd\u56fa\u9187\u70ba\u539f\u6599\uff0c\u7d93\u904e\u4e00\u7cfb\u5217\u7684\u8abf\u63a7\u8207\u8f49\u5316\u6f14\u8b8a\u800c\u4f86\uff1b\u5373\u814e\u4e0a\u817a\u7d20\u7b49\u53ef\u751f\u6210\uf9d0\u56fa\u9187\u8377\u723e\u8499\u7684\u5668\u5b98\u85c9\u7531cyp11a1\u53cahsd3b\u7b49\u4e00\u7cfb\uf99c\uf967\u540c\u9175\u7d20\u9032\u884c\u50ac\u5316\uff0c\u5148\u7522\u751f\u5b55\u70ef\u9187\u916e(pregnenolone, P5)\uff0c\u518d\u63a5\u8457\u751f\u6210\u52a9\u5b55\u7d20(progesterone, P4)\u7b49\u4e2d\u9593\u7522\u7269\uff0c\u6700\u5f8c\u751f\u6210\u9e7d\u76ae\u8cea\u7d20(Mineralocorticoids)\u3001\ufa03\u76ae\u8cea\u7d20(Glucocorticoids)\u53ca\u6027\u8377\u723e\u8499\uff08Sex Hormones\uff09\u4e09\u7d44\u7522\u7269\u3002\u9e7d\u76ae\u8cea\u7d20\u548c\ufa03\u76ae\u8cea\u7d20\u5206\u5225\u638c\u63a7\u4eba\u9ad4\u9e7d\u4efd\u8207\u7cd6\u4efd\u4ee3\u8b1d\uff0c\u7f3a\u4e4f\u5c07\u640d\u53ca\u751f\u547d\uff1b\u6027\u8377\u723e\u8499\u5247\u53ef\u884d\u751f\u5404\u7a2e\u4e0d\u540c\u7684\u6027\u8377\u723e\u8499\uff0c\u4fc3\u4f7f\u7537\u5973\u4e0d\u540c\u6027\u5fb5\u7684\u8868\u73fe\uff0c\u90e8\u5206\u7814\u7a76\u8a8d\u70ba\u985e\u56fa\u9187\u8207\u6297\u58d3\u3001\u8001\u5316\u5747\u6709\u5bc6\u4e0d\u53ef\u5206\u7684\u95dc\u4fc2\uff0c\u9019\u4e9b\u90fd\u662f\u52d5\u7269\u9ad4\u5167\uf967\u53ef\u6216\u7f3a\u7684\u7269\u8cea\u3002<\/p>\n<p>\u937e\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u4e3b\u8981\u4ee5\u8001\u9f20\u53ca\u6591\u99ac\u9b5a\u70ba\u5be6\u9a57\u5c0d\u8c61\uff0c\u4ee5\u4e0d\u540c\u7684\u5be6\u9a57\u6a21\u5f0f\u8207\u5c64\u6b21\uff0c\u4f86\u4e86\u89e3\u985e\u56fa\u9187\u8377\u723e\u8499\u529f\u80fd\u8207\u8abf\u63a7\uff1a\u5979\u9996\u5148\u88fd\u9020\u51fa\u985e\u56fa\u9187\u8377\u723e\u8499\u5408\u6210\u6709\u7f3a\u9677\u7684\u5c0f\u8001\u9f20\uff0c\u7528\u4ee5\u63a2\u8a0e\u6240\u9020\u6210\u7684\u6162\u6027\u767c\u708e\u7684\u81f4\u75c5\u6a5f\u8f49\uff1b\u540c\u6642\u4e5f\u56e0\u70ba\u6591\u99ac\u9b5a\u7684\u4e00\u4e9b\u7279\u6027\u800c\u9078\u7528\u6591\u99ac\u9b5a\u505a\u70ba\u7814\u7a76\u5668\u5b98\u767c\u80b2\u8207\u985e\u56fa\u9187\u8377\u723e\u8499\u7684\u95dc\u4fc2\u3002<\/p>\n<p><strong>\u7a81\u8b8a\u9f20\u8b8a\u6210\u8349\u8393\u9f20<\/strong><\/p>\n<p>\u5be6\u9a57\u5718\u968a\u5148\u5c07\u5