{"id":10145,"date":"2011-11-01T14:47:55","date_gmt":"2011-11-01T06:47:55","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=10145"},"modified":"2017-03-31T23:20:37","modified_gmt":"2017-03-31T15:20:37","slug":"%e3%80%90%e9%86%ab%e5%ad%b8%e7%a0%94%e7%a9%b6%e3%80%91%e8%97%a5%e5%93%81%e7%9f%ad%e7%bc%ba%e6%8b%96%e7%b4%af%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=10145","title":{"rendered":"\u3010\u91ab\u5b78\u7814\u7a76\u3011\u85e5\u54c1\u77ed\u7f3a\u62d6\u7d2f\u81e8\u5e8a\u8a66\u9a57"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong><strong>\u25a0<\/strong><\/strong><\/span><strong><span style=\"color: #333399;\">\u7531\u65bc\u5e73\u5e38\u4f7f\u7528\u7684\u5316\u7642\u7528\u85e5\u5230\u8655\u7f3a\u8ca8\uff0c\u65b0\u7684\u764c\u75c7\u7642\u6cd5\u81e8\u5e8a\u8a66\u9a57\u6b63\u9762\u81e8\u9752\u9ec3\u4e0d\u63a5\u7684\u7a98\u5883\u3002<\/span><\/strong><\/p>\n<figure id=\"attachment_10146\" aria-describedby=\"caption-attachment-10146\" style=\"width: 260px\" class=\"wp-caption alignleft\"><a rel=\"attachment wp-att-10146\" href=\"http:\/\/case.ntu.edu.tw\/blog\/?attachment_id=10146\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-10146\" title=\"news570-i1.0\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2011\/11\/news570-i1.0.jpg\" alt=\"\" width=\"260\" height=\"260\" \/><\/a><figcaption id=\"caption-attachment-10146\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1aCOLIN CUTHBERT\/SPL<\/figcaption><\/figure>\n<p><strong>\u7de8\u8b6f<\/strong> | \u9ad8\u82f1\u54f2<strong><\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u5c31\u62ff\u4e73\u764c\u81e8\u5e8a\u8a66\u9a57 I-SPY 2 \u4f86\u8aaa\u5427\uff0c\u9019\u9805\u5099\u53d7\u77da\u76ee\u7684\u5be6\u9a57\uff0c\u5176\u76ee\u7684\u662f\u6e2c\u8a66\u67d0\u4e9b\u5206\u5b50\u6a19\u8a18\u5982\u4f55\u5c0e\u5f15\u764c\u75c7\u7642\u6cd5\uff0c\u597d\u8b93\u7814\u7a76\u8005\u80fd\u5c07\u7814\u7a76\u6d41\u7a0b\uff0c\u61c9\u7528\u5728\u65e9\u671f\u6aa2\u9a57\u7d50\u679c\u7684\u53ca\u6642\u53cd\u61c9\u4e0a\u3002\u4e0d\u904e\u4e3b\u6301\u9019\u9805\u7814\u7a76\u8a08\u756b\u7684\u52a0\u5dde\u5927\u5b78\u820a\u91d1\u5c71\u5206\u6821\u816b\u7624\u5b78\u5bb6\u827e\u745f\u8513 (Laura Esserman) \uff0c\u537b\u767c\u73fe\u8981\u9069\u61c9\u85e5\u7269\u77ed\u7f3a\u7684\u73fe\u8c61\uff0c\u662f\u6108\u4f86\u6108\u8271\u96e3\u4e86\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u70ba\u4e86\u56e0\u61c9\u7528\u4e86\u5e7e\u5341\u5e74\u7684\u5316\u7642\u820a\u85e5\u827e\u9ef4\u7d20 (doxorubicin) \uff0c\u56e0\u751f\u7522\u4e0d\u53ca\u8207\u9700\u6c42\u589e\u52a0\u800c\u77ed\u7f3a\u7684\u72c0\u6cc1\uff0c\u827e\u745f\u8513\u7684\u7814\u7a76\u5718\u968a\u63db\u7528\u6cdb\u827e\u9ef4\u7d20 (epirubicin) \u3002\u7136\u800c\u7576\u6c70\u764c\u52dd (paclitaxel) \u7684\u4f9b\u7d66\u4e5f\u51fa\u4e86\u554f\u984c\u6642\uff0c\u8981\u627e\u5230\u66ff\u4ee3\u54c1\u5c31\u986f\u5f97\u6bd4\u8f03\u56f0\u96e3\u4e86\u3002\u5408\u7406\u7684\u66ff\u4ee3\u65b9\u6848\u662f\u4f7f\u7528\u4e00\u7a2e\u53eb\u505a\u7d2b\u6749\u9187 (abraxane) \u7684\u85e5\u7269\uff0c\u4f46\u662f\u537b\u6c92\u6709\u8db3\u5920\u7684\u8cc7\u6599\u8db3\u4ee5\u8b49\u660e\uff0c\u628a\u7d2b\u6749\u9187\u8ddf\u5176\u4ed6\u81e8\u5e8a\u8a66\u9a57\u4e2d\u6240\u7528\u7684\u85e5\u7269\u6df7\u7528\u5b89\u5168\u7121\u865e\u3002\u56e0\u6b64\u827e\u745f\u8513\u7684\u7814\u7a76\u5718\u968a\u8f49\u800c\u9f13\u52f5\u9032\u884c\u81e8\u5e8a\u8a66\u9a57\u7684\u90a3\u4e9b\u91ab\u9662\uff0c\u5728\u672a\u5217\u5165 I-SPY 2 \u8a66\u9a57\u540d\u55ae\u4e2d\u7684\u75c5\u4eba\u8eab\u4e0a\u4f7f\u7528\u7d2b\u6749\u9187\uff0c\u4ee5\u4fbf\u7559\u4e0b\u66f4\u591a\u6709\u9650\u7684\u6c70\u764c\u52dd\u85e5\u54c1\uff0c\u7d66\u8a66\u9a57\u75c5\u4eba\u4f7f\u7528\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u6839\u64da\u7f8e\u570b\u7336\u4ed6\u5927\u5b78\u7684\u85e5\u7269\u8cc7\u8a0a\u670d\u52d9\u7cfb\u7d71\u6307\u51fa\uff0c\u5230\u4eca\u5e74\u516b\u6708\u5e95\u70ba\u6b62\uff0c\u7f8e\u570b\u5df2\u6709\u4e00\u767e\u4e5d\u5341\u516b\u7a2e\u85e5\u7269\u77ed\u7f3a\uff0c\u5176\u4e2d\u6709\u5341\u4e94\u7a2e\u662f\u764c\u75c7\u81e8\u5e8a\u7814\u7a76\u7528\u85e5\u3002\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3 (NCI) \u8d0a\u52a9\u7684\u4e00\u767e\u4e94\u5341\u591a\u9805\u8a66\u9a57\uff0c\u90fd\u6709\u7528\u5230\u77ed\u7f3a\u7684\u85e5\u7269\u3002\u7f8e\u570b\u764c\u75c7\u5408\u4f5c\u5718\u9ad4\u806f\u76df\u4e3b\u5e2d\u67ef\u5bc6\u65af (Robert Comis) \u8868\u793a\uff0c\u5982\u679c\u764c\u75c7\u7814\u7a76\u6709\u4ec0\u9ebc\u5168\u570b\u7dca\u6025\u72c0\u6cc1\u7684\u8a71\uff0c\u73fe\u5728\u5c31\u662f\u4e86\u3002<!--more--><\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u7f8e\u570b\u85e5\u7269\u77ed\u7f3a\u7684\u73fe\u8c61\uff0c\u5f9e\u4e8c\u3007\u3007\u4e03\u5e74\u958b\u59cb\u5c31\u4e0d\u65b7\u5728\u589e\u9577\uff0c\u8d77\u56e0\u6709\u5b78\u540d\u85e5\u88fd\u9020\u5546\u7acb\u8db3\u5df2\u7a69\uff0c\u91ab\u9662\u8207\u6279\u767c\u5546\u4f9d\u64da\u9700\u6c42\u800c\u4e0d\u662f\u5b58\u8ca8\u591a\u5be1\u4f86\u4e0b\u8a02\u55ae\uff0c\u4ee5\u53ca\u8a31\u591a\u751f\u7522\u9762\u4e0a\u7684\u554f\u984c\uff0c\u5f9e\u9ef4\u83cc\u6c61\u67d3\u5230\u6ce8\u5c04\u6db2\u88e1\u51fa\u73fe\u73bb\u7483\u9846\u7c92\u90fd\u6709\u3002\u4eca\u5e74\u9084\u6709\u56db\u5206\u4e4b\u4e00\u8981\u904e\uff0c\u800c\u85e5\u7269\u77ed\u7f3a\u7684\u72c0\u6cc1\uff0c\u5df2\u7d93\u903c\u8fd1\u4e8c\u3007\u4e00\u3007\u5e74\u7684\u7e3d\u6578\u5169\u767e\u4e00\u5341\u4e00\u7a2e\uff0c\u5404\u91ab\u9662\u4e0d\u5f97\u4e0d\u958b\u59cb\u9650\u984d\u914d\u7d66\u92b3\u6e1b\u7684\u85e5\u7269\u5b58\u91cf\u3002\u54c8\u4f5b\u91ab\u5b78\u9662\u816b\u7624\u5b78\u5bb6\u4e18\u4f0a (Edwin Choy) \u8868\u793a\uff0c\u4ed6\u5fc5\u9808\u628a\u5c0d\u67d0\u7a2e\u85e5\u7269\u53cd\u61c9\u4e0d\u932f\u7684\u75c5\u4eba\uff0c\u8f49\u5230\u53e6\u4e00\u500b\u7642\u7a0b\u53bb\uff0c\u800c\u6709\u6642\u4ed6\u5011\u7684\u764c\u75c7\u5c31\u5728\u8f49\u63db\u7642\u7a0b\u5f8c\u5fa9\u767c\uff0c\u5be6\u5728\u5f88\u7cdf\u7cd5\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u96d6\u7136\u53d7\u5230\u77ed\u7f3a\u5f71\u97ff\u7684\u85e5\u7269\uff0c\u5927\u591a\u662f\u820a\u6b3e\u5b78\u540d\u85e5\uff0c\u4e0d\u904e\u81e8\u5e8a\u8a66\u9a57\u7528\u7684\u7d93\u5e38\u9084\u662f\u9019\u4e9b\u57fa\u672c\u7528\u85e5\uff0c\u4e0d\u662f\u7528\u4f86\u7576\u63a7\u5236\u7d44\uff0c\u5c31\u662f\u8ddf\u5be6\u9a57\u6027\u85e5\u7269\u5408\u7528\uff0c\u5176\u4e2d\u5305\u62ec\u8a31\u591a\u4eba\u5bc4\u671b\u80fd\u5920\u70ba\u764c\u75c7\u6cbb\u7642\u5e36\u4f86\u9769\u547d\u6027\u8f49\u8b8a\uff0c\u91dd\u5c0d\u907a\u50b3\u6027\u958b\u767c\u7684\u85e5\u7269\u3002\u764c\u75c7\u5408\u4f5c\u5718\u9ad4\u806f\u76df\u57f7\u884c\u9867\u554f\u67ef\u8cf4\u7dba (Diane Colaizzi) \u8868\u793a\uff0c\u7531\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u6574\u5408\u8af8\u591a\u5730\u9ede\u7684\u764c\u75c7\u7814\u7a76\u8005\uff0c\u9032\u884c\u5927\u578b\u81e8\u5e8a\u8a66\u9a57\u7684\u5408\u4f5c\u5718\u9ad4\u7814\u7a76\u8005\uff0c\u9664\u975e\u4ed6\u5011\u80fd\u5920\u78ba\u4fdd\u75c5\u4eba\u80fd\u5920\u5b8c\u6210\u7642\u7a0b\uff0c\u4e0d\u7136\u4e00\u822c\u4f86\u8aaa\u4e26\u4e0d\u6703\u8b93\u65b0\u75c5\u4eba\u52a0\u5165\u8a66\u9a57\u3002\u5979\u8aaa\u4e00\u65e6\u7642\u7a0b\u958b\u59cb\u9032\u884c\uff0c\u4ed6\u5011\u5c31\u4e0d\u60f3\u8981\u9020\u6210\u5e72\u64fe\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u7d50\u679c\u5462\uff0c\u672c\u4f86\u5c31\u7d93\u5e38\u662f\u4e00\u6bb5\u6f2b\u6f2b\u9577\u8def\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u5c31\u6b64\u560e\u7136\u505c\u64fa\u3002\u6709\u4e00\u9805\u5c07\u91dd\u5c0d\u8207\u611b\u6ecb\u75c5\u6709\u95dc\uff0c\u5361\u6ce2\u897f\u6c0f\u8089\u7624\u7684\u96de\u5c3e\u9152\u7642\u6cd5\u7528\u85e5\uff0c\u8207\u5316\u7642\u76f8\u7d50\u5408\u7684\u8a66\u9a57\uff0c\u9810\u6599\u8d77\u78bc\u8981\u505c\u64fa\u4e00\u5e74\u3002\u7d10\u6fa4\u897f\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u816b\u7624\u5b78\u5bb6\u8fea\u6ce2\u62c9 (Robert Dipaola) \u4e5f\u8868\u793a\uff0c\u6709\u4e00\u9805\u764c\u75c7\u8a66\u9a57\u662f\u8981\u6e2c\u8a66\u4e00\u7a2e\u7a31\u70ba PARP \uff0c\u53ef\u4ee5\u4fee\u5fa9 DNA \u7684\u86cb\u767d\u8cea\u9175\u7d20\u6291\u5236\u56e0\u5b50\uff0c\u827e\u9ef4\u7d20\u77ed\u7f3a\u9020\u6210\u9019\u9805\u8a66\u9a57\u5ef6\u8aa4\u9054\u4e94\u500b\u6708\u4e4b\u4e45\u3002\u4ed6\u8aaa\u764c\u75c7\u7814\u7a76\u8005\u9762\u81e8\u7e2e\u77ed\u9032\u884c\u81e8\u5e8a\u8a66\u9a57\u6240\u9700\u6642\u9593\u7684\u58d3\u529b\uff0c\u5728\u9019\u7a2e\u60c5\u6cc1\u4e0b\u78b0\u4e0a\u85e5\u7269\u77ed\u7f3a\uff0c\u7279\u5225\u8b93\u4eba\u53d7\u4e0d\u4e86\u3002<\/p>\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\u67ef\u8cf4\u7dba\u4e5f\u63d0\u5230\uff0c\u81e8\u5e8a\u8a66\u9a57\u8005\u4e26\u4e0d\u662f\u6c38\u9060\u90fd\u80fd\u50cf\u827e\u745f\u8513\u5728 I-SPY 2 \u5be6\u9a57\u6240\u505a\u7684\u90a3\u6a23\uff0c\u7528\u66ff\u4ee3\u85e5\u7269\u4fee\u8a02\u8a66\u9a57\u6d41\u7a0b\uff0c\u5c24\u5176\u662f\u7576\u8a66\u9a57\u6703\u9001\u5230\u7f8e\u570b\u98df\u54c1\u8207\u85e5\u7269\u7ba1\u5236\u5c40\uff0c\u5145\u7576\u85e5\u7269\u6838\u53ef\u7533\u8acb\u7684\u4e00\u90e8\u4efd\u6642\u3002\u8ca0\u8cac\u7f8e\u570b\u66fc\u6590\u65af\u8056\u7336\u9054\u5152\u7ae5\u7814\u7a76\u91ab\u9662\u7528\u85e5\u5b89\u5168\u7684\u970d\u592b\u66fc (James Hoffman) \u8868\u793a\uff0c\u5373\u4fbf\u53ef\u4ee5\u9019\u9ebc\u505a\uff0c\u7814\u7a76\u8005\u4e5f\u4e0d\u662f\u6c38\u9060\u90fd\u77e5\u9053\uff0c\u8a72\u5982\u4f55\u89e3\u8b80\u534a\u9014\u8b8a\u66f4\u6d41\u7a0b\u7684\u8a66\u9a57\u8cc7\u6599\u3002\u4ed6\u8aaa\u7531\u65bc\u4ec0\u9ebc\u90fd\u8b8a\u4e86\uff0c\u5206\u6790\u8d77\u4f86\u80af\u5b9a\u9817\u6709\u6311\u6230\u6027\u3002<\/p>\n<pre><span style=\"color: #333333;\"> \u7814\u7a76\u51fa\u8655\uff1a<strong><a href=\"http:\/\/www.nature.com\/news\/2011\/111003\/full\/news.2011.570.html\">http:\/\/www.nature.com\/news\/2011\/111003\/full\/news.2011.570.html<\/a><\/strong><\/span><\/pre>\n<p><span style=\"color: #333399;\"><strong>\u8cac\u4efb\u7de8\u8f2f\uff1aNita Hsu<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25a0\u7531\u65bc\u5e73\u5e38\u4f7f\u7528\u7684\u5316\u7642\u7528\u85e5\u5230\u8655\u7f3a\u8ca8\uff0c\u65b0\u7684\u764c<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[27],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10145"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10145"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10145\/revisions"}],"predecessor-version":[{"id":10173,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/10145\/revisions\/10173"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}