408\u6210\u985e\u56fa\u9187\u8377\u723e\u8499\u7684\u7b2c\u4e00\u500b\u9175\u7d20\u57fa\u56e0cyp11a1\u7834\u58de\uff0c\u5982\u6b64\u4e00\u4f86\u751f\u4e0b\u7684\u7a81\u8b8a\u9f20\uff0c\u5c07\u7121\u6cd5\u81ea\u884c\u88fd\u9020\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u9019\u4e9b\u8001\u9f20\u51fa\u73fe\u4e0d\u5c11\u96c4\u6027\u96cc\u6027\u5316\u7684\u75c5\u5fb5\uff1b\u5305\u62ec\u516c\u9f20\u7684\u5916\u6027\u5668\u5b98\u90fd\u50cf\u6bcd\u9f20\uff0c\u4e26\u6709\u4e73\u817a\u7684\u767c\u80b2\uff0c\u81f3\u65bc\u5167\u90e8\u6027\u5668\u5b98\uff0c\u5247\u6709\u776a\u4e38\u8207\u8f38\u7cbe\u7ba1\u7684\u9000\u5316\uff0c\u4ee5\u53ca\u524d\u5217\u817a\u8207\u8caf\u7cbe\u56ca\u672a\u5206\u5316\u7b49\u60c5\u5f62\uff0c\u5be6\u9a57\u986f\u793a\u51fa\u8001\u9f20\u7684\u96c4\u6027\u8377\u723e\u8499\u7684\u529f\u80fd\u51fa\u4e86\u554f\u984c\u3002\u7814\u7a76\u4eba\u54e1\u63a5\u8457\u7834\u58de\u8001\u9f20\u7684cyp11a1\u57fa\u56e0\u7684\u555f\u52d5\u5b50\uff0c\u767c\u73fe\u9019\u4e9b\u8001\u9f20\u6240\u7522\u751f\u7684cyp11a1\u6bd4\u6b63\u5e38\u9f20\u6e1b\u5c117\uff5e10\u500d\uff0c\u800c\u7260\u5011\u96d6\u7136\u5728\u4f11\u606f\u72c0\u614b\u53ef\u4ee5\u5206\u6ccc\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u4f46\u7576\u58d3\u529b\u4f86\u6642\uff0c\u537b\u7121\u6cd5\u50cf\u6b63\u5e38\u9f20\u4e00\u6a23\u7522\u751f\u5927\u91cf\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\u4f86\u61c9\u6025\uff0c\u5982\u540c\u8349\u8393\u65cf\u8001\u9f20\uff0c\u6b64\u5916\u4e00\u65e6\u906d\u5230\u7d30\u83cc\u611f\u67d3\uff0c\u767c\u708e\u6307\u6578\u4e0a\u5347\uff0c\u5bb9\u6613\u56e0\u53d7\u611f\u67d3\u800c\u6b7b\u4ea1\uff0c\u7576\u7136\u5982\u679c\u4ee5\u6ce8\u5c04\u65b9\u5f0f\u88dc\u5145\u7260\u5011\u6240\u7f3a\u4e4f\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u8001\u9f20\u4ecd\u7136\u53ef\u4ee5\u5b58\u6d3b\u3002<\/p>\n<p>\u9019\u9805\u5be6\u9a57\u7d50\u679c\u96d6\u7136\u8aaa\u660ecyp11a1\u57fa\u56e0\u5728\u5c0f\u9f20\u80da\u80ce\u767c\u80b2\u65e9\u671f\u626e\u6f14\u8abf\u63a7\u767c\u80b2\u7684\u91cd\u8981\u89d2\u8272\uff0c\u4f46\u56e0\u70ba\u80da\u80ce\u5728\u65e9\u671f\u5df2\u6b7b\u4ea1\uff0c\u56e0\u6b64\u7121\u6cd5\u9032\u4e00\u6b65\u5206\u6790cyp11a1\u57fa\u56e0\u5982\u4f55\u8abf\u63a7\u4e4b\u5f8c\u7684\u6027\u817a\u767c\u80b2\uff0c\u4ee5\u53cacyp11a1\u57fa\u56e0\u5230\u5e95\u662f\u900f\u904e\u4f55\u7a2e\u5206\u5b50\u6a5f\u5236\u800c\u9020\u6210\u80da\u80ce\u767c\u80b2\u7684\u7f3a\u9677\uff0c\u6b64\u5916\u4e0d\u8ad6\u662f\u8981\u5982\u4f55\u624d\u80fd\u6e05\u695a\u5730\u89c0\u5bdf\u6bcd\u9f20\u5b50\u5bae\u5167\u5c0f\u9f20\u7684\u80da\u80ce\u767c\u80b2\uff0c\u6216\u662f\u8b49\u660e\u8001\u9f20\u7684\u80da\u80ce\u7d30\u80de\u767c\u80b2\u6a5f\u5236\u80fd\u5426\u4ee3\u8868\u5305\u62ec\u4eba\u985e\u5728\u5167\u7684\u5176\u5b83\u54fa\u4e73\u52d5\u7269\u90fd\u80fd\u6709\u5f85\u5f8c\u7e8c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p><strong>\u80da\u80ce\u5167\u6697\u85cf\u7384\u6a5f<\/strong><\/p>\n<p>\u7d30\u80de\u79fb\u52d5\u662f\u6307\u7d30\u80de\u63a5\u6536\u5230\u9077\u79fb\u4fe1\u865f\u6216\u611f\u53d7\u5230\u67d0\u4e9b\u7269\u8cea\u7684\u6fc3\u5ea6\u68af\u5ea6\u800c\u7522\u751f\u7684\u79fb\u52d5\uff0c\u5b83\u662f\u810a\u690e\u52d5\u7269\u80da\u80ce\u767c\u80b2\u7684\u6838\u5fc3\u904e\u7a0b\u4e4b\u4e00\uff0c\u6b64\u5916\u7121\u8ad6\u662f\u795e\u7d93\u751f\u9577\u6216\u764c\u75c7\u8f49\u79fb\u4e5f\u8207\u7d30\u80de\u79fb\u52d5\u6709\u95dc\uff0c\u5176\u7368\u6709\u7684\u904b\u52d5\u7279\u6027\u88ab\u9810\u671f\u5728\u963b\u6b62\u764c\u75c7\u8f49\u79fb\u53ca\u7570\u9ad4\u690d\u76ae\u7b49\u91ab\u5b78\u61c9\u7528\u65b9\u9762\u5177\u6709\u7121\u7aae\u6f5b\u529b\uff0c\u4e5f\u6210\u70ba\u76ee\u524d\u751f\u7269\u91ab\u5b78\u7684\u71b1\u9580\u7814\u7a76\u65b9\u5411\u3002\u7d30\u80de\u79fb\u52d5\u5fc5\u9808\u4f9d\u9760\u5167\u5916\u56e0\u7d20\u7684\u914d\u5408\uff1b\u5167\u90e8\u56e0\u7d20\u6307\u7d30\u80de\u7684\u4fe1\u865f\u50b3\u5c0e\u7cfb\u7d71\u3001\u57f7\u884c\u904b\u52d5\u7684\u7d30\u80de\u9aa8\u67b6\u548c\u5206\u5b50\u99ac\u9054\u7b49\uff1b\u5916\u90e8\u56e0\u7d20\u5247\u6307\u662f\u7d30\u80de\u5916\u7684\u4fe1\u865f\u5206\u5b50\u3002\u96d6\u7136\u9ad4\u5916\u57f9\u990a\u7684\u7d30\u80de\u80fd\u5feb\u901f\u63d0\u4f9b\u90e8\u5206\u751f\u7269\u529f\u80fd\u7684\u8a0a\u606f\uff0c\u4f46\u85c9\u7531\u52d5\u7269\u6a21\u5f0f\u7684\u6d3b\u9ad4\u7814\u7a76\u624d\u662f\u5b8c\u6574\u7684\u7814\u7a76\u6a21\u5f0f\u3002\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u5c0f\u9f20\u662f\u54fa\u4e73\u52d5\u7269\u4e2d\u6700\u7406\u60f3\u7684\u6a21\u5f0f\u52d5\u7269\uff0c\u4f46\u53d7\u9650\u65bc\u9ad4\u5167\u53d7\u7cbe\u65b9\u5f0f\uff0c\u82e5\u8981\u5075\u6e2c\u67d0\u4e00\u57fa\u56e0\u5728\u80da\u80ce\u767c\u80b2\u5404\u968e\u6bb5\u7684\u60c5\u5f62\uff0c\u5247\u5fc5\u9808\u72a7\u7272\u8a72\u500b\u9ad4\u9032\u884c\u7d44\u7e54\u5207\u7247\u3002<\/p>\n<p>\u937e\u535a\u58eb\u5718\u968a\u9078\u7528\u6591\u99ac\u9b5a\u4f86\u7814\u7a76\u4e0d\u540c\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\u5982\u4f55\u5f71\u97ff\u7d30\u80de\u79fb\u52d5\uff0c\u5c0e\u81f4\u5c0d\u65bc\u80da\u80ce\u767c\u80b2\u7684\u5f71\u97ff\u3002\u6591\u99ac\u9b5a\u662f\u4e00\u7a2e\u5c0f\u578b\u6de1\u6c34\u9b5a\uff083~5\u516c\u5206\uff09\uff0c\u5c6c\u65bc\u810a\u690e\u52d5\u7269\uff0c\u7528\u5149\u5373\u53ef\u63a7\u5236\u7522\u5375\uff0c\u9ad4\u5916\u53d7\u7cbe\uff0c\u80da\u80ce\u6578\u91cf\u751a\u591a\uff0c\u80da\u80ce\u767c\u80b2\u4e0a\u7684\u6a5f\u5236\u8207\u54fa\u4e73\u52d5\u7269\u662f\u975e\u5e38\u76f8\u4f3c\uff0c\u8a31\u591a\u91cd\u8981\u7684\u8abf\u63a7\u86cb\u767d\u8cea\u7684\u8868\u73fe\u4f4d\u7f6e\u8207\u6642\u9593\u4e5f\u90fd\u8207\u54fa\u4e73\u52d5\u7269\u76f8\u4f3c\uff0c\u8fd1\u5341\u5e74\u4f86\u5df2\u6210\u70ba\u7814\u7a76\u810a\u690e\u52d5\u7269\u80da\u80ce\u767c\u80b2\u7684\u71b1\u9580\u6a21\u5f0f\u52d5\u7269\u3002\u7531\u65bc\u6591\u99ac\u9b5a\u80da\u80ce\u900f\u660e\u4e0d\u4f46\u53ef\u76f4\u63a5\u89c0\u5bdf\u53c8\u53ef\u4efb\u610f\u7a81\u8b8a\uff0c\u7121\u8ad6\u662f\u795e\u7d93\u3001\u808c\u8089\u3001\u6d88\u5316\u9053\u3001\u5fc3\u81df\u3001\u8840\u7ba1\u6216\u8840\u7403\u7684\u7814\u7a76\uff0c\u5747\u53ef\u5728\u53ef\u898b\u5149\u986f\u5fae\u93e1\u4e0b\u5bb9\u6613\u89c0\u5bdf\u767c\u80b2\u904e\u7a0b\uff0c\u6b64\u5916\uff0c\u53ef\u5229\u7528\u7da0\u8272\u87a2\u5149\u86cb\u767d\u7576\u5831\u5c0e\u57fa\u56e0\uff0c\u8f49\u6b96\u5230\u6591\u99ac\u9b5a\u7684\u53d7\u7cbe\u5375\u5167\uff0c\u7d93\u7be9\u9078\u3001\u57f9\u80b2\u53ca\u7e41\u6b96\uff0c\u5f97\u5230\u67d0\u4e00\u7d30\u80de\u3001\u7d44\u7e54\u6216\u5668\u5b98\u5177\u6709\u5c08\u4e00\u6027\u5e36\u6709\u87a2\u5149\u7684\u8f49\u6b96\u54c1\u7cfb\u3002<\/p>\n<p>\u6591\u99ac\u9b5a\u80da\u80ce\u7684\u65e9\u671f\u80da\u80ce\u767c\u80b2\u904e\u7a0b\u53ef\u5206\u70ba\u56db\u500b\u968e\u6bb5\u3002(\u4e00)\u5408\u5b50\u671f\uff1a\u7cbe\u5b50\u8207\uf91c\u5b50\u7d50\u5408\u5f8c\uff0c\u7d93\u904e\u534a\u5c0f\u6642\u7d30\u80de\u958b\u59cb\u5206\uf9a0\u3002(\u4e8c)\u5206\uf9a0\u671f\uff1a\u7d30\u80de\u6301\u7e8c\u5206\uf9a0\uff0c\u5728\u5206\uf9a0\u7b2c14\u6b21\u5f8c\u9032\u5165\u56ca\u80da(\u4e09)\u539f\u8178\u671f\uff1a\u7d30\u80de\u6703\u79fb\u52d5\u647a\u758a\uff0c\u5f62\u6210\u4e09\u500b\u80da\u5c64(\u5916\u80da\u5c64\u3001\u4e2d\u80da\u5c64\u3001\u5167\u80da\u5c64)\u3002(\u56db)\u9ad4\u7bc0\u5f62\u6210\u671f\uff1a\u5404\u7a2e\u5668\u5b98\u3001\u9ad4\u7bc0\u5f62\u6210\u3002\u800c\u6591\u99ac\u9b5a\u80da\u80ce\u7d30\u80de\u79fb\u52d5\u65b9\u5f0f\u5247\u6709\u62c9\u9577\u3001\u5167\u8f49\u3001\u805a\u5408\u53ca\u5916\u5305\u56db\u7a2e\u65b9\u5f0f\u3002\u7814\u7a76\u4eba\u54e1\u5229\u7528\u986f\u5fae\u6ce8\u5c04\uff0c\u5c07\u53cd\u7fa9\u55ce\u7433\u4ee3\u4f4e\u805a\u6838\u7518\u9178\uff08antisense morpholino oligonucleotide, MO\uff09\u9001\u5165\u80da\u80ce\u4e2d\uff0c\u5e72\u64fecyp11a1\u57fa\u56e0\u7684\u8868\u73fe\uff0cP5\u7684\u5408\u6210\uf965\u6d88\u5931\uff0c\u5fae\u7ba1\u7684\u805a\u5408\u4e5f\u76f8\u5c0d\u6e1b\u5c11\uff0c\u7dca\u63a5\u8457\u80da\u80ce\u7d30\u80de\u7684\u79fb\u52d5\u53d7\u5230\u5e72\u9810\uff0c\u80da\u80ce\u5f62\u614b\u56e0\u800c\u767c\u5c55\u7570\u5e38\uff0c\u800c\u9020\u6210\u80da\u80ce\u65e9\u671f\u7684\u6b7b\u4ea1\uff0c\u4e0d\u904e\u5982\u679c\u540c\u6642\u6ce8\u5c04MO\u5f8c\u52a0\u5165P5\uff0cMO\u6240\u9020\u6210\u7684\u73fe\u8c61\u5c07\u6703\u6709\u6240\u6539\u5584\u3002\u9019\u662f\u56e0\u70ba\u7d30\u80de\u9aa8\u67b6\u8ca0\u8cac\u652f\u6301\u7d30\u80de\u79fb\u52d5\uff0c\u5b83\u7684\u7d44\u6210\u5305\u62ec\u808c\u52d5\u86cb\u767d\u53ca\u5fae\u7ba1\uff0c\u5be6\u9a57\u767c\u73feP5\u53ef\u5e6b\u52a9\u7d30\u80de\u7684\u5916\u5305\u79fb\u52d5\uff0c\u5224\u65b7\u662fP5\u53ef\u7a69\u5b9a\u7d30\u80de\u9aa8\u67b6\u4e2d\u7684\u5fae\u7ba1\uff0c\u4ee5\u4fc3\u9032\u80da\u80ce\u7d30\u80de\u7684\u79fb\u52d5\u3002\u9019\u4e5f\u8aaa\u660e\u4e86\u767c\u80b2\u7684\u80da\u80ce\u4e2d\u542b\u6709\u5927\u91cf\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u800c\u985e\u56fa\u9187\u8377\u723e\u8499\u5c0d\u7d30\u80de\u7684\u79fb\u52d5\u901f\u5ea6\uff0c\u751a\u81f3\u80da\u80ce\u7684\u5f62\u72c0\u90fd\u6709\u5f88\u5927\u7684\u5f71\u97ff\uff0c\u82e5\u662f\u7f3a\u4e4f\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u4e0d\u4f46\u7d30\u80de\u79fb\u52d5\u6162\uff0c\u80da\u80ce\u767c\u5c55\u7684\u5f62\u72c0\u4e5f\u6703\u7570\u5e38\u3002<\/p>\n<p>\u9019\u9805\u7814\u7a76\u6210\u679c\u4e0d\u4f46\u63ed\u9732Pregnenolone\uff08P5\uff09\u6709\u4fc3\u9032\u7d30\u80de\u79fb\u52d5\u7684\u529f\u80fd\uff0c\u5c0d\u65bc\u80da\u80ce\u7684\u767c\u80b2\u3001\u795e\u7d93\u7d30\u80de\u7684\u4fdd\u8b77\u53ca\u764c\u7d30\u80de\u7684\u79fb\u52d5\u7686\u6709\u91cd\u8981\u610f\u7fa9\uff0c\u5be6\u9a57\u4e5f\u767c\u73fe\u88dc\u5145P5\uff0c\u53ef\u4f7f\u56e0MO\u9020\u6210\u7684\u5fae\u7ba1\u55aa\u5931\u91cd\u65b0\u56de\u5fa9\u4f86\u8b49\u660e\u5176\u5c08\u4e00\u6027\uff0c\u672a\u4f86\u5982\u80fd\u9032\u4e00\u6b65\u8b49\u660ecyp11a1\u57fa\u56e0\u5728\u8de8\u7269\u7a2e\u9593\u4fdd\u6709\u76f8\u540c\u7684\u8abf\u63a7\u6a5f\u5236\uff0c\u5c07\u53ef\u4ee5\u5e6b\u52a9\u85e5\u5ee0\u8a2d\u8a08\u85e5\u7269\u4f86\u63a7\u5236\u985e\u56fa\u9187\u8377\u723e\u8499\u7684\u529f\u80fd\u3002<\/p>\n<p>\u5728\u4eba\u985e\u57fa\u56e0\u7d44\u8a08\u5283\u5feb\u901f\u9032\u5c55\u7684\u4e8c\u5341\u4e00\u4e16\u7d00\uff0c\u751f\u7269\u91ab\u5b78\u7814\u7a76\u5df2\u9032\u5165\u4e86\u4e00\u500b\u524d\u6240\u672a\u6709\u7684\u65b0\u9818\u57df\uff0c\u800c\u5c0f\u9f20\u3001\u6591\u99ac\u9b5a\u3001\u679c\u8805\u53ca\u7dda\u87f2\u7b49\u6a21\u5f0f\u751f\u7269\u7684\u57fa\u56e0\u7d44\u8a08\u5283\u4e5f\u6b63\u540c\u6b65\u9032\u884c\u4e2d\uff0c\u9810\u671f\u5c07\u4eba\u985e\u57fa\u56e0\u5e8f\u5217\u8207\u5404\u7a2e\u52d5\u7269\u6a21\u5f0f\u7684\u57fa\u56e0\u5e8f\u5217\u6bd4\u5c0d\u5f8c\uff0c\u53ef\u52a0\u901f\u89e3\u958b\u4eba\u985e\u57fa\u56e0\u529f\u80fd\u4e4b\u8b0e\uff0c\u800c\u70ba\u4e86\u4eba\u985e\u5065\u5eb7\u798f\u7949\uff0c\u8de8\u570b\u8de8\u5b78\u79d1\u7684\u79d1\u5b78\u5bb6\u83ab\u4e0d\u70ba\u6b64\u9f4a\u5fc3\u52aa\u529b\u3002<br \/>\n--<\/p>\n<p><span style=\"color: #333333;\">\u672c\u6587\u6574\u7406\u81ea\uff1a100\/11\/19\u4e0b\u5348\u7531\u937e\u90a6\u67f1\u7814\u7a76\u54e1\u5728\u81fa\u5927\u61c9\u529b\u6240\u570b\u969b\u6f14\u8b1b\u5ef3\u6240\u4e3b\u8b1b\u4e4b\u300c\u7b2c\u516d\u671f\u63a2\u7d22\u8b1b\u5ea7\u300a\u5316\u5b78\u5927\u672a\u4f86\u300b\u8377\u723e\u8499\u8207\u5065\u5eb7\u300d\u7684\u6f14\u8b1b\u5167\u5bb9 <\/span><\/p>\n<p><span style=\"color: #333333;\">\u5ef6\u4f38\u95b1\u8b80\uff1a\u53f0\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3\u63a2\u7d22\u57fa\u790e\u79d1\u5b78\u8b1b\u5ea72011\u5e7411\u670819\u65e5\u7b2c\u4e03\u8b1b\u3008\u8377\u723e\u8499\u8207\u5065\u5eb7\u3009<\/span><a href=\"https:\/\/case.ntu.edu.tw\/CASTUDIO\/course.php?speech_ID=2783#video_top\" target=\"_blank\"><span style=\"color: #333333;\">\u5168\u7a0b\u5f71\u97f3<\/span><\/a><\/p>\n<p>\ufe5d\u672c\u6587\u4f5c\u8005\u7562\u696d\u65bc\u6de1\u6c5f\u5927\u5b78\u5316\u5b78\u7814\u7a76\u6240\uff0c\u73fe\u5f9e\u4e8b\u6d88\u8cbb\u54c1\u6aa2\u6e2c\u9818\u57df\ufe5e<br \/>\n<strong> <span style=\"color: #333399;\"><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita Hsu<\/strong><\/span><\/strong><\/p>\n<p><strong><span style=\"color: #333399;\"><strong><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=10503\" rel=\"attachment wp-att-10503\"><img decoding=\"async\" class=\"alignleft size-full wp-image-10503\" title=\"\u985e\u56fa\u9187\u8377\u723e\u8499\u2014\u2014\u751f\u547d\u7684\u9a45\u52d5\u7a0b\u5f0f\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/12\/\u985e\u56fa\u9187\u8377\u723e\u8499\u2014\u2014\u751f\u547d\u7684\u9a45\u52d5\u7a0b\u5f0f.png\" alt=\"\" width=\"140\" height=\"140\"><\/a><br \/>\n<\/strong><\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u79d1\u5b78\u7684\u57fa\u790e\u662f\u5065\u5eb7\u7684\u8eab\u9ad4\u3002-----\u5c45\u91cc<\/p>\n","protected":false},"author":1,"featured_media":10327,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,730],"tags":[2249,2248,482],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/12\/128899453.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10326"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10326"}],"version-history":[{"count":9,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10326\/revisions"}],"predecessor-version":[{"id":26408,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10326\/revisions\/26408"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/10327"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}